Abstract:
Introduction:Background and aims: intervention studies that evaluate the effect of rs16147 on metabolic response and weight change after dietary intervention are scarce. We propose to evaluate the role of the rs16147 genetic variant in the metabolic effects produced by a hypocaloric Mediterranean-pattern diet with high content of omega-9. Material and methods: a sample of 363 obese subjects was recruited. At the baseline visit the patients were randomly assigned to one of two hypocaloric diets for 12 weeks (diet M, Mediterranean pattern; diet C, standard hypocaloric). All patients, at baseline and at 12 weeks, had biochemical and anthropometric variables measured, and genotyping performed for the rs16147 variant. Results: in all subjects, and with both diets, the parameters of adiposity, blood pressure, and circulating leptin improved. In obese subjects with allele (A) insulin levels (GG vs. GA + AA) (-0.9 ± 1.1 IU/L vs. -4.4 ± 1.0 IU/L; p = 0.01) and HOMA-IR (-0.3 ± 0.1 units vs. -1.2 ± 0.3 units; p = 0.02) decreased significantly with diet M. Subjects carrying the minor allele showed a significant decrease in basal insulin levels (GG vs. GA + AA) (0.7 ± 0.3 IU/L vs. -2.2 ± 0.9 IU/L: p = 0.02) and HOMA-IR (-0.3 ± 0.2 units vs. -0.7 ± 0.1 units: p = 0.01) after diet C. This decrease in circulating insulin and HOMA-IR levels in patients with allele A was significantly higher with diet M than with diet C. Conclusions: the A allele of the rs16147 variant produces a better metabolic response in terms of insulin resistance and basal insulin secondary to weight loss with two different hypocaloric diets in obese subjects, with improvement being higher with the Mediterranean diet. Introducción:Introducción y objetivos: los estudios de intervención que evalúan el efecto del rs16147 sobre la respuesta metabólica y el cambio de peso después de una intervención dietética son escasos. Evaluamos el papel de la variante genética rs16147 en los efectos metabólicos que produce una dieta hipocalórica de patrón mediterráneo y alto contenido en omega-9. Material y métodos: se reclutó una muestra de 363 sujetos obesos. En visita basal, los pacientes se asignaron aleatoriamente, durante 12 semanas, a recibir una de dos dietas: dieta M, de patrón mediterráneo, o dieta C, hipocalórica estándar. Se determinaron momento basal y a las 12 semanas, una serie de variables bioquímicas y antropométricas, realizándose el genotipado de la variante rs16147. Resultados: en todos los sujetos con ambas dietas mejoraron los parámetros de adiposidad, tensión arterial y leptina circulante. En sujetos obesos con el alelo menor (A), los niveles de insulina (GG vs. GA + AA) (-0,9 ± 1,1 UI/L vs. -4,4 ± 1,0 UI/L; p = 0,01) y HOMA-IR (-0,3 ± 0,1 unidades vs. -1,2 ± 0,3 unidades; p = 0,02) disminuyeron significativamente con dieta M. Los sujetos portadores del alelo menor tras dieta C mostraron disminución significativa de niveles de insulina basal (GG vs. GA + AA) (0,7 ± 0,3 UI/L vs. -2,2 ± 0,9 UI/L: p = 0,02) y HOMA-IR (-0,3 ± 0,2 unidades vs. -0,7 ± 0,1 unidades: p = 0,01). Esta disminución de los niveles de insulina circulante y HOMA-IR en los pacientes con alelo A fue significativamente superior con la dieta M que con la dieta S. Conclusiones: el alelo A de la variante rs16147 se relaciona con mejor respuesta metabólica, en términos de resistencia a insulina e insulina basal secundaria a pérdida de peso, a dos dietas hipocalóricas, siendo superior el efecto obtenido con una dieta de patrón mediterráneo.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Primo Martín D,Izaola Jáuregui O,López Gómez JJ,Gómez Hoyos E,Ortolá Buigues A,Delgado E,Díaz G,Torres Torres B,de Luis Román DAdoi
10.20960/nh.02941subject
Has Abstractpub_date
2020-08-27 00:00:00pages
742-749issue
4eissn
0212-1611issn
1699-5198journal_volume
37pub_type
杂志文章abstract:Introduction:Background: catheter-related infection is one of the complications of central parenteral nutrition treatment with the highest morbidity and mortality. Objectives: the primary endpoint of this study was to analyze the prevalence of bloodstream infection in patients with central parenteral nutrition. Seconda...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03218
更新日期:2020-10-21 00:00:00
abstract:Introduction:Background: mid-upper arm circumference (MUAC), subcutaneous fat and muscle measurements are an alternative method to diagnose overweight and evaluate growth as well as protein and energy reserves. Aim: to compare MUAC, arm muscle area (AMA) and arm fat area (AFA) measurements of Argentinean boys and girls...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02426
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:breastfeeding is considered protective of osteoporosis, by endocrine changes, such as the rise of intestinal absorption of calcium and the renal conservation of the same, however, other studies demonstrate that with more one child they present a loss of bone mineral density (BMD) (2-9%). OBJECTIVE:to dete...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9047
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:Population standards of intrauterine growth are necessary to evaluate if the newborn has grown well, if their nutritional conditions are appropriate and to identify groups at risk as those small for gestational age (SGA). Differences in the number of SGA newborns identified, depending on the ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000400013
