Abstract：
:Thalidomide, originally marketed as a sedative, was introduced in West Germany in 1956 and in numerous other countries soon thereafter. In part because it did not impair coordination or respiratory function, the drug rapidly became extremely popular. By 1961, however, there were mounting reports of phocomelia and other severe congenital abnormalities associated with maternal use of thalidomide, and the drug was withdrawn from the market and its availability highly restricted. A few years later, thalidomide would find use in dermatology after it was reported that leprosy patients with erythema nodosum leprosum (ENL) experienced rapid and dramatic improvement after taking the drug as a sedative. Additional data quickly confirmed thalidomide's efficacy in ENL, and today it is the drug of choice in the condition. In subsequent decades, the drug has been successfully tried in treatment of a variety of apparently unrelated dermatologic disorders. Meanwhile, thalidomide has been shown to possess a range of biologic actions, including inhibition of tumor necrosis factor alpha, possibly relevant to its clinical efficacy. Dermatologic disorders in addition to ENL in which thalidomide's effectiveness is well documented include aphthous stomatitis, discoid lupus erythematosus, actinic prurigo, Behçet's disease, and prurigo nodularis. More recently, the drug has been employed in dermatologic conditions associated with HIV infection. When used with safeguards to prevent teratogenicity and the drug's other major adverse effect, peripheral neuropathy, thalidomide may offer a good therapeutic option for many patients in whom other drug therapies have proven inadequate.
journal_name
Semin Cutan Med Surgjournal_title
Seminars in cutaneous medicine and surgeryauthors
Stirling DIdoi
10.1016/s1085-5629(98)80019-9subject
Has Abstractpub_date
1998-12-01 00:00:00pages
231-42issue
4eissn
1085-5629issn
1558-0768pii
S1085-5629(98)80019-9journal_volume
17pub_type
杂志文章,评审abstract：:Among the newer medications for treating psoriasis are the interleukin-17A inhibitor secukinumab and the phosphodiesterase 4 inhibitor apremilast. Secukinumab offers a level of efficacy greater than that of the tumor necrosis factor-α inhibitor adalimumab. Apremilast is associated with lower levels of efficacy than th...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2016.020
更新日期：2016-06-01 00:00:00
abstract：:This review highlights melanoma trends observed among African-, Asian-, Latino- and Native-American populations. Melanoma is the most lethal form of skin cancer, accounting for about 75% of all skin cancer deaths. Generally, incidence rates increase with age, peak after age 40, and are greater in men than women. Howev...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2009.04.005
更新日期：2009-06-01 00:00:00
abstract：:Cellulite is a common dermatologic condition and frequent cause of cosmetic concern among women. This paper aims to update what is known about the pathogenesis of cellulite and reviews targeted treatment modalities that address its underlying components of microvascular dysfunction, endocrine-mediated inflammation, an...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2018.056
更新日期：2018-12-01 00:00:00
abstract：:This article discusses the approach to the acute, generalized, blistering patient from the perspective of the dermatologic consultant. Initially, a case is presented, followed by a discussion of the relevant evaluation, differential diagnosis, and treatment options. ...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2007.09.006
更新日期：2007-09-01 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The imbalance of the Th2 and Th1 pathways and their associated cytokines in AD presents as one facet of the pathogenic mechanisms. Changes in the T-cell populations...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.0018
更新日期：2013-09-01 00:00:00
abstract：:The prevalence of onychomycosis in the United States is estimated to be at least 12%; prevalence increases with increasing age and is highest in individuals more than 65 years of age. Trichophyton rubrum, which also causes tinea pedis, is responsible for approximately 90% of cases of toenail onychomycosis. Risk factor...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.0014
更新日期：2013-06-01 00:00:00
abstract：:The term "epidermal nevus syndrome" (ENS) has been used to describe the association of epidermal hamartomas and extra-cutaneous abnormalities. Epidermal nevi follow the lines of Blaschko. The majority of the extra-cutaneous manifestations involve the brain, eye, and skeletal systems. Several subsets with characteristi...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2008.03.006
更新日期：2007-12-01 00:00:00
abstract：:The intraepidermal vesiculobullous disorders constitute a wide variety of pathogenically unrelated disorders that share in common the formation of cleft or bullae formation within the epithelium. The etiologic, pathogenic, clinical and, in particular, the histopathologic attributes of the most important intraepidermal...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(03)00082-8
更新日期：2004-03-01 00:00:00
abstract：:Soft tissue augmentation has become increasingly important as more individuals seek aesthetic improvement without major surgical procedures. The choice of an appropriate subcutaneous implant, whether solid or injectable, requires a thorough understanding of the materials available. This review of the literature addres...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(99)80036-4
更新日期：1999-06-01 00:00:00
abstract：:The techniques of noninvasive facial rejuvenation are forever being redefined and improved. This article will review historical as well as present approaches to resurfacing, discussing the nonablative tools that can complement resurfacing procedures. Current thoughts on the pre- and postoperative care of resurfacing p...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 历史文章,杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:"Venous disease consists of a spectrum with significant medical and economic morbidities. For lack of exposure, however, it is a poorly understood subject. The evaluation and approach to diagnosing venous disease requires a firm understanding of venous anatomy and pathophysiology. With a targeted history and physical,...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2005.10.001
更新日期：2005-12-01 00:00:00
abstract：:The expansion of telemedicine nationwide has resulted in many states adopting specific telemedicine regulations to avoid the issue of requiring a full medical license to practice telemedicine. How these laws and regulations relate to the practice of telepathology and teledermatology has not been well delineated. It is...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.0037
