Abstract：
PURPOSE:To report a case of porphyria cutanea tarda presenting as cicatricial conjunctivitis. DESIGN:Observational study. METHODS:A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection. RESULTS:Four years after initial presentation, the patient developed hepatitis C, and 2 years later blisters on his scalp and hands. Direct immunofluorescence studies of biopsies taken from the palpebral conjunctiva of the right lower lid were negative for cicatricial pemphigoid. A twenty-four hour urine specimen analysis revealed elevated levels of uroporphyrins and polycarboxylated porphyrins, confirming the diagnosis of porphyria cutanea tarda. The patient was treated with repeated phlebotomies and oral hydroxychloroquine, which resulted in a significant decrease in the skin lesions, conjunctival injection, and concretions under the upper lids. CONCLUSIONS:Cicatricial conjunctivitis may be a manifestation of porphyria cutanea tarda.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Park AJ,Webster GF,Penne RB,Raber IMdoi
10.1016/s0002-9394(02)01623-9subject
Has Abstractpub_date
2002-10-01 00:00:00pages
619-21issue
4eissn
0002-9394issn
1879-1891pii
S0002939402016239journal_volume
134pub_type
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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pub_type： 临床试验,杂志文章
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