Abstract:
:Comamonas testosteroni YZW-D was isolated from Passaic River sediment for its ability to degrade isophthalate and terephthalate. Degradation of the two isomeric compounds proceeds via separately inducible catabolic pathways that converge at protocatechuate. Analysis of the catabolic pathways by which these two isomers are degraded demonstrated that a cis-dihydrodiol intermediate is involved in both pathways. The genes for the conversion of isophthalate and terephthalate to protocatechuate were cloned on a single fragment of genomic DNA from C. testosteroni YZW-D. The two operons were located by subcloning and mutant complementation experiments. The regions coding for the two degradative pathways were sequenced. Analysis of the nucleotide sequence for the isophthalate degradation operon located genes for a dioxygenase, a transport protein, a cis-dihydrodiol dehydrogenase, and a reductase. Analysis of the nucleotide sequence for the terephthalate degradation operon located genes for a regulatory protein, a transport protein, a dioxygenase large subunit, a dioxygenase small subunit, a cis-dihydrodiol dehydrogenase, and a reductase.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Wang YZ,Zhou Y,Zylstra GJdoi
10.1289/ehp.95103s49subject
Has Abstractpub_date
1995-06-01 00:00:00pages
9-12eissn
0091-6765issn
1552-9924journal_volume
103 Suppl 5pub_type
杂志文章abstract:BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9014
更新日期:2006-08-01 00:00:00
abstract::One of the many forms that biological warfare may take is the targeting of major food crops. In a poor country where millions of citizens depend on staple crops such as rice, an act of bioterrorism that destroys the crop would create a famine, resulting not only in malnutrition and starvation but also in reduced immun...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.108-a126
更新日期:2000-03-01 00:00:00
abstract::[35S]t-Butylbicyclophosphorothionate or [35S]TBPS is an improved radioligand for the picrotoxinin binding site in rat brain synaptic membranes. The toxic isomers of the hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes displace [35S]TBPS with a stereospecificity and potency generally correlated w...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561123
更新日期:1985-09-01 00:00:00
abstract::An association between human illness and exposure to Pfiesteria was first observed among laboratory personnel working with the microorganism. In 1997, in the setting of Pfiesteria activity on the Pocomoke River in Maryland, difficulties with learning and memory were epidemiologically associated with high-level exposur...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.01109s5787
更新日期:2001-10-01 00:00:00
abstract::In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108709
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Health risks differ by fine particle (aerodynamic diameter ≤ 2.5 μm) component, although with substantial variability. Traditional methods to assess component-specific risks are limited, suggesting the need for alternative methods. OBJECTIVES:We examined whether the odds of daily hospital admissions differ ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002646
更新日期:2011-10-01 00:00:00
abstract::We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7826121
更新日期:1978-10-01 00:00:00
abstract::In recent years there have been a significant number of publications on the benefits and challenges of community-based participatory research (CBPR). In this introduction we give an overview of three projects presented in this mini-monograph and highlight their commonalities and differences in developing community-uni...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7911
更新日期:2005-12-01 00:00:00
abstract::N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. De...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.834943
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Accordingly, these agents may differ in their effects on specific brain circuits. OBJECTIVES:We gave parathion to neonatal rats [postnatal days (PNDs) 1-4], at daily...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11451
更新日期:2008-10-01 00:00:00
abstract::Stable associations of syntrophic fermentative organisms and populations that consume fermentation products play key roles in the anaerobic biodegradation of chlorinated organic contaminants. The involvement of these syntrophic populations is essential for mineralization of chlorinated aromatic compounds under methano...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6933
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2192
更新日期:2018-01-22 00:00:00
abstract::Many substances are active in in vitro tests for estrogenic activity, but data from multigenerational and other toxicity studies are not available for many of those substances. Controversy has arisen, therefore, concerning the likelihood of adverse health effects. Based on a toxic equivalence factor risk assessment ap...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s3655
更新日期:1997-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5992
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized. OBJECTIVES:We aimed to characterize within-day, between-da...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1994
更新日期:2018-03-16 00:00:00
abstract::Chlorination has been the major strategy for disinfection of drinking water in the United States. Concern about the potential health effects of the reaction by-products of chlorine has prompted use of alternative strategies. One such method is chloramination, a treatment process that does not appear to have carcinogen...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8669275
更新日期:1986-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP4434
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Sulfation plays an important role both in detoxification and in the control of steroid activity. Studies in rodents have shown that the conversion of dehydroepiandrosterone (DHEA) to DHEA-sulfate is involved in learning and the memory process. METHODS:The effects of a range of plasticizers and related compo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9365
更新日期:2007-12-01 00:00:00
abstract::Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with 57Co. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 salin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9297209
更新日期:1992-07-01 00:00:00
abstract::Widespread and persistent organochlorine (OC) contaminants, such as polychlorinated biphenyls (PCBs) and pesticides, are known to have broad-ranging toxicities in wildlife. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Nonlethal fat biopsi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6923
更新日期:2004-07-01 00:00:00
abstract::Humans are exposed to a large number of environmental chemicals: Some of these may be toxic, and many others have unknown or poorly characterized health effects. There is intense interest in determining the impact of exposure to environmental chemical mixtures on human health. As the study of mixtures continues to evo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1510569
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Few studies have examined the relationship between long-term exposure to ambient fine particulate matter (PM2.5) and nonaccidental mortality in rural populations. OBJECTIVE:We examined the relationship between PM2.5 and nonaccidental and cardiovascular mortality in the U.S. Agricultural Health Study cohort....
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307277
更新日期:2014-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110791
更新日期:2002-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104594
更新日期:2012-04-01 00:00:00
abstract::Rats were instilled intrabronchially with 1 mg UICC amosite suspended in 0.2 mL of filtered saline; control animals received the saline instillation only. Five animals from each group were killed on various days after instillation, up to day 128/129. Total retrieved cell counts and differential cell analysis were perf...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.835141
更新日期:1983-09-01 00:00:00
abstract::Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different patterns of excess risk related to duration of exposure, age at initial exposure, and follow-up time since exposure stopped, depending upon which s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350293
更新日期:1983-04-01 00:00:00
abstract::In this study, the cohort consisted of 18,135 distribution employees with potential exposure to gasoline for at least one year at land-based terminals (n = 9,026) or on marine vessels (n = 9,109) between 1946 and 1985. The primary objective of the study was to determine the relationship, if any, between exposure to ga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s663
更新日期:1993-12-01 00:00:00
abstract::To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102298
更新日期:1994-03-01 00:00:00
abstract::For decades, a number of guinea pig tests have been used to identify human contact allergens in workplace and consumer products, but these tests have limitations. In addition to using large numbers of test animals, they also provide only subjective measurements, because the allergic activity is measured by watching th...
journal_title:Environmental health perspectives
pub_type: 新闻
doi:10.1289/ehp.98106a488
更新日期:1998-10-01 00:00:00
abstract::The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106649
更新日期:1998-10-01 00:00:00