The future of biological therapies.

Abstract:

:The last decade has witnessed a significant advance in the management of refractory moderate-to-severe psoriasis. This advance is the introduction of biological therapies to clinical practice. Three classes of biological therapies have been used. Of the first 2 classes to be introduced, the T-cell inhibitors and tumor necrosis factor (TNF)-alpha inhibitors, there have been differing fates with one of the T-cell inhibitors, efalizumab, being withdrawn because of a rare, unpredictable association with a usually fatal neurological condition, progressive multifocal leukoencephalopathy. In contrast, anti-TNF treatments are now firmly established offering a high level of efficacy and a good safety record across several indications, including psoriasis. A new approach involves targeting the p40 subunit, common to interleukins 12 and 23. Ustekinumab, the first drug in this class, now offers a viable alternative to anti-TNFs in the treatment of moderate-to-severe psoriasis. In this article, we discuss approaches that may be utilized to refine these existing therapies and examine future therapeutic targets for biological therapies.

journal_name

Semin Cutan Med Surg

authors

Warren RB,Griffiths CE

doi

10.1016/j.sder.2010.02.004

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

63-6

issue

1

eissn

1085-5629

issn

1558-0768

pii

S1085-5629(10)00015-5

journal_volume

29

pub_type

杂志文章,评审
  • Bed bugs.

    abstract::The term bed bug is applied to 2 species of genus Cimex: lectularius describes the common or temperate bed bug, and hemipterus its tropical cousin. Cimex lectularius is aptly named; its genus and species derive from the Latin words for bug and bed, respectively. Though the tiny pest is receiving increased public atten...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.12788/j.sder.0106

    authors: Foulke GT,Anderson BE

    更新日期:2014-09-01 00:00:00

  • Are all infrared lasers equally effective in skin rejuvenation.

    abstract::In an attempt to limit the prolonged postoperative healing associated with ablative laser skin resurfacing and in response to growing public interest in less invasive treatment modalities, nonablative laser and light source technology was developed. Over the past few years, several clinical and histologic research stu...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1053/sder.2002.36766

    authors: Alster TS,Lupton JR

    更新日期:2002-12-01 00:00:00

  • Antifungal Drugs for Onychomycosis: Efficacy, Safety, and Mechanisms of Action.

    abstract::In 1996, oral terbinafine joined itraconazole and fluconazole on the short list of systemic medications that could be used to treat onychomycosis (although fluconazole was not approved for this indication by the US Food and Drug Administration [FDA], it was commonly used for this purpose). In 1999, ciclopirox was the ...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.12788/j.sder.2016.009

    authors: Rosen T,Stein Gold LF

    更新日期:2016-03-01 00:00:00

  • The epidemiology, etiology, and pathophysiology of onychomycosis.

    abstract::The prevalence of onychomycosis in the United States is estimated to be at least 12%; prevalence increases with increasing age and is highest in individuals more than 65 years of age. Trichophyton rubrum, which also causes tinea pedis, is responsible for approximately 90% of cases of toenail onychomycosis. Risk factor...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.12788/j.sder.0014

    authors: Scher RK,Rich P,Pariser D,Elewski B

    更新日期:2013-06-01 00:00:00

  • Staging and prognosis of melanoma.

    abstract::Prognosis and survival for patients diagnosed with melanoma depends on a number of interrelated factors, including histological, clinical, immunologic, and surgical parameters. Tumor thickness and depth of invasion is the most important prognostic factor, and helps to guide treatment and management plans. Besides tumo...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1085-5629(97)80005-3

    authors: Brown M

    更新日期:1997-06-01 00:00:00

  • Antibiotic-resistant acne: getting under the skin.

    abstract::Propionibacterium acnes is a key pathogenic factor in the development of acne. Antibiotics are the first choice of treatment for mild-to-moderate, mixed, papular/pustular, and moderate nodular acne, and an alternative choice in severe, nodular/conglobate acne. The emergence of resistance to the currently available ant...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.12788/j.sder.2016.031

    authors: Sinha M,Sadhasivam S,Bhattacharyya A,Jain S,Ghosh S,Arndt KA,Dover JS,Sengupta S

    更新日期:2016-06-01 00:00:00

  • DNA microarray technology in dermatology.

    abstract::In recent years, DNA microarray technology has been used for the analysis of gene expression patterns in a variety of skin diseases, including malignant melanoma, psoriasis, lupus erythematosus, and systemic sclerosis. Many of the studies described herein confirmed earlier results on individual genes or functional gro...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2007.12.004

    authors: Kunz M

    更新日期:2008-03-01 00:00:00

  • Principles of dermatoscopy of pigmented skin lesions.

