Prophylaxis of gastrointestinal tract bleeding in patients admitted to a general hospital ward. Comparative study of sucralfate and cimetidine.

Abstract:

:Gastrointestinal bleeding prophylaxis is well known in patients admitted to intensive care units, but only a few reports have analyzed this problem in patients admitted to a general hospital ward. In a previous study we demonstrated that close to 20% of such seriously ill placebo-treated patients bled. We conducted a prospective, randomized trial comparing cimetidine in a single dose of 800 mg and sucralfate at a dose of 1g/6h in a group of 139 patients from a cohort of 2010 patients consecutively admitted during a 10-month period to a department of internal medicine at a teaching hospital. The severity of their illness was assessed by the simplified acute physiologic score (SAPS). Gastrointestinal bleeding was assessed at the beginning of the study and daily during the hospitalization by means of Hemoccult paper tests or when frank hematemesis or melena occurred. Two of the 71 patients assigned to cimetidine and 2 of the 68 assigned to sucralfate presented with acute gastrointestinal bleeding, which was more severe in the sucralfate group. The drugs had similar safety profiles and were well tolerated, but the easier administration of cimetidine in a single dose, together with its low cost (25% less than sucralfate) argues in favor of cimetidine to prevent gastrointestinal bleeding in seriously ill patients admitted to general hospital wards.

journal_name

Scand J Gastroenterol

authors

Grau JM,Casademont J,Fernández-Solá J,Cardellach F,Urbano-Márquez A

doi

10.3109/00365529309096080

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

244-8

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

28

pub_type

临床试验,杂志文章,随机对照试验
  • Health-related quality of life in patients with different stages of liver disease induced by hepatitis C.

    abstract:OBJECTIVE:Patients with hepatitis C have been shown to have impaired health-related quality of life (HRQoL). The aim of this study was to determine HRQoL in patients in different stages of hepatitis C virus (HCV) and to compare HRQoL in HCV cirrhosis with non-HCV-induced cirrhosis. MATERIAL AND METHODS:Out of 489 cons...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365520902898135

    authors: Björnsson E,Verbaan H,Oksanen A,Frydén A,Johansson J,Friberg S,Dalgård O,Kalaitzakis E

    更新日期:2009-01-01 00:00:00

  • Is transcatheter arterial embolization a safer alternative than surgery when endoscopic therapy fails in bleeding duodenal ulcer?

    abstract:OBJECTIVE:Emergency surgery after unsuccessful endoscopic therapy for bleeding duodenal ulcer has been reported to have a high mortality. Transcatheter arterial embolization (TAE) of the gastroduodenal artery is an alternative strategy when endoscopic therapy fails. This study is a retrospective analysis comparing thes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903486109

    authors: Venclauskas L,Bratlie SO,Zachrisson K,Maleckas A,Pundzius J,Jönson C

    更新日期:2010-03-01 00:00:00

  • Self-medication of dyspepsia: how appropriate is it?

    abstract:BACKGROUND:The scope of self-medication is increasing in many countries, and drugs for dyspepsia are a popular group for deregulative activities. This study investigated what kind of upper gastrointestinal symptoms people self-medicate and how appropriate this self-medication is. METHODS:An anonymous questionnaire was...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709011191

    authors: Sihvo S,Hemminki E

    更新日期:1997-09-01 00:00:00

  • Treatment with interferon-alpha2a alone or interferon-alpha2a plus ribavirin in patients with chronic hepatitis C previously treated with interferon-alpha2a. CONSTRUCT Group.

    abstract:BACKGROUND:Preliminary results from combination therapy with interferon-alpha and ribavirin (IFN/Rib) in patients with chronic hepatitis C have been promising, with up to 50% sustained hepatitis C virus (HCV) RNA response. The aim of this study was to investigate whether a sustained HCV RNA response could be obtained w...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1080/00365529950173087

    authors: Bell H,Hellum K,Harthug S,Myrvang B,Ritland S,Maeland A,von der Lippe B,Bjøro K,Skaug K,Gutigard BG,Raknerud N,Simmonds P

    更新日期:1999-02-01 00:00:00

  • Effects of atropine on GIP-induced insulin and pancreatic polypeptide release in man.

