Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis.

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:The aim of the present study was to elucidate the impact of liver transplantation (LTX) on myeloid dendritic cell (MDC) homeostasis. We observed a threefold reduction of circulating CD1c(+) MDC immediately after LTX (n = 16; P < 0.01), and normalization between 3 and 12 months after LTX. This decline was not due to re...

journal_title：Clinical and experimental immunology

authors： Bosma BM,Metselaar HJ,Tra WM,Mancham S,Kuipers EJ,Tilanus HW,Kwekkeboom J

更新日期：2007-09-01 00:00:00

abstract：:Serum IgG-antilipoprotein-autoantibody activity (at 4 degrees C) of a plane xanthoma patient was shown by double-immunodiffusion method. Cryoglobulins in the serum were dissociated to polyclonal IgG and alpha- and beta-lipoproteins by acidification and were reconstructed by neutralization. IgG fraction of the cryoglob...

journal_title：Clinical and experimental immunology

authors： Kodama H

更新日期：1977-06-01 00:00:00

abstract：:It is generally accepted that multiple sclerosis (MS) is mediated by autoreactive T cells and that myelin basic protein (MBP) is one of the target autoantigens. The T-cell response to MBP has been analysed extensively, largely through the use of T-cell lines (TCL) and T-cell clones (TCC), and to date, three immunodomi...

journal_title：Clinical and experimental immunology

authors： Mazza G,Ponsford M,Lowrey P,Campbell MJ,Zajicek J,Wraith DC

更新日期：2002-06-01 00:00:00

abstract：:In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

journal_title：Clinical and experimental immunology

authors： Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

更新日期：2001-08-01 00:00:00

abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

journal_title：Clinical and experimental immunology

authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

更新日期：1994-06-01 00:00:00

abstract：:The presence of autoantibodies detected by immunofluorescence to single endocrine cells, of human duodenum is described in three groups of patients and two control groups. Of 173 coeliac cases, four had GIP cell antibodies, one had secretin cell antibodies and twenty-one reacted with both cell types. Of twelve tropica...

journal_title：Clinical and experimental immunology

authors： Mirakian R,Bottazzo GF,Doniach D

更新日期：1980-07-01 00:00:00

abstract：:alpha 1-Microglobulin (alpha 1-m) was purified by column chromatography from a supernatant fluid of cultured T and B lymphocytes stimulated with mitogens. This protein had a molecular weight of 33,000 as determined by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, migrated in the alpha 1-region on i...

journal_title：Clinical and experimental immunology

authors： Itoh Y,Kin K,Kasahara T,Sakurabayashi I,Kawai T,Shiori-Nakano K,Takagi K

更新日期：1979-07-01 00:00:00

abstract：:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. ...

journal_title：Clinical and experimental immunology

authors： Zanetti M,Bellon B,Verroust P,Druet P

更新日期：1980-10-01 00:00:00

abstract：:We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 +/- 0.8 years) were found to have HIV antibodies and there was a significant increase (P less than 0.01) in the frequency of HIV antibody positivi...

journal_title：Clinical and experimental immunology

authors： Fernandez-Cruz E,Fernandez AM,Gutierrez C,Garcia-Montes M,de la Morena MT,Rodriguez-Villanueva J,Longo N,Zabay JM

更新日期：1988-05-01 00:00:00

abstract：:CD30 is a surface molecule which can be expressed by normal B and T lymphocytes. Our study focused on the CD30 expression and release compared with IL-4 expression as well as CD23-alpha/beta in peripheral blood mononuclear cells (PBMC) from atopic subjects and controls. Data showed a lack of CD30 mRNA expression in th...

journal_title：Clinical and experimental immunology

authors： Esnault S,Benbernou N,Lavaud F,Guenounou M

更新日期：1996-10-01 00:00:00

abstract：:In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating a...

journal_title：Clinical and experimental immunology

authors： Bolton WK,Benton FR,Lobo PI

更新日期：1978-09-01 00:00:00

abstract：UNLABELLED:OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY:Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and ...

