Immortalization of cloned mouse splenic macrophages with a retrovirus containing the v-raf/mil and v-myc oncogenes.

abstract：:Eighty-seven murine monoclonal antibodies (MAb) produced against human tumors of various origins and representing six different immunoglobulin classes were tested for antitumor reactivity in antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) assays. Mouse splenocytes, thio...

journal_title：Cellular immunology

authors： Herlyn D,Herlyn M,Steplewski Z,Koprowski H

更新日期：1985-04-15 00:00:00

abstract：:The alloreactive feature of CD4+ cytotoxic T-cell clone that could specifically lyse the cells bearing DPB1*0202 sequence was described. The clone was generated from a mixed culture of peripheral blood lymphocytes derived from siblings who were HLA-A, B, C, DR, and DQ identical by serological typing and whose DNA sequ...

journal_title：Cellular immunology

authors： Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

更新日期：1994-01-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) ...

journal_title：Cellular immunology

authors： Su M,Lin Y,Cui C,Tian X,Lu X,He Z,Lai L

更新日期：2017-12-01 00:00:00

abstract：:Accessory cell (A-cell) function in a Con A response was analyzed. Irradiated P388D1 cells efficiently induced a proliferative response to Con A of T cells purified from spleen cells, whereas paraformaldehyde-fixed P388D1 cells failed to serve as A cells. Although IL-1 containing culture supernatant (SN) of a macropha...

journal_title：Cellular immunology

authors： Kohno K,Kakiuchi T,Takeuchi M,Taira S,Nariuchi H

更新日期：1987-05-01 00:00:00

abstract：:The cellular requirements for the in vitro induction of antigen-specific suppressor T cells were examined. Previous reports indicated that Ia-bearing macrophages and anti-idiotypic B cells are required as accessory cells to facilitate the generation of suppressor effector (TS3) cells which regulate the response to the...

journal_title：Cellular immunology

authors： O'Hara RM Jr,Hausman PB,Sherr DH,Abromson-Leeman SR,Dorf ME

更新日期：1988-10-15 00:00:00

abstract：:NK activity is regulated by arachidonic acid metabolites. More precisely PGE2 and LTB4 decreases and increases respectively non-MHC-restricted cytotoxicity in humans. We have observed similar data in mice since NK activity was inhibited by PGE2 (10(-6) to 10(-8) M) and enhanced by LTB4 (10(-8) to 10(-12) M). On the ot...

journal_title：Cellular immunology

authors： Vaillier D,Daculsi R,Gualde N,Bezian JH

更新日期：1992-01-01 00:00:00

abstract：:The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...

journal_title：Cellular immunology

authors： Wu JY,Gardner BH,Kushner NN,Pozzi LA,Kensil CR,Cloutier PA,Coughlin RT,Newman MJ

更新日期：1994-04-01 00:00:00

abstract：:It has been documented that interleukin-6 (IL-6) supports the proliferation of purified, anti-CD3-stimulated murine T cells. We found that stimulation of human peripheral blood mononuclear cells (PBMCs) with anti-CD3 induced a significant accumulation of IL-6 mRNA, indicating that antigen-mediated T-cell activation ma...

journal_title：Cellular immunology

authors： Walz G,Stevens C,Zanker B,Melton LB,Clark SC,Suthanthiran M,Strom TB

更新日期：1991-05-01 00:00:00

abstract：:We compared TLR responsiveness in PBMC from HIV-1-infected and uninfected individuals using the TLR agonists: TLR7 (3M-001), TLR8 (3M-002), and TLR7/8 (3M-011). Activation and maturation of plasmacytoid dendritic cells (pDC) were measured by evaluating CD86, CD40, and CD83 expression and myeloid dendritic cell (mDC) a...

journal_title：Cellular immunology

authors： Martinson JA,Roman-Gonzalez A,Tenorio AR,Montoya CJ,Gichinga CN,Rugeles MT,Tomai M,Krieg AM,Ghanekar S,Baum LL,Landay AL

更新日期：2007-11-01 00:00:00

abstract：:In vivo adoptive transfer of T-cell-mediated immunity to the facultative intracellular bacterium Listeria monocytogenes is restricted, not only by the H-2 haplotype of the mice, but also by incompatibilities at non-H-2 loci. Thus, transfer between H-2 identical strains of mice with different background genes was repro...

journal_title：Cellular immunology

authors： Cheers C,McKenzie IF

更新日期：1983-03-01 00:00:00

abstract：:Dexamethasone is a potent anti-inflammatory and immunosupressive agent that has complex, yet incompletely defined, effects on the immune response. Here, we explored the effect of dexamethasone on the expression of TCR zeta chain and TCR/CD3-induced early signaling events in human T lymphocytes. Immunoblotting studies ...

journal_title：Cellular immunology

authors： Nambiar MP,Enyedy EJ,Fisher CU,Warke VG,Juang YT,Tsokos GC

更新日期：2001-02-25 00:00:00

abstract：:Human peripheral blood T cells lysed autologous or allogeneic monocytes, but not polymorphonuclear cells (PMN) or lymphocytes, in the presence of anti-CD3 (OKT3 (IgG2a) or anti-Leu 4 (IgG1)) monoclonal antibody (mAb). Other mAbs such as OKT4 (IgG2b), OKT8 (IgG2a), OKT11 (IgG2a), and OKM1 (IgG2a) did not mediate lysis ...

