Abstract:
PURPOSE:To present a case of cancer-associated retinopathy (CAR) in a patient with small cell carcinoma of the lung and antiretinal antibodies who experienced visual symptoms before diagnosis of cancer. DESIGN:Case report. METHODS:A 61-year-old man with a sudden loss of vision and photophobia was referred to the ophthalmology service. Antiretinal antibodies were determined by Western blot analysis. RESULTS:The patient was found to have small cell carcinoma of the lung without metastasis and was surgically treated. His visual loss was asymmetrical. The full field ERG was normal, even though his vision in the right eye became progressively worse. The patient was treated with methylprednisolone and showed significant improvement. Before surgery, serum tests showed antiretinal protein 35-kD; 1 week after surgery, antiretinal protein 35-kD and 46-kD (alpha-enolase); and 1 month after surgery, anti-alpha-enolase. CONCLUSIONS:Typical visual symptoms for paraneoplastic retinopathy are not always present. The absence of antirecoverin antibodies does not exclude a diagnosis of CAR.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Dot C,Guigay J,Adamus Gdoi
10.1016/j.ajo.2004.10.044subject
Has Abstractpub_date
2005-04-01 00:00:00pages
746-7issue
4eissn
0002-9394issn
1879-1891pii
S0002-9394(04)01290-5journal_volume
139pub_type
杂志文章abstract::In August 1989, the Tokyo Metropolitan Government officially began a vision screening program for children aged 3 years 1 month. A 1988 pilot study of 1,303 children this age disclosed five cases (0.38%) of amblyopia. The home vision test, which uses picture cards of familiar figures, proved to be an efficient and ine...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71851-3
更新日期:1992-10-15 00:00:00
abstract:PURPOSE:To determine the incidence of developing an idiopathic full-thickness macular hole in fellow eyes that have vitreofoveal attachments and perifoveal vitreous detachment in patients with unilateral idiopathic macular hole. DESIGN:Retrospective cross-sectional observational study. METHODS:The fellow eyes of 201 ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.03.070
更新日期:2005-09-01 00:00:00
abstract::The in vivo sites of the blood-aqueous barrier were determined in five animal species, using acriflavine neutral (224 mol. wt.), ultrafreezing and drying, fluorescence microscopy, and fluorometry. Not toxic, acriflavine had specific in vivo affinity for nuclear DNA and RNA, produced intense fluorescence, and did not p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90405-5
更新日期:1975-10-01 00:00:00
abstract:PURPOSE:To evaluate the anatomic and visual outcomes in patients with initially closed macular holes after vitreoretinal surgery and with 1 to 7 years of follow-up. DESIGN:Retrospective, noncomparative, consecutive case series. METHODS:Eighty-seven consecutive eyes of 79 patients with previous closure of the macular ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.11.006
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To determine if asymmetry in thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer, ganglion cell complex, and total retina between upper and lower macula halves can predict glaucoma. DESIGN:Retrospective case-control series. METHODS:One hundred twenty-two eyes of 122 patients (30 normal eyes...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.08.040
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To investigate visual function and optical quality in eyes with epiphora undergoing lacrimal passage intubation. DESIGN:Prospective case series. METHODS:Thirty-four eyes of 30 patients with lacrimal passage obstruction were enrolled. Before and 1 month after lacrimal passage intubation, functional visual acui...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2017.06.022
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate the safety of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage. DESIGN:Two prospective, randomized, placebo-controlled, double-masked studies. Pooled efficacy data are presented in a companion article in this issue of The Journal. METHODS:Subjects with vitreous hemorrhag...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2005.06.022
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:Low docosahexaenoic acid (DHA) in X-linked retinitis pigmentosa (XLRP) may influence retinal function. The goals of this study were to elevate blood DHA levels and determine the effect on the rate of disease progression. DESIGN:In a 4-year prospective randomized clinical trial, male patients with XLRP (mean ag...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ajo.2003.10.045
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To describe a technique that uses a transcorneal suture for safe delivery and fixation of donor tissue during Descemet stripping automated endothelial keratoplasty in patients that are at risk of graft dislocation into the vitreous cavity as a result of minimal or absent iris-lens diaphragm. DESIGN:Interventio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.08.043
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To determine if topical dorzolamide, as observed with the use of systemic acetazolamide and methazolamide, would be effective in treating cystoid macular edema (CME) in patients with retinitis pigmentosa (RP). DESIGN:Prospective, nonrandomized clinical trial. METHODS:setting: Institutional. patients: Fifteen ...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ajo.2005.12.030
更新日期:2006-05-01 00:00:00
abstract::An ultrastructural study of Bruch's membrane in 68 human eyes including at least five individuals from each of ten decades of life showed that changes began in the second decade in macular specimens but were delayed in nonmacular specimens. All specimens from 20-year-old donors had altered macular Bruch's membranes. T...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(85)90625-7
更新日期:1985-11-15 00:00:00
abstract:PURPOSE:To ascertain deformation of the optic nerve head (ONH) and peripapillary tissues caused by horizontal duction. DESIGN:Prospective, experimental study. METHODS:Optical coherence tomography of the ONH region was performed in 23 eyes of 12 normal volunteers in central gaze and increasing (10, 20, and 30 degrees)...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.10.001
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To highlight the challenges of postmarketing surveillance for drug-related adverse events in the practice of ophthalmology. DESIGN:A retrospective review of the medical literature and postmarketing surveillance databases. METHODS:MEDLINE literature review of sildenafil-associated or amiodarone-associated opti...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.10.005
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To evaluate the ocular biometric parameters associated with intraocular pressure (IOP) reduction after phacoemulsification. DESIGN:Prospective, observational case series. METHODS:The study included 999 patients who had undergone uncomplicated phacoemulsification. IOP and ocular biometric parameters were check...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.02.003
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:To report the association of antiretinal antibodies in patients with bilateral cystoid macular edema and retinitis pigmentosa. METHODS:In a prospective study, 30 consecutive patients with bilateral cystoid macular edema and retinitis pigmentosa were tested for antiretinal antibodies. As control subjects, 30 co...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00446-2
更新日期:1999-05-01 00:00:00
abstract:PURPOSE:To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year. DESIGN:Prospective longitudinal cohort study. METHODS:Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions....
