Immunogenetic aspects in primary open-angle glaucoma in family members of Mexican mestizo glaucomatous patients.

Abstract:

:We determined antigens of the major histocompatibility complex classes I, II, and III in 25 families of Mexican mestizo glaucomatous patients. Patients and family members were examined, and the predisposition of first-degree relatives to a corticosteroid-provocative test was determined. The results showed a high frequency of the HLA-DR3 antigen in patients with primary open-angle glaucoma compared with controls (32.5% vs 4.0%, P = .001, odds ratio = 10.25). We suggest that the increased presence of the HLA-DR3 antigen could be an important factor in the genetic susceptibility to glaucoma.

journal_name

Am J Ophthalmol

authors

Gil-Carrasco F,Granados J,Barojas-Weber E,Gilbert-Lucido ME,Vargas-Alarcón G

doi

10.1016/s0002-9394(14)72553-x

subject

Has Abstract

pub_date

1994-12-15 00:00:00

pages

744-8

issue

6

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)72553-X

journal_volume

118

pub_type

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