    abstract::There has been a dramatic increase in the incidence of malignant melanoma in most parts of the world. Because the tumor thickness is the most important prognostic factor for the prognosis of the malignant melanoma, the early detection of thin melanomas is essential. Dermatoscopy allows the physician to discriminate be...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1053/sder.2003.50001

    authors: Stolz W,Semmelmayer U,Johow K,Burgdorf WH

    更新日期:2003-03-01 00:00:00

  • Merkel cell carcinoma: update and review.

    abstract::Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal cutaneous malignancy that is not usually suspected at the time of biopsy. Because of its increasing incidence and the discovery of a possible viral association, interest in MCC has escalated. Recent effort has broadened our breadth of knowledge regardi...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2011.02.001

    authors: Wang TS,Byrne PJ,Jacobs LK,Taube JM

    更新日期:2011-03-01 00:00:00

  • Understanding therapeutic pathways and comorbidities in psoriasis.

    abstract::Psoriasis is now recognized as an immunologically mediated systemic disease that may be expressed in cutaneous and joint symptoms. Medications that were once thought to control psoriasis by reducing keratinocyte proliferation are now known to act on immunologic pathways. In recent years, the emerging understanding of ...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.12788/j.sder.0067

    authors: Gordon KB,Strober BE

    更新日期:2014-03-01 00:00:00

  • The Aging Face: Global Approach With Fillers and Neuromodulators.

    abstract::The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.12788/j.sder.2016.038

    authors: Solish N

    更新日期:2016-06-01 00:00:00

  • Innovative cosmeceuticals: sirtuin activators and anti-glycation compounds.

    abstract::Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of el...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2011.05.004

    authors: Farris PK

    更新日期:2011-09-01 00:00:00

  • Ustekinumab for the treatment of psoriasis: an evidence update.

    abstract::Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment ...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.12788/j.sder.2018.040

    authors: Yiu ZZ,Warren RB

    更新日期:2018-09-01 00:00:00

  • The place of laser resurfacing within the range of medical and surgical skin resurfacing techniques.

    abstract::The history of resurfacing procedures used to treat the aging face is reviewed, and the place of laser resurfacing within this context is described. The changing medical reimbursement system and desire by "baby boomers" to maintain a youthful image have driven the technical development of laser resurfacing. Medical ma...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1085-5629(96)80052-6

    authors: Roenigk HH Jr

    更新日期:1996-09-01 00:00:00

  • Dermatologic lupus: Hopkins Lupus Cohort.

    abstract::Dermatologic manifestations are among the most common signs of systemic lupus erythematosus (SLE). The Hopkins Lupus Cohort study is a prospective study in which patients with SLE are seen on a quarterly basis for measurement of disease activity, laboratory tests, and assessment of morbidity and quality of life. This ...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1016/s1085-5629(98)80017-5

    authors: Petri M

    更新日期:1998-09-01 00:00:00

  • Laser treatment of acne, psoriasis, leukoderma, and scars.

    abstract::Lasers frequently are used by dermatologists for their multiple aesthetic applications, but they also can be used to treat a variety of medical dermatology conditions. Conditions such as acne vulgaris, psoriasis, and vitiligo can all be successfully treated with laser, thereby providing the patient with additional the...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1016/j.sder.2008.10.003

    authors: Railan D,Alster TS

    更新日期:2008-12-01 00:00:00

  • Issues in physician contracting.

    abstract::Dermatologists will enter into a number of different contracts during their professional careers. It is important that in each agreement they enter, dermatologists reap the benefits that they aspire for and understand the consequences of each provision. This article addresses just a few of the different issues that ar...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2005.05.004

    authors: Fanburg JD,Leone AM

    更新日期:2005-09-01 00:00:00

  • Treatment strategies for atopic dermatitis: optimizing the available therapeutic options.

    abstract::Bathing and moisturization to control dryness, applications of topical anti-inflammatory agents (including corticosteroids and calcineurin inhibitors [TCIs]) to control flares, minimization of the risk for infection, and relief of pruritus are the cornerstones of effective therapy for atopic dermatitis. Education of p...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2012.07.004

    authors: Paller AS,Simpson EL,Eichenfield LF,Ellis CN,Mancini AJ

    更新日期:2012-09-01 00:00:00

  • Infectious disease update: new anti-microbials.

    abstract::Effective antimicrobials are critical in controlling one of the most common conditions encountered in medicine, namely, skin and skin structure infections. Unfortunately, the identification of appropriate and novel antimicrobials is continually challenged by the emergence of antimicrobial resistance among bacteria, fu...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2006.04.006

    authors: Yang A,Kerdel FA

    更新日期:2006-06-01 00:00:00

  • Aesthetic and anatomic analysis of the aging skin.

