Abstract：
PURPOSE:To determine if topical dorzolamide, as observed with the use of systemic acetazolamide and methazolamide, would be effective in treating cystoid macular edema (CME) in patients with retinitis pigmentosa (RP). DESIGN:Prospective, nonrandomized clinical trial. METHODS:setting: Institutional. patients: Fifteen patients with CME and RP. intervention: A baseline visual acuity and optical coherence tomography (OCT) measurements were obtained in all patients. Each one of them was then treated with topical dorzolamide, three times a day, for at least four weeks in both eyes. main outcome measures: Significant decrease in "foveal thickness" (more than 16%) and "foveal zone thickness" (more than 11%), as measured by OCT. RESULTS:Thirteen (87%) of 15 patients showed a significant decrease in retinal thickness in at least one eye after use of topical dorzolamide for at least four weeks. Five patients (33%) demonstrated improvement in both eyes. All patients, except one, who responded showed the effect within four weeks, but were monitored for a period of two to nine months (average 4.5 months). Four patients (31%) who showed an initial improvement in macular edema showed worsening with continued treatment. CONCLUSIONS:The present study documents the potential efficacy of topical dorzolamide for treating CME in patients with RP. We observed that some patients may show a "rebound phenomenon" with continued use of the medication; hence, there is a need for careful follow-up in patients being treated.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Grover S,Apushkin MA,Fishman GAdoi
10.1016/j.ajo.2005.12.030subject
Has Abstractpub_date
2006-05-01 00:00:00pages
850-8issue
5eissn
0002-9394issn
1879-1891pii
S0002-9394(05)01350-4journal_volume
141pub_type
临床试验,杂志文章abstract：PURPOSE:To describe a case of bone marrow transplantation retinopathy in a patient in the absence of prior radiation therapy. METHODS:Case report. RESULTS:Bilateral scotomata developed in a 26-year-old woman because of a retinal microvasculopathy two years after receiving an autologous bone marrow transplantation for...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72023-9
更新日期：1996-08-01 00:00:00
abstract：PURPOSE:To describe microscopic changes in the structure of human sclera immediately after enucleation (negative control group) and to compare them after being stored for three months in four different media: pure glycerin, absolute alcohol, benzalkonium chloride diluted in absolute alcohol (1:5000), and benzalkonium c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.05.015
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To describe the immune alterations associated with age-related macular degeneration (AMD); and, based on these findings, to offer an approach to possibly prevent the expression of late disease. DESIGN:Perspective. METHODS:Review of the existing literature dealing with epidemiology, models, and immunologic fin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2014.03.014
更新日期：2014-07-01 00:00:00
abstract：:Conjunctivodacryocystorhinostomy with a Jones tube is an accepted procedure for the treatment of epiphora resulting from obstructed canaliculi. Because of our clinical impression that a high rate of functional success after surgery is associated with a lower rate of patient satisfaction, we analyzed the results and pa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70070-4
更新日期：1994-05-15 00:00:00
abstract：:The location of repository corticosteroid after subtenon injection was determined in 24 patients with macular edema associated with uveitis or anterior segment surgery. Standardized A-scan and B-scan echography were performed immediately before and after each injection. Localization was compared after subtenon injecti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1987-03-15 00:00:00
abstract：PURPOSE:To evaluate the influence of the extent of myopia on the progression rate of normal-tension glaucoma (NTG). DESIGN:Retrospective, observational case series. METHODS:One hundred forty-three eyes of 143 patients with NTG who were treated from 1994 through 2006 and followed up with standard automated perimetry w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.12.033
更新日期：2010-05-01 00:00:00
abstract：:In two patients, a 55-year-old man and a 49-year-old man, who had fungal keratitis initially undiagnosed by corneal scrapings the condition was successfully diagnosed by corneal biopsy. We compared corneal biopsy specimens and corneal scraping in the diagnosis of keratomycosis in rabbits with experimental bilateral fu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90821-4
更新日期：1986-03-15 00:00:00
abstract：PURPOSE:To measure lead and cadmium in retinal tissues of human donor eyes with and without age-related macular degeneration (AMD). DESIGN:Laboratory investigation. METHODS:Lead and cadmium concentrations in retinal tissues (neural retina and retinal pigment epithelium [RPE]-choroid complex) in 25 subjects with AMD (...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.07.001
更新日期：2009-12-01 00:00:00
abstract：PURPOSE:To describe follow-up rates for patients referred for outpatient ophthalmic care after emergency department (ED) discharge and identify patient and visit characteristics associated with loss to follow-up (LTFU). DESIGN:Single-institution retrospective cohort study. METHODS:We analyzed the medical records of 2...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.08.038
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To report a surgical procedure for excising subfoveal neovascular membranes and translocating the fovea in an attempt to maintain the function of the sensory retina to preserve central vision, based on the technique of macular relocation. METHODS:Three patients with subfoveal neovascular membranes underwent su...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70479-9
更新日期：1996-11-01 00:00:00
abstract：PURPOSE:To compare prospectively detection of progressive retinal nerve fiber layer thickness (RNFL) atrophy identified using time-domain optical coherence tomography with visual field progression using standard automated perimetry in glaucoma suspect and preperimetric glaucoma patients or perimetric glaucoma patients....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.07.005
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year. DESIGN:Prospective longitudinal cohort study. METHODS:Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.04.033
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To measure the area of the optic nerve subarachnoid space (ONSASA) in patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), and controls and examine its association with relevant ocular and systemic parameters. DESIGN:Cross-sectional study. METHODS:The study included 40 patients wit...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2017.11.024
