abstract：:The influences of information technology have touched almost all aspects of our lives, and health care delivery has been no exception. Law, policy, and regulation have driven the adoption of electronic medical records, particularly over the past decade, driving fundamental changes to the practice of medicine in genera...

journal_title：Seminars in cutaneous medicine and surgery

authors： Park AJ,Maruther MK,Swerlick RA

更新日期：2019-03-01 00:00:00

abstract：:Cellulite is a common dermatologic condition and frequent cause of cosmetic concern among women. This paper aims to update what is known about the pathogenesis of cellulite and reviews targeted treatment modalities that address its underlying components of microvascular dysfunction, endocrine-mediated inflammation, an...

journal_title：Seminars in cutaneous medicine and surgery

authors： Hogan S,Velez MW,Kaminer MS

更新日期：2018-12-01 00:00:00

abstract：:Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Yiu ZZ,Warren RB

更新日期：2018-09-01 00:00:00

abstract：:Immunotherapy for the treatment of advanced melanoma has become a primary treatment in the clinic. Current therapies include systemic cytokines, immune checkpoint inhibitors, and localized intratumoral therapies. Checkpoint inhibitors block natural pathways that dampen or inhibit an immune response to stimulus. These ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Cuevas LM,Daud AI

更新日期：2018-06-01 00:00:00

abstract：:Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are ra...

journal_title：Seminars in cutaneous medicine and surgery

authors： Chen ST,Barnes J,Duncan L

更新日期：2018-03-01 00:00:00

abstract：:The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. Th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Connolly D,Schilling L,Saedi N

更新日期：2017-12-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic skin condition affecting children and adults, with a significant negative impact on patient and caregiver quality of life (QOL). Although effective treatments for AD are available, outcomes are often limited by poor adherence to treatment plans. Effective patient and caregiver educa...

journal_title：Seminars in cutaneous medicine and surgery

authors： LeBovidge J,Borok J,Udkoff J,Yosipovitch G,Eichenfield LF

更新日期：2017-09-01 00:00:00

abstract：:Hidradenitis suppurativa (HS) is a complex dermatological disease characterized by recurrent painful nodules and suppuration in areas such as the axilla and groin. The disease is poorly understood and treatment is not satisfactory. In October 2016, the Canadian and United States Hidradenitis Suppurativa Foundations or...

journal_title：Seminars in cutaneous medicine and surgery

authors： Hoffman LK,Ghias MH,Garg A,Hamzavi IH,Alavi A,Lowes MA

更新日期：2017-06-01 00:00:00

abstract：:Teledermatology (TD) is a health care delivery modality that uses telecommunication technology to provide dermatologic care. It has grown to be a reliable and diagnostically accurate means of producing quality care while increasing access and reducing wait times in the outpatient setting. In the inpatient setting, TD ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Tull R,Wanat KA

更新日期：2017-03-01 00:00:00

abstract：:The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improve...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stein Gold LF,Eichenfield LF

更新日期：2017-03-01 00:00:00

abstract：:There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may...

journal_title：Seminars in cutaneous medicine and surgery

authors： Ascha M,Irfan M

更新日期：2016-12-01 00:00:00

abstract：:Congenital hemangiomas are rare solitary vascular tumors that do not proliferate after birth. They are characterized as either rapidly involuting congenital hemangiomas (RICHs) or noninvoluting congenital hemangiomas (NICHs) based on their clinical progression. NICHs have no associated complications, but are persisten...

journal_title：Seminars in cutaneous medicine and surgery

authors： Boull C,Maguiness SM

更新日期：2016-09-01 00:00:00

abstract：:Propionibacterium acnes is a key pathogenic factor in the development of acne. Antibiotics are the first choice of treatment for mild-to-moderate, mixed, papular/pustular, and moderate nodular acne, and an alternative choice in severe, nodular/conglobate acne. The emergence of resistance to the currently available ant...

journal_title：Seminars in cutaneous medicine and surgery

authors： Sinha M,Sadhasivam S,Bhattacharyya A,Jain S,Ghosh S,Arndt KA,Dover JS,Sengupta S

更新日期：2016-06-01 00:00:00

abstract：:Among the newer medications for treating psoriasis are the interleukin-17A inhibitor secukinumab and the phosphodiesterase 4 inhibitor apremilast. Secukinumab offers a level of efficacy greater than that of the tumor necrosis factor-α inhibitor adalimumab. Apremilast is associated with lower levels of efficacy than th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Strober BE

更新日期：2016-06-01 00:00:00

abstract：:Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborn...