    abstract::One of the most interesting medical conditions that now afflicts the baby boomer generation is photoaging. Clinical signs of photoaging of the skin include rhytids, lentigines, keratoses, telangiectasia, loss of translucency, loss of elasticity, and sallow color. A systematic classification of patient photoaging types...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1085-5629(96)80003-4

    authors: Glogau RG

    更新日期:1996-09-01 00:00:00

  • The pathogenesis of cutaneous fibrosis.

    abstract::Cutaneous fibrosis is an integral component of a variety of human disorders including keloids, hypertrophic scar, and most notably, scleroderma. Each has its own etiology and unique clinical characteristics, but all involve the dysregulation of connective tissue metabolism, in particular, the activation of dermal fibr...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1085-5629(98)80055-2

    authors: Liu B,Connolly MK

    更新日期:1998-03-01 00:00:00

  • Ultraviolet radiation and melanoma.

    abstract::Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2011.08.003

    authors: Kanavy HE,Gerstenblith MR

    更新日期:2011-12-01 00:00:00

  • Vitiligo.

    abstract::Vitiligo involves a progressive loss of melanocytes from the epidermis and hair follicles. Milky-white patches appear resulting in cosmetic disfiguration that is most apparent in dark-skinned individuals. The disease is further classified according to distribution pattern and extent of depigmentation. The presence of ...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s1085-5629(97)80030-2

    authors: Le Poole C,Boissy RE

    更新日期:1997-03-01 00:00:00

  • Hyaluronic acid fillers in facial rejuvenation.

    abstract::Nonsurgical procedures have become very popular for the rejuvenation of the aging face. Trends now are for less invasive procedures as well as for more preventative intervention to slow the damage from ultraviolet light and environmental factors, as well as from intrinsic aging. The goal of these procedures is to elim...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2006.06.011

    authors: Lupo MP

    更新日期:2006-09-01 00:00:00

  • Phototherapy in pediatric patients: choosing the appropriate treatment option.

    abstract::Phototherapeutic modalities, including narrowband-UVB, broadband-UVB, PUVA photochemotherapy, and excimer laser therapy are valuable tools that can be used for photoresponsive dermatoses in children. As a systematically safer alternative compared with internal agents, including the prebiologic and biological therapies...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2010.03.006

    authors: Pugashetti R,Koo J

    更新日期:2010-06-01 00:00:00

  • Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity.

    abstract::The ascomycin macrolactam derivative pimecrolimus (Elidel, SDZ ASM 981; Novartis Pharma AG, Basel Switzerland) is a cell-selective inhibitor of inflammatory cytokines specifically developed for the treatment of inflammatory skin diseases, such as atopic dermatitis, allergic contact dermatitis, irritant contact dermati...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1053/sder.2001.29066

    authors: Stuetz A,Grassberger M,Meingassner JG

    更新日期:2001-12-01 00:00:00

  • Update on Epidemiology, Diagnosis, and Disease Course of Atopic Dermatitis.

    abstract::Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborn...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.12788/j.sder.2016.041

    authors: Simpson EL Md McR,Irvine AD Md,Eichenfield LF Md,Friedlander SF Md

    更新日期:2016-06-01 00:00:00

  • Nonpharmacologic strategies and topical agents for treating atopic dermatitis: an update.

    abstract::The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improve...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.12788/j.sder.2017.011

    authors: Stein Gold LF,Eichenfield LF

    更新日期:2017-03-01 00:00:00

  • Dermoscopy research--an update.

    abstract::Dermoscopy increases the clinician's diagnostic accuracy by as much as 30% over that of unaided visual clinical inspection alone and has been confirmed in 3 separate evidence-based publications using a meta-analysis of the literature. It can be viewed as an in vivo bridge between clinical morphology and histopathology...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.sder.2009.07.001

    authors: Braun RP,Rabinovitz H,Tzu JE,Marghoob AA

    更新日期:2009-09-01 00:00:00

  • The use of nonablative radiofrequency technology to tighten the lower face and neck.

    abstract::The ThermaCool TC system is a radiofrequency device capable of delivering higher energy fluences to a greater volume of tissue than nonablative lasers, with no epidermal injury. It has been successful in treating periorbital rhytides and lifting eyebrows. Given these positive finding for treatment of the upper face, t...

    journal_title:Seminars in cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1053/sder.2003.50011

    authors: Hsu TS,Kaminer MS

    更新日期:2003-06-01 00:00:00