Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases.

Abstract:

:Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to determine serum BAFF levels and relate the results to the clinical features in patients with organ-specific autoimmune diseases of the skin, such as localized scleroderma and autoimmune bullous diseases. Serum BAFF levels were examined by enzyme-linked immunosorbent assay in 44 patients with localized scleroderma, 20 with pemphigus vulgaris/pemphigus foliaceus, 20 with bullous pemphigoid and 30 healthy controls. Twenty patients with SSc and 20 with SLE were also examined as disease controls. Serum BAFF levels were elevated in localized scleroderma patients compared with healthy controls. Concerning localized scleroderma subgroups, patients with generalized morphea, the severest form of localized scleroderma, had higher serum BAFF levels than linear scleroderma or morphea patients. The BAFF levels of generalized morphea were comparable with those of SSc or SLE. Furthermore, serum BAFF levels correlated positively with antihistone antibody levels and the severity of skin lesion as well as the number of skin lesions. By contrast, serum BAFF levels were not significantly elevated in patients with pemphigus or pemphigoid. These results suggest that BAFF may be contributing to autoimmunity and disease development in localized scleroderma.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato S

doi

10.1111/j.1600-0625.2006.00485.x

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

87-93

issue

2

eissn

0906-6705

issn

1600-0625

pii

EXD485

journal_volume

16

pub_type

杂志文章
  • Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.

    abstract::Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression incr...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/exd.12568

    authors: Lessard JC,Kalinin A,Bible PW,Morasso MI

    更新日期:2015-01-01 00:00:00

  • Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production.

    abstract::This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. Alpha-melanocyte-stimulating hormone, which had no effect on mel...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/j.1600-0625.2010.01098.x

    authors: Masoodi M,Nicolaou A,Gledhill K,Rhodes LE,Tobin DJ,Thody AJ

    更新日期:2010-08-01 00:00:00

  • Effect of skin barrier competence on SLS and water-induced IL-1alpha expression.

    abstract::For screening of a potential irritant it is essential that an early marker for irritation should be chosen which could be detected before the physiological signs of irritation occur. Interleukin 1 alpha (IL-1alpha) is widely accepted as such a marker in both in vivo and in vitro test systems. In this study, we have de...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0625.2001.110304.x

    authors: Gibbs S,Vietsch H,Meier U,Ponec M

    更新日期:2002-06-01 00:00:00

  • Non-steroidal and steroidal anti-inflammatory drugs vary in their modulation of dendritic cell function in the elicitation phase of allergic contact dermatitis.

    abstract::The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.0906-6705.2006.00412.x

    authors: Bäumer W,Krekeler S,DeVries VC,Niedorf F,Tschernig T,Kietzmann M

    更新日期:2006-04-01 00:00:00

  • Molecular and cellular basis of depigmentation in vitiligo patients.

    abstract::Vitiligo is a chronic skin disease characterized by the appearance of zones of depigmentation. It is mostly described as an autoimmune disease in which the immune system destroys the melanocytes. Consistent with this origin, genetic studies have implicated genes encoding proteins mediating the immune response targetin...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/exd.13858

    authors: Delmas V,Larue L

    更新日期:2019-06-01 00:00:00

  • Enzymes involved in the conversion of arachidonic acid to eicosanoids in the skin of atopic dogs.

    abstract::Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/j.1600-0625.2009.01037.x

    authors: Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

    更新日期:2010-08-01 00:00:00

  • The single-chain anti-TNF-α antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis.

    abstract::It is not clear whether TNF-α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin-produced TNF-α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double-blinded, randomized, placebo-controlled clinical tria...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/exd.12927

    authors: Tsianakas A,Brunner PM,Ghoreschi K,Berger C,Loser K,Röcken M,Stingl G,Luger T,Jung T

    更新日期:2016-06-01 00:00:00

  • Involvement of changes in stratum corneum keratin in wrinkle formation by chronic ultraviolet irradiation in hairless mice.