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:To report a patient who was initially examined with optic tract syndrome caused by a focal metastasis to the lateral geniculate body and optic tract. METHOD:Case report. RESULTS:A 44-year-old woman with metastatic breast cancer was initially examined with normal central visual acuity, afferent pupillary defec...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80251-7
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To report two patients with ocular burns from explosion of microwaved eggs that caused direct vision-threatening corneal damage. METHODS:The initial examination and treatment of both patients are described. RESULTS:Both patients were initially examined with severe decrease in the visual acuity of both eyes. T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80153-6
更新日期：1998-03-01 00:00:00
abstract：:We examined two eyes from two noninsulin-dependent diabetic patients that developed vitreous hemorrhage secondary to retinal neovascularization after branch retinal arterial obstruction. Although there was no ophthalmoscopic evidence of diabetic retinopathy, diabetes mellitus may have predisposed the retinas to a neov...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(87)90420-x
更新日期：1987-09-15 00:00:00
abstract：PURPOSE:To report a case of congenital superior oblique palsy with an unusually large Bielschowsky head-tilt phenomenon (BHP) and disproportional inconspicuous vertical deviation. METHODS:Case report. RESULTS:An 18-year-old woman presented with slight compensatory head tilting and a Bielschowsky head-tilt phenomenon ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00639-5
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To examine the development and management of glaucoma in patients with ocular chemical burns. DESIGN:Retrospective, observational case series. METHODS:setting: University of Washington Eye Clinics. patient population: Twenty-nine eyes (18 patients) with ocular chemical burns seen between 1997 and 2010 with a ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.03.026
更新日期：2012-09-01 00:00:00
abstract：:Histopathologic slides from 170 failed grafts, excised between 1983 and 1990 were reviewed. The overall incidence of retrocorneal fibrous membrane was 54% (92 grafts). The incidence of diffuse (extensive) retrocorneal fibrous membrane was 17% (29 grafts) and that of focal (peripheral) retrocorneal fibrous membrane was...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74450-2
更新日期：1993-04-15 00:00:00
abstract：PURPOSE:To assess the state of knowledge of photoreceptor dystrophies. METHODS:The current literature concerning photoreceptor dystrophies is reviewed, and their potential impact on concepts of pathogenesis of disease and clinical practice is assessed. RESULTS:As a result of cooperative investigative work between res...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9394(14)70212-0
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To elucidate molecular risk factors for posterior segment uveitis using a functional genomics approach. DESIGN:Genetic association cohort study. METHODS:Setting: Single-center study at an academic referral center. STUDY POPULATION:164 patients with clinically diagnosed uveitis of the posterior segment. MA...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.07.021
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:To analyze the features of retinal detachment (RD) occurring after cataract surgery performed by Kelman phacoemulsification (KPE) and to identify any potential correlations between KPE intraoperative complications and the features of RD (incidence apart) as well as the final visual outcome. DESIGN:Intervention...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01347-8
更新日期：2002-05-01 00:00:00
abstract：:Patients with presumed ocular histoplasmosis syndrome were typed for HLA-A, B, C, and DR antigens. It was found that 21 (81%) of 26 of the presumed ocular histoplasmosis syndrome patients with disciform macular scarring and 8 (62%) of 13 of the presumed ocular histoplasmosis syndrome patients with peripheral atrophic ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90232-9
更新日期：1980-01-01 00:00:00
abstract：PURPOSE:To report unusual fundus findings in two cases of melanoma-associated retinopathy. METHODS:Observational case reports. The histories of two patients with melanoma-associated retinopathy were reviewed. Sera from both patients were examined for antibodies against retinal bipolar cells. Immunofluorescence was per...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)00915-1
更新日期：2001-08-01 00:00:00
abstract：:After penetrating keratoplasty, visual rehabilitation can be slow and is largely a function of corneal surface configuration. Computerized topographic analysis allows the detailed study of corneal surface factors that determine the optical function of the graft. We performed a prospective, longitudinal study of eight ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73925-x
更新日期：1993-02-15 00:00:00
abstract：PURPOSE:To evaluate the efficacy and safety of transpupillary thermotherapy (TTT) for subfoveal neovascularization (SRNVM) in patients with group 2A Idiopathic Juxtafoveolar Telangiectasis (IJFT). DESIGN:Nonrandomized interventional case series. METHODS:We performed TTT for subfoveal SRNVM in 14 eyes of 13 patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.01.047
更新日期：2004-07-01 00:00:00
abstract：:In a prospective study of 415 consecutive eyes operated on for retinal detachment, there were no apparent retinal breaks in 41 eyes. Examination of the most likely site for breaks during, or shortly after, cryotherapy was helpful in detecting tiny breaks in several cases. All detachments without apparent breaks were o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90297-x
更新日期：1976-04-01 00:00:00
abstract：PURPOSE:To report associations between prognosis, total tumor necrosis, scleritis, and episcleritis in choroidal and ciliary body melanomas. METHODS:In this retrospective observational histopathologic study, 157 totally necrotic melanomas and 177 melanomas that were not totally necrotic of choroidal and ciliary body w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00783-2
更新日期：2001-02-01 00:00:00
abstract：:To determine the hereditary pattern of acute anterior uveitis, we examined seven families-one family with four cases, one family with three cases, and four families with two cases of acute anterior uveitis. A total of 16 patients with uveitis and 28 relatives underwent ocular examinations and serologic determination o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90003-9
更新日期：1981-06-01 00:00:00
abstract：PURPOSE:To investigate the prevalence of and risk factors associated with dry eye syndrome (DES) in South Korea. DESIGN:Cross-sectional study. METHODS:In 2010 and 2011, 11,666 subjects, ranging in age from 19 to 95, were randomly selected as nationally representative participants in the Korea National Health and Nutr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.08.021
更新日期：2014-12-01 00:00:00
