Abstract:
PURPOSE:To compare the accuracy and speed of using the computerized MatchedFlicker software program (EyeIC Inc, Narberth, Pennsylvania, USA) to evaluate glaucomatous optic disc change against the traditional gold standard of manually examining stereoscopic disc photographs. DESIGN:A prospective evaluation of diagnostic technology. METHODS:Two resident ophthalmologists and 1 glaucoma fellow at the University of Florida independently evaluated 140 image pairs from 100 glaucomatous/ocular hypertensive patient eyes using a handheld stereo viewer and the MatchedFlicker program. Fifty had progression to glaucoma as determined by the Ocular Hypertension Treatment Study (OHTS) Optic Disc Reading Group and the OHTS Endpoint Committee in the OHTS, and 50 more had photographs taken a few minutes apart, which were negative controls with no progression. Twenty photograph pairs from each group were duplicated to determine reviewer variability. Photographs were examined in alternating blocks of 70 photograph pairs for each method, with the starting viewing method randomized. Reviewer accuracy and time to review for each method were measured. RESULTS:Using the handheld stereo viewer, the reviewers correctly identified progression or nonprogression in 76.0% of the slide pairs. Using the MatchedFlicker software, 87.6% were correctly identified (P = .011). Evaluator speed averaged 34.1 seconds per image pair with the stereo viewer vs 24.9 seconds with the MatchedFlicker program (P = .044). Overall, Flicker was significantly more specific but less sensitive than stereo slides. Trainees appeared more reluctant to identify glaucoma progression from slides than from Flicker. For the 2 less experienced trainees Flicker was significantly more accurate. CONCLUSION:The MatchedFlicker software had a greater accuracy and was quicker to perform than using a handheld stereoscopic viewer.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Schaefer JL,Lukowski ZL,Meyer AM,Leoncavallo AJ,Greer A,Martorana GM,Zou B,Shuster JJ,Sherwood MBdoi
10.1016/j.ajo.2016.03.031subject
Has Abstractpub_date
2016-07-01 00:00:00pages
88-95eissn
0002-9394issn
1879-1891pii
S0002-9394(16)30135-0journal_volume
167pub_type
杂志文章abstract::A 1:2000 solution of a radiomimetic alkylating agent-triethylene thiophosphoramide (thio-tepa, Lederle Laboratories) with a proven inhibitory action on proliferating vascular endothelium, was used topically as an adjunct to pterygium surgery in an attempt to decrease the incidence of recurrence. A bare-sclera techniqu...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(66)90931-7
更新日期:1966-05-01 00:00:00
abstract:PURPOSE:To measure accurately the amount of cyclotorsion. METHODS:A horizontal light beam of the slit lamp is projected on the retina, crossing the fovea. The slit light will normally cross between the middle and lower thirds of the disk. Cyclotorsion of the eye will cause the horizontal slit-light beam to be projecte...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70402-7
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:To evaluate clinically a recently developed confocal scanning laser ophthalmoscope for simultaneous fluorescein and indocyanine green angiography. METHODS:After comprehensive ophthalmic examination, including stereoscopic biomicroscopy, and after color fundus photographs, simultaneous confocal scanning laser f...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)80095-6
更新日期:1998-02-01 00:00:00
abstract:PURPOSE:To report an uncommon case of multifocal choroiditis as the result of disseminated Cryptococcus neoformans infection in a patient who is HIV-positive. DESIGN:Interventional case report. METHODS:A 27-year-old HIV-positive woman with fever, headache, and vomiting was examined. Lumbar puncture was performed and ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.03.024
更新日期:2006-08-01 00:00:00
abstract::A 32-year-old woman developed bilateral blindness along with severe preeclampsia of pregnancy. Ophthalmoscopic examination disclosed chalky-white optic disks with only minimal changes in the retinal vasculature. After caesarean section, the preeclampsia improved, and complete return of visual acuity occurred during a ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74914-1
更新日期:1980-09-01 00:00:00
abstract:PURPOSE:We present two cases with early macular holes (MH) complicated by retinoschisis and foveal detachment (RSFD). DESIGN:Case reports. CASE REPORT:A 46-year-old woman and a 70-year-old woman, both with high myopia, presented visual loss and a small MH associated with RSFD. Vitrectomy and gas tamponade were perfor...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00319-2
更新日期:2003-10-01 00:00:00
