当前位置： SCI文献检索 > AMERICAN JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > Retinal arteriolar wall signs and early age-related macular degeneration: the singapore malay eye study.

Retinal arteriolar wall signs and early age-related macular degeneration: the singapore malay eye study.

Abstract：

PURPOSE:To determine whether retinal arteriolar wall signs are associated with early age-related macular degeneration (AMD). DESIGN:Population-based cross-sectional study. METHODS:The Singapore Malay Eye Study (SiMES) is a population-based eye survey including 3,280 (78.7% response) persons aged 40 to 80 years. Retinal arteriolar wall signs and AMD were assessed from photographs by trained technicians, according to standardized protocols. Data on major cardiovascular risk factors and blood pressure were collected. RESULTS:Of the 3,280 participants, 2,541 had photographs that were gradable for both AMD and retinal arteriolar wall signs. Early AMD was present in 76 subjects. There were no significant associations of any retinal arteriolar wall signs with early AMD. For specific AMD signs, retinal arteriolar wall opacification was associated with presence of soft distinct drusen (odds ratio [OR] 1.58, 95% confidence interval [CI]: 1.06, 2.35). This association was most significant among non-statin users (OR 1.90, 95% CI: 1.23, 2.93). Focal arteriolar narrowing was associated with retinal hypopigmentation (OR 1.67, 95% CI: 1.02, 2.73). Arteriovenous nicking was not associated with soft drusen (OR 0.89, 95% CI: 0.51, 1.57), hyperpigmentation (OR 0.49, 95% CI: 0.22, 1.08), or hypopigmentation (OR 0.86, 95% CI: 0.46, 1.61). CONCLUSIONS:Retinal arteriolar wall signs are not consistently associated with early AMD. We report a new association of retinal arteriolar wall opacification and the presence of soft drusen. This finding could support the hypothesis of a link between lipids and drusen formation.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Cheung CM,Cheung CY,Yang EL,Mitchell P,Wang JJ,Wong TY

doi

10.1016/j.ajo.2011.01.012

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

108-113.e1

issue

1

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(11)00050-X

journal_volume

152

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OPHTHALMOLOGY文献大全
  • Height measurement of astigmatic test surfaces by a keratoscope that uses plane geometry surface reconstruction.

    abstract：PURPOSE:To assess the accuracy with which the Keratron keratoscope (Optikon 2000, Rome, Italy) measured astigmatic test surfaces by a profile reconstruction algorithm within a plane geometry model and to discriminate between error caused by the model and error caused by other factors. METHODS:Height was reported by th...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)70633-6

    authors： Tripoli NK,Cohen KL,Obla P,Coggins JM,Holmgren DE

    更新日期：1996-06-01 00:00:00

  • Testability of vision and refraction in preschoolers: the strabismus, amblyopia, and refractive error study in singaporean children.

    abstract：PURPOSE:To determine the testability of several vision and refraction tests in preschool-aged children. DESIGN:Population-based study of Chinese preschool-aged children in Singapore. METHODS:One thousand five hundred and forty-two Singaporean Chinese children aged 6 to 72 months were recruited through door-to-door sc...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2009.02.037

    authors： Trager MJ,Dirani M,Fan Q,Gazzard G,Selvaraj P,Chia A,Wong TY,Young TL,Varma R,Saw SM

    更新日期：2009-08-01 00:00:00

  • Measurement by nerve fiber analyzer of retinal nerve fiber layer thickness in normal subjects and patients with ocular hypertension.

    abstract：PURPOSE:To measure retinal nerve fiber layer (NFL) thickness in normal subjects and patients with ocular hypertension and examine the relationship between age and normal NFL thickness. METHODS:Nerve fiber layer thickness was determined by scanning laser polarimetry in 210 normal subjects and 100 patients with ocular h...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)72013-6

    authors： Tjon-Fo-Sang MJ,de Vries J,Lemij HG

    更新日期：1996-08-01 00:00:00

  • Prolonged Cone b-Wave on Electroretinography Is Associated with Severity of Inflammation in Noninfectious Uveitis.

