Therapeutic granulocyte and monocyte apheresis (GMA) for treatment refractory sarcoidosis: a pilot study of clinical effects and possible mechanisms of action.

abstract：:Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leucocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated c...

journal_title：Clinical and experimental immunology

authors： Rowe D,Isenberg DA,Beverley PC

更新日期：1983-11-01 00:00:00

abstract：:Cells from the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL) and acute lymphoblastic leukaemia (ALL) were examined for the expression of MHC class II antigens, using a number of monoclonal antibodies (MoAb) including L243 (anti-DR) and TU22 (anti-DQ). There was wide variation in expres...

journal_title：Clinical and experimental immunology

authors： Guy K,Docherty LJ,Dewar AE

更新日期：1986-02-01 00:00:00

abstract：:We analysed human anti-mouse antibodies (HAMA) in 12 patients (six with multiple myeloma (MM) and six with metastatic renal cell carcinoma (MRCC) who were treated with B-E8, an IgG1 MoAb against IL-6. Efficiency of the treatment was evidenced by the drop in the serum levels of C-reactive protein (CRP), the in vivo pro...

journal_title：Clinical and experimental immunology

authors： Legouffe E,Liautard J,Gaillard JP,Rossi JF,Wijdenes J,Bataille R,Klein B,Brochier J

更新日期：1994-11-01 00:00:00

abstract：:In essential mixed, type II, cryoglobulinaemia (EMC) monoclonal autoantibodies with rheumatoid factor activity are synthesized at an accelerated rate by non-malignant B lymphocytes. In order to determine if the high cryoglobulin production rate is related to a clonal B cell expansion, cell surface markers of periphera...

journal_title：Clinical and experimental immunology

authors： Perl A,Gorevic PD,Ryan DH,Condemi JJ,Ruszkowski RJ,Abraham GN

更新日期：1989-04-01 00:00:00

abstract：:During the innate immune response against infections, Natural Killer (NK) cells are as important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic stimulation in the adaptative response. NK cells increase in numbers, after viral infection or vaccination. We investigated the NK cell and CD8 ...

journal_title：Clinical and experimental immunology

authors： Azeredo EL,De Oliveira-Pinto LM,Zagne SM,Cerqueira DI,Nogueira RM,Kubelka CF

更新日期：2006-02-01 00:00:00

abstract：:Both CC- and CXC-chemokines are known to be potent leucocyte activators and chemoattractants and play important roles in inflammatory responses. However, chemokine response to bacillus Calmette-Guérin (BCG) infection remains incompletely defined. In this study, we investigated human CC- [macrophage-derived chemokine (...

journal_title：Clinical and experimental immunology

authors： Luo Y,Chen X,O'Donnell MA

更新日期：2007-02-01 00:00:00

abstract：:In vitro lymphocyte function of 13 patients with selective IgA deficiency was studied. IgG, IgA and IgM secretion by pokeweed mitogen-stimulated peripheral blood lymphocytes from normal donors and IgA deficient patients was measured by an enzyme-linked immunosorbent assay. Addition of concanavalin A or hydrocortisone ...

journal_title：Clinical and experimental immunology

authors： De la Concha EG,Subiza JL,Fontán G,Pascual-Salcedo D,Sequí J,Bootello A

更新日期：1982-08-01 00:00:00

abstract：:Although increasing evidence demonstrates the association between intestinal dysbiosis and pancreatic diseases such as chronic pancreatitis and pancreatic cancer, it remains largely unknown whether intestinal dysbiosis is involved in the immunopathogenesis of autoimmune pancreatitis (AIP). Recently, we found that inte...

journal_title：Clinical and experimental immunology

authors： Kamata K,Watanabe T,Minaga K,Hara A,Sekai I,Otsuka Y,Yoshikawa T,Park AM,Kudo M

更新日期：2020-12-01 00:00:00

abstract：:A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monoc...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Alvaro S,Triolo G,Giacomelli R

更新日期：2015-10-01 00:00:00

abstract：:The complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste ...

journal_title：Clinical and experimental immunology

authors： Lubbers R,van Essen MF,van Kooten C,Trouw LA

更新日期：2017-05-01 00:00:00

abstract：:Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

journal_title：Clinical and experimental immunology

authors： James JA,Mamula MJ,Harley JB

更新日期：1994-12-01 00:00:00

abstract：:Pleural tuberculosis (TB) remains a common presentation of Mycobacterium tuberculosis (MTB) infection in HIV/TB dually infected subjects, and both cellular and acellular components of the pleural milieu promote HIV-1 replication; however, they remain uncharacterized. Using cytokine array of pleural fluid and real-time...

journal_title：Clinical and experimental immunology

authors： Toossi Z,Hirsch CS,Wu M,Mayanja-Kizza H,Baseke J,Thiel B

更新日期：2011-03-01 00:00:00

abstract：:To investigate the role of seminal plasma in human B cell functions, its effect on the proliferation and antibody secretion of tonsillar B cells and an Epstein-Barr virus (EBV) transformed human B cell line, A4, was examined. Seminal plasma inhibited both the proliferation and differentiation of normal B cells only wh...

journal_title：Clinical and experimental immunology

authors： Lee HK,Lee HH,Park YM,Lee JH,Ha TY

更新日期：1991-07-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:Oral immunization with 25 mg/day of ovalbumin resulted in a number of changes in non-specific immune responsiveness, including increases in antibody produced to T-dependent but not T-independent antigens and the abrogation of tolerance induced by both oral and intravenous routes. The effect was transient, sex- and str...

