Abstract:
PURPOSE:To investigate the spectrum of organisms causing culture-proven endophthalmitis and their susceptibilities to commonly used antimicrobial agents over 10 years. DESIGN:Retrospective, noncomparative, consecutive case series. METHODS:Medical records were reviewed of all cases with culture-proven endophthalmitis at a single institution from 2002 through 2011. The outcome measures included all intravitreal isolates identified as well as antibiotic susceptibilities. RESULTS:A total of 448 organisms were isolated during the study interval. The most common organisms identified were Staphylococcus epidermidis in 30.1% (135/448), Streptococcus viridians group in 10.9% (49/448), Staphylococcus aureus in 7.8% (35/448), Candida albicans in 5.8% (26/443), other coagulase-negative staphylococci in 6.0% (27/448), Propionibacterium acnes in 4.7% (21/448), and Pseudomonas aeruginosa in 3.1% (14/448). Overall, 327 (72.9%) of 448 isolates were gram-positive organisms, 48 (10.7%) of 448 isolates were gram-negative organisms, 71 (15.8%) of 448 isolates were fungi, and 2 (0.4%) of 448 isolates were viruses. For gram-positive organisms, susceptibilities were the following: vancomycin, 100%; gentamicin, 88.0%; sulfamethoxazole/trimethoprim, 77.5%; levofloxacin, 58.5%; oxacillin, 54.7%; ciprofloxacin, 51.0%; gatifloxacin, 51.0%; and moxifloxacin, 47.0%. For gram-negative organisms, susceptibilities were the following: ceftazidime, 100%; levofloxacin, 100%; ciprofloxacin, 95.0%; tobramycin, 90.6%; gentamicin, 80.6%; and sulfamethoxazole/trimethoprim, 59.4%. CONCLUSIONS:In the current study, no single antibiotic provided coverage for all of the microbes isolated from eyes with endophthalmitis. Combination therapy generally is the recommendation as the initial empiric treatment of suspected bacterial endophthalmitis. Appropriate history and characteristic clinical features may guide the use of initial antifungal agents.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Schimel AM,Miller D,Flynn HW Jrdoi
10.1016/j.ajo.2013.01.027subject
Has Abstractpub_date
2013-07-01 00:00:00pages
50-52.e1issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(13)00099-8journal_volume
156pub_type
杂志文章abstract::We devised a new binocular indirect ophthalmoscope and a complimentary examination technique that provide enhanced fundus magnification and optimum stereopsis through a wide range of patient pupillary apertures. The lightweight, mechanically simple instrument uses a variable focus Galilean telescopic observation syste...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(78)90182-4
更新日期:1978-11-01 00:00:00
abstract:PURPOSE:To compare the long-term surgical outcomes of augmented bilateral lateral rectus (LR) recession with original surgery. DESIGN:Retrospective, nonrandomized clinical study. METHODS:A total of 447 children with ≤35 prism diopters (PD) of basic and divergence excess-type intermittent exotropia, who underwent orig...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.12.003
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To report the clinical outcome in 48 eyes of 48 children who received a Baerveldt glaucoma implant (BGI) for the management of pediatric glaucoma. DESIGN:Retrospective, noncomparative case series. METHODS:The medical records of all patients with pediatric glaucoma who underwent a BGI at two tertiary care refe...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2004.12.028
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:This study sought to investigate retinal function in patients with noninfectious uveitis by using full-field electroretinography (ERG) and correlate the ERG to disease duration and severity of inflammation. DESIGN:Prospective cohort study. METHODS:Patients (n = 200) with noninfectious uveitis and a disease du...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2019.05.028
更新日期:2019-11-01 00:00:00
abstract::We studied the use of human retinal pigment epithelial cells cultured on a collagen support as a potential transplantation therapy to replace diseased or damaged retinal pigment epithelium. Using a transvitreal approach, we transplanted human retinal pigment epithelial cells attached to either a sheet of noncross-link...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73079-x
更新日期:1994-02-15 00:00:00
abstract:PURPOSE:To report a case of recurrent bleeding after photodynamic therapy (PDT) in an eye with polypoidal choroidal vasculopathy (PCV). DESIGN:Interventional case report. METHODS:A 73-year-old man was treated in the left eye for PCV with PDT. RESULTS:Two weeks after PDT, his left eye showed extensive subretinal hemo...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.12.002
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To evaluate the use of disk diameter as an indicator in the identification of glaucomatous optic neuropathy. METHODS:We evaluated all available stereofundus photographs for 1,040 right eyes obtained in the Reykjavik Eye Study. Horizontal and vertical disk diameters were determined in a masked manner by a glauc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01928-1
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:The Vogt-Koyanagi-Harada's (VKH) Disease Committee established the "Revised diagnostic criteria for VKH disease" in 2001. The purpose of the present study was to assess the concordance between these criteria and the traditional Sugiura's diagnosis system. DESIGN:Observational case series. METHODS:The medical ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.01.046
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:Autosomal recessive congenital fibrosis of the extraocular muscles (CFEOM2) has been described in families from Saudi Arabia. Affected individuals have ptosis and exotropic ophthalmoplegia, and their disease has been mapped to chromosome 11q13. Here, we describe the phenotypic findings in a similarly affected Y...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00467-5
更新日期:2000-05-01 00:00:00
abstract::Three patients with leukemia developed corneal toxicity while receiving high doses (3 g/m2) of systemic cytarabine. Symptoms began five to seven days after initiation of treatment with high doses of systemic cytarabine and consisted of ocular pain, tearing, foreign-body sensation, photophobia, and blurred vision. All ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(81)90240-3
更新日期:1981-04-01 00:00:00
abstract:PURPOSE:To establish a rat model of acute increase in intraocular pressure (IOP) and to investigate the therapeutic window for protection against death of retinal ganglion cells (RGCs) by vaccination with glatiramer acetate (Cop-1) or by treatment with brimonidine or MK-801. DESIGN:Animal study, laboratory investigati...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.01.073
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of ophthalmic formulations of bimatoprost 0.01% and 0.0125% compared with bimatoprost 0.03%. DESIGN:Prospective, randomized, double-masked, multicenter clinical trial. METHODS:Patients with glaucoma or ocular hypertension were randomized ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2009.12.003
