Abstract：
PURPOSE:To investigate visual outcome and prognostic factors following cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease. DESIGN:Retrospective, interventional case series. METHODS:The history, clinical characteristics, best-corrected visual acuity (BCVA), full-field electroretinogram (ERG), intraocular inflammation, complications, and extraocular manifestations were analyzed retrospectively. RESULTS:One hundred and forty-eight male (214 eyes) and 138 female (194 eyes) VKH patients with complicated cataract were included. Surgery was performed on 352 eyes after complete control of intraocular inflammation for at least 3 months. In another set of 56 eyes, surgery was done 1 month after intraocular inflammation control. There was no difference in postoperative complications or BCVA between these 2 groups. The main complications after surgery were hyphema, ocular hypertension, and moderate anterior chamber reaction. Average preoperative visual acuity was 0.08. At last visit, BCVA was improved in 405 eyes (99.3%). The preoperative BCVA, treatment delay after disease onset, preoperative intraocular hypertension, and iris synechiae were associated with final visual outcome. Other parameters such as postoperative inflammation, IOL type, and presence of extraocular VKH features did not affect final BCVA. Poor visual acuity was caused by optic nerve atrophy, choroidoretinal neovascularization, and subretinal fibrosis. Poor postoperative BCVA was associated with an abnormal preoperative ERG profile. CONCLUSIONS:Phacoemulsification and IOL implantation in VKH patients can be safely and successfully performed in quiet eyes even after 1 month following the last signs of inflammation. Visual prognosis was associated with preoperative BCVA, treatment delay after disease onset, preoperative intraocular hypertension, iris synechiae, and presence of preoperative ERG abnormalities.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Ji Y,Hu K,Li C,Li P,Kijlstra A,Eghrari AO,Lei B,Du L,Wan W,Yang Pdoi
10.1016/j.ajo.2018.08.041subject
Has Abstractpub_date
2018-12-01 00:00:00pages
121-128eissn
0002-9394issn
1879-1891pii
S0002-9394(18)30502-6journal_volume
196pub_type
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