Major gaps in understanding and treatment of hidradenitis suppurativa.

abstract：:Thalidomide, originally marketed as a sedative, was introduced in West Germany in 1956 and in numerous other countries soon thereafter. In part because it did not impair coordination or respiratory function, the drug rapidly became extremely popular. By 1961, however, there were mounting reports of phocomelia and othe...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stirling DI

更新日期：1998-12-01 00:00:00

abstract：:In an attempt to limit the prolonged postoperative healing associated with ablative laser skin resurfacing and in response to growing public interest in less invasive treatment modalities, nonablative laser and light source technology was developed. Over the past few years, several clinical and histologic research stu...

journal_title：Seminars in cutaneous medicine and surgery

authors： Alster TS,Lupton JR

更新日期：2002-12-01 00:00:00

abstract：:Although the majority of hemangiomas of infancy can be expected to follow a benign course, a significant subset may result in serious complications. Recently, hemangiomas of segmental morphology, or those which are large, plaque-like, and patterned in distribution, have been recognized as important markers for potenti...

journal_title：Seminars in cutaneous medicine and surgery

authors： Metry DW

更新日期：2004-06-01 00:00:00

abstract：:Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinic...

journal_title：Seminars in cutaneous medicine and surgery

authors： Howard MS,Smoller BR

更新日期：2000-06-01 00:00:00

abstract：:Phototherapeutic modalities, including narrowband-UVB, broadband-UVB, PUVA photochemotherapy, and excimer laser therapy are valuable tools that can be used for photoresponsive dermatoses in children. As a systematically safer alternative compared with internal agents, including the prebiologic and biological therapies...

journal_title：Seminars in cutaneous medicine and surgery

authors： Pugashetti R,Koo J

更新日期：2010-06-01 00:00:00

abstract：:Cutaneous fibrosis is an integral component of a variety of human disorders including keloids, hypertrophic scar, and most notably, scleroderma. Each has its own etiology and unique clinical characteristics, but all involve the dysregulation of connective tissue metabolism, in particular, the activation of dermal fibr...

journal_title：Seminars in cutaneous medicine and surgery

authors： Liu B,Connolly MK

更新日期：1998-03-01 00:00:00

abstract：:Closing surgical defects of the external ear poses unique challenges because of the convoluted shape and thin tethered skin. Choice of repair is often dictated by the site of the wound. If the defect is central and anterior with intact cartilage, most defects will do well by second intention healing or grafting. If th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Olbricht S,Liégeois NJ

更新日期：2003-12-01 00:00:00

abstract：:The history of burn scars can best be found in military medical history. The care of wounded soldiers documented in the Illiad reflected the trauma of the weapons of war, arrow, spear, sword, and ax. The introduction of gunpowder in the 14th century, increasingly sophisticated explosives, and in modern times, petroleu...

journal_title：Seminars in cutaneous medicine and surgery

authors： Petro JA

更新日期：2015-03-01 00:00:00

abstract：:Lasers frequently are used by dermatologists for their multiple aesthetic applications, but they also can be used to treat a variety of medical dermatology conditions. Conditions such as acne vulgaris, psoriasis, and vitiligo can all be successfully treated with laser, thereby providing the patient with additional the...

journal_title：Seminars in cutaneous medicine and surgery

authors： Railan D,Alster TS

更新日期：2008-12-01 00:00:00

abstract：:The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improve...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stein Gold LF,Eichenfield LF

更新日期：2017-03-01 00:00:00

abstract：:This review highlights important considerations in obtaining good skin biopsy specimens to optimize results of direct immunofluorescence (IF) studies and also summarizes the various patterns of cutaneous IF deposition and their associated diagnoses. IF findings of immunobullous diseases, lupus erythematosus, vasculiti...

journal_title：Seminars in cutaneous medicine and surgery

authors： Morrison LH

更新日期：1999-03-01 00:00:00

abstract：:"Venous disease consists of a spectrum with significant medical and economic morbidities. For lack of exposure, however, it is a poorly understood subject. The evaluation and approach to diagnosing venous disease requires a firm understanding of venous anatomy and pathophysiology. With a targeted history and physical,...

journal_title：Seminars in cutaneous medicine and surgery

authors： Nguyen TH

更新日期：2005-12-01 00:00:00

abstract：:The expansion of telemedicine nationwide has resulted in many states adopting specific telemedicine regulations to avoid the issue of requiring a full medical license to practice telemedicine. How these laws and regulations relate to the practice of telepathology and teledermatology has not been well delineated. It is...

journal_title：Seminars in cutaneous medicine and surgery

authors： Marsch A,High WA

更新日期：2013-12-01 00:00:00

abstract：:The history of resurfacing procedures used to treat the aging face is reviewed, and the place of laser resurfacing within this context is described. The changing medical reimbursement system and desire by "baby boomers" to maintain a youthful image have driven the technical development of laser resurfacing. Medical ma...

journal_title：Seminars in cutaneous medicine and surgery

authors： Roenigk HH Jr

更新日期：1996-09-01 00:00:00

abstract：:Propionibacterium acnes is a key pathogenic factor in the development of acne. Antibiotics are the first choice of treatment for mild-to-moderate, mixed, papular/pustular, and moderate nodular acne, and an alternative choice in severe, nodular/conglobate acne. The emergence of resistance to the currently available ant...

