Abstract：
:Psoriasis is now recognized as an immunologically mediated systemic disease that may be expressed in cutaneous and joint symptoms. Medications that were once thought to control psoriasis by reducing keratinocyte proliferation are now known to act on immunologic pathways. In recent years, the emerging understanding of immunologic pathways in psoriasis has resulted in the use of biologic medications (eg, inhibitors of tumor necrosis factor) to treat psoriasis. More recently, other pathophysiologic pathways have been identified that have the potential to expand the therapeutic armamentarium. Other avenues of research within the past decade have demonstrated that a range of health risks and comorbid inflammatory diseases are associated with psoriasis, and they have the potential to increase morbidity and mortality and adversely affect quality of life.
journal_name
Semin Cutan Med Surgjournal_title
Seminars in cutaneous medicine and surgeryauthors
Gordon KB,Strober BEdoi
10.12788/j.sder.0067subject
Has Abstractpub_date
2014-03-01 00:00:00pages
S20-3issue
2 Suppl 2eissn
1085-5629issn
1558-0768journal_volume
33pub_type
杂志文章abstract：:Cellulite is a common dermatologic condition and frequent cause of cosmetic concern among women. This paper aims to update what is known about the pathogenesis of cellulite and reviews targeted treatment modalities that address its underlying components of microvascular dysfunction, endocrine-mediated inflammation, an...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2018.056
更新日期：2018-12-01 00:00:00
abstract：:There are many hair disorders, all of which involve alterations in normal hair biology. Essentially, hair disorders involve changes to hair fiber caliber, density per unit area, and/or the duration of anagen and telogen in the hair growth cycle. Hair disorders may be triggered by inflammation, genetics, the environmen...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2015.0133
更新日期：2015-06-01 00:00:00
abstract：:Hair shaft abnormalities are fascinating and can provide a diagnostic challenge. Current knowledge of structural changes in hair has been amplified by scanning and transmission electron microscopy (SEM and TEM). Dermatologists using the light microscope and polarization in the office can diagnose the great majority of...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2006.01.004
更新日期：2006-03-01 00:00:00
abstract：:The history of resurfacing procedures used to treat the aging face is reviewed, and the place of laser resurfacing within this context is described. The changing medical reimbursement system and desire by "baby boomers" to maintain a youthful image have driven the technical development of laser resurfacing. Medical ma...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(96)80052-6
更新日期：1996-09-01 00:00:00
abstract：:In 1996, oral terbinafine joined itraconazole and fluconazole on the short list of systemic medications that could be used to treat onychomycosis (although fluconazole was not approved for this indication by the US Food and Drug Administration [FDA], it was commonly used for this purpose). In 1999, ciclopirox was the ...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2016.009
更新日期：2016-03-01 00:00:00
abstract：:Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer pred...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2012.08.005
更新日期：2012-12-01 00:00:00
abstract：:Dermatologists will enter into a number of different contracts during their professional careers. It is important that in each agreement they enter, dermatologists reap the benefits that they aspire for and understand the consequences of each provision. This article addresses just a few of the different issues that ar...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2005.05.004
更新日期：2005-09-01 00:00:00
abstract：:Closing surgical defects of the external ear poses unique challenges because of the convoluted shape and thin tethered skin. Choice of repair is often dictated by the site of the wound. If the defect is central and anterior with intact cartilage, most defects will do well by second intention healing or grafting. If th...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/S1085-5629(03)00077-4
更新日期：2003-12-01 00:00:00
abstract：:Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinic...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(00)80005-x
更新日期：2000-06-01 00:00:00
abstract：:The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improve...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2017.011
更新日期：2017-03-01 00:00:00
abstract：:Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are ra...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2018.014
更新日期：2018-03-01 00:00:00
abstract：:Cutaneous fibrosis is an integral component of a variety of human disorders including keloids, hypertrophic scar, and most notably, scleroderma. Each has its own etiology and unique clinical characteristics, but all involve the dysregulation of connective tissue metabolism, in particular, the activation of dermal fibr...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(98)80055-2
更新日期：1998-03-01 00:00:00
abstract：:Several nonsurgical strategies for managing hidradenitis suppurativa (HS) are used that are successful in many patients. The overall goals of pharmacologic therapy are to clear or reduce the number and extent of current lesions and to prevent new lesions from forming. No pharmacologic agent is universally effective in...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.0094
更新日期：2014-06-01 00:00:00
abstract：:Lasers, both in single and multiple wavelength designs, have recently been introduced to enhance the results of liposuction. Safe parameters of fluence and temperature have not yet been described. In this study, I describe a series of laser lipolysis patients treated with a dual wavelength (1064/1319 nm) laser where i...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1016/j.sder.2009.11.002
