Current and emerging nonsurgical treatment options for hidradenitis suppurativa.

abstract：:Thalidomide, originally marketed as a sedative, was introduced in West Germany in 1956 and in numerous other countries soon thereafter. In part because it did not impair coordination or respiratory function, the drug rapidly became extremely popular. By 1961, however, there were mounting reports of phocomelia and othe...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stirling DI

更新日期：1998-12-01 00:00:00

abstract：:In 1996, oral terbinafine joined itraconazole and fluconazole on the short list of systemic medications that could be used to treat onychomycosis (although fluconazole was not approved for this indication by the US Food and Drug Administration [FDA], it was commonly used for this purpose). In 1999, ciclopirox was the ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Rosen T,Stein Gold LF

更新日期：2016-03-01 00:00:00

abstract：:Cutaneous fibrosis is an integral component of a variety of human disorders including keloids, hypertrophic scar, and most notably, scleroderma. Each has its own etiology and unique clinical characteristics, but all involve the dysregulation of connective tissue metabolism, in particular, the activation of dermal fibr...

journal_title：Seminars in cutaneous medicine and surgery

authors： Liu B,Connolly MK

更新日期：1998-03-01 00:00:00

abstract：:Oral mucosal bullous/desquamative/ulcerative diseases involve immunopathological mechanisms that account for loss of adhesion between contiguous keratinocytes or to structures within the basal lamina. Some are antibody mediated, in which specific adhesion molecules of the desmosome, hemidesmosome, and basement membran...

journal_title：Seminars in cutaneous medicine and surgery

authors： Eversole LR

更新日期：1997-12-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal cutaneous malignancy that is not usually suspected at the time of biopsy. Because of its increasing incidence and the discovery of a possible viral association, interest in MCC has escalated. Recent effort has broadened our breadth of knowledge regardi...

journal_title：Seminars in cutaneous medicine and surgery

authors： Wang TS,Byrne PJ,Jacobs LK,Taube JM

更新日期：2011-03-01 00:00:00

abstract：:Infections with organisms of the genus Bartonella, for many years important only in South and Central America, have assumed significance in developing countries, especially in conjunction with the advent of the pandemic of the human immunodeficiency virus infection. New molecular and culture techniques have determined...

journal_title：Seminars in cutaneous medicine and surgery

authors： Wong R,Tappero J,Cockerell CJ

更新日期：1997-09-01 00:00:00

abstract：:The ascomycin macrolactam derivative pimecrolimus (Elidel, SDZ ASM 981; Novartis Pharma AG, Basel Switzerland) is a cell-selective inhibitor of inflammatory cytokines specifically developed for the treatment of inflammatory skin diseases, such as atopic dermatitis, allergic contact dermatitis, irritant contact dermati...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stuetz A,Grassberger M,Meingassner JG

更新日期：2001-12-01 00:00:00

abstract：:Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk...

journal_title：Seminars in cutaneous medicine and surgery

authors： Kanavy HE,Gerstenblith MR

更新日期：2011-12-01 00:00:00

abstract：:Dermoscopy increases the clinician's diagnostic accuracy by as much as 30% over that of unaided visual clinical inspection alone and has been confirmed in 3 separate evidence-based publications using a meta-analysis of the literature. It can be viewed as an in vivo bridge between clinical morphology and histopathology...

journal_title：Seminars in cutaneous medicine and surgery

authors： Braun RP,Rabinovitz H,Tzu JE,Marghoob AA

更新日期：2009-09-01 00:00:00

abstract：:There are many hair disorders, all of which involve alterations in normal hair biology. Essentially, hair disorders involve changes to hair fiber caliber, density per unit area, and/or the duration of anagen and telogen in the hair growth cycle. Hair disorders may be triggered by inflammation, genetics, the environmen...

journal_title：Seminars in cutaneous medicine and surgery

authors： Chu TW,Santos L,McElwee KJ

更新日期：2015-06-01 00:00:00

abstract：:The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improve...

journal_title：Seminars in cutaneous medicine and surgery

authors： Stein Gold LF,Eichenfield LF

更新日期：2017-03-01 00:00:00

abstract：:Nonsurgical procedures have become very popular for the rejuvenation of the aging face. Trends now are for less invasive procedures as well as for more preventative intervention to slow the damage from ultraviolet light and environmental factors, as well as from intrinsic aging. The goal of these procedures is to elim...

journal_title：Seminars in cutaneous medicine and surgery

authors： Lupo MP

更新日期：2006-09-01 00:00:00

abstract：:Teledermatology (TD) is a health care delivery modality that uses telecommunication technology to provide dermatologic care. It has grown to be a reliable and diagnostically accurate means of producing quality care while increasing access and reducing wait times in the outpatient setting. In the inpatient setting, TD ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Tull R,Wanat KA

更新日期：2017-03-01 00:00:00

abstract：:The pathophysiology of atopic dermatitis (AD) is complex, and future treatment options will likely be incorporated in a multimodal approach to management. The new, directed therapies that have been developed will likely be used in conjunction with concomitant continuous or intermittent use of standard therapies; the g...

journal_title：Seminars in cutaneous medicine and surgery

authors： Friedlander SF Md,Simpson EL Md McR,Irvine AD Md,Eichenfield LF Md

更新日期：2016-06-01 00:00:00

abstract：:Idiosyncratic reactions (type B) are a major complication of drug therapy, because they are related to both the drug and to individual factors in the host. In comparison with other organs, the skin is quite frequently a target of allergic reactions, which are mainly elicited by small molecular weight compounds. This i...

