The effect of age on the nerve fiber population of the human optic nerve.

Abstract:

:Nerve fiber counts of 16 normal human optic nerves from subjects aged 3.5 to 82 years showed a significant effect of age (P = .0207). The delay between death or enucleation and fixation also significantly affected the result (P = .0078). The mean (+/- S.E.M.) count for the 16 nerves was 1,244,005 +/- 20,033 fibers, giving a 99% confidence level between 1,192,400 and 1,295,610 fibers.

journal_name

Am J Ophthalmol

authors

Balazsi AG,Rootman J,Drance SM,Schulzer M,Douglas GR

doi

10.1016/0002-9394(84)90509-9

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

760-6

issue

6

eissn

0002-9394

issn

1879-1891

pii

0002-9394(84)90509-9

journal_volume

97

pub_type

杂志文章
  • Reliability of optic nerve head topographic measurements with computerized image analysis.

    abstract::We evaluated the reliability of optic disk area and disk rim area measurements obtained with the Humphrey Retinal Analyzer from ten repeat fundus images each of one eye of ten normal subjects and ten subjects with increased intraocular pressure. Variability of rim and disk areas was not significantly different between...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)73309-4

    authors: Dandona L,Quigley HA,Jampel HD

    更新日期:1989-10-15 00:00:00

  • Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung.

    abstract:PURPOSE:To present a case of cancer-associated retinopathy (CAR) in a patient with small cell carcinoma of the lung and antiretinal antibodies who experienced visual symptoms before diagnosis of cancer. DESIGN:Case report. METHODS:A 61-year-old man with a sudden loss of vision and photophobia was referred to the opht...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2004.10.044

    authors: Dot C,Guigay J,Adamus G

    更新日期:2005-04-01 00:00:00

  • Choroidal neovascularization in pathologic myopia: three-year results after photodynamic therapy.

    abstract:PURPOSE:To examine whether the encouraging functional results one year after photodynamic therapy (PDT) can be maintained up to three years. DESIGN:Prospective interventional case series. METHODS:Highly myopic eyes that had been treated with PDT for subfoveal choroidal neovascularization and had been observed at leas...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2005.03.050

    authors: Krebs I,Binder S,Stolba U,Glittenberg C,Brannath W,Goll A

    更新日期:2005-09-01 00:00:00

  • Comparison of optic disk and retinal nerve fiber layer thickness in nonglaucomatous and glaucomatous patients with high myopia.

    abstract:PURPOSE:To assess the optic nerve head (ONH) by optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (CSLO), and the retinal nerve fiber layer (RNFL) by OCT and scanning laser polarimetry (GDx) in highly myopic subjects. DESIGN:Observational cross-sectional study. METHODS:Thirty-five eyes of hig...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2006.05.022

    authors: Melo GB,Libera RD,Barbosa AS,Pereira LM,Doi LM,Melo LA Jr

    更新日期:2006-11-01 00:00:00

  • Coagulation and platelet adhesion-inducing factor in the endothelium of the retinal vessels.

    abstract::By means of an immunofluorescent technique, we found factors promoting blood coagulation and platelet adhesion in the intima of retinal vessels. These factors coexisted with other agents causing the opposite process, fibrin dissolution. The components of this vascular hemostatic balance are possibly involved in the th...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90867-3

    authors: Pandolfi M,Holmberg L,Turesson I

    更新日期:1975-07-01 00:00:00

  • Removal of the intruding Miragel's scleral buckle by pars plana ultrasonic fragmentation.

    abstract:PURPOSE:To introduce a surgical approach for removing intruded scleral buckle resulting from Miragel's implant. DESIGN:Interventional case report. METHODS:After cutting and releasing scleral band externally, a pars plana Fragmatome was used to break up and aspirate pieces of the Miragel's implant that had grown into ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2004.07.032

    authors: Cekiç O,Chang S,Schiff WM,Barile GR

    更新日期:2005-01-01 00:00:00

  • Cyclocryotherapy of chronic open-angle glaucoma in aphakic eyes.

