Abstract:
:Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to determine serum BAFF levels and relate the results to the clinical features in patients with organ-specific autoimmune diseases of the skin, such as localized scleroderma and autoimmune bullous diseases. Serum BAFF levels were examined by enzyme-linked immunosorbent assay in 44 patients with localized scleroderma, 20 with pemphigus vulgaris/pemphigus foliaceus, 20 with bullous pemphigoid and 30 healthy controls. Twenty patients with SSc and 20 with SLE were also examined as disease controls. Serum BAFF levels were elevated in localized scleroderma patients compared with healthy controls. Concerning localized scleroderma subgroups, patients with generalized morphea, the severest form of localized scleroderma, had higher serum BAFF levels than linear scleroderma or morphea patients. The BAFF levels of generalized morphea were comparable with those of SSc or SLE. Furthermore, serum BAFF levels correlated positively with antihistone antibody levels and the severity of skin lesion as well as the number of skin lesions. By contrast, serum BAFF levels were not significantly elevated in patients with pemphigus or pemphigoid. These results suggest that BAFF may be contributing to autoimmunity and disease development in localized scleroderma.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato Sdoi
10.1111/j.1600-0625.2006.00485.xsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
87-93issue
2eissn
0906-6705issn
1600-0625pii
EXD485journal_volume
16pub_type
杂志文章abstract::Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression incr...
journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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pub_type: 信件
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 临床试验,杂志文章
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abstract::Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...
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pub_type: 信件
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journal_title:Experimental dermatology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/exd.12086
更新日期:2013-02-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 信件
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pub_type: 杂志文章
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pub_type: 评论,杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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pub_type: 信件
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 信件
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更新日期:2015-07-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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journal_title:Experimental dermatology
pub_type: 信件
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更新日期:2013-12-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00