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:the purpose of this investigation was to investigate the associations between nutritional status by Mini Nutritional Assessment (MNA) test and dysphagia by EAT-10 in elderly individuals requiring nutritional oral care in an acute hospital. PATIENTS:this was a cross-sectional survey covering a sample of 560 e...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1698
更新日期:2018-06-28 00:00:00
abstract::We have performed a clinical study involving patients with symptomatic gallstones and indications for surgery, to analyze the biliary and pancreatic response to the quality of dietary fat (degree of unsaturation). As part of the investigative method, we have designed a clinical protocol adapted to the needs of the stu...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::Registering the ingestive activity of laboratory animals can be carried out by using electronic scales connected to personal computers, thus gathering data files that allow calculation of the daily ingestion standards. The ingestion parameters most often used in the standard analysis include the number, size, and dura...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Increased serum homocysteine levels are related to vascular disease and increased mortality. The decrease of homocysteine is also associated with a worse prognosis in patients on hemodialysis; however, this relationship has not been well studied in other patients. Our goal is to study the prog...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.6.9011
更新日期:2015-06-01 00:00:00
abstract::Objective: To estimate the prevalence of chronic obstructive pulmonary disease (COPD) phenotypes in the province of Leon. Methods: Multicenter epidemiological cross-sectional study (30 health centers in the province of Leon). It included patients older than 35 years diagnosed and treated for COPD. Study variables: ag...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,多中心研究
doi:10.20960/nh.995
更新日期:2017-02-01 00:00:00
abstract::For years now, a stronger tendency towards overweight among diabetes 1 population has been described, a tendency already observed during childhood and pubescence. Insulin replacement therapy to be one of the main underlying factors. Clarifying these issues and determining whether this weight gain may bring in an incre...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2014.30.6.7878
更新日期:2014-12-01 00:00:00
abstract::Continuous physical exercise leads the athlete to maintain an unstable balance between dietary intake, energy expenditure and the additional demands of a high amount of physical activity. Thus, an accurate assessment of nutritional status is essential to optimize the performance, since it affects health, body composit...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.31.sup3.8770
更新日期:2015-02-26 00:00:00
abstract::Sedentary behavior and physical exercise seem to influence the nutritional status of the population independently. In this sense, sedentary behavior is associated inversely with healthy eating patterns and directly with BMI, body fat, risk of chronic diseases and psychological problems. By contrast, regular exercise i...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.sup1.9473
更新日期:2015-07-18 00:00:00
abstract::Obesity has become an important problem of public health in all developed countries. It has slightly different connotations in women because, apart from its greater prevalence, low socio-economic level is a risk factor solely for women. As well as a cardiovascular risk factor in women, it is associated with an increas...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
abstract:INTRODUCTION:Body weight measurement is of critical importance when evaluating the nutritional status of patients entering a hospital. In some situations, such as the case of patients who are bedridden or in wheelchairs, these measurements cannot be obtained using standardized methods. We have designed and validated a ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.3.6455
更新日期:2013-05-01 00:00:00
abstract::Most of acute pancreatitis cases present as mild cases for which nutritional support is not recommended provided the patient is able to restart normal oral intake within 5- days. By contrast, severe pancreatitis associates metabolic stress and requires early nutritional support. In these cases, enteral nutrition is re...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::After 36 years of continued publication of the journal Nutrición Hospitalaria, a list with the ten most cited articles published in it is elaborated. The top ten most cited articles in the world literature and stratification according to language, English or Spanish, subject, or period of time published are also analy...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9922
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:the purpose was to evaluate the nutritional status in hospitalized children according to their socio-demographic variables, underlying pathology and based on hospital length of stay. METHODS:seven-hundred and sixty-three hospitalized patients of the Civil Hospital of Guadalajara Dr. Juan I. Menchaca were inc...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1513
