Combined use of cyclosporine and ketoconazole in the treatment of endogenous uveitis.

Abstract:

:Ten patients with endogenous uveitis were in clinical remission attributable to treatment with cyclosporine and prednisone. After the cyclosporine dose was reduced by two thirds, these patients were randomly assigned to treatment with or without ketoconazole, a potent inhibitor of cytochrome P-450, in a double-masked placebo-controlled study. The dose was reduced over three days. During a three-month follow-up, no patients treated with ketoconazole had a relapse of uveitis, while four of six (66%) control subjects had a flare-up. Toxicity in the ketoconazole-treated group was limited to a transient decrease in glomerular filtration rate (20% from baseline) at one month in two of six (33%) patients. Renal function was stabilized by further reduction of the cyclosporine dose.

journal_name

Am J Ophthalmol

authors

de Smet MD,Rubin BI,Whitcup SM,Lopez JS,Austin HA,Nussenblatt RB

doi

10.1016/s0002-9394(14)74795-6

subject

Has Abstract

pub_date

1992-06-15 00:00:00

pages

687-90

issue

6

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)74795-6

journal_volume

113

pub_type

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