abstract::We determined antigens of the major histocompatibility complex classes I, II, and III in 25 families of Mexican mestizo glaucomatous patients. Patients and family members were examined, and the predisposition of first-degree relatives to a corticosteroid-provocative test was determined. The results showed a high frequ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72553-x
更新日期:1994-12-15 00:00:00
abstract:PURPOSE:To determine the type of herpes simplex virus in acute retinal necrosis syndrome associated with herpes simplex virus. METHODS:Herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus were examined by polymerase chain reaction in intraocular spec...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00391-8
更新日期:2000-03-01 00:00:00
abstract:PURPOSE:To evaluate clinically the efficacy of 3600 minimally invasive endoscopic surgery in patients with orbital intraconal tumors. DESIGN:Retrospective interventional case series. METHODS:A series of consecutive patients with orbital intraconal tumors were treated by minimally invasive surgery using an endonasal e...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.07.035
更新日期:2020-07-29 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70479-9
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To elucidate molecular risk factors for posterior segment uveitis using a functional genomics approach. DESIGN:Genetic association cohort study. METHODS:Setting: Single-center study at an academic referral center. STUDY POPULATION:164 patients with clinically diagnosed uveitis of the posterior segment. MA...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.07.021
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Progressive change in optic disk appearance has been suggested as the best available reference standard for glaucoma diagnosis. We evaluated the accuracy of scanning laser polarimetry (SLP) with variable corneal compensation to discriminate patients with documented progressive optic disk change from healthy sub...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.01.003
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:To use the capillary-free zone along retinal arteries, a physiologic area of superficial avascularization, as an anatomic paradigm to investigate the reliability of optical coherence tomography angiography (OCTA) for visualizing the deep retinal circulation. DESIGN:Validity analysis and laboratory investigatio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.02.007
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:To identify clinical and microbiologic factors influencing the prevalence and visual outcomes in endophthalmitis after deadly-weapon-related open-globe injuries. METHODS:In a retrospective study of 228 eyes of 212 patients with deadly-weapon-related open-globe injuries, clinical and microbiologic factors influ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01320-4
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To examine the ability of current surveillance systems to assess and monitor disparities in: (1) vision impairment, (2) eye disease, (3) vision-related functioning, (4) access to vision and eye care, and (5) access to supports and services for those needing vision rehabilitation. DESIGN:Review of surveillance ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2012.06.006
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To assess the state of knowledge of photoreceptor dystrophies. METHODS:The current literature concerning photoreceptor dystrophies is reviewed, and their potential impact on concepts of pathogenesis of disease and clinical practice is assessed. RESULTS:As a result of cooperative investigative work between res...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0002-9394(14)70212-0
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To investigate ocular involvement (prevalence, incidence, lesion characteristics) following postnatally acquired infection with an "atypical" genotype of Toxoplasma gondii during a well-characterized 2001 outbreak in Santa Isabel do Ivaí, Brazil, attributed to a contaminated municipal reservoir. DESIGN:Prospec...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.02.017
更新日期:2015-06-01 00:00:00
abstract::Long-term medical therapy and laser trabeculoplasty have been implicated as risk factors in the outcome of glaucoma filtration surgery. A retrospective analysis was performed of patients undergoing primary trabeculectomy during three key periods: before use of beta-blockers and laser trabeculoplasty (1975 and 1976), a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73068-5
更新日期:1994-02-15 00:00:00
