Abstract：
:Subconjunctival 5-fluorouracil has been an effective adjunct in glaucoma filtering surgery. We investigated the effectiveness of 5-fluorouracil in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation (glaucoma triple procedure). Seventy-four patients were enrolled and randomly assigned into two groups to receive either no 5-fluorouracil (control patients) or low-dose 5-fluorouracil (mean total dose, 24.8 mg; mean number of injections, 5.0 +/- 1.3). The mean preoperative intraocular pressure was 20.1 +/- 5.4 mm Hg for the 5-fluorouracil group and 21.0 +/- 5.2 mm Hg for the control group (P = .48, Student's unpaired t-test). The mean number of medications was 2.2 +/- 1.0 and 2.0 +/- 1.0 (P = .49, Mann Whitney U test), respectively. At all postoperative visits, there were no statistically significant differences in mean intraocular pressures between the two groups. Mean follow-up was 13.2 months for 5-fluorouracil-treated patients and 15.0 months for control patients. At the last postoperative visit, mean intraocular pressures were 15.4 +/- 3.7 mm Hg and 15.0 +/- 5.0 mm Hg, respectively (P = .45, Student's unpaired t-test). Both groups showed comparable visual outcome (20/40 or better in 31 of 38 5-fluorouracil-treated patients [82%] vs 32 of 36 control patients [89%]) and a decrease in number of medications needed, 0.7 +/- 1.0 and 0.7 +/- 0.9, respectively (P = .96, Mann Whitney U test). Thus, 5-fluorouracil administered as in our study did not seem to have any effect in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
O'Grady JM,Juzych MS,Shin DH,Lemon LC,Swendris RPdoi
10.1016/s0002-9394(14)73202-7subject
Has Abstractpub_date
1993-11-15 00:00:00pages
594-9issue
5eissn
0002-9394issn
1879-1891pii
S0002-9394(14)73202-7journal_volume
116pub_type
临床试验,杂志文章,随机对照试验abstract：PURPOSE:To assess whether alcohol consumption is associated with the long-term incidence of cataract or cataract surgery. DESIGN:Population-based prospective cohort study. METHODS:A total of 3654 persons aged 49+ years were examined at baseline and 2564 were re-examined after 5 and/or 10 years. Lens photographs were ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.04.020
更新日期：2010-09-01 00:00:00
abstract：:We studied cell-mediated immunity to staphylococcal antigens in 116 patients with chronic blepharitis and eight normal subjects. Antibodies in tears and blood were measured. Enhanced cell-mediated immunity to Staphylococcus aureus was demonstrated in 46 of 116 patients (40%) in the absence of antibodies to teichoic ac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72383-9
更新日期：1991-04-15 00:00:00
abstract：:Histopathologic slides from 170 failed grafts, excised between 1983 and 1990 were reviewed. The overall incidence of retrocorneal fibrous membrane was 54% (92 grafts). The incidence of diffuse (extensive) retrocorneal fibrous membrane was 17% (29 grafts) and that of focal (peripheral) retrocorneal fibrous membrane was...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74450-2
更新日期：1993-04-15 00:00:00
abstract：PURPOSE:To report a case of porphyria cutanea tarda presenting as cicatricial conjunctivitis. DESIGN:Observational study. METHODS:A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection. RESULTS:Four ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01623-9
更新日期：2002-10-01 00:00:00
abstract：PURPOSE:To report a new method to perform intraoperative video fluorescein angiography (VFA) using an optical fiber-free intravitreal surgery system (OFFISS) and retinal blood flow analysis during surgery. DESIGN:Observational case series. METHODS:Four eyes of four patients with macular edema as a result of branch re...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.079
更新日期：2004-12-01 00:00:00
abstract：PURPOSE:To report reduction in the area of anterior capsule opening at various postoperative intervals after continuous capsulorrhexis and to compare any differences in the area reduction between polymethylmethacrylate, silicone, and soft acrylic intraocular lenses. METHODS:Prospectively, 240 eyes of 240 patients unde...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)70169-2
更新日期：1997-04-01 00:00:00
abstract：:The development of subfoveal choroidal neovascularization is a major cause of visual loss in age-related macular degeneration and other disorders of the retinal pigment epithelium-Bruch's membrane complex. We designed a new subretinal laser delivery system and used it to treat subfoveal neovascular membranes in three ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71344-3
更新日期：1993-09-15 00:00:00