    abstract：PURPOSE:This study sought to investigate retinal function in patients with noninfectious uveitis by using full-field electroretinography (ERG) and correlate the ERG to disease duration and severity of inflammation. DESIGN:Prospective cohort study. METHODS:Patients (n = 200) with noninfectious uveitis and a disease du...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2019.05.028

    authors： Brouwer AH,de Wit GC,Ten Dam NH,Wijnhoven R,van Genderen MM,de Boer JH

    更新日期：2019-11-01 00:00:00

  • Monitoring compliance with pilocarpine therapy.

    abstract：:I used a recording medication monitor to obtain objective information on self-medication by date and hour from a group of 82 patients using pilocarpine three times daily to prevent visual loss from glaucoma. Doses meant to be taken during the day were missed more than twice as often as morning or evening doses. Of the...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)74670-7

    authors： Norell SE

    更新日期：1981-11-01 00:00:00

  • Outcome of cataract operations performed to permit diagnosis, to determine eligibility for laser therapy, or to perform laser therapy of retinal disorders.

    abstract：:Cataract operations may be recommended when retinal disease is suspected but cannot be adequately diagnosed or treated because of lens opacity. We evaluated the outcome of cataract operations performed under those circumstances. We reviewed the records of 119 patients who were examined at the Wilmer Retinal Vascular C...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)75793-9

    authors： Edwards MG,Schachat AP,Bressler SB,Bressler NM

    更新日期：1994-10-15 00:00:00

  • Correction of residual hyperopia after cataract surgery using the light adjustable intraocular lens technology.

    abstract：PURPOSE:To determine whether residual hyperopia could be corrected postoperatively using the light adjustable lens technology in patients undergoing cataract surgery and light adjustable lens implantation. DESIGN:Prospective, nonrandomized clinical trial. METHODS:Fourteen eyes of 14 patients were studied. The manifes...

    journal_title：American journal of ophthalmology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ajo.2008.08.039

    authors： Chayet A,Sandstedt CA,Chang SH,Rhee P,Tsuchiyama B,Schwartz D

    更新日期：2009-03-01 00:00:00

  • In Vivo Corneal Confocal Microscopy and Histopathology of Keratitis Fugax Hereditaria From a Pathogenic Variant in NLRP3.

    abstract：PURPOSE:To apply in vivo corneal confocal microscopy (IVCM) to study the pathogenesis of keratitis (keratoendotheliitis) fugax hereditaria, an autosomal dominant cryopyrin-associated periodic keratitis, associated with the c.61G>C pathogenic variant in the NLRP3 gene, in its acute and chronic phase, and to report histo...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2020.02.002

    authors： Turunen JA,Immonen AT,Järvinen RS,Kawan S,Repo P,Korsbäck A,Ala-Fossi O,Jaakkola AM,Majander A,Vesaluoma M,Kivelä TT

    更新日期：2020-05-01 00:00:00

  • Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy.

    abstract：PURPOSE:To determine a correlation between foveal morphologic changes and visual outcomes in patients with resolved central serous chorioretinopathy (CSC). DESIGN:Observational case series. METHODS:We measured the outer nuclear layer (ONL) thickness at the central fovea and evaluated the integrity of the photorecepto...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2009.01.018

    authors： Matsumoto H,Sato T,Kishi S

    更新日期：2009-07-01 00:00:00

  • Photoreceptor oxidative damage in sympathetic ophthalmia.

    abstract：PURPOSE:To determine photoreceptor oxidative stress and damage in sympathetic ophthalmia (SO). DESIGN:Immunohistologic study. METHODS:Eight formalin-fixed and paraffin-embedded human globes with typical histologic features of SO and five age-matched globes without intraocular inflammation (controls) were retrieved fr...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2008.03.026

    authors： Parikh JG,Saraswathy S,Rao NA

    更新日期：2008-12-01 00:00:00

  • Peripheral Changes Associated With Delayed Dark Adaptation in Age-related Macular Degeneration.

