Abstract:
:Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer predisposition, such as basal cell nevus syndrome, xeroderma pigmentosum, epidermolysis bullosa, or oculocutaneous albinism. Different genes and signaling pathways have been shown to play a central role in the development and growth of these tumors. This article overviews the clinical features, diagnostic criteria, and the most recent data on genetic routes of the major hereditary syndromes predisposed to the development of nonmelanoma skin cancer.
journal_name
Semin Cutan Med Surgjournal_title
Seminars in cutaneous medicine and surgeryauthors
Nikolaou V,Stratigos AJ,Tsao Hdoi
10.1016/j.sder.2012.08.005subject
Has Abstractpub_date
2012-12-01 00:00:00pages
204-10issue
4eissn
1085-5629issn
1558-0768pii
S1085-5629(12)00095-8journal_volume
31pub_type
杂志文章,评审abstract::The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pad...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.2016.038
更新日期:2016-06-01 00:00:00
abstract::The expansion of telemedicine nationwide has resulted in many states adopting specific telemedicine regulations to avoid the issue of requiring a full medical license to practice telemedicine. How these laws and regulations relate to the practice of telepathology and teledermatology has not been well delineated. It is...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0037
更新日期:2013-12-01 00:00:00
abstract::Electronic billing systems make dermatology practices more efficient and productive. The decision to purchase and install such a system, however, involves a significant amount of time and is often accompanied by many mistakes. This article presents errors commonly made in the evaluation and purchase process and offers...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(00)80025-5
更新日期:2000-09-01 00:00:00
abstract::Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment ...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2018.040
更新日期:2018-09-01 00:00:00
abstract::The term "epidermal nevus syndrome" (ENS) has been used to describe the association of epidermal hamartomas and extra-cutaneous abnormalities. Epidermal nevi follow the lines of Blaschko. The majority of the extra-cutaneous manifestations involve the brain, eye, and skeletal systems. Several subsets with characteristi...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2008.03.006
更新日期:2007-12-01 00:00:00
abstract::Idiosyncratic reactions (type B) are a major complication of drug therapy, because they are related to both the drug and to individual factors in the host. In comparison with other organs, the skin is quite frequently a target of allergic reactions, which are mainly elicited by small molecular weight compounds. This i...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(96)80035-6
更新日期:1996-12-01 00:00:00
abstract::Soft tissue augmentation has become increasingly important as more individuals seek aesthetic improvement without major surgical procedures. The choice of an appropriate subcutaneous implant, whether solid or injectable, requires a thorough understanding of the materials available. This review of the literature addres...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(99)80036-4
更新日期:1999-06-01 00:00:00
abstract::Lasers, both in single and multiple wavelength designs, have recently been introduced to enhance the results of liposuction. Safe parameters of fluence and temperature have not yet been described. In this study, I describe a series of laser lipolysis patients treated with a dual wavelength (1064/1319 nm) laser where i...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1016/j.sder.2009.11.002
更新日期:2009-12-01 00:00:00
abstract::Safety remains paramount to the clinical utility of a therapy. Evaluation of safety is an ongoing process that does not end when a therapy becomes commercially available. This article reviews recent data pertaining to the safety profile of two therapeutic classes widely used in the treatment of psoriasis: inhibitors o...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.0099
更新日期:2014-06-01 00:00:00
abstract::Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinic...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(00)80005-x
更新日期:2000-06-01 00:00:00
abstract::The history of resurfacing procedures used to treat the aging face is reviewed, and the place of laser resurfacing within this context is described. The changing medical reimbursement system and desire by "baby boomers" to maintain a youthful image have driven the technical development of laser resurfacing. Medical ma...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(96)80052-6
更新日期:1996-09-01 00:00:00
abstract::Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborn...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2016.041
更新日期:2016-06-01 00:00:00
abstract::The intraepidermal vesiculobullous disorders constitute a wide variety of pathogenically unrelated disorders that share in common the formation of cleft or bullae formation within the epithelium. The etiologic, pathogenic, clinical and, in particular, the histopathologic attributes of the most important intraepidermal...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(03)00082-8
更新日期:2004-03-01 00:00:00
abstract::There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.2016.064
更新日期:2016-12-01 00:00:00
abstract::Spitz nevus (SN) and Spitzoid malignant melanoma (SMM) represent benign and malignant counterparts at both ends of the spectrum of Spitzoid lesions. Atypical Spitzoid neoplasm (ASN) is a poorly defined and characterized category of melanocytic tumors with histologic features of both benign Spitz nevi and malignant mel...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2010.06.003
更新日期:2010-09-01 00:00:00