abstract：PURPOSE:To report a case of small cell carcinoma of the thymus metastatic to the orbit. METHODS:At age 37 years, a man who had been previously diagnosed and treated for small cell carcinoma of the thymus was initially examined for vertical diplopia and left proptosis. Computed tomographic scan disclosed a soft tissue ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70836-0
更新日期：1997-09-01 00:00:00
abstract：PURPOSE:To describe a technique that uses a transcorneal suture for safe delivery and fixation of donor tissue during Descemet stripping automated endothelial keratoplasty in patients that are at risk of graft dislocation into the vitreous cavity as a result of minimal or absent iris-lens diaphragm. DESIGN:Interventio...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.043
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:To evaluate the retinal toxicity of intravitreal bevacizumab in an animal model. DESIGN:Animal study. METHODS:Bevacizumab was injected into the vitreous of one eye of each of eight Dutch-belted rabbits; the other eye served as a control. Four rabbits received a dose of 1.25 mg/0.05 ml of bevacizumab intravitr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.058
更新日期：2006-07-01 00:00:00
abstract：:Antibiotics in a corneal preservation solution probably have little effect during storage at 4 C, but are effective as the tissue is warmed. The tissue acts as a sponge, soaking up the antibiotic from the solution and releasing it into the eye, where the bactericidal effect is achieved. Currently, high concentrations ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74729-4
更新日期：1992-05-15 00:00:00
abstract：PURPOSE:To analyze the risk factors, clinical characteristics, management, and treatment outcomes of culture-proven cases of Moraxella keratitis at our center. DESIGN:Retrospective observational case series. METHODS:Thirty-nine culture-proven cases of Moraxella keratitis (39 eyes) diagnosed and treated between Januar...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.08.055
更新日期：2019-01-01 00:00:00
abstract：:We treated 23 consecutive cases of giant retinal tears with inverted retinal flaps. We used pars plana vitrectomy together with an intravitreal bubble to unfold the posterior retinal flap, combined with cryotherapy to cause a chorioretinal adhesion and a broad scleral buckle. The vitrectomy was done after applying cry...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90132-6
更新日期：1984-10-15 00:00:00
abstract：:In the elderly patient with a massive vitreous hemorrhage in one eye and senile macular choroidal degenerative changes in the fellow eye, a hemorrhagic disciform detachment causing this massive vitreous hemorrhage must be considered in the differential diagnosis. Ultrasonography selectively combined with radioactive p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75023-8
更新日期：1980-10-01 00:00:00
abstract：:We made 344 stereoacuity determinations (Titmus Stereotest) on 321 children, ages 1 1/2 to 13 years, who had normal binocular single vision tested by other factors. The data showed a gradual improvement in stereoacuity scores with increasing age--up to age 9--when a normal stereoacuity of 40 seconds of arc was consist...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90679-0
更新日期：1975-06-01 00:00:00
abstract：:Four patients observed for a three- to four-year period had a hole in an epiretinal membrane overlying the macula that mimicked a macular hole. In two patients the clinical appearance remained essentially constant. In one, the epiretinal membrane contracted further, reducing the apparent macular hole to a slit and cau...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90002-7
更新日期：1976-11-01 00:00:00
abstract：PURPOSE:To present the carbon dioxide laser as an effective tool for surgical debulking of eyelid and orbital neurofibromas. METHOD:Two patients with neurofibromatosis underwent surgical debulking of their eyelid and orbital plexiform neurofibromas by means of the carbon dioxide laser. RESULTS:Acceptable cosmetic res...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00454-2
更新日期：2000-07-01 00:00:00
abstract：PURPOSE:To report one-year results of the Tube Versus Trabeculectomy (TVT) Study. DESIGN:Multicenter randomized clinical trial. METHODS: SETTING:17 Clinical Centers. STUDY POPULATION:Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and unco...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2006.07.020
更新日期：2007-01-01 00:00:00
abstract：:On the basis of preoperative assessment of patient characteristics, intraoperative obtainment of a lens-capsule and epithelium specimen, histopathologic investigation of lens capsule and epithelium, and biochemical analysis of glutathione reductase in lens epithelium, age-related cataract was studied in 50 adult patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76729-7
