Risk for chronic kidney disease increases with obesity: Health Survey for England 2010.

Abstract:

OBJECTIVE:Studies of the relationship between obesity and chronic kidney disease (CKD) in nationally representative population samples are limited. Our study aimed to determine if overweight and obesity were independently associated with the risk for CKD in the 2010 Health Survey for England (HSE). DESIGN:The HSE is an annually conducted cross-sectional study. In 2010 serum creatinine was included to determine the incidence of CKD in the population. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Multivariable logistic regression models were developed to calculate odds ratios and 95% confidence intervals for CKD risk by BMI (reference category: BMI=18.5-24.9 kg/m2) and adjusted for age, gender, ethnicity, smoking, diabetes and hypertension. SETTING:A random sample of nationally representative households in England. SUBJECTS:Adults (n 3463) with calculable eGFR and BMI were included. RESULTS:The prevalence of CKD was 5.9%. The risk of CKD was over 2.5 times higher in obese participants compared with normal-weight participants in the fully adjusted model (BMI=30.0-39.9 kg/m2: adjusted OR=2.78 (95% CI 1.75, 4.43); BMI ≥ 40.0 kg/m2: adjusted OR=2.68 (95% CI 1.05, 6.85)). CONCLUSIONS:Obesity is associated with an increased risk of CKD in a national sample of the UK population, even after adjustment for known CKD risk factors, which may have implications for CKD screening and future national health service planning and delivery.

journal_name

Public Health Nutr

journal_title

Public health nutrition

authors

MacLaughlin HL,Hall WL,Sanders TA,Macdougall IC

doi

10.1017/S1368980015000488

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

3349-54

issue

18

eissn

1368-9800

issn

1475-2727

pii

S1368980015000488

journal_volume

18

pub_type

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