abstract::The influences of information technology have touched almost all aspects of our lives, and health care delivery has been no exception. Law, policy, and regulation have driven the adoption of electronic medical records, particularly over the past decade, driving fundamental changes to the practice of medicine in genera...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2019.005
更新日期:2019-03-01 00:00:00
abstract::This review highlights important considerations in obtaining good skin biopsy specimens to optimize results of direct immunofluorescence (IF) studies and also summarizes the various patterns of cutaneous IF deposition and their associated diagnoses. IF findings of immunobullous diseases, lupus erythematosus, vasculiti...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(99)80006-6
更新日期:1999-03-01 00:00:00
abstract::Cellulite is a condition that affects the vast majority of women. Although it is of no danger to one's overall health, cellulite can be psychosocially debilitating. Consequently, much research has been devoted to understanding cellulite and its etiopathogenesis. With additional insights into the underlying causes of i...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2015.0169
更新日期:2015-09-01 00:00:00
abstract::The use of video in the informed consent process has been well documented in the literature to improve patient satisfaction, understanding, comprehension, and to decrease anxiety. At the MD Anderson Mohs Surgery Unit, we use high-definition (HD) audiovisual (AV) modules to assist with the delivery of informed consent ...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.1016/j.sder.2008.02.001
更新日期:2008-03-01 00:00:00
abstract::This is a very exciting time in cutaneous laser surgery with an ever-expanding therapeutic armamentarium and an increased sophistication of available technology. These recent trends have allowed for both a rapid development of interest and exploration of laser-assisted drug delivery and its potential applications. We ...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.0119
更新日期:2014-12-01 00:00:00
abstract::There has been a dramatic increase in the incidence of malignant melanoma in most parts of the world. Because the tumor thickness is the most important prognostic factor for the prognosis of the malignant melanoma, the early detection of thin melanomas is essential. Dermatoscopy allows the physician to discriminate be...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1053/sder.2003.50001
更新日期:2003-03-01 00:00:00
abstract::This review highlights melanoma trends observed among African-, Asian-, Latino- and Native-American populations. Melanoma is the most lethal form of skin cancer, accounting for about 75% of all skin cancer deaths. Generally, incidence rates increase with age, peak after age 40, and are greater in men than women. Howev...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2009.04.005
更新日期:2009-06-01 00:00:00
abstract::Medical imaging has dramatically transformed the practice of medicine, especially the field of dermatology. Imaging is used to facilitate the transfer of information between providers, document cutaneous disease, assess response to therapy, and plays a crucial role in monitoring and diagnosing skin cancer. Advancement...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2016.001
更新日期:2016-03-01 00:00:00
abstract::In recent years, DNA microarray technology has been used for the analysis of gene expression patterns in a variety of skin diseases, including malignant melanoma, psoriasis, lupus erythematosus, and systemic sclerosis. Many of the studies described herein confirmed earlier results on individual genes or functional gro...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2007.12.004
更新日期:2008-03-01 00:00:00
abstract::There are many hair disorders, all of which involve alterations in normal hair biology. Essentially, hair disorders involve changes to hair fiber caliber, density per unit area, and/or the duration of anagen and telogen in the hair growth cycle. Hair disorders may be triggered by inflammation, genetics, the environmen...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章
doi:10.12788/j.sder.2015.0133
更新日期:2015-06-01 00:00:00
abstract::Superficial chemical peels and microdermabrasion are used for many dermatologic conditions. A common condition treated with these modalities is acne vulgaris. In this review, we discuss the theory behind the technique of these procedures and describe the application and complications of each of these procedures in the...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/j.sder.2008.06.003
更新日期:2008-09-01 00:00:00
abstract::The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. Th...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2017.039
更新日期:2017-12-01 00:00:00
abstract::Closing surgical defects of the external ear poses unique challenges because of the convoluted shape and thin tethered skin. Choice of repair is often dictated by the site of the wound. If the defect is central and anterior with intact cartilage, most defects will do well by second intention healing or grafting. If th...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/S1085-5629(03)00077-4
更新日期:2003-12-01 00:00:00
abstract::Atopic dermatitis (AD) is a chronic skin condition affecting children and adults, with a significant negative impact on patient and caregiver quality of life (QOL). Although effective treatments for AD are available, outcomes are often limited by poor adherence to treatment plans. Effective patient and caregiver educa...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.12788/j.sder.2017.029
更新日期:2017-09-01 00:00:00
abstract::Prognosis and survival for patients diagnosed with melanoma depends on a number of interrelated factors, including histological, clinical, immunologic, and surgical parameters. Tumor thickness and depth of invasion is the most important prognostic factor, and helps to guide treatment and management plans. Besides tumo...
journal_title:Seminars in cutaneous medicine and surgery
pub_type: 杂志文章,评审
doi:10.1016/s1085-5629(97)80005-3
更新日期:1997-06-01 00:00:00