更新日期：2013-12-01 00:00:00
abstract：:Dermatologists will enter into a number of different contracts during their professional careers. It is important that in each agreement they enter, dermatologists reap the benefits that they aspire for and understand the consequences of each provision. This article addresses just a few of the different issues that ar...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2005.05.004
更新日期：2005-09-01 00:00:00
abstract：:Bathing and moisturization to control dryness, applications of topical anti-inflammatory agents (including corticosteroids and calcineurin inhibitors [TCIs]) to control flares, minimization of the risk for infection, and relief of pruritus are the cornerstones of effective therapy for atopic dermatitis. Education of p...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2012.07.004
更新日期：2012-09-01 00:00:00
abstract：:Congenital hemangiomas are rare solitary vascular tumors that do not proliferate after birth. They are characterized as either rapidly involuting congenital hemangiomas (RICHs) or noninvoluting congenital hemangiomas (NICHs) based on their clinical progression. NICHs have no associated complications, but are persisten...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2016.045
更新日期：2016-09-01 00:00:00
abstract：:Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are ra...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2018.014
更新日期：2018-03-01 00:00:00
abstract：:Cutaneous fibrosis is an integral component of a variety of human disorders including keloids, hypertrophic scar, and most notably, scleroderma. Each has its own etiology and unique clinical characteristics, but all involve the dysregulation of connective tissue metabolism, in particular, the activation of dermal fibr...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(98)80055-2
更新日期：1998-03-01 00:00:00
abstract：:Hidradenitis suppurativa (HS) is a complex dermatological disease characterized by recurrent painful nodules and suppuration in areas such as the axilla and groin. The disease is poorly understood and treatment is not satisfactory. In October 2016, the Canadian and United States Hidradenitis Suppurativa Foundations or...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2017.024
更新日期：2017-06-01 00:00:00
abstract：:Hair shaft abnormalities are fascinating and can provide a diagnostic challenge. Current knowledge of structural changes in hair has been amplified by scanning and transmission electron microscopy (SEM and TEM). Dermatologists using the light microscope and polarization in the office can diagnose the great majority of...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2006.01.004
更新日期：2006-03-01 00:00:00
abstract：:Teledermatology (TD) is a health care delivery modality that uses telecommunication technology to provide dermatologic care. It has grown to be a reliable and diagnostically accurate means of producing quality care while increasing access and reducing wait times in the outpatient setting. In the inpatient setting, TD ...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2017.004
更新日期：2017-03-01 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic skin condition affecting children and adults, with a significant negative impact on patient and caregiver quality of life (QOL). Although effective treatments for AD are available, outcomes are often limited by poor adherence to treatment plans. Effective patient and caregiver educa...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2017.029
更新日期：2017-09-01 00:00:00
abstract：:Artecoll was developed about 20 years ago and underwent a number of production changes until it recently became FDA approved under the new name of Artefill. This product contains 20% polymethyl methacrylate (PMMA) microspheres with a diameter of 30 to 40 microm, which are suspended in a 3.5% atelo-collagen solution. T...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2004.08.002
更新日期：2004-12-01 00:00:00
abstract：:The ascomycin macrolactam derivative pimecrolimus (Elidel, SDZ ASM 981; Novartis Pharma AG, Basel Switzerland) is a cell-selective inhibitor of inflammatory cytokines specifically developed for the treatment of inflammatory skin diseases, such as atopic dermatitis, allergic contact dermatitis, irritant contact dermati...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1053/sder.2001.29066
更新日期：2001-12-01 00:00:00
abstract：:Nonsurgical procedures have become very popular for the rejuvenation of the aging face. Trends now are for less invasive procedures as well as for more preventative intervention to slow the damage from ultraviolet light and environmental factors, as well as from intrinsic aging. The goal of these procedures is to elim...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2006.06.011
更新日期：2006-09-01 00:00:00
abstract：:The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.12788/j.sder.2016.038
更新日期：2016-06-01 00:00:00
abstract：:Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborn...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.12788/j.sder.2016.041
更新日期：2016-06-01 00:00:00
abstract：:Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinic...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(00)80005-x
更新日期：2000-06-01 00:00:00
abstract：:Although the majority of hemangiomas of infancy can be expected to follow a benign course, a significant subset may result in serious complications. Recently, hemangiomas of segmental morphology, or those which are large, plaque-like, and patterned in distribution, have been recognized as important markers for potenti...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2004.01.004
更新日期：2004-06-01 00:00:00
abstract：:One of the most interesting medical conditions that now afflicts the baby boomer generation is photoaging. Clinical signs of photoaging of the skin include rhytids, lentigines, keratoses, telangiectasia, loss of translucency, loss of elasticity, and sallow color. A systematic classification of patient photoaging types...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/s1085-5629(96)80003-4
更新日期：1996-09-01 00:00:00
abstract：:Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal cutaneous malignancy that is not usually suspected at the time of biopsy. Because of its increasing incidence and the discovery of a possible viral association, interest in MCC has escalated. Recent effort has broadened our breadth of knowledge regardi...
journal_title：Seminars in cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1016/j.sder.2011.02.001
更新日期：2011-03-01 00:00:00