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.04.033
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To examine the ability of current surveillance systems to assess and monitor disparities in: (1) vision impairment, (2) eye disease, (3) vision-related functioning, (4) access to vision and eye care, and (5) access to supports and services for those needing vision rehabilitation. DESIGN:Review of surveillance ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2012.06.006
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To investigate visual outcome and prognostic factors following cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease. DESIGN:Retrospective, interventional case series. METHODS:The history, clinical characteristics, best-corrected visual acuity (BCVA), full-field electroretinogram (ERG), intraoc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.08.041
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity. DESIGN:Observational case series. METHODS:Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy. All patients expressed a concomitant p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00076-x
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To develop comprehensive predictive models for choroidal neovascularization (CNV) and geographic atrophy (GA) incidence within 3 years that can be applied realistically to clinical practice. DESIGN:Retrospective evaluation of data from a longitudinal study to develop and validate predictive models of CNV and G...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.03.021
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To summarize observational studies that focus on the use of glaucoma medications and to identify gaps in knowledge to guide future investigation. DESIGN:Literature study. METHODS:We searched the electronic databases MEDLINE, EMBASE, and PubMed for English language articles published through December 2009 usin...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.05.005
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To report a case of nodular scleritis and panuveitis associated with erythema elevatum diutinum, a rare immunocomplex-mediated skin disease. DESIGN:Observational case report. METHODS:A 22-year-old woman who was diagnosed with erythema elevatum diutinum developed nodular scleritis and panuveitis of the right e...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/S0002-9394(03)00907-3
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:To determine the testability of several vision and refraction tests in preschool-aged children. DESIGN:Population-based study of Chinese preschool-aged children in Singapore. METHODS:One thousand five hundred and forty-two Singaporean Chinese children aged 6 to 72 months were recruited through door-to-door sc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.02.037
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To demonstrate that hairy cell leukemia may involve the eye. METHODS:We examined a patient who had a unique ocular manifestation of hairy cell leukemia with severe panuveitis in one eye and leukemic retinopathy in the fellow eye. RESULTS:Therapy with 2-chloro-deoxy-adenosine, a drug recently introduced for tr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70543-4
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To report refractive changes after cataract surgery and intraocular lens implantation in infants and children. METHODS:In an ongoing prospective study, the refractive errors of all patients younger than 18 years undergoing intraocular lens implantation were determined at 6 weeks, 3 months, 6 months, and 1 year...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00247-5
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:To describe a case of bone marrow transplantation retinopathy in a patient in the absence of prior radiation therapy. METHODS:Case report. RESULTS:Bilateral scotomata developed in a 26-year-old woman because of a retinal microvasculopathy two years after receiving an autologous bone marrow transplantation for...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72023-9
更新日期:1996-08-01 00:00:00
abstract:PURPOSE:To determine whether the healing response of the human cornea after photoablation with a midinfrared solid-state laser was more pronounced than after excimer laser keratectomies because of the increased thermal damage in adjacent tissue. METHODS:We treated five blind human eyes with an erbium:YAG (Er:YAG) lase...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72215-9
更新日期:1995-11-01 00:00:00
abstract::We followed up 32 eyes of 32 patients with early glaucoma (22 with capsular glaucoma and ten with simple glaucoma) who received laser trabeculoplasty as a primary therapy. These eyes were compared with a matched control group of 32 eyes treated with medication initially. The success rate (intraocular pressure below 22...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(87)90220-0
更新日期:1987-10-15 00:00:00
abstract::A 46-year old woman and a 59-year-old man had corneal crystals, multiple myeloma, and IgG kappa hypergammaglobulinemia. In one case, crystalline deposits were also present in the lens. In both patients there was a marked decrease in the amount of crystals during chemotherapy. The crystals within the cornea of one case...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(78)90230-1
更新日期:1978-09-01 00:00:00
abstract::We performed visual contrast sensitivity testing with Regan's low-contrast letter charts on 30 patients with optic neuropathies and good Snellen visual acuity. Results of this testing were compared with color vision and the presence of an afferent pupillary defect. Regan's low-contrast letter charts were found to be 9...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(88)90176-6
更新日期:1988-02-15 00:00:00