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To determine the safety and efficacy of verteporfin photodynamic therapy (PDT) for the treatment of persistent choroidal neovascularization (CNV) previously treated with external beam radiotherapy (EBRT). DESIGN:Retrospective case series. METHODS:Verteporfin PDT was performed on 14 eyes of 13 patients with sy...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.09.019
更新日期:2005-03-01 00:00:00
abstract::A controlled chemotherapy trial of trachoma was carried out in a Tunisian oasis among schoolchildren with active disease. We compared 1% tetracycline ointment (79 patients) or 1% rifampicin ointment (76 patients) with 5% boric acid ointment (79 patients). Medications were administered twice daily, six days a week, for...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/0002-9394(75)90740-0
更新日期:1975-05-01 00:00:00
abstract:PURPOSE:To compare the accuracy and speed of using the computerized MatchedFlicker software program (EyeIC Inc, Narberth, Pennsylvania, USA) to evaluate glaucomatous optic disc change against the traditional gold standard of manually examining stereoscopic disc photographs. DESIGN:A prospective evaluation of diagnosti...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.03.031
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To report a case of bilateral acute retinal necrosis caused by cytomegalovirus. METHODS:A diagnostic vitrectomy was performed on a patient with non-Hodgkin lymphoma who presented with a bilateral, rapidly progressing necrotizing retinitis and uveitis. RESULTS:Immunohistochemical studies and polymerase chain r...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00250-5
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity. DESIGN:Observational case series. METHODS:Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy. All patients expressed a concomitant p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00076-x
更新日期:2003-07-01 00:00:00
abstract::Beta-aminopropionitrile, an inhibitor of collagen cross-linking, effectively limited the degree of posttraumatic vitreous proliferation in rabbits three weeks after double perforating injury. Light microscopic examination of the sites of perforating injury after five weeks showed minimal intravitreal fibrous prolifera...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(83)90337-9
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:To report the outcome of balloon catheter dilation of the lacrimal duct for treatment of children with persistent nasolacrimal duct obstruction after previous surgery. DESIGN:Interventional case series. METHODS:Thirty-two consecutive children with a history of persistent nasolacrimal duct obstruction followin...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01403-9
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To measure accurately the amount of cyclotorsion. METHODS:A horizontal light beam of the slit lamp is projected on the retina, crossing the fovea. The slit light will normally cross between the middle and lower thirds of the disk. Cyclotorsion of the eye will cause the horizontal slit-light beam to be projecte...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70402-7
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes after penetrating keratoplasty (PK). DESIGN:Randomized controlled trial. METHODS:One hundred sixteen eyes of 116 patients with keratoconus from Zhongshan Ophthalmic Ce...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2017.10.003
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG). DESIGN:Cross-sectional study. METHODS:One hundred ninety-two eyes of 120 subjects from ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.12.002
更新日期:2020-12-10 00:00:00
abstract:PURPOSE:To investigate thermal changes produced by a chandelier fiber probe (CFP). DESIGN:Interventional single case report and laboratory investigation. METHODS:When CFP was used for 25-gauge vitrectomy, an abnormal odor was emitted, and the CFP was instantly removed. To investigate this incident, the thermal change...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.07.049
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To investigate the ocular manifestations of patients with severe acute respiratory syndrome (SARS) and to monitor the possible ocular complications arising from the treatment regimen with high-dose systemic corticosteroid drugs. DESIGN:Prospective, observational cohort case series. METHODS:Ninety eyes from 45...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2003.09.060
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To report two cases of diffuse unilateral subacute neuroretinitis (DUSN) with unusual findings. DESIGN:Observational and interventional case series. METHODS:Two patients with DUSN were found to have the unusual findings of a large live worm in one eye and macular cyst in the other. Both patients underwent fun...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.06.005
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To describe the incidence of vision loss and of ocular complications attributable to birdshot retinochoroidopathy and to describe the association between therapy and the incidence thereof. DESIGN:Retrospective cohort study. METHODS: SETTING:Single-center, academic practice. STUDY POPULATION:Forty patients w...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.01.035
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To evaluate reported ocular side effects associated with isotretinoin usage. METHODS:One thousand seven hundred forty-one case reports received from spontaneous reporting systems, data from the Drug Safety Section of Roche Pharmaceuticals, and the world's literature were evaluated using the World Health Organi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01024-8
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:We evaluated quantitatively, with electromyography, the function of orbicularis oculi muscle flaps in modified Hughes reconstructions of the lower eyelids. METHODS:A modified Hughes procedure with a bipedicle orbicularis oculi flap was used to reconstruct large left lower eyelid defects after tumor excision in...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73877-2
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:To describe the usage patterns of pharmacological treatments for neovascular age-related macular degeneration (AMD) in Medicare fee-for-service beneficiaries. DESIGN:Retrospective review of all Medicare fee-for-service Part B claims for neovascular AMD during 2008. METHODS:Medicare beneficiaries having underg...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.11.017
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To study the association between peripheral changes in age-related macular degeneration (AMD) and dark adaptation (DA). DESIGN:Prospective, cross-sectional study. METHODS:We recruited patients with AMD and a control group (>50 years) without any vitreoretinal disease. Ultra-widefield (UWF) pseudocolor and fun...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.03.035
更新日期:2018-06-01 00:00:00