    abstract：PURPOSE:To study the association between peripheral changes in age-related macular degeneration (AMD) and dark adaptation (DA). DESIGN:Prospective, cross-sectional study. METHODS:We recruited patients with AMD and a control group (>50 years) without any vitreoretinal disease. Ultra-widefield (UWF) pseudocolor and fun...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2018.03.035

    authors： Laíns I,Park DH,Mukai R,Silverman R,Oellers P,Mach S,Kim IK,Vavvas DG,Miller JW,Miller JB,Husain D

    更新日期：2018-06-01 00:00:00

  • Fundus autofluorescence in type 2 idiopathic macular telangiectasia: correlation with optical coherence tomography and microperimetry.

    abstract：PURPOSE:To use multiple imaging methods to investigate patients with type 2 idiopathic macular telangiectasia (IMT) at different disease severity stages so as to characterize and categorize disease progression through the full spectrum of disease phenotypes. DESIGN:Observational case series. METHODS:Twelve patients w...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajo.2009.04.030

    authors： Wong WT,Forooghian F,Majumdar Z,Bonner RF,Cunningham D,Chew EY

    更新日期：2009-10-01 00:00:00

  • Trends in Prevalence of Diagnosed Ocular Disease and Utilization of Eye Care Services in American Veterans.

    abstract：PURPOSE:To assess trends in prevalence of diagnosed ocular disease and use of eye care services in the Veterans Affairs (VA) health care system. DESIGN:Prevalence study. METHODS:We performed a retrospective study of all eligible veterans in the VA Capitol Health Care Network from 2007 to 2011. The VA database was use...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajo.2016.09.030

    authors： Saeedi O,Ashraf H,Slade EP,Medoff DR,Li L,Friedman DS,Kreyenbuhl J

    更新日期：2017-01-01 00:00:00

  • Peripheral Visual Fields in ABCA4 Stargardt Disease and Correlation With Disease Extent on Ultra-widefield Fundus Autofluorescence.

    abstract：PURPOSE:To evaluate the disease extent on ultra-widefield fundus autofluorescence (UWF-FAF) in patients with ABCA4 Stargardt disease (STGD) and correlate these data with functional outcome measures. DESIGN:Retrospective cross-sectional study. METHODS:Setting: Kellogg Eye Center, University of Michigan. STUDY POPULAT...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2017.10.006

    authors： Abalem MF,Otte B,Andrews C,Joltikov KA,Branham K,Fahim AT,Schlegel D,Qian CX,Heckenlively JR,Jayasundera T

    更新日期：2017-12-01 00:00:00

  • Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial.

    abstract：PURPOSE:To assess the safety of rAAV.sFlt-1 subretinal injection in neovascular age-related macular degeneration (wet AMD) over 36 months. DESIGN:Phase 1 dose escalation trial. METHODS:Eight subjects with advanced, treatment-experienced wet AMD were randomly assigned (3:1) to treatment and non-gene therapy control gr...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajo.2017.02.018

    authors： Constable IJ,Lai CM,Magno AL,French MA,Barone SB,Schwartz SD,Blumenkranz MS,Degli-Esposti MA,Rakoczy EP

    更新日期：2017-05-01 00:00:00

  • Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and Older.

    abstract：PURPOSE:To provide current estimates of the prevalence of diagnosed dry eye disease (DED) and associated demographics among US adults aged ≥18 years. DESIGN:Cross-sectional, population-based survey. METHODS:Data were analyzed from 75 000 participants in the 2013 National Health and Wellness Survey to estimate prevale...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2017.06.033

    authors： Farrand KF,Fridman M,Stillman IÖ,Schaumberg DA

    更新日期：2017-10-01 00:00:00

  • A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome in Africa.

    abstract：:A prospective study of ophthalmologic findings in 20 African patients with the acquired immunodeficiency syndrome (Group 1) and nine patients with acquired immune deficiency syndrome related complex (Group 2) disclosed that 11 patients in Group 1 and two patients in Group 2 had ocular involvement. Cotton-wool spots, R...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(85)90787-1

    authors： Kestelyn P,Van de Perre P,Rouvroy D,Lepage P,Bogaerts J,Nzaramba D,Clumeck N

    更新日期：1985-08-15 00:00:00

  • Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.