journal_title：Clinical and experimental immunology

authors： Stokes CR,Newby TJ,Bourne FJ

更新日期：1983-05-01 00:00:00

abstract：:The recommended control option against onchocerciasis is repeated ivermectin treatment, which will need to be implemented for decades, and it remains unknown how repeated ivermectin therapy might affect immunity against Onchocerca volvulus in the long term. O. volvulus-specific antibody reactivity and cellular cytokin...

journal_title：Clinical and experimental immunology

authors： Mai CS,Hamm DM,Banla M,Agossou A,Schulz-Key H,Heuschkel C,Soboslay PT

更新日期：2007-03-01 00:00:00

abstract：:Eleven Norwegian patients (aged 2-33 years, seven males and four females) with Ataxia-telangiectasia (A-T) and their parents were investigated. Five of the patients were homozygous for the same ATM mutation, 3245delATCinsTGAT, a Norwegian founder mutation. They had the lowest IgG2 levels; mean (95% confidence interval...

journal_title：Clinical and experimental immunology

authors： Stray-Pedersen A,Jónsson T,Heiberg A,Lindman CR,Widing E,Aaberge IS,Borresen-Dale AL,Abrahamsen TG

更新日期：2004-07-01 00:00:00

abstract：:HLA class II-restricted proliferative and cytotoxic T cell (CTL) responses to B cell chronic lymphocytic leukaemia (B-CLL) can be generated using autologous dendritic cells (DCs) pulsed with tumour cell lysate. In this study a number of different approaches were used to optimize further the in vitro system. First, the...

journal_title：Clinical and experimental immunology

authors： Goddard RV,Prentice AG,Copplestone JA,Kaminski ER

更新日期：2003-01-01 00:00:00

abstract：:Intravenous immune globulin (IVIG) preparations are efficacious and safe products in use world-wide. Although rare, side-effects of IVIG may be serious, even life-threatening, and clinicians should be aware of their potential occurrence. This article summarizes most of the adverse experiences with IVIG reported in the...

journal_title：Clinical and experimental immunology

authors： Duhem C,Dicato MA,Ries F

更新日期：1994-07-01 00:00:00

abstract：:The immune and bone systems maintain homeostasis by interacting closely with each other. Rheumatoid arthritis is a pathological consequence of their interplay, as activated T cell immune responses result in osteoclast-mediated bone erosion. An imbalance between forkhead box protein 3 (Foxp3)+ regulatory T (Treg ) cell...

journal_title：Clinical and experimental immunology

authors： Komatsu N,Takayanagi H

更新日期：2018-10-01 00:00:00

abstract：:A serial prospective study of cell-mediated immunity to rabbit liver-specific lipoprotein (RLSP) has been done in 26 patients with acute viral hepatitis (AH) (18 HBsAg+ and eight HBsAg-) using a lymphocyte transformation test. An increased stimulation index was recorded in 56% of HBsAg+ cases and in 63% of the HBsAg- ...

journal_title：Clinical and experimental immunology

authors： Ortona L,Laghi V,Cauda R,Nervo P

更新日期：1980-12-01 00:00:00

abstract：:Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

journal_title：Clinical and experimental immunology

authors： Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

更新日期：1995-08-01 00:00:00

abstract：:We have previously demonstrated that HIV envelope gp41 binding to specific antibodies decreases after preincubation of fluid-phase gp41 in normal human serum. This inhibition is proven to be mediated by the classical complement pathway. In this study recombinant gp41 (rgp41) and/or synthetic peptides were preadsorbed ...

journal_title：Clinical and experimental immunology

authors： Hidvégi T,Prohászka Z,Ujhelyi E,Thielens NM,Dierich MP,Hampl H,Arlaud G,Nagy K,Füst G

更新日期：1993-12-01 00:00:00

abstract：:By using a flow cytometric technique which allows direct identification of proliferating cells within mixed cell populations, we have previously described that soluble extracts obtained from Mycobacterium tuberculosis or M. avium represent strong stimuli for human gammadelta+ T cells. In the present study, we demonstr...

journal_title：Clinical and experimental immunology

authors： Batoni G,Esin S,Harris RA,Källenius G,Svenson SB,Andersson R,Campa M,Wigzell H

更新日期：1998-04-01 00:00:00

abstract：:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. A...

journal_title：Clinical and experimental immunology

authors： Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

更新日期：1984-06-01 00:00:00

abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

journal_title：Clinical and experimental immunology

authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

更新日期：2019-05-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:We found that IgA is predominant among the immune deposits in the renal glomeruli of mice infected with Schistosoma mansoni, and thus conducted an analysis of the deposition of different immunoglobulin isotypes in the glomeruli throughout the course of infection in mice. Both immunofluorescent and immunoperoxidase met...

journal_title：Clinical and experimental immunology

authors： el-Sherif AK,Befus D

更新日期：1988-01-01 00:00:00

abstract：:Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue haemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue viru...

journal_title：Clinical and experimental immunology

authors： Saito M,Oishi K,Inoue S,Dimaano EM,Alera MT,Robles AM,Estrella BD Jr,Kumatori A,Moji K,Alonzo MT,Buerano CC,Matias RR,Morita K,Natividad FF,Nagatake T

更新日期：2004-11-01 00:00:00

abstract：:T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relative expression of intact forkhead box protein 3 (FoxP3) compared to FoxP3Δ2, ...

journal_title：Clinical and experimental immunology

authors： Kristensen B,Hegedüs L,Madsen HO,Smith TJ,Nielsen CH

更新日期：2015-04-01 00:00:00