Abstract:
:Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment of psoriasis. We also review observational data emerging from psoriasis registries reporting the effectiveness and safety of ustekinumab. Overall, new evidence suggests that ustekinumab has a favorable balance between efficacy/effectiveness, safety, and tolerability and should remain a first-line biologic therapy option for patients with severe psoriasis at present.
journal_name
Semin Cutan Med Surgjournal_title
Seminars in cutaneous medicine and surgeryauthors
Yiu ZZ,Warren RBdoi
10.12788/j.sder.2018.040subject
Has Abstractpub_date
2018-09-01 00:00:00pages
143-147issue
3eissn
1085-5629issn
1558-0768journal_volume
37pub_type
杂志文章,评审abstract::Several nonsurgical strategies for managing hidradenitis suppurativa (HS) are used that are successful in many patients. The overall goals of pharmacologic therapy are to clear or reduce the number and extent of current lesions and to prevent new lesions from forming. No pharmacologic agent is universally effective in...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.0094
更新日期:2014-06-01 00:00:00
abstract::Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2011.08.003
更新日期:2011-12-01 00:00:00
abstract::The expansion of telemedicine nationwide has resulted in many states adopting specific telemedicine regulations to avoid the issue of requiring a full medical license to practice telemedicine. How these laws and regulations relate to the practice of telepathology and teledermatology has not been well delineated. It is...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0037
更新日期:2013-12-01 00:00:00
abstract::Closing surgical defects of the external ear poses unique challenges because of the convoluted shape and thin tethered skin. Choice of repair is often dictated by the site of the wound. If the defect is central and anterior with intact cartilage, most defects will do well by second intention healing or grafting. If th...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/S1085-5629(03)00077-4
更新日期:2003-12-01 00:00:00
abstract::Congenital hemangiomas are rare solitary vascular tumors that do not proliferate after birth. They are characterized as either rapidly involuting congenital hemangiomas (RICHs) or noninvoluting congenital hemangiomas (NICHs) based on their clinical progression. NICHs have no associated complications, but are persisten...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2016.045
更新日期:2016-09-01 00:00:00
abstract::Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of el...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2011.05.004
更新日期:2011-09-01 00:00:00
abstract::Electronic billing systems make dermatology practices more efficient and productive. The decision to purchase and install such a system, however, involves a significant amount of time and is often accompanied by many mistakes. This article presents errors commonly made in the evaluation and purchase process and offers...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(00)80025-5
更新日期:2000-09-01 00:00:00
abstract::Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborn...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2016.041
更新日期:2016-06-01 00:00:00
abstract::Topical retinoic acid was introduced for acne treatment three decades ago. Since that time, researchers have discovered thousands of retinoids, originally defined as chemical analogs of vitamin A. After the identification of nuclear retinoid receptors in 1987, the definition of this class expanded to include molecules...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1053/sder.2001.27555
更新日期:2001-09-01 00:00:00
abstract::"Venous disease consists of a spectrum with significant medical and economic morbidities. For lack of exposure, however, it is a poorly understood subject. The evaluation and approach to diagnosing venous disease requires a firm understanding of venous anatomy and pathophysiology. With a targeted history and physical,...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2005.10.001
更新日期:2005-12-01 00:00:00
abstract::Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus. Topical and systemic agents as well as broadband ultraviolet photo...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2011.04.005
更新日期:2011-06-01 00:00:00
abstract::Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The imbalance of the Th2 and Th1 pathways and their associated cytokines in AD presents as one facet of the pathogenic mechanisms. Changes in the T-cell populations...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0018
更新日期:2013-09-01 00:00:00
abstract::Deep morphea encompasses a variety of clinical entities in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. Morphea profunda, eosinophilic fasciitis, and disabling pansclerotic morphea of children are included in this group, but overlapping of the extent and dep...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2007.02.005
更新日期:2007-06-01 00:00:00
abstract::Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are ra...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2018.014
更新日期:2018-03-01 00:00:00
abstract::The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.2016.038
更新日期:2016-06-01 00:00:00
abstract::This article discusses the approach to the acute, generalized, blistering patient from the perspective of the dermatologic consultant. Initially, a case is presented, followed by a discussion of the relevant evaluation, differential diagnosis, and treatment options. ...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2007.09.006
更新日期:2007-09-01 00:00:00