更新日期:2018-02-27 00:00:00
abstract:AIM:To analyse the calcium contribution of one unit of fermented milk enriched with calcium and vitamin D in the daily calcium intake for postmenoupausic women. SUBJECTS:261 postmenoupausic women. METHODS:28 day duration of exploratory, nutritional trial. All subjects received dietary advice on how to increase calciu...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章
doi:10.1590/S0212-16112012000200028
更新日期:2012-03-01 00:00:00
abstract::Neurocritical patients have a metabolic condition that makes them particularly sensitive to protein-caloric malnutrition in a short period of time. Due to this, it is essential nutritional support treatment. But the neurocritical patient has physiological connotations that makes it difficult to be able to establish an...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:The transmission of harmful pathogens by arthropods is an increasing health concern. More concretely, flies are known to be able to transmit the infectious agent mechanically. OBJECTIVE:The present work shows a case report occurred from foodservice establishments where were isolated and identified, at the...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.6.8971
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:The lifestyle changes in college, students go through periods of physical inactivity and irregular meal times, which leads to increased consumption of processed foods and fast food. OBJECTIVE:To calculate vitamins and minerals intakes for groups in the diet of Chilean university students. METHODS:We stud...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.3.6397
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:"tight calorie control" concept arose to avoid over- and under-feeding of patients. OBJECTIVE:to describe and validate a simplified predictive equation of total energy expenditure (TEE) in mechanically ventilated critically ill patients. METHODS:this was a secondary analysis of measurements of TEE by ind...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.3.9359
更新日期:2015-09-01 00:00:00
abstract:INTRODUCTION:apart from the known effects of vitamin D on phospho-calcium homeostasis, in recent years there is great interest in its extrabone effects. OBJECTIVES:to know the concentration of 25-hydroxyvitamin D (25[OH] D) in newly diagnosed patients of cancer and to verify if there are differences between the differ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1675
更新日期:2018-04-05 00:00:00
abstract::One of the generic indications of parenteral peripheral malnutrition is the immediate postoperative period following surgery of the digestive tract. In the series presented, fifty patients with digestive neoplasia of different locations were studied, with slight or moderate malnutrition upon admittance. After the oper...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::Children obesity is considered a serious public health problem around the world. In Spain, the prevalence of overweight/obesity is reaching alarming figures, exceeding 35% of the children. Several hypotheses suggest that the energy balance model does not fit very well when analyzing the causes of the current obesity e...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2013.28.sup5.6925
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Various experimental studies have shown that a deficient intake of zinc increases the proliferation of cells, the effect of carcinogens and the progression of colonic adenomas to carcinomas. The purpose of our study is to determine whether this relationship between zinc intake deficit and co...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:Introduction:Introduction: disease-related malnutrition (DRM) is a specific type of malnutrition caused by the inflammatory response to the underlying disease. Its prevalence worldwide varies from 30 % to 50 %, being similar in Spanish hospitals. DRE is not commonly recognized but is usually misdiagnosed and generally ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03062
更新日期:2020-08-27 00:00:00
abstract:OBJECTIVE:To evaluate body composition differences between children that were born small (SGA) or large for gestational age (LGA) compared with their counterparts born adequate for gestational age (AGA). METHODS:Body composition was assessed in 124 healthy Caucasian children (50% girls) aged 6-10, classified according...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000500008
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To check the correlation between gastric intolerance and hypertension intracranial pressure and their association with the clinical parameters and severity indexes in patients with severe head injury (HI); to evaluate the advantages of transpyloric feeding. DESIGN:Prospective and observational clinical study...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract:Introduction:Background: the Mediterranean diet (MD) has been related to a good state of health. There are different index to evaluate the adherence to Mediterranean dietary pattern. Objective: the purpose of the study was to evaluate the classification of the adult population of the Comunitat Valenciana according to t...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02625
更新日期:2019-10-17 00:00:00