    abstract::Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0625.12.s2.4.x

    authors: Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

    更新日期:2003-01-01 00:00:00

  • Hair growth-promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β-catenin and MAPK pathway.

    abstract::Electrical stimulation is being used in variable skin therapeutic conditions. There have been clinical studies demonstrating the positive effect of electrical stimuli on hair regrowth. However, the underlying exact mechanism and optimal parameter settings are not clarified yet. To investigate the effects of different ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/exd.12827

    authors: Sohn KM,Jeong KH,Kim JE,Park YM,Kang H

    更新日期:2015-12-01 00:00:00

  • Shprintzen-Goldberg syndrome associated with a novel missense mutation in TGFBR2.

    abstract::Shprintzen-Goldberg syndrome (SGS) is a rare disorder characterized by a Marfan-like habitus, mental retardation and craniosynostosis. Cardiac abnormalities, such as aortic root dilation have also been noted as well as several skeletal abnormalities. Its nosological status is unclear as it is hard to delineate SGS fro...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0625.2007.00648.x

    authors: van Steensel MA,van Geel M,Parren LJ,Schrander-Stumpel CT,Marcus-Soekarman D

    更新日期:2008-04-01 00:00:00

  • Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris.

    abstract::The potentially severe side effects of systemic corticosteroids and immunosuppressants used in Pemphigus vulgaris (PV) call for novel therapeutic approaches. In this context, pharmacological inhibition of major pathogenic signalling effectors represents a promising alternative. However, we have also shown that overinh...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/exd.13458

    authors: Hariton WVJ,Galichet A,Vanden Berghe T,Overmiller AM,Mahoney MG,Declercq W,Müller EJ

    更新日期:2017-12-01 00:00:00

  • Possible involvement of epidermodysplasia verruciformis human papillomaviruses in the immunopathogenesis of psoriasis: a proposed hypothesis.

    abstract::We have shown previously in psoriasis a very high prevalence of epidermodysplasia verruciforms-associated human papillomavirus 5 (EVHPV5) DNA and antibodies to human papillomavirus 5 (HPV5) virus-like particle (VLP) L1, and we suggested that this benign hyperproliferative disorder could be a reservoir for EVHPVs. Here...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.0906-6705.2003.00125.x

    authors: Majewski S,Jablonska S

    更新日期:2003-12-01 00:00:00

  • In vivo reflectance confocal microscopy of erythematosquamous skin diseases.

    abstract:BACKGROUND:In vivo reflectance confocal microscopy (RCM) represents a promising imaging tool that allows a non-invasive examination of skin morphology in real time at nearly histological resolution, showing microanatomical structures and individual cells. OBJECTIVES:The aim of our study was to evaluate the diagnostic ...

    journal_title:Experimental dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0625.2008.00822.x

    authors: Koller S,Gerger A,Ahlgrimm-Siess V,Weger W,Smolle J,Hofmann-Wellenhof R

    更新日期:2009-06-01 00:00:00

  • Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas.

    abstract::Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/j.1600-0625.2010.01139.x

    authors: Flohil SC,de Vries E,van Meurs JB,Fang Y,Stricker BH,Uitterlinden AG,Nijsten T

    更新日期:2010-12-01 00:00:00

  • In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.

    abstract::The anti-inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. They seem particularly related to the modulation of the non-specific immunity. Recent studies have shown that Toll-like receptor (TLR)-2 expression, a receptor of the innate immune sys...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0625.2007.00552.x

    authors: Tenaud I,Khammari A,Dreno B

    更新日期:2007-06-01 00:00:00

  • The antihistamines clemastine and desloratadine inhibit STAT3 and c-Myc activities and induce apoptosis in cutaneous T-cell lymphoma cell lines.

