Abstract:
:We examined the migratory properties of the mouse serum protein responsible for specific neutralization of the endogenous mouse xenotropic type C virus and demonstrated that this neutralizing factor can be transferred from mouse lipoproteins to human and to nonreactive mouse lipoproteins. After acceptance of this activity by these lipoproteins, it could be back-transferred to human and to mouse lipoproteins. This result was compatible with equilibrium binding of the responsible proteins by several classes of lipoproteins. The best expression of the transferred activity occurred with human chylomicrons. Small quantities of neutralizing factor which exist in free dispersion in serum were also detected by mixing the p greater than 1.21 g/ml density fraction of mouse serum with human chylomicrons; antiviral activity was subsequently found associated with the human lipoproteins. This result reflects the potentiation of antiviral activity of the protein in a lipoprotein environment. These observations offer a useful approach for the eventual purification and characterization of the neutralizing factor.
journal_name
J Viroljournal_title
Journal of virologyauthors
Levy JA,Dimpfl J,Hardman D,Kane JPdoi
10.1128/JVI.42.2.365-371.1982subject
Has Abstractpub_date
1982-05-01 00:00:00pages
365-71issue
2eissn
0022-538Xissn
1098-5514journal_volume
42pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.64.4.1517-1522.1990
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.69.6.3441-3448.1995
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.4877-4883.1996
更新日期:1996-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2018-03-14 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00