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Serum sAPRIL: a potential tumor-associated biomarker to colorectal cancer.

Abstract：

OBJECTIVE:The purpose of our study was to investigate the serum levels of soluble a-proliferation-inducing ligand (sAPRIL) in patients with colorectal cancer (CRC), benign intestinal disease and healthy volunteers and explore the potential possibility of sAPRIL severing as a CRC biomarker. METHODS:Our investigation was conducted on 35 blood samples obtained from CRC patients, 32 blood samples from patients with benign intestinal diseases and 31 blood samples from healthy volunteers. The sAPRIL concentrations were examined by an enzyme-linked immunosorbent assay (ELISA) and data were analyzed with non-parametric Mann-Whitney U-test and X²-test. The correlation relationship between sAPRIL and CEA, as well as sAPRIL and CA19-9 was assessed by non-parametric Spearmen's correlation test, respectively. RESULTS:The median value of sAPRIL in the malignant group was 10.43 ng/mL, compared with those of the benign group (4.89 ng/mL) and control group (3.30 ng/mL), respectively, which had an obvious significance (P<0.0003). Area under the receiver-operating characteristic (ROC) curve for sAPRIL was 0.854 (95% CI, 0.776-0.933). The optimal cut-off level of sAPRIL was 5.49 ng/mL. Serum sAPRIL had a positive correlation with CEA (r=0.637, P=0.000) and CA19-9 (r=0.357, P=0.008) in 35 patients with colorectal cancer. sAPRIL showed higher sensitivity (82.9%) than those of CEA (74.3%) and CA19-9 (65.7%) in CRC, respectively. CONCLUSION:The results indicated that serum sAPRIL, as a potential biomarker, had a positive diagnostic value for colorectal cancer.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Ding W,Wang J,Wang F,Wang G,Wu Q,Ju S,Cong H,Wang H

doi

10.1016/j.clinbiochem.2013.06.008

keywords:

["Biomarker","CA19-9","CEA","Colorectal cancer","Diagnosis","sAPRIL"]

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1590-4

issue

15

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(13)00285-3

journal_volume

46

pub_type

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