journal_title：Clinical and experimental immunology

authors： Mankan AK,Kubarenko A,Hornung V

更新日期：2012-03-01 00:00:00

abstract：:Lymphocytes and plasma cells in the peripheral blood and bone marrow of patients with multiple myeloma, benign monoclonal gammopathy and Waldenström's macroglobulinaemia were investigated for their cytoplasmic immunoglobulin distribution. Anti-idiotypic sera were used as markers for monoclonality. Double-wavelength fl...

journal_title：Clinical and experimental immunology

authors： Van Camp B,Reynaert P,Broodtaerts L

更新日期：1981-04-01 00:00:00

abstract：:The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin...

journal_title：Clinical and experimental immunology

authors： Walters HM,Pan N,Lehman TJ,Adams A,Kalliolias GD,Zhu YS,Santiago F,Nguyen J,Sitaras L,Cunningham-Rundles S,Walsh TJ,Toussi SS

更新日期：2016-06-01 00:00:00

abstract：:Complement C5a is aetiologically linked to inflammatory tissue damage in conditions like septicaemia, immune complex diseases and ischaemia-reperfusion injury. We here describe a monoclonal antibody (mAb), 137-26, that binds to the C5a moiety of human C5 and neutralizes the effects of C5a without interfering with C5 c...

journal_title：Clinical and experimental immunology

authors： Fung M,Lu M,Fure H,Sun W,Sun C,Shi NY,Dou Y,Su J,Swanson X,Mollnes TE

更新日期：2003-08-01 00:00:00

abstract：:An adult twin with recurrent bacterial infections was found to have a partial functional deficiency of complement factor D. Full restoration of alternative pathway activity and zymosan- or cobra venom factor-induced consumption of C3 and B was found after reconstitution of patient's serum with purified D. Family studi...

journal_title：Clinical and experimental immunology

authors： Kluin-Nelemans HC,van Velzen-Blad H,van Helden HP,Daha MR

更新日期：1984-12-01 00:00:00

abstract：:We have reported previously that Lactobacillus casei ssp. casei, together with specific substrate dextran, exhibited an adjuvant effect of stimulating humoral immune responses against bovine serum albumin (BSA) as a model antigen in BALB/c mice. In the present study, among the Lactobacillus species tested, L. casei ss...

journal_title：Clinical and experimental immunology

authors： Ogawa T,Asai Y,Tamai R,Makimura Y,Sakamoto H,Hashikawa S,Yasuda K

更新日期：2006-01-01 00:00:00

abstract：:The immunopathology of patch test reactions to aeroallergens in patients with atopic dermatitis (AD) has been compared to that of contact sensitivity reactions to nickel in non-atopic individuals. Both reactions were found to exhibit equivalent erythema and induration on gross examination at 48 h. Four millimetre punc...

journal_title：Clinical and experimental immunology

authors： Buckley C,Ivison C,Poulter LW,Rustin MH

更新日期：1993-03-01 00:00:00

abstract：:The number of thymic epithelial cells containing the serum thymic factor (FTS or thymulin), assessed by indirect immunofluorescence using an anti-FTS monoclonal antibody, was studied in the thymus of normal and autoimmune mice as a function of age. In normal mice the number of FTS+ cells was constant until the age of ...

journal_title：Clinical and experimental immunology

authors： Savino W,Dardenne M,Bach JF

更新日期：1983-04-01 00:00:00

abstract：:The role of macrophage infiltrates in oral mucosal acute graft-versus-host disease (AGVHD) remains unclear, although clinical studies suggest that macrophage infiltration correlates directly with the severity of AGVHD. In this study, we investigated the role of M1 macrophage infiltration in the oral mucosa of rats wit...

journal_title：Clinical and experimental immunology

authors： Seno K,Yasunaga M,Kajiya H,Izaki-Hagio K,Morita H,Yoneda M,Hirofuji T,Ohno J