    abstract::Twenty-six eyes of 25 patients with chronic open-angle glaucoma and surgical aphakia with inadequate control of intraocular pressure (IOP) despite maximal medical treatment were treated with cyclocryotherapy, according to a prospective protocol and specific technique. (Neovascular and synechial glaucoma were excluded ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)77093-x

    authors: Bellows AR,Grant WM

    更新日期:1978-05-01 00:00:00

  • Height measurement of astigmatic test surfaces by a keratoscope that uses plane geometry surface reconstruction.

    abstract:PURPOSE:To assess the accuracy with which the Keratron keratoscope (Optikon 2000, Rome, Italy) measured astigmatic test surfaces by a profile reconstruction algorithm within a plane geometry model and to discriminate between error caused by the model and error caused by other factors. METHODS:Height was reported by th...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)70633-6

    authors: Tripoli NK,Cohen KL,Obla P,Coggins JM,Holmgren DE

    更新日期:1996-06-01 00:00:00

  • The Diagnostic Utility of Multifocal Electroretinography in Detecting Chloroquine and Hydroxychloroquine Retinal Toxicity.

    abstract:PURPOSE:To evaluate multifocal electroretinography (mfERG) as a screening test for detecting hydroxychloroquine and chloroquine toxicity. DESIGN:Diagnostic accuracy study. METHODS:Patients referred to the University of Ottawa for hydroxychloroquine or chloroquine retinopathy screening during 2011-2014 underwent 10-2 ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2019.04.025

    authors: Tsang AC,Ahmadi S,Hamilton J,Gao J,Virgili G,Coupland SG,Gottlieb CC

    更新日期:2019-10-01 00:00:00

  • Suturing forceps for microsurgery.

    abstract::A microsurgical modification of the Rizzuti scleral fixation forceps for corneal and cataract surgery employs Bonn 0.12-mm teeth on an angled handle with an appropriate curve between the teeth to fix the tissue more adequately to allow accurate placement of sutures. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(76)90077-5

    authors: Lieberman DM

    更新日期:1976-12-01 00:00:00

  • Treatment of Pseudomonas endophthalmitis associated with prosthetic intraocular lens implantation.

    abstract::Eight patients were treated for Pseudomonas endophthalmitis associated with the implantation of contaminated intraocular lenses. All patients showed clinical signs of infection (loss of red reflex, diminished visual acuity, and intraocular lens coagulum) and P. aeruginosa was isolated from vitreous aspirates and unuse...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(79)90569-5

    authors: Gerding DN,Poley BJ,Hall WH,LeWin DP,Clark MD

    更新日期:1979-11-01 00:00:00

  • Quantitative analysis of wide-field endothelial specular photomicrographs.

    abstract::Samples from the center of a wide-field specular micrograph adequately assessed cell density and frequency distribution of cell areas. A preliminary analysis of the spread of values indicated whether an increased sample size was required. An algorithm determined how large a sample taken from the central photograph (th...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)76133-1

    authors: Hirst LW,Auer C,Abbey H,Cohn J,Kues H

    更新日期:1984-04-01 00:00:00

  • Comparison of different techniques of anterior chamber depth and keratometric measurements.

    abstract:PURPOSE:To compare measurements of anterior chamber depth (ACD) and corneal curvature obtained with the Pentacam to other commonly used devices. DESIGN:Prospective, nonrandomized clinical trial. METHODS:Measurements of ACD and keratometry were prospectively obtained in 22 eyes of 11 subjects with the Pentacam compare...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ajo.2006.08.031

    authors: Elbaz U,Barkana Y,Gerber Y,Avni I,Zadok D

    更新日期:2007-01-01 00:00:00

  • Neutrophil margination as a possible mechanism for verteporfin infusion-associated pain.

    abstract:PURPOSE:To investigate the changes in absolute neutrophil counts in patients with and without pain after verteporfin infusion. DESIGN:Experimental study. METHODS:The absolute neutrophil counts were obtained from the blood samples taken at the beginning of infusion and after the end of verteporfin infusion. RESULTS:F...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(02)01983-9

    authors: Spaide RF,Maranan L

    更新日期:2003-04-01 00:00:00

  • Self-inflicted ocular mutilation.

