Abstract:
:The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model of allergic contact dermatitis and to evaluate the effects of steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) on DC migration through skin in the elicitation phase of allergic contact dermatitis. Topically and systemically administered acetylsalicylic acid (ASA) did not reduce the inflammatory response. However, systemically administered ASA significantly reduced the DC migration to the draining lymph node. In contrast, topically administered indomethacin reduced the inflammatory response, but had only minor effects on DC migration, whereas diflorasone diacetate reduced both inflammatory reaction and DC migration. Thus, NSAIDs may differ in their inhibitory action in immunological inflammation.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Bäumer W,Krekeler S,DeVries VC,Niedorf F,Tschernig T,Kietzmann Mdoi
10.1111/j.0906-6705.2006.00412.xsubject
Has Abstractpub_date
2006-04-01 00:00:00pages
322-9issue
4eissn
0906-6705issn
1600-0625pii
EXD412journal_volume
15pub_type
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