Abstract：
PURPOSE:To ascertain deformation of the optic nerve head (ONH) and peripapillary tissues caused by horizontal duction. DESIGN:Prospective, experimental study. METHODS:Optical coherence tomography of the ONH region was performed in 23 eyes of 12 normal volunteers in central gaze and increasing (10, 20, and 30 degrees) adduction and abduction. Main outcome measures were changes from central gaze in the configuration of the ONH and peripapillary tissues in eccentric gazes. RESULTS:Adduction but not abduction was associated with significant, progressive relative posterior displacement of the temporal peripapillary retinal pigment epithelium (tRPE) from its position in central gaze reaching 49 ± 10 μm in 30-degree adduction (standard error of mean, P < .0001). Absolute (anterior or posterior) optic cup displacement (OCD) averaged 41 ± 7 μm in 30-degree adduction. Linear regression showed significant effect of adduction on absolute OCD (slope 1.09 ± 0.36 μm/degree, P = .0037). In 20-degree and 30-degree adduction, all eyes exhibited significant progressive temporal ONH tilting reaching 3.1 ± 0.4 degrees in 30-degree adduction (P < .0001). Abduction was not associated with significant peripapillary RPE displacement, OCD, or ONH tilt. Both nasal and temporal peripapillary choroid averaged 9-19 μm thinner in adduction and abduction than in central gaze (P < .02). CONCLUSIONS:Adduction temporally tilts and displaces the prelaminar ONH and peripapillary tissues. Both adduction and abduction compress the peripapillary choroid. These effects support magnetic resonance imaging and biomechanical evidence that adduction imposes strain on the ONH and peripapillary tissues. Repetitive strain from eye movements over decades might in susceptible individuals lead to optic neuropathies such as normal tension glaucoma.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Chang MY,Shin A,Park J,Nagiel A,Lalane RA,Schwartz SD,Demer JLdoi
10.1016/j.ajo.2016.10.001subject
Has Abstractpub_date
2017-02-01 00:00:00pages
85-94eissn
0002-9394issn
1879-1891pii
S0002-9394(16)30504-9journal_volume
174pub_type
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journal_title：American journal of ophthalmology
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pub_type： 杂志文章
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