abstract:PURPOSE:To determine the necessity for the heightened level of monitoring for cataract development in patients taking quetiapine (Seroquel, AstraZeneca Pharmaceuticals, Wilmington, Delaware) dictated by the Physicians' Desk Reference. Also, to explore the possibility of cataractogenesis because of quetiapine therapy. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.05.038
更新日期:2004-11-01 00:00:00
abstract::Self-inflicted mutilation of the eyes is an uncommon but fairly distinct entity. Patients are typically young men; they often have criminal records and histories of drug abuse. Underlying schizophrenia is a common feature. The patients frequently suffer from castration fears, oedipal conflicts, repressed homosexual im...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(81)90070-2
更新日期:1981-05-01 00:00:00
abstract:PURPOSE:To compare race-related differences in estimated rate of change of Bruch's membrane opening-minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) in healthy, glaucoma suspect, and glaucoma eyes of individuals of European (ED) and African descent (AD). DESIGN:Prospective co...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.08.050
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To determine the test-retest reliability and diagnostic accuracy of a binocular optical coherence tomography (OCT) prototype (Envision Diagnostics, El Segundo, California, USA) for pupillometry. DESIGN:Assessment of diagnostic reliability and accuracy. METHODS:Fifty participants with relative afferent pupilla...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.02.013
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To report a young girl with spontaneous separation of an idiopathic epiretinal membrane and notable visual recovery. METHOD:Case report. RESULT:A 12-year-old girl had spontaneous improvement in visual acuity of the left eye from 20/100 to 20/40 attributable to spontaneous peeling of an idiopathic epiretinal m...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00021-5
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To provide additional evidence that anterior uveitis can be a manifestation of poststreptococcal syndrome. METHOD:A case report providing follow-up information on a previously described patient. RESULTS:An adolescent girl in whom anterior uveitis was the only manifestation of poststreptococcal syndrome subseq...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:To present the first detailed assessment of the clinical features of CL-induced subconjunctival hemorrhage and associated risk factors. DESIGN:Cross-sectional and case-control study of age-matched randomized groups. METHODS:A total of 45 CL wearers with subconjunctival hemorrhage aged 18 to 45 years (CL-Hemor...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.05.028
更新日期:2010-11-01 00:00:00
abstract::We investigated albumin and IgG concentrations in the aqueous humor of 41 patients before intracapsular cataract extraction (primary samples) and at the end of surgery (secondary samples). Albumin and IgG concentrations were determined in all samples by means of a quantitative fluoroimmunoassay. A short-term topical a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71914-2
更新日期:1983-12-01 00:00:00
abstract::Nerve fiber counts of 16 normal human optic nerves from subjects aged 3.5 to 82 years showed a significant effect of age (P = .0207). The delay between death or enucleation and fixation also significantly affected the result (P = .0078). The mean (+/- S.E.M.) count for the 16 nerves was 1,244,005 +/- 20,033 fibers, gi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(84)90509-9
更新日期:1984-06-01 00:00:00
abstract:PURPOSE:To evaluate the significance of the surgical scar of external dacryocystorhinostomy (DCR) as assessed by the patients. DESIGN:Cross-sectional questionnaire-based study. METHODS:Two hundred ninety-seven external DCRs were performed in 263 patients at the private practices of consultants who were attached to th...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.04.039
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:To investigate whether retina damaged in the process of air/fluid exchange could be visualized in situ using trypan blue staining. METHODS:Vitrectomy and air/fluid exchange with continuous air infusion for various periods of time was performed in adult pigmented rabbits, followed by injection of 0.4% trypan bl...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00927-2
更新日期:2001-06-01 00:00:00
abstract::A white male infant was born with multiple hemangiomas of the skin and mucous membrane. At 7 months of age he exhibited the signs and symptoms of infantile glaucoma in each eye, but goniotomy was not possible because of vascularity in the angles. Cyclocryotherapy was used on multiple occasions to control intraocular p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90733-9
更新日期:1976-02-01 00:00:00