journal_title：Seminars in cutaneous medicine and surgery

authors： Simpson EL Md McR,Irvine AD Md,Eichenfield LF Md,Friedlander SF Md

更新日期：2016-06-01 00:00:00

abstract：:The pathophysiology of atopic dermatitis (AD) is complex, and future treatment options will likely be incorporated in a multimodal approach to management. The new, directed therapies that have been developed will likely be used in conjunction with concomitant continuous or intermittent use of standard therapies; the g...

journal_title：Seminars in cutaneous medicine and surgery

authors： Friedlander SF Md,Simpson EL Md McR,Irvine AD Md,Eichenfield LF Md

更新日期：2016-06-01 00:00:00

abstract：:The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...

journal_title：Seminars in cutaneous medicine and surgery

authors： Solish N

更新日期：2016-06-01 00:00:00

abstract：:Medical imaging has dramatically transformed the practice of medicine, especially the field of dermatology. Imaging is used to facilitate the transfer of information between providers, document cutaneous disease, assess response to therapy, and plays a crucial role in monitoring and diagnosing skin cancer. Advancement...

journal_title：Seminars in cutaneous medicine and surgery

authors： Hibler BP,Qi Q,Rossi AM

更新日期：2016-03-01 00:00:00

abstract：:In 1996, oral terbinafine joined itraconazole and fluconazole on the short list of systemic medications that could be used to treat onychomycosis (although fluconazole was not approved for this indication by the US Food and Drug Administration [FDA], it was commonly used for this purpose). In 1999, ciclopirox was the ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Rosen T,Stein Gold LF

更新日期：2016-03-01 00:00:00

abstract：:Cellulite is a condition that affects the vast majority of women. Although it is of no danger to one's overall health, cellulite can be psychosocially debilitating. Consequently, much research has been devoted to understanding cellulite and its etiopathogenesis. With additional insights into the underlying causes of i...

journal_title：Seminars in cutaneous medicine and surgery

authors： Green JB,Cohen JL,Kaufman J,Metelitsa AI,Kaminer MS

更新日期：2015-09-01 00:00:00

abstract：:There are many hair disorders, all of which involve alterations in normal hair biology. Essentially, hair disorders involve changes to hair fiber caliber, density per unit area, and/or the duration of anagen and telogen in the hair growth cycle. Hair disorders may be triggered by inflammation, genetics, the environmen...

journal_title：Seminars in cutaneous medicine and surgery

authors： Chu TW,Santos L,McElwee KJ

更新日期：2015-06-01 00:00:00

abstract：:The history of burn scars can best be found in military medical history. The care of wounded soldiers documented in the Illiad reflected the trauma of the weapons of war, arrow, spear, sword, and ax. The introduction of gunpowder in the 14th century, increasingly sophisticated explosives, and in modern times, petroleu...

journal_title：Seminars in cutaneous medicine and surgery

authors： Petro JA

更新日期：2015-03-01 00:00:00

abstract：:This is a very exciting time in cutaneous laser surgery with an ever-expanding therapeutic armamentarium and an increased sophistication of available technology. These recent trends have allowed for both a rapid development of interest and exploration of laser-assisted drug delivery and its potential applications. We ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Brauer JA,Krakowski AC,Bloom BS,Nguyen TA,Geronemus RG

更新日期：2014-12-01 00:00:00

abstract：:The term bed bug is applied to 2 species of genus Cimex: lectularius describes the common or temperate bed bug, and hemipterus its tropical cousin. Cimex lectularius is aptly named; its genus and species derive from the Latin words for bug and bed, respectively. Though the tiny pest is receiving increased public atten...

journal_title：Seminars in cutaneous medicine and surgery

authors： Foulke GT,Anderson BE

更新日期：2014-09-01 00:00:00

abstract：:Several nonsurgical strategies for managing hidradenitis suppurativa (HS) are used that are successful in many patients. The overall goals of pharmacologic therapy are to clear or reduce the number and extent of current lesions and to prevent new lesions from forming. No pharmacologic agent is universally effective in...

journal_title：Seminars in cutaneous medicine and surgery

authors： Kerdel FA

更新日期：2014-06-01 00:00:00

abstract：:Safety remains paramount to the clinical utility of a therapy. Evaluation of safety is an ongoing process that does not end when a therapy becomes commercially available. This article reviews recent data pertaining to the safety profile of two therapeutic classes widely used in the treatment of psoriasis: inhibitors o...

journal_title：Seminars in cutaneous medicine and surgery

authors： Leonardi CL

更新日期：2014-06-01 00:00:00

abstract：:Psoriasis is now recognized as an immunologically mediated systemic disease that may be expressed in cutaneous and joint symptoms. Medications that were once thought to control psoriasis by reducing keratinocyte proliferation are now known to act on immunologic pathways. In recent years, the emerging understanding of ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Gordon KB,Strober BE