    abstract::Mycosis fungoides and its leukaemic counterpart Sézary syndrome are the most frequent cutaneous T-cell lymphomas (CTCL), and there is no cure for these diseases. We evaluated the effect of clinically approved antihistamines on the growth of CTCL cell lines. CTCL cell lines as well as blood lymphocytes from patients wi...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/exd.12086

    authors: Döbbeling U,Waeckerle-Men Y,Zabel F,Graf N,Kündig TM,Johansen P

    更新日期:2013-02-01 00:00:00

  • Filaggrin compound heterozygous patients carry mutations in trans position.

    abstract::More than 40 null mutations in the filaggrin (FLG) gene are described. It is therefore possible to find two different null mutations in one individual (compound heterozygosity). It has been generally perceived that homozygous and compound heterozygous individuals were genotypically comparable; however, this has not be...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/exd.12199

    authors: Carlsen BC,Meldgaard M,Johansen JD,Thyssen JP,Menné T,Szecsi PB,Stender S

    更新日期:2013-09-01 00:00:00

  • Sebaceous gland: Milestones of 30-year modelling research dedicated to the "brain of the skin".

    abstract::In 2018, Schneider and Zouboulis analysed the available tools for studying sebaceous gland pathophysiology in vitro. Since then, the interest in this field remains unbroken, as demonstrated by recent reviews on sebaceous gland physiology, endocrinology and neurobiology, the role of sebaceous glands beyond acne, and se...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/exd.14184

    authors: Zouboulis CC,Yoshida GJ,Wu Y,Xia L,Schneider MR

    更新日期:2020-09-02 00:00:00

  • Lesional Th17 cells and regulatory T cells in bullous pemphigoid.

    abstract::Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations ...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/j.1600-0625.2011.01378.x

    authors: Arakawa M,Dainichi T,Ishii N,Hamada T,Karashima T,Nakama T,Yasumoto S,Tsuruta D,Hashimoto T

    更新日期:2011-12-01 00:00:00

  • Inhibition of keratin 17 expression with antisense and RNAi strategies: exploring novel therapy for psoriasis.

    abstract::Psoriasis is now considered to be a chronic, immune-mediated and inflammatory skin disease. As the precise cause of psoriasis remains unknown, its treatment is challenging for dermatologists. Keratin 17 (K17), an intermediate filament protein, is highly expressed in psoriatic lesions, while not normally expressed in h...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0625.2010.01235.x

    authors: Chang T,Sun L,Wang Y,Wang D,Li W,Li C,Gao T,Liu Y,Wang G

    更新日期:2011-07-01 00:00:00

  • Quantifying activity: a new assay reveals T-cell signalling in tiny skin biopsy samples.

    abstract::Tissue-invasive T cells are observed in many inflammatory dermatological diseases, but in most cases, it is not known how they were attracted, what they might recognize, and to which extent they are activated. Answering these questions is surely essential for understanding pathogeneses of the diseases. In a recent iss...

    journal_title:Experimental dermatology

    pub_type: 评论,杂志文章

    doi:10.1111/exd.12387

    authors: Dornmair K

    更新日期:2014-06-01 00:00:00

  • Leishmaniasis, contact hypersensitivity and graft-versus-host disease: understanding the role of dendritic cell subsets in balancing skin immunity and tolerance.

    abstract::Dendritic cells (DC) are key elements of the immune system. In peripheral tissues, they function as sentinels taking up and processing antigens. After migration to the draining lymph nodes, the DC either present antigenic peptides by themselves or transfer them to lymph node-resident DC. The skin is the primary interf...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0625.2010.01116.x

    authors: Kautz-Neu K,Meyer RG,Clausen BE,von Stebut E

    更新日期:2010-08-01 00:00:00

  • The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes.

