Abstract:
INTRODUCTION:The aim of the study was to estimate if B12 deficiency is associated with the use of metformin in the elderly diabetics. METHODS:Case-control study in diabetic OP. Cases (n = 137) were defined as elderly with B12 < 221 pmol/L and controls (n = 279) elderly with B12 > 221 pmol/L. Four categories of metformin use were defined: non-users, ≤850 mg/day, > 850 and < 2,550 mg/day and ≥2,550 mg/day. Metformin ≥2,550 mg/day was high doses considered. The crude OR for B12 deficiency and consumption of Metformin were calculated. Logistic regression models were developed to explore the association between B12 deficiency and metformin dose. The research protocol was approved by the Ethics Committee of INTA. RESULTS:The age of cases and controls was (70.2 years vs 68.6 years (p < 0.05). The 62% were women in cases vs 74.9% in controls (p < 0.05). The 73% of cases and 76% of controls used metformin (p < 0.05) the average consumption of metformin was de 1,954.3 mg/day (SD: 1,063.2) in cases and 1,696.6 mg/day (SD: 1,074.4) in controls (p < 0.05). The use of 2,550 mg/day was observed in 29.2% of cases and 19.3% for controls (p < 0.05). It was observed that OP who consumed high doses of metformin had 1.9 times the risk of B12 deficiency (OR: 1.9; 95%CI: 1,08- 3,30). CONCLUSION:These results show a strong association between high doses of metformin and low levels of vitamin B12 in diabetic elderly. This project was funded by FONIS SA11I2092. :Introducción: El objetivo del estudio es estimar si el déficit de B12 se asocia con el uso de la metformina en adultos mayores (AM) diabéticos. Métodos: Estudio de casos y controles en AM diabéticos. Los casos (n = 137) se definieron como AM con B12 < 221 pmol/L y los controles(n = 279) como AM con B12 > 221 pmol/L. Se definieron 4 categorías de uso de metformina: no usuarios, ≤850 mg/día; > 850 y < 2.550 mg/día; ≥2.550 mg/día. Se consideró altas dosis de metformina (≥2.550 mg/día). Se calcularon los OR crudos para déficit de B12 y consumo de Metformina. Se elaboraron modelos de regresión logística para explorar la asociación entre déficit B12 y dosis de metformina. El protocolo de investigación fue aprobado por el Comité de Ética deI INTA. Resultados: La edad de casos y controles fue (70,2 años vs 68,6 años (p < 0,05); 62% fueron mujeres en los casos vs 74,9% en los controles (p < 0,05). El 73% de los casos y el 76% de los controles usaban metformina (p < 0,05). El promedio de uso de metformina fue de 1.954,3 mg/día (DS: 1.063,2) en los casos y 1696.6 mg/día (DS: 1.074,4) en los controles(p < 0,05). La dosis de 2.550 mg/día se observó en el 29,2% de los casos y en 19,3 de los controles (p < 0,05). Se observó que los adultos mayores que consumían altas dosis de metformina presentaban 1,9 veces más riesgo de déficit de B12 (OR:1,9; 95%IC: 1,08-3,30). Conclusión: Estos resultados muestran una fuerte asociación entre altas dosis de metformina y niveles bajos de vitamina B12. Este proyecto fue financiado por FONIS SA11I2092.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Sánchez H,Masferrer D,Lera L,Arancibia E,Angel B,Albala Cdoi
10.3305/nh.2014.29.6.7405subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1394-400issue
6eissn
0212-1611issn
1699-5198journal_volume
29pub_type
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journal_title:Nutricion hospitalaria
pub_type: 历史文章,杂志文章
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journal_title:Nutricion hospitalaria
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doi:
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
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journal_title:Nutricion hospitalaria
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doi:10.3305/nh.2015.32.6.9760
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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doi:
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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更新日期:2015-02-07 00:00:00
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