更新日期：2009-12-01 00:00:00
abstract：:Electronic billing systems make dermatology practices more efficient and productive. The decision to purchase and install such a system, however, involves a significant amount of time and is often accompanied by many mistakes. This article presents errors commonly made in the evaluation and purchase process and offers...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(00)80025-5
更新日期：2000-09-01 00:00:00
abstract：:Cutaneous infections are common in dermatology. They occur in all populations and all ages. This review will focus on 3 emerging infections encountered by dermatologists; community-acquired methicillin-resistant Staphylococcus aureus, Epstein-Barr virus infections, and the atypical mycobacterial infections. The backgr...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2006.08.003
更新日期：2006-12-01 00:00:00
abstract：:Hair disorders include hair loss, increased hair growth, and hair structure defects with increased breakage, as well as unacceptable cosmetic appearance, such as reduced shine, strength, curliness, and elasticity. It is the task of the dermatologist to choose the right diagnostic tool depending on the suspected clinic...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2008.12.005
更新日期：2009-03-01 00:00:00
abstract：:Idiosyncratic reactions (type B) are a major complication of drug therapy, because they are related to both the drug and to individual factors in the host. In comparison with other organs, the skin is quite frequently a target of allergic reactions, which are mainly elicited by small molecular weight compounds. This i...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(96)80035-6
更新日期：1996-12-01 00:00:00
abstract：:Hidradenitis suppurativa (HS) is a complex dermatological disease characterized by recurrent painful nodules and suppuration in areas such as the axilla and groin. The disease is poorly understood and treatment is not satisfactory. In October 2016, the Canadian and United States Hidradenitis Suppurativa Foundations or...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2017.024
更新日期：2017-06-01 00:00:00
abstract：:In recent years, DNA microarray technology has been used for the analysis of gene expression patterns in a variety of skin diseases, including malignant melanoma, psoriasis, lupus erythematosus, and systemic sclerosis. Many of the studies described herein confirmed earlier results on individual genes or functional gro...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2007.12.004
更新日期：2008-03-01 00:00:00
abstract：:There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2016.064
更新日期：2016-12-01 00:00:00
abstract：:The use of video in the informed consent process has been well documented in the literature to improve patient satisfaction, understanding, comprehension, and to decrease anxiety. At the MD Anderson Mohs Surgery Unit, we use high-definition (HD) audiovisual (AV) modules to assist with the delivery of informed consent ...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1016/j.sder.2008.02.001
更新日期：2008-03-01 00:00:00
abstract：:Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of el...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2011.05.004
更新日期：2011-09-01 00:00:00
abstract：:Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborn...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2016.041
更新日期：2016-06-01 00:00:00
abstract：:Oral mucosal bullous/desquamative/ulcerative diseases involve immunopathological mechanisms that account for loss of adhesion between contiguous keratinocytes or to structures within the basal lamina. Some are antibody mediated, in which specific adhesion molecules of the desmosome, hemidesmosome, and basement membran...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(97)80018-1
更新日期：1997-12-01 00:00:00
abstract：:The prevalence of onychomycosis in the United States is estimated to be at least 12%; prevalence increases with increasing age and is highest in individuals more than 65 years of age. Trichophyton rubrum, which also causes tinea pedis, is responsible for approximately 90% of cases of toenail onychomycosis. Risk factor...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.0014
更新日期：2013-06-01 00:00:00
abstract：:The last decade has witnessed a significant advance in the management of refractory moderate-to-severe psoriasis. This advance is the introduction of biological therapies to clinical practice. Three classes of biological therapies have been used. Of the first 2 classes to be introduced, the T-cell inhibitors and tumor...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2010.02.004
更新日期：2010-03-01 00:00:00
abstract：:Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal cutaneous malignancy that is not usually suspected at the time of biopsy. Because of its increasing incidence and the discovery of a possible viral association, interest in MCC has escalated. Recent effort has broadened our breadth of knowledge regardi...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2011.02.001
更新日期：2011-03-01 00:00:00
abstract：:Propionibacterium acnes is a key pathogenic factor in the development of acne. Antibiotics are the first choice of treatment for mild-to-moderate, mixed, papular/pustular, and moderate nodular acne, and an alternative choice in severe, nodular/conglobate acne. The emergence of resistance to the currently available ant...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2016.031
更新日期：2016-06-01 00:00:00
abstract：:Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2011.08.003
更新日期：2011-12-01 00:00:00
