Abstract：
PURPOSE:To measure lead and cadmium in retinal tissues of human donor eyes with and without age-related macular degeneration (AMD). DESIGN:Laboratory investigation. METHODS:Lead and cadmium concentrations in retinal tissues (neural retina and retinal pigment epithelium [RPE]-choroid complex) in 25 subjects with AMD (50 donor eyes) and 36 normal subjects (72 donor eyes) were determined by using inductively coupled plasma-mass spectrometry. Severity of AMD was graded by using color fundus photographs and the Minnesota Grading System. Differences in metal concentrations were compared by using Wilcoxon rank-sum tests. RESULTS:The neural retinas of subjects with AMD had increased lead concentrations (median, 12.0 ng/g; 25% to 75% interquartile range, 8 to 18 ng/g; n = 25) compared with normal subjects (median, 8.0 ng/g; 25% to 75% interquartile range, 0 to 11 ng/g; P = .04; n = 36). There was no difference in lead concentration in the RPE-choroid complex between subjects with AMD (median, 198 ng/g; 25% to 75% interquartile range, 87 to 381 ng/g) and normal subjects (median, 172 ng/g; 25% to 75% interquartile range, 100 to 288 ng/g; P = .25). Cadmium concentration in the neural retina (median, 0.9 microg/g; 25% to 75% interquartile range, 0.7 to 1.8 microg/g) and RPE-choroid complex (median, 2.2 microg/g; 25% to 75% interquartile range, 1.8 to 3.7 microg/g) in subjects with AMD was not different from concentrations in the neural retina (median, 0.9 microg/g; 25% to 75% interquartile range, 0.7 to 1.4 microg/g; P = .32) and RPE-choroid complex (median, 1.5 microg/g; 25% to 75% interquartile range, 0.9 to 2.5 microg/g; P = .12) of normal subjects. CONCLUSIONS:AMD is associated with excess lead in the neural retina, and this relationship suggests that metal homeostasis in AMD eyes is different from normal.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Erie JC,Good JA,Butz JAdoi
10.1016/j.ajo.2009.07.001subject
Has Abstractpub_date
2009-12-01 00:00:00pages
890-4issue
6eissn
0002-9394issn
1879-1891pii
S0002-9394(09)00495-4journal_volume
148pub_type
杂志文章abstract：PURPOSE:To report a physician survey, laboratory studies, and clinical observations of intraoperative crystallization on the surface of the intraocular lens (IOL). METHOD:We sent a survey to all ophthalmologists in the states of Wyoming, Idaho, Montana, Utah, and Colorado asking whether crystallization on the IOL surf...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00076-2
更新日期：1998-08-01 00:00:00
abstract：PURPOSE:To report a patient with ocular ischemic syndrome due to an internal carotid artery stenosis in whom we confirmed improved retinal blood flow noninvasively after carotid endarterectomy. DESIGN:Observational case report. METHODS:Retinal flowmetry. RESULTS:In a 72-year-old hypertensive man with a transient isc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2002-08-01 00:00:00
abstract：:A 32-year-old obese woman with hypertension and a three-year history of pseudotumor cerebri developed bilateral juxtapapillary subretinal neovascular membranes. To our knowledge, this is the first reported case of bilateral subretinal neovascular membranes complicating the course of this disease. The subretinal neovas...
journal_title：American journal of ophthalmology
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更新日期：1981-03-01 00:00:00
abstract：PURPOSE:To determine the optical coherence tomographic images that are commonly observed in eyes with choroidal osteoma (choroidal ossification). METHODS:Three patients with choroidal osteoma were examined by optical coherence tomography. RESULTS:We found two optical coherence tomographic patterns in the eyes with ch...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00503-1
更新日期：2000-07-01 00:00:00
abstract：PURPOSE AND METHODS:To describe the clinical and histopathologic features of a patient with viral retinitis secondary to subacute sclerosing panencephalitis. RESULTS:The patient was a human immunodeficiency virus-negative intravenous drug abuser with an acute retinitis that later progressed to encephalitis despite agg...
journal_title：American journal of ophthalmology
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abstract：PURPOSE:To investigate the retention rate and complications of 2 different types of silicon lacrimal punctal plugs with the focus on the relationship to punctum size. DESIGN:A prospective, nonrandomized, interventional, comparative study. METHOD:Forty-four patients with dry eye syndrome received lacrimal punctal plug...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.10.024
更新日期：2013-04-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1999-12-01 00:00:00
abstract：PURPOSE:Report of a case of acquired Brown syndrome caused by infestation of the superior oblique muscle by Cysticercus cellulosae. METHOD:Case seen in a referral practice. A 20-year-old man presented with recurrent attacks of conjunctivitis and diplopia in upgaze. Clinical examination of ocular motility established a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：2015-02-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.003
更新日期：2013-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72656-x
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:To determine whether an association exists between dry eye disease (DED) and statin use and/or dyslipidemia. DESIGN:Retrospective, case-control study. METHODS:Setting: University of North Carolina (UNC)-affiliated healthcare facilities. STUDY POPULATION:72,931 patients seen at UNC ophthalmology clinics over ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
abstract：PURPOSE:To document and study the relationship between perimetric sensitivity and retinal thickness at the foveal and parafoveal points in eyes with macular edema associated with branch retinal vein occlusion. METHODS:A prospective study was performed using the central 10-2 Humphrey perimetry program and optical coher...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00722-4
更新日期：2001-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.061
更新日期：2004-12-01 00:00:00
abstract：:Four patients, two men 25 and 43 years old and two women 20 and 40 years old, had complete monocular temporal hemianopsias, suggesting that it may be a more common functional deficit than has been recognized. The initial symptoms were visual loss and headache, and eye pain also occurred. Correct diagnosis is possible ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90600-8
更新日期：1986-02-15 00:00:00
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journal_title：American journal of ophthalmology
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doi：10.1016/j.ajo.2009.10.011
更新日期：2010-03-01 00:00:00
abstract：:Subconjunctival 5-fluorouracil has been an effective adjunct in glaucoma filtering surgery. We investigated the effectiveness of 5-fluorouracil in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation (glaucoma triple procedure). Seventy-four patients were enrolle...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-11-15 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2007-04-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
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更新日期：2005-10-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2003-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1997-03-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1990-09-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76854-0
更新日期：1991-11-15 00:00:00
abstract：PURPOSE:To evaluate the long-term risk of endothelial rejection, graft survival, and associated factors following penetrating keratoplasty (PK) for keratoconus, with and without prior resolved corneal hydrops. DESIGN:Retrospective cohort study. METHODS:Primary outcome measures were endothelial rejection-free survival...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
abstract：:Eikenella corrodens is a gram-negative, facultative anaerobic bacillus with specific culture and growth requirements and unusual antibacterial susceptibilities. It has only recently been recognized as a human pathogen. Ocular and adnexal infections with this organism are rare especially in children. We treated two chi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1992-11-15 00:00:00
abstract：PURPOSE:To determine provider compliance with hydroxychloroquine screening following the revised recommendations published in 2011 by the American Academy of Ophthalmology. DESIGN:Evaluation of adherence to a screening protocol. METHODS:Subjects were identified with hydroxychloroquine as a medication by electronic qu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2014-01-01 00:00:00