    abstract::Self-inflicted mutilation of the eyes is an uncommon but fairly distinct entity. Patients are typically young men; they often have criminal records and histories of drug abuse. Underlying schizophrenia is a common feature. The patients frequently suffer from castration fears, oedipal conflicts, repressed homosexual im...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(81)90070-2

    authors: Yang HK,Brown GC,Magargal LE

    更新日期:1981-05-01 00:00:00

  • Current practices in the management of ocular toxoplasmosis.

    abstract::To determine current practices in the management of ocular toxoplasmosis, 72 of 85 uveitis specialists (85%) in the American Uveitis Society completed a detailed questionnaire. Questions involved the indications for beginning treatment, choice of antiparasitic/antimicrobial agents, and experience with treatment of ocu...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)73706-7

    authors: Engstrom RE Jr,Holland GN,Nussenblatt RB,Jabs DA

    更新日期:1991-05-15 00:00:00

  • Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial.

    abstract:PURPOSE:To evaluate the safety and potential efficacy of gevokizumab, an anti-interleukin 1β (IL-1β) monoclonal antibody, in the treatment of active, noninfectious, non-necrotizing anterior scleritis. DESIGN:Phase 1/2, open label, nonrandomized, prospective, single-arm pilot trial. METHODS:Eight patients with active,...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ajo.2016.09.017

    authors: Knickelbein JE,Tucker WR,Bhatt N,Armbrust K,Valent D,Obiyor D,Nussenblatt RB,Sen HN

    更新日期:2016-12-01 00:00:00

  • Postoperative Complications in the Ahmed Baerveldt Comparison Study During Five Years of Follow-up.

    abstract:PURPOSE:To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. DESIGN:Multicenter, prospective randomized clinical trial. METHODS:setting: Sixteen international clinical centers. STUDY POPULATION:Two hundred seventy-six subjects aged 18-85 years with previous intraocul...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ajo.2015.11.023

    authors: Budenz DL,Feuer WJ,Barton K,Schiffman J,Costa VP,Godfrey DG,Buys YM,Ahmed Baerveldt Comparison Study Group.

    更新日期:2016-03-01 00:00:00

  • Using Electronic Health Records to Build an Ophthalmologic Data Warehouse and Visualize Patients' Data.

    abstract:PURPOSE:To develop a near-real-time data warehouse (DW) in an academic ophthalmologic center to gain scientific use of increasing digital data from electronic medical records (EMR) and diagnostic devices. DESIGN:Database development. METHODS:Specific macular clinic user interfaces within the institutional hospital in...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2017.03.026

    authors: Kortüm KU,Müller M,Kern C,Babenko A,Mayer WJ,Kampik A,Kreutzer TC,Priglinger S,Hirneiss C

    更新日期:2017-06-01 00:00:00

  • Prophylactic laser treatment hastens choroidal neovascularization in unilateral age-related maculopathy: final results of the drusen laser study.

    abstract:PURPOSE:The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization (CNV) and vision loss in high-risk age-related maculopathy (ARM). DESIGN:Prospective, interventional, randomized, controlled clinical trial in five hospital centers. METHODS:Patients in the unilateral group had neovascular ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ajo.2005.08.019

    authors: Owens SL,Bunce C,Brannon AJ,Xing W,Chisholm IH,Gross M,Guymer RH,Holz FG,Bird AC,Drusen Laser Study Group.

    更新日期:2006-02-01 00:00:00

  • Surgical outcomes of combined phacoemulsification and glaucoma drainage implant surgery for Asian patients with refractory glaucoma with cataract.

    abstract:PURPOSE:To examine the safety and efficacy of combined phacoemulsification and glaucoma drainage implant surgery in providing reduction of intraocular pressure (IOP) and visual rehabilitation in eyes with refractory glaucoma and cataract. DESIGN:Interventional case series. METHODS:A retrospective chart review was per...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2003.08.036

    authors: Chung AN,Aung T,Wang JC,Chew PT

    更新日期:2004-02-01 00:00:00

  • Scleritis, uveitis, and glaucoma in a patient with rheumatic fever.

    abstract:PURPOSE:To determine the origin of scleritis, uveitis, and glaucoma in a boy with fever, sore throat, joint pains, and malaise. METHODS:The patient underwent extensive hematologic, serologic, rheumatologic, and radiologic examinations. RESULTS:The patient recovered after extensive medical therapy. He met the Jones cr...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)72676-5

    authors: Ortiz JM,Kamerling JM,Fischer D,Baxter J

    更新日期:1995-10-01 00:00:00

  • Association of xerophthalmia, flecked retina, and pseudotumor cerebri caused by hypovitaminosis A.