更新日期：2017-12-01 00:00:00

abstract：:Conversion of arginyl to citrullyl residues (citrullination) is essential for the formation of the epitopes recognized by rheumatoid arthritis (RA)-associated autoantibodies to citrullinated proteins (ACPA). ACPA are secreted by plasma cells of the rheumatoid synovial tissue where their major target, citrullinated fib...

journal_title：Clinical and experimental immunology

authors： Duplan V,Foulquier C,Clavel C,Al Badine R,Serre G,Saoudi A,Sebbag M

更新日期：2006-09-01 00:00:00

abstract：:XLA bone marrow samples were shown to contain B cells expressing IgM, and pre-B cells that express the mu-surrogate light chain (mu psiLC) complex, albeit at a reduced frequency to that found in normal bone marrow. Antibody ligation of mu heavy chain on these cells and an XLA B cell line did not induce a Ca2+ flux, wh...

journal_title：Clinical and experimental immunology

authors： Genevier HC,Callard RE

更新日期：1997-12-01 00:00:00

abstract：:This study presents data on more than 300 RA and allergic patients analysed for their serum levels of anti-immunoglobulin isotype autoantibodies and IgE. We observed high levels of IgE in sera of RA and allergic patients. Interestingly, we measured significantly higher specific IgE levels against Alternaria but not ag...

journal_title：Clinical and experimental immunology

authors： Millauer N,Zuercher AW,Miescher SM,Gerber HA,Seitz M,Stadler BM

更新日期：1999-01-01 00:00:00

abstract：:A simple and efficient method of extracting complement-fixing immune complexes (IC) from whole serum and recovering them has been developed. 125I-labelled, in vitro prepared IC in whole serum were incubated with Sepharose 4B covalently linked to monoclonal anti-C3g or anti-C1q and the binding and recovery of IC was mo...

journal_title：Clinical and experimental immunology

authors： Samuel DJ,Amlot PL,Shepherd P,Lachmann PJ

更新日期：1986-08-01 00:00:00

abstract：:Monoclonal anti-dermatan sulphate antibodies were produced with hybridization after immunizing BALB/c mice with dermatan sulphate (DS). These antibodies were tested for cross-reactivity to double-stranded DNA (dsDNA) and heat-denatured DNA (ssDNA). Five clones had binding activity to DS, dsDNA and ssDNA in enzyme-link...

journal_title：Clinical and experimental immunology

authors： Ohnishi K,Sagawa A,Nakabayashi T,Ohmoto A,Megumi,Yoshikawa M,Watanabe I,Mukai M,Yasuda I,Nakagawa S

更新日期：1989-01-01 00:00:00

abstract：:Adjuvant arthritis in Lewis rats is a model of T cell-mediated autoimmune arthritis resembling human rheumatoid arthritis. A nonapeptide from the 65-kD heat-shock protein of Mycobacterium bovis BCG, amino acid sequence 180-188, has been described to carry the dominant immunogenic epitope(s) for both arthritis-protecti...

journal_title：Clinical and experimental immunology

authors： Yang XD,Gasser J,Feige U

更新日期：1990-08-01 00:00:00

abstract：:Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays ...

journal_title：Clinical and experimental immunology

authors： Mallone R,Mannering SI,Brooks-Worrell BM,Durinovic-Belló I,Cilio CM,Wong FS,Schloot NC,T-Cell Workshop Committee, Immunology of Diabetes Society.

更新日期：2011-01-01 00:00:00

abstract：:The prevalence of atopic diseases in children has increased during the last decades. Atopic symptoms usually appear early in life. This implies an early priming for atopic disease, possibly even at the fetal level. We therefore compared the presence and production of IgE in the local in utero environment during pregna...

journal_title：Clinical and experimental immunology

authors： Sverremark Ekstrom E,Nilsson C,Holmlund U,van der Ploeg I,Sandstedt B,Lilja G,Scheynius A

更新日期：2002-02-01 00:00:00