    abstract::Eight fasting students were given an infusion of porcine gastric inhibitory polypeptide (GIP) and glucose with or without atropine on two separate days. Mean serum insulin levels increased significantly and similarly on both occasions, indicating that both the glucose- and GIP-induced insulin release is unaffected by ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528509091658

    authors: Amland PF,Jorde R,Burhol PG,Giercksky KE

    更新日期:1985-04-01 00:00:00

  • Non-esophageal symptoms cannot differentiate between erosive reflux esophagitis and non-erosive reflux disease in a referred population.

    abstract:BACKGROUND:Non-esophageal symptoms are highly prevalent in non-erosive reflux disease (NERD). However, their prevalence in erosive esophagitis (ErE) is unclear. The aims of this study were to compare patients with pH-positive NERD and ErE in terms of non-esophageal symptoms and to investigate whether such symptoms can ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.579997

    authors: Zimmerman J,Hershcovici T

    更新日期:2011-07-01 00:00:00

  • Studies of the choledocho-duodenal sphincter in patients with and without juxta-papillary duodenal diverticula.

    abstract::The function of the choledocho-duodenal sphincter was studied in 16 patients, 8 with juxta-papillary duodenal diverticula. All patients had calculi in the gallbladder. The common bile duct was normal. At cholecystectomy two catheters were introduced into the common bile duct through the stump of the cystic duct and fi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181545

    authors: Løtveit T,Osnes M,Aune S,Larsen S

    更新日期:1980-01-01 00:00:00

  • Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla.

    abstract:OBJECTIVE:The use of endoscopic papillectomy for resecting adenomas in the major duodenal papilla is increasing. This study focuses on the following three issues: Can endoscopic papillectomy be performed as a safe diagnostic and/or therapeutic procedure in biopsy-verified or suspected ampullary adenoma? Does expression...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1046912

    authors: Haraldsson E,Swahn F,Verbeke C,Mattsson JS,Enochsson L,Ung KA,Lundell L,Heuchel R,Löhr JM,Arnelo U

    更新日期:2015-01-01 00:00:00

  • Smoking is associated with severity of liver fibrosis but not with histological severity in nonalcoholic fatty liver disease. Results from a cross-sectional study.

    abstract:OBJECTIVES:To assess the influence of smoking on histological disease severity and fibrosis in real-world NAFLD patients. MATERIAL AND METHODS:Consecutive NAFLD patients were identified with liver biopsies performed between 2008 and 2015. Characteristics such as smoking status and total number of pack years were colle...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1315169

    authors: Munsterman ID,Smits MM,Andriessen R,van Nieuwkerk CMJ,Bloemena E,Mulder CJJ,Tjwa ETTL,van Geenen EJM

    更新日期:2017-08-01 00:00:00

  • Modulation of the adrenergic system in the treatment of postoperative bowel atonia.

    abstract::Sympathetic hyperactivity is considered to be the most important factor in the development of postoperative bowel atonia. In a double-blind study we evaluated the gut motor effects of dihydroergotamine, which predominantly acts as a sympatholytic agent in the gastrointestinal tract. Forty-six patients undergoing chole...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Altaparmakov I,Erckenbrecht JF,Wienbeck M

    更新日期:1984-11-01 00:00:00

  • Interdigestive motility and motilin in hypophysectomized patients.

    abstract::Basal fluctuations of motilin and their correlation to intestinal motor activity were studied in five hypophysectomized (anterior lobe resection) patients. A cyclic pattern of motor activity identical to the one described in normal volunteers was observed. The mean interval between two activity fronts (AF) was 115 min...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093850

    authors: Peeters TL,Janssens J,Plets C,Vantrappen G

    更新日期:1988-01-01 00:00:00

  • Gastric IgA in cystic fibrosis in relation to the migrating motor complex.

    abstract:BACKGROUND:Gastrointestinal symptoms in cystic fibrosis are frequent, but little is known about the underlying pathophysiology. Mucosal secretion of IgA is important for the immunologic function in the human gastrointestinal tract but has not been studied in cystic fibrosis. The aim of this study was to quantify the re...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750313379

    authors: Hallberg K,Mattsson-Rydberg A,Fändriks L,Strandvik B

    更新日期:2001-08-01 00:00:00

  • The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992-2006).

    abstract:BACKGROUND:There is a striking male predominance in esophageal cancer patients. Sex hormones have been suggested as a contributing factor and these are influenced by age and race. In this study, we examined the male-to-female incidence rate ratios of esophageal cancer in the United States. METHODS:We used data from 13...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.551890

    authors: Nordenstedt H,El-Serag H

    更新日期:2011-05-01 00:00:00

  • Health literacy levels in outpatients with liver cirrhosis.