更新日期：1991-09-15 00:00:00
abstract：PURPOSE:To determine the population-based incidence and cause of cranial nerve palsies affecting ocular motility in children in the circumscribed population of Olmsted County, Minnesota. METHODS:The Rochester Epidemiology Project medical records linkage system captures virtually all medical care provided to Olmsted Co...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00424-3
更新日期：1999-04-01 00:00:00
abstract：:Ten patients with endogenous uveitis were in clinical remission attributable to treatment with cyclosporine and prednisone. After the cyclosporine dose was reduced by two thirds, these patients were randomly assigned to treatment with or without ketoconazole, a potent inhibitor of cytochrome P-450, in a double-masked ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)74795-6
更新日期：1992-06-15 00:00:00
abstract：:A 57-year-old man had a clinically suspected malignant melanoma in his left eye. On microscopic study, the enucleated eye harbored an unusual choroidal tumor that had extended extraocularly. This tumor had been variously interpreted microscopically as an angiosarcoma, an atpical angioma, a glioma, or a neurilemoma. El...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90419-0
更新日期：1976-08-01 00:00:00
abstract：PURPOSE:To report the response of calcification in choroidal melanoma after transpupillary thermotherapy. METHODS:Interventional case report. A 66-year-old male with a posterior uveal melanoma measuring 10 x 8 x 4.4 mm underwent infrared diode laser transpupillary thermotherapy three times, each 12 weeks apart. For ea...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01186-2
更新日期：2001-12-01 00:00:00
abstract：PURPOSE:To report two patients with ocular burns from explosion of microwaved eggs that caused direct vision-threatening corneal damage. METHODS:The initial examination and treatment of both patients are described. RESULTS:Both patients were initially examined with severe decrease in the visual acuity of both eyes. T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80153-6
更新日期：1998-03-01 00:00:00
abstract：PURPOSE:To evaluate the ocular surface inflammatory response to the presence of preservatives in nonselective beta-blocker eyedrops. DESIGN:Prospective, crossover, single-masked, randomized clinical study. METHODS:study population: Twenty primary open-angle glaucoma or ocular hypertensive patients were divided in two...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ajo.2004.08.028
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:To present a case of congenital toxoplasmosis in a newborn whose mother had a 20-year history of a chorioretinal macular scar and positive serology for toxoplasmosis. DESIGN/METHODS:Case report. SETTING/RESULTS: A 38-year-old woman who had been treated for ocular toxoplasmosis 20 years earlier delivered a newb...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00191-0
更新日期：2003-08-01 00:00:00
abstract：:Eight patients with manifest latent nystagmus, as noted by ocular movement recordings, were examined for nystagmus reduction after surgical or optical treatment. Seven of the patients had strabismus. Five patients underwent strabismus surgery, had no tropia postoperatively, and the manifest latent nystagmus converted ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76985-5
更新日期：1990-08-15 00:00:00
abstract：PURPOSE:To describe a simplified new technique for repositioning and attaching a suture to the haptic of a displaced posterior chamber intraocular lens (IOL). METHODS:We describe a double-knot technique for repositioning and transscleral suture fixation of a subluxed posterior chamber IOL after penetrating keratoplast...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00244-5
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:To determine risk factors for poor visual acuity outcomes in patients with endogenous Klebsiella pneumoniae endophthalmitis. DESIGN:Retrospective case-control study. METHODS:We reviewed all consecutive patients diagnosed with endogenous Klebsiella pneumoniae endophthalmitis over 20 years. Data collected inclu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.036
更新日期：2011-02-01 00:00:00
abstract：:A 46-year old woman and a 59-year-old man had corneal crystals, multiple myeloma, and IgG kappa hypergammaglobulinemia. In one case, crystalline deposits were also present in the lens. In both patients there was a marked decrease in the amount of crystals during chemotherapy. The crystals within the cornea of one case...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90230-1
更新日期：1978-09-01 00:00:00