journal_title：Seminars in cutaneous medicine and surgery

authors： Merk HF,Hertl M

更新日期：1996-12-01 00:00:00

abstract：:The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...

journal_title：Seminars in cutaneous medicine and surgery

authors： Solish N

更新日期：2016-06-01 00:00:00

abstract：:One of the most interesting medical conditions that now afflicts the baby boomer generation is photoaging. Clinical signs of photoaging of the skin include rhytids, lentigines, keratoses, telangiectasia, loss of translucency, loss of elasticity, and sallow color. A systematic classification of patient photoaging types...

journal_title：Seminars in cutaneous medicine and surgery

authors： Glogau RG

更新日期：1996-09-01 00:00:00

abstract：:Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are ra...

journal_title：Seminars in cutaneous medicine and surgery

authors： Chen ST,Barnes J,Duncan L

更新日期：2018-03-01 00:00:00

abstract：:This review highlights melanoma trends observed among African-, Asian-, Latino- and Native-American populations. Melanoma is the most lethal form of skin cancer, accounting for about 75% of all skin cancer deaths. Generally, incidence rates increase with age, peak after age 40, and are greater in men than women. Howev...

journal_title：Seminars in cutaneous medicine and surgery

authors： Shoo BA,Kashani-Sabet M

更新日期：2009-06-01 00:00:00

abstract：:This review highlights important considerations in obtaining good skin biopsy specimens to optimize results of direct immunofluorescence (IF) studies and also summarizes the various patterns of cutaneous IF deposition and their associated diagnoses. IF findings of immunobullous diseases, lupus erythematosus, vasculiti...

journal_title：Seminars in cutaneous medicine and surgery

authors： Morrison LH

更新日期：1999-03-01 00:00:00

abstract：:Artecoll was developed about 20 years ago and underwent a number of production changes until it recently became FDA approved under the new name of Artefill. This product contains 20% polymethyl methacrylate (PMMA) microspheres with a diameter of 30 to 40 microm, which are suspended in a 3.5% atelo-collagen solution. T...

journal_title：Seminars in cutaneous medicine and surgery

authors： Haneke E

更新日期：2004-12-01 00:00:00

abstract：:The last decade has witnessed a significant advance in the management of refractory moderate-to-severe psoriasis. This advance is the introduction of biological therapies to clinical practice. Three classes of biological therapies have been used. Of the first 2 classes to be introduced, the T-cell inhibitors and tumor...

journal_title：Seminars in cutaneous medicine and surgery

authors： Warren RB,Griffiths CE

更新日期：2010-03-01 00:00:00

abstract：:Effective antimicrobials are critical in controlling one of the most common conditions encountered in medicine, namely, skin and skin structure infections. Unfortunately, the identification of appropriate and novel antimicrobials is continually challenged by the emergence of antimicrobial resistance among bacteria, fu...

journal_title：Seminars in cutaneous medicine and surgery

authors： Yang A,Kerdel FA

更新日期：2006-06-01 00:00:00

abstract：:Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinic...

journal_title：Seminars in cutaneous medicine and surgery

authors： Howard MS,Smoller BR

更新日期：2000-06-01 00:00:00

abstract：:Topical retinoic acid was introduced for acne treatment three decades ago. Since that time, researchers have discovered thousands of retinoids, originally defined as chemical analogs of vitamin A. After the identification of nuclear retinoid receptors in 1987, the definition of this class expanded to include molecules...

journal_title：Seminars in cutaneous medicine and surgery

authors： Bershad S

更新日期：2001-09-01 00:00:00

abstract：:Psoriasis is now recognized as an immunologically mediated systemic disease that may be expressed in cutaneous and joint symptoms. Medications that were once thought to control psoriasis by reducing keratinocyte proliferation are now known to act on immunologic pathways. In recent years, the emerging understanding of ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Gordon KB,Strober BE

更新日期：2014-03-01 00:00:00

abstract：:Phototherapeutic modalities, including narrowband-UVB, broadband-UVB, PUVA photochemotherapy, and excimer laser therapy are valuable tools that can be used for photoresponsive dermatoses in children. As a systematically safer alternative compared with internal agents, including the prebiologic and biological therapies...

journal_title：Seminars in cutaneous medicine and surgery

authors： Pugashetti R,Koo J

更新日期：2010-06-01 00:00:00

abstract：:Closing surgical defects of the external ear poses unique challenges because of the convoluted shape and thin tethered skin. Choice of repair is often dictated by the site of the wound. If the defect is central and anterior with intact cartilage, most defects will do well by second intention healing or grafting. If th...

journal_title：Seminars in cutaneous medicine and surgery

authors： Olbricht S,Liégeois NJ

更新日期：2003-12-01 00:00:00

abstract：:Immunotherapy for the treatment of advanced melanoma has become a primary treatment in the clinic. Current therapies include systemic cytokines, immune checkpoint inhibitors, and localized intratumoral therapies. Checkpoint inhibitors block natural pathways that dampen or inhibit an immune response to stimulus. These ...

journal_title：Seminars in cutaneous medicine and surgery

authors： Cuevas LM,Daud AI

更新日期：2018-06-01 00:00:00

abstract：:The history of resurfacing procedures used to treat the aging face is reviewed, and the place of laser resurfacing within this context is described. The changing medical reimbursement system and desire by "baby boomers" to maintain a youthful image have driven the technical development of laser resurfacing. Medical ma...

journal_title：Seminars in cutaneous medicine and surgery

authors： Roenigk HH Jr

更新日期：1996-09-01 00:00:00