    abstract：PURPOSE:To report a 49-year-old woman with unilateral central retinal vein occlusion and ipsilateral cilioretinal artery occlusion who showed familial dysplasminogenemia associated with elevated lipoprotein(a). METHOD:Case report. RESULTS:Extensive hemostatic and coagulation studies for causes of thrombosis, as well ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(98)00163-9

    authors： Iijima H,Gohdo T,Tsukahara S

    更新日期：1998-08-01 00:00:00

  • Distribution and determinants of choroidal thickness and volume using automated segmentation software in a population-based study.

    abstract：PURPOSE:To objectively quantify choroidal thickness and choroidal volume using fully automated choroidal segmentation software applied to images obtained from enhanced depth imaging spectral-domain optical coherence tomography (EDI SD OCT) in a population-based study; and evaluate the ocular and systemic determinants o...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2014.10.034

    authors： Gupta P,Jing T,Marziliano P,Cheung CY,Baskaran M,Lamoureux EL,Wong TY,Cheung CM,Cheng CY

    更新日期：2015-02-01 00:00:00

  • Direct Versus Indirect Corneal Neurotization for the Treatment of Neurotrophic Keratopathy: A Multicenter Prospective Comparative Study.

    abstract：PURPOSE:To analyze the comparative safety and efficacy of two techniques of corneal neurotization (CN) (direct corneal neurotization [DCN] vs indirect corneal neurotization [ICN]) for the treatment of neurotrophic keratopathy (NK). DESIGN:Multicenter interventional prospective comparative case series. METHODS:This st...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajo.2020.07.003

    authors： Fogagnolo P,Giannaccare G,Bolognesi F,Digiuni M,Tranchina L,Rossetti L,Dipinto A,Allevi F,Lozza A,Rabbiosi D,Mariani S,Pellegrini M,Cazzola FE,Bagaglia S,Mazzotta C,Gabriele G,Gennaro P,Badiali G,Marchetti C,Campos

    更新日期：2020-12-01 00:00:00

  • Relationship Between Retinal Fractal Dimension and Nonperfusion in Diabetic Retinopathy on Ultrawide-Field Fluorescein Angiography.

    abstract：PURPOSE:To correlate fractal dimension (FD) of the retinal vasculature with the extent of retinal nonperfusion area in diabetic retinopathy (DR) on ultrawide-field fluorescein angiography (FA). DESIGN:Cross-sectional study. METHODS:Baseline Optos 200Tx ultrawide-field FA images of 80 eyes with DR from the DAVE (NCT01...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajo.2019.08.015

    authors： Fan W,Nittala MG,Fleming A,Robertson G,Uji A,Wykoff CC,Brown DM,van Hemert J,Ip M,Wang K,Falavarjani KG,Singer M,Sagong M,Sadda SR

    更新日期：2020-01-01 00:00:00

  • Metastatic adenocarcinoma to the retina in a patient with Muir-Torre syndrome.

    abstract：PURPOSE/METHODS:A 74-year-old woman had multiple tumors including a retinal mass. Her medical history included cutaneous sebaceous adenomas, adenocarcinoma of the breast, and colonic adenocarcinoma. Her involved eye became painful and was enucleated. RESULTS/CONCLUSIONS:Examination of the enucleated eye disclosed meta...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)72616-9

    authors： Spraul CW,Lang GE,Grossniklaus HE,Lang GK

    更新日期：1995-08-01 00:00:00

  • Analysis of corneal crystalline deposits in multiple myeloma.

    abstract：:A 46-year old woman and a 59-year-old man had corneal crystals, multiple myeloma, and IgG kappa hypergammaglobulinemia. In one case, crystalline deposits were also present in the lens. In both patients there was a marked decrease in the amount of crystals during chemotherapy. The crystals within the cornea of one case...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(78)90230-1

    authors： Klintworth GK,Bredehoeft SJ,Reed JW

    更新日期：1978-09-01 00:00:00

  • Association of HLA-DRw2 antigen with presumed ocular histoplasmosis.

