Correlation of psoriasis activity with abundance of CD25+CD8+ T cells: conditions for cloning T cells from psoriatic plaques.

abstract：:Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutc...

journal_title：Experimental dermatology

authors： van der Kooi-Pol MM,Veenstra-Kyuchukova YK,Duipmans JC,Pluister GN,Schouls LM,de Neeling AJ,Grundmann H,Jonkman MF,van Dijl JM

更新日期：2012-06-01 00:00:00

abstract：:Using the indirect immunohistochemical approach, the occurrence of gamma-melanocyte stimulating hormone (gamma-MSH)-like immunoreactivity in human normal keratinocytes is described. The positive cells were observed in each layer of the epidermis (except stratum corneum) and often, at the level of the stratum spinosum,...

journal_title：Experimental dermatology

authors： Johansson O,Liu PY

更新日期：1993-10-01 00:00:00

abstract：:We have identified a spliced mRNA transcript of CD20 (named D393-CD20) which was associated with resistance to RTX in primary B cell from patients with lymphoma and leukaemia. In the present work, we wished to investigate whether D393-CD20 variant was expressed by B cells from patients with pemphigus. Ten patients wit...

journal_title：Experimental dermatology

authors： Gamonet C,Ferrand C,Colliou N,Musette P,Joly P,Girardin M,Humbert P,Aubin F

更新日期：2014-01-01 00:00:00

abstract：:Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to d...

journal_title：Experimental dermatology

authors： Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato S

更新日期：2007-02-01 00:00:00

abstract：:It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP) expression. We were interested whether common treatments in AD affect antimicrobial defense. We investigated the effects of topically applied corticosteroids betamethasone...

journal_title：Experimental dermatology

authors： Jensen JM,Ahrens K,Meingassner J,Scherer A,Bräutigam M,Stütz A,Schwarz T,Fölster-Holst R,Harder J,Gläser R,Proksch E

更新日期：2011-10-01 00:00:00

abstract：:Hair loss (alopecia) can result from a variety of metabolic, endocrine, immunologic, and environmental causes. This investigation was undertaken to determine the mechanisms underlying the sporadic development of alopecia in litters from C57BL/6 interleukin-10-deficient (Il10(-/-)) mice. All pups in affected litters de...

journal_title：Experimental dermatology

authors： Vanderford DA,Greer PK,Sharp JM,Chichlowski M,Rouse DC,Selim MA,Hale LP

更新日期：2010-06-01 00:00:00

abstract：:The contribution of immune checkpoint receptors in the immunopathogenesis of various autoimmune diseases has been addressed in previous reports. In this study,  the expression profile of T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) and programmed cell death-1 (PD-1) checkpoint molecules was investigated...

journal_title：Experimental dermatology

authors： Rahimi A,Hossein-Nataj H,Hajheydari Z,Aryanian Z,Shayannia A,Ajami A,Asgarian-Omran H

更新日期：2019-06-01 00:00:00

abstract：:Directed migration of keratinocytes and fibroblasts is a fundamental prerequisite in wound healing. Cation-dependent affinity changes of integrins are responsible for cell adhesion to and deadhesion from extracellular matrix proteins and have been implicated in driving cell migration. The specific requirements for div...

journal_title：Experimental dermatology

authors： Lange TS,Kirchberg J,Bielinsky AK,Leuker A,Bank I,Ruzicka T,Scharffetter-Kochanek K

更新日期：1995-06-01 00:00:00

abstract：:For many years, the function of the sebaceous gland (SG) was underestimated and suggested by Albert M. Kligman as a remnant of human development, a 'living fossil with a past but no future'. However, the last two decades of studies and the discovery of neuro-endocrine pathways in skin have determined the importance of...

journal_title：Experimental dermatology

authors： Nejati R,Skobowiat C,Slominski AT

更新日期：2013-10-01 00:00:00

abstract：:Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have i...