    abstract:PURPOSE:To report an unusual case of hypovitaminosis A with bilateral papilledema and flecked retina that regressed after restoration of vitamin A deficiency. METHOD:Case report. A 27-year-old woman had undergone a biliopancreatic bypass for obesity in 1990. In 1995, she presented with bilateral xerophthalmia, bilater...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(98)00011-7

    authors: Panozzo G,Babighian S,Bonora A

    更新日期:1998-05-01 00:00:00

  • Nontraumatic rupture of the globe secondary to orbital cellulitis.

    abstract::A 53-year-old woman had a spontaneous nontraumatic rupture of the globe secondary to severely increased orbital pressure from an orbital cellulitis. To our knowledge this is the first such case reported. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(79)90477-x

    authors: Forstot SL,Ellis PP

    更新日期:1979-08-01 00:00:00

  • Changes in postoperative refractive outcomes following combined phacoemulsification and pars plana vitrectomy for rhegmatogenous retinal detachment.

    abstract:PURPOSE:To evaluate changes in postoperative refractive outcomes following combined phacoemulsification and pars plana vitrectomy for rhegmatogenous retinal detachment (RRD) compared with other retinal diseases. DESIGN:Retrospective observational case-control study. METHODS:A total of 55 patients who had combined sur...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2014.04.023

    authors: Cho KH,Park IW,Kwon SI

    更新日期:2014-08-01 00:00:00

  • The impact of contact lens wear and visual display terminal work on ocular surface and tear functions in office workers.

    abstract:PURPOSE:To evaluate the effect of contact lens (CL) wear and visual display terminal (VDT) work on the ocular surface and tear functions. DESIGN:Prospective case-control study. METHODS:Sixty-nine CL wearers (45 women and 24 men; mean age, 35.2 ± 7.3 years), and 102 age- and sex-matched non-CL wearers were enrolled in...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2011.05.025

    authors: Kojima T,Ibrahim OM,Wakamatsu T,Tsuyama A,Ogawa J,Matsumoto Y,Dogru M,Tsubota K

    更新日期:2011-12-01 00:00:00

  • Calcification in choroidal melanoma after transpupillary thermotherapy.

    abstract:PURPOSE:To report the response of calcification in choroidal melanoma after transpupillary thermotherapy. METHODS:Interventional case report. A 66-year-old male with a posterior uveal melanoma measuring 10 x 8 x 4.4 mm underwent infrared diode laser transpupillary thermotherapy three times, each 12 weeks apart. For ea...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(01)01186-2

    authors: Kiratli H,Bilgiç S

    更新日期:2001-12-01 00:00:00

  • Comparison of results of excimer laser correction of all degrees of myopia at 12 months postoperatively. The Melbourne Excimer Laser Group.

    abstract:UNLABELLED:To examine prospectively the efficacy and safety of photorefractive keratectomy and photoastigmatic refractive keratectomy. METHODS:We treated 645 eyes (440 patients) with a VisX Twenty/Twenty excimer laser and followed them up for 12 months. RESULTS:The percentage of eyes with myopia between -5.01 and -10...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)70433-7

    authors: McCarty CA,Aldred GF,Taylor HR

    更新日期:1996-04-01 00:00:00

  • Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma.

    abstract:PURPOSE:beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS:We compared the e...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-9394(14)72604-2

    authors: Harris A,Spaeth GL,Sergott RC,Katz LJ,Cantor LB,Martin BJ

    更新日期:1995-08-01 00:00:00

  • Serratia Marcescens corneal ulcer as a complication of orthokeratology.

    abstract:PURPOSE:To report a case of Serratia Marcescens corneal ulcer as a complication of orthokeratology treatment. METHODS:Case report. RESULTS:A 9-year-old male who underwent orthokeratology treatment for 6 months suffered from a corneal ulcer. The refractive state of lesion eye was -5.5D/-1.25D x 180 degrees, and visual...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(01)00931-x

    authors: Chen KH,Kuang TM,Hsu WM

    更新日期:2001-08-01 00:00:00