Antifungal Drugs for Onychomycosis: Efficacy, Safety, and Mechanisms of Action.

abstract：:Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are ra...

journal_title：Seminars in cutaneous medicine and surgery

authors： Chen ST,Barnes J,Duncan L

更新日期：2018-03-01 00:00:00

abstract：:The intraepidermal vesiculobullous disorders constitute a wide variety of pathogenically unrelated disorders that share in common the formation of cleft or bullae formation within the epithelium. The etiologic, pathogenic, clinical and, in particular, the histopathologic attributes of the most important intraepidermal...

journal_title：Seminars in cutaneous medicine and surgery

authors： Cassandra M,Morgan M

更新日期：2004-03-01 00:00:00

abstract：:The term bed bug is applied to 2 species of genus Cimex: lectularius describes the common or temperate bed bug, and hemipterus its tropical cousin. Cimex lectularius is aptly named; its genus and species derive from the Latin words for bug and bed, respectively. Though the tiny pest is receiving increased public atten...

journal_title：Seminars in cutaneous medicine and surgery

authors： Foulke GT,Anderson BE

更新日期：2014-09-01 00:00:00

abstract：:Prognosis and survival for patients diagnosed with melanoma depends on a number of interrelated factors, including histological, clinical, immunologic, and surgical parameters. Tumor thickness and depth of invasion is the most important prognostic factor, and helps to guide treatment and management plans. Besides tumo...

journal_title：Seminars in cutaneous medicine and surgery

authors： Brown M

更新日期：1997-06-01 00:00:00

abstract：:Perioral dermatitis is a unique skin disorder of childhood. Its exact origin is unknown; it is probably an idiosyncratic response to exogenous factors such as the use of a topical fluorinated corticosteroid or other substances on the face. It is uncommon but not rare. The age of affected children has ranged from 7 mon...

journal_title：Seminars in cutaneous medicine and surgery

authors： Laude TA,Salvemini JN

更新日期：1999-09-01 00:00:00

abstract：:Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinic...

journal_title：Seminars in cutaneous medicine and surgery

authors： Howard MS,Smoller BR

更新日期：2000-06-01 00:00:00

abstract：:Safety remains paramount to the clinical utility of a therapy. Evaluation of safety is an ongoing process that does not end when a therapy becomes commercially available. This article reviews recent data pertaining to the safety profile of two therapeutic classes widely used in the treatment of psoriasis: inhibitors o...

journal_title：Seminars in cutaneous medicine and surgery

authors： Leonardi CL

更新日期：2014-06-01 00:00:00

abstract：:Several nonsurgical strategies for managing hidradenitis suppurativa (HS) are used that are successful in many patients. The overall goals of pharmacologic therapy are to clear or reduce the number and extent of current lesions and to prevent new lesions from forming. No pharmacologic agent is universally effective in...

journal_title：Seminars in cutaneous medicine and surgery

authors： Kerdel FA

更新日期：2014-06-01 00:00:00

abstract：:Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of el...

journal_title：Seminars in cutaneous medicine and surgery

authors： Farris PK

更新日期：2011-09-01 00:00:00

abstract：:In dermatology, botulinum toxin is now most often used to reduce dynamic facial creases and treat primary focal hyperhidrosis. The exemplary safety record of this medication is such that after nearly 2 decades, it is not known to have any long-term adverse events. Transient adverse events, such as mild injection pain,...

journal_title：Seminars in cutaneous medicine and surgery

authors： Pena MA,Alam M,Yoo SS

更新日期：2007-03-01 00:00:00

abstract：:Dermatologists will enter into a number of different contracts during their professional careers. It is important that in each agreement they enter, dermatologists reap the benefits that they aspire for and understand the consequences of each provision. This article addresses just a few of the different issues that ar...

journal_title：Seminars in cutaneous medicine and surgery

authors： Fanburg JD,Leone AM

更新日期：2005-09-01 00:00:00

abstract：:Hair shaft abnormalities are fascinating and can provide a diagnostic challenge. Current knowledge of structural changes in hair has been amplified by scanning and transmission electron microscopy (SEM and TEM). Dermatologists using the light microscope and polarization in the office can diagnose the great majority of...

journal_title：Seminars in cutaneous medicine and surgery

authors： Whiting DA,Dy LC

更新日期：2006-03-01 00:00:00

abstract：:Electronic billing systems make dermatology practices more efficient and productive. The decision to purchase and install such a system, however, involves a significant amount of time and is often accompanied by many mistakes. This article presents errors commonly made in the evaluation and purchase process and offers...

journal_title：Seminars in cutaneous medicine and surgery

authors： Dinehart S

更新日期：2000-09-01 00:00:00

abstract：:Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer pred...

journal_title：Seminars in cutaneous medicine and surgery

authors： Nikolaou V,Stratigos AJ,Tsao H

更新日期：2012-12-01 00:00:00

abstract：:The influences of information technology have touched almost all aspects of our lives, and health care delivery has been no exception. Law, policy, and regulation have driven the adoption of electronic medical records, particularly over the past decade, driving fundamental changes to the practice of medicine in genera...

journal_title：Seminars in cutaneous medicine and surgery

authors： Park AJ,Maruther MK,Swerlick RA

更新日期：2019-03-01 00:00:00

abstract：:One of the most interesting medical conditions that now afflicts the baby boomer generation is photoaging. Clinical signs of photoaging of the skin include rhytids, lentigines, keratoses, telangiectasia, loss of translucency, loss of elasticity, and sallow color. A systematic classification of patient photoaging types...