journal_title：Cellular immunology

authors： Itoh K,Balch CM,Trial J,Platsoucas CD

更新日期：1988-07-01 00:00:00

abstract：:The purpose of this project was to characterize changes in murine T lymphocyte subpopulations during thymic atrophy induced by protein malnutrition and to determine the role of elevated serum corticosterone in this process. A suitable animal model was generated by placing mice on protein-sufficient (PS) and protein-de...

journal_title：Cellular immunology

authors： Barone KS,O'Brien PC,Stevenson JR

更新日期：1993-04-15 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:We have recently established a new animal model for primary Sjögren's syndrome in NFS/sld mutant mice thymectomized 3 days after birth (3dTX) bearing an autosomal recessive gene with sublingual gland differentiation arrest. In this study, we analyze developing mechanisms of experimental autoimmune sialadenitis (EAS) i...

journal_title：Cellular immunology

authors： Hayashi Y,Haneji N,Hamano H,Yanagi K,Takahashi M,Ishimaru N

更新日期：1996-08-01 00:00:00

abstract：:Germ-free (GF) mice have increased bone mass that is normalized by colonization with gut microbiota (GM) from conventionally raised (CONV-R) mice. To determine if innate immune signaling pathways mediated the effect of the GM, we studied the skeleton of GF and CONV-R mice with targeted inactivation of MYD88, NOD1 or N...

journal_title：Cellular immunology

authors： Ohlsson C,Nigro G,Boneca IG,Bäckhed F,Sansonetti P,Sjögren K

更新日期：2017-07-01 00:00:00

abstract：:Monoclonal-nonspecific suppressor factor (MNSF) is a lymphokine derived from murine T cell hybridoma. The target tissues are both LPS-stimulated B cells and Con A-stimulated T cells. Since the action of MNSF may be mediated by its binding to specific cell surface receptors, we characterized the mode of this binding. T...

journal_title：Cellular immunology

authors： Nakamura M,Ogawa H,Tsunematsu T

更新日期：1990-10-15 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

journal_title：Cellular immunology

authors： Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

更新日期：1998-07-10 00:00:00

abstract：:Neuroinflammation plays a pivotal role in the incidence and progression of Alzheimer's disease (AD). Cathelicidin-related antimicrobial peptide (CRAMP) is critically involved in the innate neuronal responses of chronic neuroinflammation in AD and thus plays a key role in the disease. Here, we show that Aβ42 induced mi...

journal_title：Cellular immunology

authors： Xu X,Cai X,Zhu Y,He W,Wu Q,Shi X,Fang Y,Pei Z

更新日期：2018-09-01 00:00:00

abstract：:In this study the influence of a non-mitogenic anti-CD3 antibody on accessory cell-dependent antigen and mitogen-induced T-lymphocyte proliferation has been investigated. The antibody was found to completely inhibit PHA, Con A, PWM, and tetanus toxoid stimulation, with no effect on the proliferation induced by the cal...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Stockinger H,Liszka K,Fischer G,Knapp W

更新日期：1986-06-01 00:00:00

abstract：:We now report two healthy individuals whose T lymphocytes were over 95% positive for CD45RA antigen expression. However, these donors normally expressed both the CD29 high (CD29+) and CD45RO high (CD45RO+) antigens on approximately 40 and 50% of their CD4 cells, respectively. Despite the strong CD45RA expression on th...

journal_title：Cellular immunology

authors： Matsuyama T,Yamada A,Rothstein DM,Anderson KC,Schlossman SF,Morimoto C

更新日期：1991-10-15 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:The phenotype, T-cell antigen receptor (TCR) usage and specificity of intestinal intraepithelial lymphocytes (IEL), and hybridomas derived from IEL have been examined. In young conventionally reared mice, approximately 50% of the IEL express TCR alpha beta and 50% express TCR gamma delta, although there is considerabl...

journal_title：Cellular immunology

authors： Sydora BC,Mixter PF,Houlden B,Hershberg R,Levy R,Comay M,Bluestone J,Kronenberg M

更新日期：1993-12-01 00:00:00

abstract：:Antigen processing in B cells is initiated by antigen binding to the surface B cell antigen receptor (BCR). The BCR is a signaling receptor which also functions to endocytose bound antigen for subsequent intracellular processing and presentation with class II molecules. Previously, using subcellular fractionation, we ...

journal_title：Cellular immunology

authors： Wagle NM,Kim JH,Pierce SK

更新日期：1998-02-25 00:00:00

abstract：:Six OKT4+ human T-cell lines that require continuing PHA stimulation and TCGF for continuous growth were established. The cells from all six of these T-cell lines became smaller in size and lost the cell surface Ia antigen when they were grown in phytohemagglutinin (PHA)-depleted growth factor. These cells were unable...

journal_title：Cellular immunology

authors： Tsui F,Underdown BJ,Klein M,Zimmerman B

更新日期：1984-04-15 00:00:00

abstract：:Mice were infected with Plasmodium (P.) yoelii blood-stage parasites. Both the liver and spleen were the sites of inflammation during malarial infection at the beginning of day 7. The major expanding cells were found to be NK1.1(-) intermediate alphabetaTCR (alphabetaTCR(int)) in the liver and spleen, although the pop...

journal_title：Cellular immunology

authors： Weerasinghe A,Sekikawa H,Watanabe H,Mannoor K,Morshed SR,Halder RC,Kawamura T,Kosaka T,Miyaji C,Kawamura H,Seki S,Abo T

更新日期：2001-01-10 00:00:00

abstract：:We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...

journal_title：Cellular immunology

authors： Denis M

更新日期：1994-07-01 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00