更新日期：2014-03-01 00:00:00

abstract：:The expansion of telemedicine nationwide has resulted in many states adopting specific telemedicine regulations to avoid the issue of requiring a full medical license to practice telemedicine. How these laws and regulations relate to the practice of telepathology and teledermatology has not been well delineated. It is...

journal_title：Seminars in cutaneous medicine and surgery

authors： Marsch A,High WA

更新日期：2013-12-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The imbalance of the Th2 and Th1 pathways and their associated cytokines in AD presents as one facet of the pathogenic mechanisms. Changes in the T-cell populations...

journal_title：Seminars in cutaneous medicine and surgery

authors： Harskamp CT,Armstrong AW

更新日期：2013-09-01 00:00:00

abstract：:The prevalence of onychomycosis in the United States is estimated to be at least 12%; prevalence increases with increasing age and is highest in individuals more than 65 years of age. Trichophyton rubrum, which also causes tinea pedis, is responsible for approximately 90% of cases of toenail onychomycosis. Risk factor...

journal_title：Seminars in cutaneous medicine and surgery

authors： Scher RK,Rich P,Pariser D,Elewski B

更新日期：2013-06-01 00:00:00

abstract：:Nonpharmacologic management of psychodermatologic conditions includes both structured and unstructured interventions that may ameliorate skin disorders, reduce psychological distress, and improve the functional status of the affected individual. Nonpharmacologic techniques are often referred to as psychocutaneous inte...

journal_title：Seminars in cutaneous medicine and surgery

authors： Fried RG

更新日期：2013-06-01 00:00:00

abstract：:The techniques of noninvasive facial rejuvenation are forever being redefined and improved. This article will review historical as well as present approaches to resurfacing, discussing the nonablative tools that can complement resurfacing procedures. Current thoughts on the pre- and postoperative care of resurfacing p...

journal_title：Seminars in cutaneous medicine and surgery

authors： Kleinerman R,Eisen DB,Kilmer SL,Ibrahimi OA

更新日期：2013-03-01 00:00:00

abstract：:Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer pred...

journal_title：Seminars in cutaneous medicine and surgery

authors： Nikolaou V,Stratigos AJ,Tsao H

更新日期：2012-12-01 00:00:00

abstract：:Bathing and moisturization to control dryness, applications of topical anti-inflammatory agents (including corticosteroids and calcineurin inhibitors [TCIs]) to control flares, minimization of the risk for infection, and relief of pruritus are the cornerstones of effective therapy for atopic dermatitis. Education of p...

journal_title：Seminars in cutaneous medicine and surgery

authors： Paller AS,Simpson EL,Eichenfield LF,Ellis CN,Mancini AJ

更新日期：2012-09-01 00:00:00

abstract：:The development of fractional photothermolysis is a milestone in the history of laser technology and cutaneous resurfacing. Based on the concept that skin is treated in a fractional manner, where narrow cylinders of tissue are thermally heated and normal adjacent skin is left unaffected, the fractional devices have sh...

journal_title：Seminars in cutaneous medicine and surgery

authors： Saedi N,Jalian HR,Petelin A,Zachary C

更新日期：2012-06-01 00:00:00

abstract：:Skin cancers are the most common form of malignancy. Early diagnosis and treatment provides the best chance for survival and reduced morbidity. However, some patients have recurrent or resistant lesions. In patients with basal cell carcinoma (BCC), prognosis is relatively good for all four types of lesions (superficia...

journal_title：Seminars in cutaneous medicine and surgery

authors： Marghoob AA

更新日期：2011-12-01 00:00:00

abstract：:Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk...

journal_title：Seminars in cutaneous medicine and surgery

authors： Kanavy HE,Gerstenblith MR

更新日期：2011-12-01 00:00:00

abstract：:Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of el...

journal_title：Seminars in cutaneous medicine and surgery

authors： Farris PK

更新日期：2011-09-01 00:00:00

abstract：:Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus. Topical and systemic agents as well as broadband ultraviolet photo...

journal_title：Seminars in cutaneous medicine and surgery

authors： Berger TG,Steinhoff M

更新日期：2011-06-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal cutaneous malignancy that is not usually suspected at the time of biopsy. Because of its increasing incidence and the discovery of a possible viral association, interest in MCC has escalated. Recent effort has broadened our breadth of knowledge regardi...

journal_title：Seminars in cutaneous medicine and surgery

authors： Wang TS,Byrne PJ,Jacobs LK,Taube JM

更新日期：2011-03-01 00:00:00