journal_title：Seminars in cutaneous medicine and surgery

authors： Glogau RG

更新日期：1996-09-01 00:00:00

abstract：:Among the newer medications for treating psoriasis are the interleukin-17A inhibitor secukinumab and the phosphodiesterase 4 inhibitor apremilast. Secukinumab offers a level of efficacy greater than that of the tumor necrosis factor-α inhibitor adalimumab. Apremilast is associated with lower levels of efficacy than th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Strober BE

更新日期：2016-06-01 00:00:00

abstract：:Deep morphea encompasses a variety of clinical entities in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. Morphea profunda, eosinophilic fasciitis, and disabling pansclerotic morphea of children are included in this group, but overlapping of the extent and dep...

journal_title：Seminars in cutaneous medicine and surgery

authors： Bielsa I,Ariza A

更新日期：2007-06-01 00:00:00

abstract：:There are many hair disorders, all of which involve alterations in normal hair biology. Essentially, hair disorders involve changes to hair fiber caliber, density per unit area, and/or the duration of anagen and telogen in the hair growth cycle. Hair disorders may be triggered by inflammation, genetics, the environmen...

journal_title：Seminars in cutaneous medicine and surgery

authors： Chu TW,Santos L,McElwee KJ

更新日期：2015-06-01 00:00:00

abstract：:Cellulite is a common dermatologic condition and frequent cause of cosmetic concern among women. This paper aims to update what is known about the pathogenesis of cellulite and reviews targeted treatment modalities that address its underlying components of microvascular dysfunction, endocrine-mediated inflammation, an...

journal_title：Seminars in cutaneous medicine and surgery

authors： Hogan S,Velez MW,Kaminer MS

更新日期：2018-12-01 00:00:00

abstract：:Propionibacterium acnes is a key pathogenic factor in the development of acne. Antibiotics are the first choice of treatment for mild-to-moderate, mixed, papular/pustular, and moderate nodular acne, and an alternative choice in severe, nodular/conglobate acne. The emergence of resistance to the currently available ant...

journal_title：Seminars in cutaneous medicine and surgery

authors： Sinha M,Sadhasivam S,Bhattacharyya A,Jain S,Ghosh S,Arndt KA,Dover JS,Sengupta S

更新日期：2016-06-01 00:00:00

abstract：:Cellulite is a condition that affects the vast majority of women. Although it is of no danger to one's overall health, cellulite can be psychosocially debilitating. Consequently, much research has been devoted to understanding cellulite and its etiopathogenesis. With additional insights into the underlying causes of i...

journal_title：Seminars in cutaneous medicine and surgery

authors： Green JB,Cohen JL,Kaufman J,Metelitsa AI,Kaminer MS

更新日期：2015-09-01 00:00:00

abstract：:Stromal relationships are crucial to metastatic spread of solid malignancies. Some aspects of this stroma interaction are obviously associated with particular morphological features, which may carry prognostic significance. In cutaneous melanoma, level of invasion, arrangement of cells (horizontal or vertical growth p...

journal_title：Seminars in cutaneous medicine and surgery

authors： Smolle J,Hofmann-Wellenhof R,Fink-Puches R

更新日期：1996-12-01 00:00:00

abstract：:Nonpharmacologic management of psychodermatologic conditions includes both structured and unstructured interventions that may ameliorate skin disorders, reduce psychological distress, and improve the functional status of the affected individual. Nonpharmacologic techniques are often referred to as psychocutaneous inte...

journal_title：Seminars in cutaneous medicine and surgery

authors： Fried RG

更新日期：2013-06-01 00:00:00

abstract：:Nonsurgical procedures have become very popular for the rejuvenation of the aging face. Trends now are for less invasive procedures as well as for more preventative intervention to slow the damage from ultraviolet light and environmental factors, as well as from intrinsic aging. The goal of these procedures is to elim...

journal_title：Seminars in cutaneous medicine and surgery

authors： Lupo MP

更新日期：2006-09-01 00:00:00

abstract：:The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. Th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Connolly D,Schilling L,Saedi N

更新日期：2017-12-01 00:00:00

abstract：:This review highlights important considerations in obtaining good skin biopsy specimens to optimize results of direct immunofluorescence (IF) studies and also summarizes the various patterns of cutaneous IF deposition and their associated diagnoses. IF findings of immunobullous diseases, lupus erythematosus, vasculiti...

journal_title：Seminars in cutaneous medicine and surgery

authors： Morrison LH

更新日期：1999-03-01 00:00:00

abstract：:The ascomycin macrolactam derivative pimecrolimus (Elidel, SDZ ASM 981; Novartis Pharma AG, Basel Switzerland) is a cell-selective inhibitor of inflammatory cytokines specifically developed for the treatment of inflammatory skin diseases, such as atopic dermatitis, allergic contact dermatitis, irritant contact dermati...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stuetz A,Grassberger M,Meingassner JG

更新日期：2001-12-01 00:00:00

abstract：:There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may...

journal_title：Seminars in cutaneous medicine and surgery

authors： Ascha M,Irfan M

更新日期：2016-12-01 00:00:00

abstract：:Although the majority of hemangiomas of infancy can be expected to follow a benign course, a significant subset may result in serious complications. Recently, hemangiomas of segmental morphology, or those which are large, plaque-like, and patterned in distribution, have been recognized as important markers for potenti...

journal_title：Seminars in cutaneous medicine and surgery

authors： Metry DW

更新日期：2004-06-01 00:00:00