journal_title：Experimental dermatology

authors： Niyonsaba F,Kiatsurayanon C,Chieosilapatham P,Ogawa H

更新日期：2017-11-01 00:00:00

abstract：:TNF is critically involved in the pathogenesis of psoriasis. TL1A is a TNF-like cytokine, which, after binding to death domain receptor DR3, provides costimulatory signals to lymphocytes, amplifies Th1- and Th17-mediated immune responses and induces apoptotic cell death. These functions are inhibited when TL1A associa...

journal_title：Experimental dermatology

authors： Bamias G,Evangelou K,Vergou T,Tsimaratou K,Kaltsa G,Antoniou C,Kotsinas A,Kim S,Gorgoulis V,Stratigos AJ,Sfikakis PP

更新日期：2011-09-01 00:00:00

abstract：:We applied atomic force microscopy (AFM) to visualize ultrastructural changes of the keratinocyte morphology after narrow-band ultraviolet B (NB-UVB) irradiation. Immortalized human keratinocytes were cultured under standard conditions, irradiated with NB-UVB light at doses ranging from 50 to 800 mJ/cm2 and imaged by ...

journal_title：Experimental dermatology

authors： Reich A,Lehmann B,Meurer M,Muller DJ

更新日期：2007-12-01 00:00:00

abstract：:Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic...

journal_title：Experimental dermatology

authors： Matsushita A,Seike M,Okawa H,Kadawaki Y,Ohtsu H

更新日期：2012-09-01 00:00:00

abstract：:UVA(Ultraviolet A)-induced gene expression is supposed to be a hallmark for inflammation, for immunosuppression and in long-term cancer formation. In previous studies, we have shown for keratinocytes that physiological doses of UVA radiation result in the upregulation of gene expression mediated by ceramide formation ...

journal_title：Experimental dermatology

authors： Bayer M,Proksch P,Felsner I,Brenden H,Kohne Z,Walli R,Duong TN,Götz C,Krutmann J,Grether-Beck S

更新日期：2011-11-01 00:00:00

abstract：:Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via solub...

journal_title：Experimental dermatology

authors： Becker JC

更新日期：2014-03-01 00:00:00

abstract：:We have shown previously in psoriasis a very high prevalence of epidermodysplasia verruciforms-associated human papillomavirus 5 (EVHPV5) DNA and antibodies to human papillomavirus 5 (HPV5) virus-like particle (VLP) L1, and we suggested that this benign hyperproliferative disorder could be a reservoir for EVHPVs. Here...

journal_title：Experimental dermatology

authors： Majewski S,Jablonska S

更新日期：2003-12-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool...

journal_title：Experimental dermatology

authors： Takae Y,Nishikawa T,Amagai M

更新日期：2009-03-01 00:00:00

abstract：:Plasmatic proteasome (p-proteasome) also called circulating proteasome has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in a melanoma population classified according to the American Joint Committee on Cancer staging system. Using an ELISA te...

journal_title：Experimental dermatology

authors： Henry L,Lavabre-Bertrand T,Douche T,Uttenweiler-Joseph S,Fabbro-Peray P,Monsarrat B,Martinez J,Meunier L,Stoebner PE

更新日期：2010-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) gene amplification and protein overexpression are common in several cancers. EGFR status has seldom been studied in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein overexpr...

journal_title：Experimental dermatology

authors： Toll A,Salgado R,Yébenes M,Martín-Ezquerra G,Gilaberte M,Baró T,Solé F,Alameda F,Espinet B,Pujol RM

更新日期：2010-02-01 00:00:00

abstract：:The best characterized signalling pathway employed by transforming growth factor-beta (TGF-β) is the Smad pathway. We focused on Smad4, because it is essential for the activation of Smad-dependent target genes. We aimed to explore the possibility of inhibiting scar formation after wounding by blocking TGF-β signalling...

journal_title：Experimental dermatology

authors： Tan WQ,Gao ZJ,Xu JH,Yao HP

更新日期：2011-02-01 00:00:00

abstract：:T cells play a major role in inflammatory skin disorders such as psoriasis vulgaris and atopic dermatitis. They are both active on the level of cell-to-cell interaction and by the secretion of pro-inflammatory mediators. CD26 is a lymphocyte membrane-associated dipeptidyl peptidase IV (DPP IV), which is able to inacti...