abstract::The intraepidermal vesiculobullous disorders constitute a wide variety of pathogenically unrelated disorders that share in common the formation of cleft or bullae formation within the epithelium. The etiologic, pathogenic, clinical and, in particular, the histopathologic attributes of the most important intraepidermal...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(03)00082-8
更新日期:2004-03-01 00:00:00
abstract::Superficial chemical peels and microdermabrasion are used for many dermatologic conditions. A common condition treated with these modalities is acne vulgaris. In this review, we discuss the theory behind the technique of these procedures and describe the application and complications of each of these procedures in the...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2008.06.003
更新日期:2008-09-01 00:00:00
abstract::The prevalence of onychomycosis in the United States is estimated to be at least 12%; prevalence increases with increasing age and is highest in individuals more than 65 years of age. Trichophyton rubrum, which also causes tinea pedis, is responsible for approximately 90% of cases of toenail onychomycosis. Risk factor...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0014
更新日期:2013-06-01 00:00:00
abstract::This is a very exciting time in cutaneous laser surgery with an ever-expanding therapeutic armamentarium and an increased sophistication of available technology. These recent trends have allowed for both a rapid development of interest and exploration of laser-assisted drug delivery and its potential applications. We ...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0119
更新日期:2014-12-01 00:00:00
abstract::The ascomycin macrolactam derivative pimecrolimus (Elidel, SDZ ASM 981; Novartis Pharma AG, Basel Switzerland) is a cell-selective inhibitor of inflammatory cytokines specifically developed for the treatment of inflammatory skin diseases, such as atopic dermatitis, allergic contact dermatitis, irritant contact dermati...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1053/sder.2001.29066
更新日期:2001-12-01 00:00:00
abstract::Immunotherapy for the treatment of advanced melanoma has become a primary treatment in the clinic. Current therapies include systemic cytokines, immune checkpoint inhibitors, and localized intratumoral therapies. Checkpoint inhibitors block natural pathways that dampen or inhibit an immune response to stimulus. These ...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2018.028
更新日期:2018-06-01 00:00:00
abstract::Lasers, both in single and multiple wavelength designs, have recently been introduced to enhance the results of liposuction. Safe parameters of fluence and temperature have not yet been described. In this study, I describe a series of laser lipolysis patients treated with a dual wavelength (1064/1319 nm) laser where i...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1016/j.sder.2009.11.002
更新日期:2009-12-01 00:00:00
abstract::Oral mucosal bullous/desquamative/ulcerative diseases involve immunopathological mechanisms that account for loss of adhesion between contiguous keratinocytes or to structures within the basal lamina. Some are antibody mediated, in which specific adhesion molecules of the desmosome, hemidesmosome, and basement membran...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(97)80018-1
更新日期:1997-12-01 00:00:00
abstract::Hair disorders include hair loss, increased hair growth, and hair structure defects with increased breakage, as well as unacceptable cosmetic appearance, such as reduced shine, strength, curliness, and elasticity. It is the task of the dermatologist to choose the right diagnostic tool depending on the suspected clinic...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2008.12.005
更新日期:2009-03-01 00:00:00
abstract::Medical imaging has dramatically transformed the practice of medicine, especially the field of dermatology. Imaging is used to facilitate the transfer of information between providers, document cutaneous disease, assess response to therapy, and plays a crucial role in monitoring and diagnosing skin cancer. Advancement...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2016.001
更新日期:2016-03-01 00:00:00
abstract::The pathophysiology of atopic dermatitis (AD) is complex, and future treatment options will likely be incorporated in a multimodal approach to management. The new, directed therapies that have been developed will likely be used in conjunction with concomitant continuous or intermittent use of standard therapies; the g...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.2016.044
更新日期:2016-06-01 00:00:00
abstract::Nonpharmacologic management of psychodermatologic conditions includes both structured and unstructured interventions that may ameliorate skin disorders, reduce psychological distress, and improve the functional status of the affected individual. Nonpharmacologic techniques are often referred to as psychocutaneous inte...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0011
更新日期:2013-06-01 00:00:00
abstract::Cutaneous fibrosis is an integral component of a variety of human disorders including keloids, hypertrophic scar, and most notably, scleroderma. Each has its own etiology and unique clinical characteristics, but all involve the dysregulation of connective tissue metabolism, in particular, the activation of dermal fibr...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(98)80055-2
更新日期:1998-03-01 00:00:00
abstract::Soft tissue augmentation has become increasingly important as more individuals seek aesthetic improvement without major surgical procedures. The choice of an appropriate subcutaneous implant, whether solid or injectable, requires a thorough understanding of the materials available. This review of the literature addres...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(99)80036-4
更新日期:1999-06-01 00:00:00