    abstract:OBJECTIVE:Health literacy (HL) is a concept covering a range of cognitive and social skills that comprises aspects necessary for patients to navigate in the healthcare system. Our study aimed to investigate HL in patients with liver cirrhosis and determine factors associated with low HL. METHODS:Data were collected am...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1545045

    authors: Freundlich Grydgaard M,Bager P

    更新日期:2018-12-01 00:00:00

  • Inhibitory effect of aprotinin on gastric acid secretion.

    abstract::Aprotinin was found to inhibit the amplitude of electrically stimulated contractions of the isolated guinea pig ileum with an ID50 of 6.75 X 10(-6) M. Aprotinin inhibited pentagastrin-stimulated gastric acid secretion in the rat, cat, and pig after oral or intraventricular administration. No inhibition of gastric acid...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Jørgensen KD,Diamant B

    更新日期:1984-11-01 00:00:00

  • Idiosyncratic drug allergic phenprocoumon-induced hepatitis with subacute liver failure initially misdiagnosed as autoimmune hepatitis.

    abstract:BACKGROUND:Coumarin anticoagulants are known to cause hepatotoxicity, but only a few cases have been reported. Coumarins are usually administered following cardiovascular surgery and the differential diagnosis is post-transfusion hepatitis. METHODS:We report the case of a 46-year-old woman who presented with jaundice,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201300192076

    authors: Hinrichsen H,Lüttges J,Klöppel G,Fölsch UR,Schmidt WE

    更新日期:2001-07-01 00:00:00

  • Hepatocellular carcinoma surveillance with liver imaging is not associated with improved survival.

    abstract::Objective: International guidelines recommend hepatocellular carcinoma (HCC) surveillance with ultrasound in high-risk patients with chronic liver diseases. However, there is low-strength evidence about the effects on mortality. The aim of our study was to assess the impact of surveillance on the clinical course and s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1718747

    authors: Lang S,Martin A,Kasper P,Schramm C,Kütting F,Goeser T,Steffen HM,Demir M

    更新日期:2020-02-01 00:00:00

  • The CCK-2 receptor is located on the ECL cell, but not on the parietal cell.

    abstract:BACKGROUND:The interrelationship between histamine and gastrin in the physiological regulation of gastric acid secretion is still a matter of dispute. CCK-2 receptors are located on enterochromaffin-like (ECL) cells in corpus mucosa and gastrin stimulates acid production by releasing histamine from the ECL cells, which...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520152584734

    authors: Bakke I,Qvigstad G,Sandvik AK,Waldum HL

    更新日期:2001-11-01 00:00:00

  • Cardiovascular risk factors in obese patients treated with jejunoileal bypass operation: a 25-year follow-up study.

    abstract:OBJECTIVE:Jejunoileal (JI) bypass was a widely performed surgical procedure for morbid obesity in the 1970s. The purpose of this study was to assess cardiovascular risk factors and mortality in patients 25 years or more after this operation. MATERIAL AND METHODS:All (n = 36) patients operated on for obesity with JI by...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410009393

    authors: Våge V,Berstad A,Solhaug JH,Viste A

    更新日期:2005-01-01 00:00:00

  • Canine gastric ulcer produced by hemorrhagic shock and aspirin.

    abstract::Ischemia of the gastric mucosa, for example during hemorrhagic shock, appears to be an important pathogenetic factor in acute bleeding from the upper gastrointestinal tract. In the present experiment the effects on the canine gastric mucosa of hemorrhagic shock (ischemia) and intragastric aspirin in acid and neutral s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Casalnuovo CA,Kraglund K,Kristensen IB,Amdrup E

    更新日期:1984-06-01 00:00:00

  • Ambulatory 24-hour pH-metry in the diagnosis of gastroesophageal reflux disease. Determination of criteria and relation to endoscopy.

    abstract::The results of ambulatory 24-h esophageal pH monitoring in 67 patients with gastroesophageal reflux symptoms (endoscopic esophagitis, n = 44; normal endoscopy, n = 23) were compared with those of 27 normal subjects without reflux symptoms. Patients with reflux symptoms had significantly increased gastroesophageal refl...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Masclee AA,de Best AC,de Graaf R,Cluysenaer OJ,Jansen JB

    更新日期:1990-03-01 00:00:00

  • Effect of pentagastrin on regional gastric blood flow in conscious cats.