journal_title：Experimental dermatology

authors： Bock O,Kreiselmeyer I,Mrowietz U

更新日期：2001-12-01 00:00:00

abstract：:Angiotensin II (Ang II) stimulation has been shown to regulate proliferation of skin fibroblasts and the production of extracellular matrix, which are very important processes in skin wound healing and fibrosis; however, there is little knowledge about the mechanisms involved in this process. We investigated the molec...

journal_title：Experimental dermatology

authors： Zhang GY,Li X,Yi CG,Pan H,He GD,Yu Q,Jiang LF,Xu WH,Li ZJ,Ding J,Lin DS,Gao WY

更新日期：2009-11-01 00:00:00

abstract：:Dendritic cells (DCs) show a Janus-like functional behavior. They help us by their orchestration of numerous immune responses to defend our body against invading pathogenic micro-organisms and also induce regulatory T cells to inhibit immune reactions against autoantigens as well as diverse harmless environmental anti...

journal_title：Experimental dermatology

authors： Schäkel K

更新日期：2009-03-01 00:00:00

abstract：:Pimecrolimus (SDZ ASM981) is a non-steroid member of calcineurin inhibitors recently developed for the treatment of inflammatory skin diseases. In this study, we compared the effect of pimecrolimus and corticosteroids on the differentiation, maturation and function of murine bone marrow-derived dendritic cells (BM-DC)...

journal_title：Experimental dermatology

authors： Krummen MB,Varga G,Steinert M,Stuetz A,Luger TA,Grabbe S

更新日期：2006-01-01 00:00:00

abstract：:Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as oedema, flushing, erythema, telangiectasia and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro-inflammatory cytokines, especially k...

journal_title：Experimental dermatology

authors： Son M,Park J,Oh S,Choi J,Shim M,Kang D,Byun K

更新日期：2020-05-20 00:00:00

abstract：:Given that metastasized melanoma is a fatal disease in most cases, it is tempting to develop strategies to a priori prevent metastasis. We have stimulated the pulmonary innate immune system by macrophage-activating lipopeptide-2 (MALP-2), a specific agonist at Toll-like receptor (TLR) 2/6, and investigated its impact ...

journal_title：Experimental dermatology

authors： Schill T,Schön MP,Pletz N,Emmert S,Schön M

更新日期：2012-02-01 00:00:00

abstract：:Cowden syndrome (CS) is an autosomal dominant inherited disorder characterized by hamartomas in a variety of tissues including the skin, thyroid, breast, endometrium, and the brain. Individuals with CS are predisposed to development of malignancy in these organs, especially the breast and the thyroid. We describe 3 un...

journal_title：Experimental dermatology

authors： Celebi JT,Ping XL,Zhang H,Remington T,Sulica VI,Tsou HC,Peacocke M

更新日期：2000-04-01 00:00:00

abstract：:Macrophages play important roles in immunity and inflammation, and in allergic, granulomatous and neoplastic diseases. Here, we present the indepth results of an ongoing study of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro. Up to now, a total of 40 cases of cutaneous macrophage d...

journal_title：Experimental dermatology

authors： Kodelja V,Goerdt S

更新日期：1994-12-01 00:00:00

abstract：:Nitric oxide (NO) is a potent intercellular mediator of melanogenesis, whereas metallothionein (MT) is an inducible intracellular antioxidant that has been reported to scavenge NO. We investigated the existence and induction of MT in melanocytes, and its inhibitory effect on NO-induced melanogenesis. The expression of...

journal_title：Experimental dermatology

authors： Sasaki M,Kizawa K,Igarashi S,Horikoshi T,Uchiwa H,Miyachi Y

更新日期：2004-08-01 00:00:00

abstract：:In the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), there is clinical heterogeneity with variable scarring and susceptibility to malignancy. Currently, however, there are few biochemical markers of tissue inflammation or disease progression. We assessed whether the non-histone ...

journal_title：Experimental dermatology

authors： Petrof G,Abdul-Wahab A,Proudfoot L,Pramanik R,Mellerio JE,McGrath JA

更新日期：2013-06-01 00:00:00