Abstract:
:Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.
journal_name
J Viroljournal_title
Journal of virologyauthors
Wang F,Zhang Z,Wang X,Li J,Zha L,Yuan CG,Weissmann C,Ma Jdoi
10.1128/JVI.06216-11subject
Has Abstractpub_date
2012-02-01 00:00:00pages
1874-6issue
3eissn
0022-538Xissn
1098-5514pii
JVI.06216-11journal_volume
86pub_type
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