    abstract：:Patients with presumed ocular histoplasmosis syndrome were typed for HLA-A, B, C, and DR antigens. It was found that 21 (81%) of 26 of the presumed ocular histoplasmosis syndrome patients with disciform macular scarring and 8 (62%) of 13 of the presumed ocular histoplasmosis syndrome patients with peripheral atrophic ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(80)90232-9

    authors： Meredith TA,Smith RE,Duquesnoy RJ

    更新日期：1980-01-01 00:00:00

  • Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.

    abstract：PURPOSE:To perform a quantitative trait locus (QTL) analysis and evaluate whether a locus between SIX1 and SIX6 is associated with retinal nerve fiber layer (RNFL) thickness in individuals of European descent. DESIGN:Observational, multicenter, cross-sectional study. METHODS:A total of 231 participants were recruited...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajo.2015.04.001

    authors： Kuo JZ,Zangwill LM,Medeiros FA,Liebmann JM,Girkin CA,Hammel N,Rotter JI,Weinreb RN

    更新日期：2015-07-01 00:00:00

  • Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities Study.

    abstract：PURPOSE:Age-related maculopathy (ARM) and cognitive impairment are both neurodegenerative disorders associated with aging and have been hypothesized to share common pathogenic pathways. We describe the association between cognitive function and ARM in middle-aged persons. DESIGN:Population-based, cross-sectional study...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(02)01672-0

    authors： Wong TY,Klein R,Nieto FJ,Moraes SA,Mosley TH,Couper DJ,Klein BE,Boland LL,Hubbard LD,Sharrett AR

    更新日期：2002-12-01 00:00:00

  • Prevalence and Clinical Patterns of Ocular Complications Associated With Anti-PD-1/PD-L1 Anticancer Immunotherapy.

    abstract：PURPOSE:Immune checkpoint inhibitors (ICI) targeting the programmed cell death protein 1 (PD-1), or its ligand PD-L1, are the mainstay of metastatic cancer treatment. Patients receiving these treatments may develop immune-related adverse events (irAEs). This study aimed to estimate the prevalence and describe the clini...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2019.02.012

    authors： Bitton K,Michot JM,Barreau E,Lambotte O,Haigh O,Marabelle A,Voisin AL,Mateus C,Rémond AL,Couret C,Champiat S,Labetoulle M,Rousseau A

    更新日期：2019-06-01 00:00:00

  • Blue light-filter intraocular lenses in vitrectomy combined with cataract surgery: results of a randomized controlled clinical trial.

    abstract：PURPOSE:To evaluate the effect of the blue light-filter intraocular lenses (IOLs) in vitrectomy combined with cataract surgery, focusing on the surgeon's ability to perform specific vitreoretinal procedures and on the patients' outcome. DESIGN:Randomized clinical trial. METHODS:Sixty patients, recruited from our outp...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajo.2007.10.021

    authors： Falkner-Radler CI,Benesch T,Binder S

    更新日期：2008-03-01 00:00:00

  • Vaccinia keratouveitis manifesting as a masquerade syndrome.

    abstract：:A patient who used contact lenses and had a history of blunt trauma developed vaccinia keratouveitis after accidental ocular autoinoculation from a recent vaccination site. Corneal and conjunctival cultures were taken for bacteria, fungi, Acanthamoeba, and viruses. Viral-like cytopathic effects became evident in tissu...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)70008-x

    authors： Lee SF,Buller R,Chansue E,Hanika WC,Brunt EM,Aquino T,Storch GA,Pepose JS

    更新日期：1994-04-15 00:00:00

  • Spontaneous dislocation of fluocinolone acetonide implant pellets from their suture struts.

    abstract：PURPOSE:To characterize spontaneous dislocation of the fluocinolone acetonide sustained release implant (Retisert; Bausch & Lomb) drug pellet from its strut. DESIGN:Retrospective, observational case series. METHODS:The medical records of 224 patients in whom 407 fluocinolone acetonide implants were placed by either o...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajo.2015.01.031

    authors： Itty S,Callanan D,Jones R,Pecen P,Martel J,Jaffe GJ

    更新日期：2015-05-01 00:00:00