    abstract::Keratinocytes (KCs) play a critical role in maintaining the cutaneous structure and are involved in various physiological and pathologic processes of the skin. Many inflammatory skin diseases and skin cancers result from excessive proliferation and insufficient apoptosis of KCs. Recent data suggested that the sonic he...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/exd.12556

    authors: Liu H,Jian Q,Xue K,Ma C,Xie F,Wang R,Liao W,Liu Y,Chi S,Li C

    更新日期:2014-12-01 00:00:00

  • Suppression of UV-induced damage by a liposomal sunscreen: a prospective, open-label study in patients with cutaneous lupus erythematosus and healthy controls.

    abstract::This study aimed to determine whether a broad-spectrum liposomal sunscreen with a very high sun protection factor (Daylong actinica) can prevent damage induced by ultraviolet (UV) irradiation in patients with cutaneous lupus erythematosus (CLE) and healthy controls (HCs) under standardised conditions. In 20 patients w...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/exd.12035

    authors: Patsinakidis N,Wenzel J,Landmann A,Koch R,Gerß J,Luger TA,Metze D,Surber C,Kuhn A

    更新日期:2012-12-01 00:00:00

  • Diagnostic value and prognostic significance of plasmatic proteasome level in patients with melanoma.

    abstract::Plasmatic proteasome (p-proteasome) also called circulating proteasome has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in a melanoma population classified according to the American Joint Committee on Cancer staging system. Using an ELISA te...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0625.2010.01151.x

    authors: Henry L,Lavabre-Bertrand T,Douche T,Uttenweiler-Joseph S,Fabbro-Peray P,Monsarrat B,Martinez J,Meunier L,Stoebner PE

    更新日期:2010-12-01 00:00:00

  • Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis.

    abstract::During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the ...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/exd.12701

    authors: Ohgo S,Hasegawa S,Hasebe Y,Mizutani H,Nakata S,Akamatsu H

    更新日期:2015-07-01 00:00:00

  • Decreased frequency of interferon-gamma-producing CD4+ cells in the peripheral blood of patients with atopic dermatitis.

    abstract::Recently, decreased interferon-gamma (IFN-gamma) and increased interleukin (IL)-4 production have been reported in measurements of the content of the cytokines in culture supernatants of peripheral blood mononuclear cells (PBMC) obtained from patients with atopic dermatitis (AD). These data suggest deviation of PBMC i...

    journal_title:Experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0625.1998.tb00310.x

    authors: Nakagawa S,Aiba S,Tagami H

    更新日期:1998-04-01 00:00:00

  • The skin: an indispensable barrier.

    abstract::The skin forms an effective barrier between the organism and the environment preventing invasion of pathogens and fending off chemical and physical assaults, as well as the unregulated loss of water and solutes. In this review we provide an overview of several components of the physical barrier, explaining how barrier...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0625.2008.00786.x

    authors: Proksch E,Brandner JM,Jensen JM

    更新日期:2008-12-01 00:00:00

  • Effluent syntaxin3 from dying cells affords protection against apoptosis in epidermal keratinocytes.

    abstract::Ultra-violet B (UVB)-induced oxidative stress crucially perturbs the epidermal homeostasis, and the skin is endowed with protective mechanisms to take action against such damage. Here, we show the possible involvement of t-SNARE protein syntaxin3, a membrane fusion mediator of cytoplasmic vesicles, and which is releas...

    journal_title:Experimental dermatology

    pub_type: 信件

    doi:10.1111/exd.12278

    authors: Miyazaki T,Kadono N,Konishi Y,Hagiwara N,Maekubo K,Hirai Y

    更新日期:2013-12-01 00:00:00

  • Regenerative healing, scar-free healing and scar formation across the species: current concepts and future perspectives.

    abstract::All species have evolved mechanisms of repair to restore tissue function following injury. Skin scarring is an inevitable and permanent endpoint for many postnatal organisms except for non-amniote vertebrates such as amphibians, which are capable of tissue regeneration. Furthermore, mammalian foetuses through mid-gest...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/exd.12457

    authors: Ud-Din S,Volk SW,Bayat A

    更新日期:2014-09-01 00:00:00