journal_title：Seminars in cutaneous medicine and surgery

authors： Sinha M,Sadhasivam S,Bhattacharyya A,Jain S,Ghosh S,Arndt KA,Dover JS,Sengupta S

更新日期：2016-06-01 00:00:00

abstract：:There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may...

journal_title：Seminars in cutaneous medicine and surgery

authors： Ascha M,Irfan M

更新日期：2016-12-01 00:00:00

abstract：:Deep morphea encompasses a variety of clinical entities in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. Morphea profunda, eosinophilic fasciitis, and disabling pansclerotic morphea of children are included in this group, but overlapping of the extent and dep...

journal_title：Seminars in cutaneous medicine and surgery

authors： Bielsa I,Ariza A

更新日期：2007-06-01 00:00:00

abstract：:The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...

journal_title：Seminars in cutaneous medicine and surgery

authors： Solish N

更新日期：2016-06-01 00:00:00

abstract：:Topical retinoic acid was introduced for acne treatment three decades ago. Since that time, researchers have discovered thousands of retinoids, originally defined as chemical analogs of vitamin A. After the identification of nuclear retinoid receptors in 1987, the definition of this class expanded to include molecules...

journal_title：Seminars in cutaneous medicine and surgery

authors： Bershad S

更新日期：2001-09-01 00:00:00

abstract：:Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Yiu ZZ,Warren RB

更新日期：2018-09-01 00:00:00

abstract：:Bathing and moisturization to control dryness, applications of topical anti-inflammatory agents (including corticosteroids and calcineurin inhibitors [TCIs]) to control flares, minimization of the risk for infection, and relief of pruritus are the cornerstones of effective therapy for atopic dermatitis. Education of p...

journal_title：Seminars in cutaneous medicine and surgery

authors： Paller AS,Simpson EL,Eichenfield LF,Ellis CN,Mancini AJ

更新日期：2012-09-01 00:00:00

abstract：:Spitz nevus (SN) and Spitzoid malignant melanoma (SMM) represent benign and malignant counterparts at both ends of the spectrum of Spitzoid lesions. Atypical Spitzoid neoplasm (ASN) is a poorly defined and characterized category of melanocytic tumors with histologic features of both benign Spitz nevi and malignant mel...

journal_title：Seminars in cutaneous medicine and surgery

authors： Miteva M,Lazova R

更新日期：2010-09-01 00:00:00

abstract：:Infections with organisms of the genus Bartonella, for many years important only in South and Central America, have assumed significance in developing countries, especially in conjunction with the advent of the pandemic of the human immunodeficiency virus infection. New molecular and culture techniques have determined...

journal_title：Seminars in cutaneous medicine and surgery

authors： Wong R,Tappero J,Cockerell CJ

更新日期：1997-09-01 00:00:00

abstract：:The prevalence of onychomycosis in the United States is estimated to be at least 12%; prevalence increases with increasing age and is highest in individuals more than 65 years of age. Trichophyton rubrum, which also causes tinea pedis, is responsible for approximately 90% of cases of toenail onychomycosis. Risk factor...

journal_title：Seminars in cutaneous medicine and surgery

authors： Scher RK,Rich P,Pariser D,Elewski B

更新日期：2013-06-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal cutaneous malignancy that is not usually suspected at the time of biopsy. Because of its increasing incidence and the discovery of a possible viral association, interest in MCC has escalated. Recent effort has broadened our breadth of knowledge regardi...

journal_title：Seminars in cutaneous medicine and surgery

authors： Wang TS,Byrne PJ,Jacobs LK,Taube JM

更新日期：2011-03-01 00:00:00

abstract：:The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. Th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Connolly D,Schilling L,Saedi N

更新日期：2017-12-01 00:00:00

abstract：:The last decade has witnessed a significant advance in the management of refractory moderate-to-severe psoriasis. This advance is the introduction of biological therapies to clinical practice. Three classes of biological therapies have been used. Of the first 2 classes to be introduced, the T-cell inhibitors and tumor...

journal_title：Seminars in cutaneous medicine and surgery

authors： Warren RB,Griffiths CE

更新日期：2010-03-01 00:00:00

abstract：:Idiosyncratic reactions (type B) are a major complication of drug therapy, because they are related to both the drug and to individual factors in the host. In comparison with other organs, the skin is quite frequently a target of allergic reactions, which are mainly elicited by small molecular weight compounds. This i...

journal_title：Seminars in cutaneous medicine and surgery

authors： Merk HF,Hertl M

更新日期：1996-12-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic skin condition affecting children and adults, with a significant negative impact on patient and caregiver quality of life (QOL). Although effective treatments for AD are available, outcomes are often limited by poor adherence to treatment plans. Effective patient and caregiver educa...

journal_title：Seminars in cutaneous medicine and surgery

authors： LeBovidge J,Borok J,Udkoff J,Yosipovitch G,Eichenfield LF

更新日期：2017-09-01 00:00:00

abstract：:Soft tissue augmentation has become increasingly important as more individuals seek aesthetic improvement without major surgical procedures. The choice of an appropriate subcutaneous implant, whether solid or injectable, requires a thorough understanding of the materials available. This review of the literature addres...

journal_title：Seminars in cutaneous medicine and surgery

authors： Krauss MC

更新日期：1999-06-01 00:00:00