    abstract::Total gastric flow studies indicated that a transient, considerable flow increase was followed by a more moderate increase of total gastric flow during pentagastrin stimulation in anesthetized cats. In conscious cats regional gastric flow studies, using hydrogen clearance techniques, suggested that raised flow to the ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182080

    authors: Semb BK

    更新日期:1982-04-01 00:00:00

  • Alpha1-antitrypsin genotypes in patients with chronic pancreatitis.

    abstract:BACKGROUND:An association between alpha1-antitrypsin deficiency and chronic pancreatitis (CP) has been reported in several case reports and two systematic studies. However, conflicting results have been shown in other studies of patients with CP. All previous studies were performed by phenotyping or by measurement of s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202317284282

    authors: Witt H,Kage A,Luck W,Becker M

    更新日期:2002-03-01 00:00:00

  • Simultaneous measurement of gastric acid and bicarbonate secretion in man.

    abstract::Experiments were performed to validate the computerized pH/PCO2 technique for measurement of HCO3 secretion at a physiologic pH in the human stomach. In bench-side experiments the system detected 103 +/- 2% (mean +/- SE, n = 66) of boluses or infusions of NaHCO3. The standard curve was linear in the physiologic concen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909090782

    authors: Sjövall H,Forssell H,Olbe L

    更新日期:1989-12-01 00:00:00

  • Endoscopic manometry of the sphincter of Oddi and pancreatic duct in chronic pancreatitis.

    abstract::Pancreatic duct pressure was studied by endoscopic manometry in 12 patients with chronic pancreatitis and in 9 patients with a normal pancreas (suspected biliary dyskinesia). To study the effect of increased intraduodenal concentration of pancreatic enzymes, the duct pressure was measured before and after intraduodena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609015156

    authors: Rolny P,Arlebäck A,Järnerot G,Andersson T

    更新日期:1986-05-01 00:00:00

  • Selective inhibitors of COX-2--are they safe for the stomach?

    abstract::NSAIDs are widely used and beneficial for patients with inflammatory pain. However, NSAIDs cause significant adverse upper gastrointestinal effects, including increased mortality from serious ulcer complications. NSAIDs exert their anti-inflammatory effects by inhibiting the activity of the COX enzyme, which was recen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/003655200750056565

    authors: Giercksky KE,Haglund U,Rask-Madsen J

    更新日期:2000-11-01 00:00:00

  • In vitro effects of gastrin on the movement of electrolytes across the human colon.

    abstract::Using an in vitro system, the effect of gastrin on the colonic handling of water and electrolytes has been investigated. Gastrin converted the normal mucosal absorption of water and sodium into a net secretion. The colonic response to gastrin was done-related with respect to sodium, and the effects were greater when i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709181364

    authors: El Masri SH,Lewin MR,Clark CG

    更新日期:1977-01-01 00:00:00

  • Analysis of the CTLA4 gene in Swedish coeliac disease patients.

    abstract:BACKGROUND:A genetic susceptibility to coeliac disease is well established, involving HLA and non-HLA components. CTLA4 is an important regulator of T-cell function and some studies have suggested that sequence variation in the gene might be a determinant of disease susceptibility, although the evidence is conflicting....

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202753387310

    authors: Popat S,Hearle N,Wixey J,Hogberg L,Bevan S,Lim W,Stenhammar L,Houlston RS

    更新日期:2002-01-01 00:00:00

  • Immunologic and absorptive tests in celiac disease: can they replace intestinal biopsies?

    abstract::The sensitivity and specificity of several immunologic and absorption tests were determined in infants with celiac disease (31 male, 39 female; median age, 2.6 years) in different phases of the disease and in a group of control subjects with chronic diarrhea of different etiologies (32 male, 28 female; median age, 1.2...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098270

    authors: Carroccio A,Iacono G,Montalto G,Cavataio F,Soresi M,Kazmierska I,Notarbartolo A

    更新日期:1993-08-01 00:00:00

  • Chronic pancreatitis in patients with sclerosing cholangitis and ulcerative colitis.

    abstract::In the 4-year period 1980-83 sclerosing cholangitis was demonstrated in 7 out of 151 patients with ulcerative colitis hospitalized in our department. Total ulcerative colitis was demonstrated in all patients with sclerosing cholangitis, whereas abnormal pancreatograms compatible with chronic pancreatitis were seen in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089693

    authors: Børkje B,Vetvik K,Odegaard S,Schrumpf E,Larssen TB,Kolmannskog F

    更新日期:1985-05-01 00:00:00