Abstract:
PURPOSE:To objectively quantify choroidal thickness and choroidal volume using fully automated choroidal segmentation software applied to images obtained from enhanced depth imaging spectral-domain optical coherence tomography (EDI SD OCT) in a population-based study; and evaluate the ocular and systemic determinants of choroidal thickness and choroidal volume. DESIGN:Prospective cross-sectional study. METHODS:Participants ranging in age from 45 to 85 years were recruited from the Singapore Malay Eye Study-2 (SiMES-2), a follow-up population-based study. All participants (n = 540) underwent a detailed ophthalmic examination, including EDI SD OCT for measurements of thickness and volume of the choroid. RESULTS:The intrasession repeatability of choroidal thickness at 5 measured horizontal locations and macular choroidal volume using automated choroidal segmentation software was excellent (intraclass correlation coefficient, 0.97-0.99). Choroid was significantly thicker under the fovea (242.28 ± 97.58 μm), followed by 3 mm temporal (207.65 ± 80.98 μm), and was thinnest at 3 mm nasal (142.44 ± 79.19 μm) location. The mean choroidal volume at central macular region (within a circle of 1 mm diameter) was 0.185 ± 0.69 mm(3). Among the range of ocular and systemic factors studied, age, sex, and axial length were the only significant predictors of choroidal thickness and choroidal volume (all P < .05). CONCLUSIONS:Using a new automated choroidal segmentation software, we provide fast, reliable, and objective measurements of choroidal thickness and volume in a population-based sample. Male sex, younger age, and shorter axial length are the factors independently associated with thicker choroid and larger choroidal volume. These factors should be taken into consideration when interpreting EDI SD OCT-based choroidal thickness measurements in clinics.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Gupta P,Jing T,Marziliano P,Cheung CY,Baskaran M,Lamoureux EL,Wong TY,Cheung CM,Cheng CYdoi
10.1016/j.ajo.2014.10.034subject
Has Abstractpub_date
2015-02-01 00:00:00pages
293-301.e3issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(14)00699-0journal_volume
159pub_type
杂志文章abstract:PURPOSE:To report a group of patients with symptoms of pain, strabismus, sensation of orbital fullness, and presence of a subconjunctival mass many years after successful scleral buckling surgery using hydrogel explants. DESIGN:We present an interventional consecutive case series of patients who underwent scleral buck...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00873-0
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma. DESIGN:Analytical nonexperimental study of published peer-reviewed data. METHODS:Literature search and analysis of pertinent articles published between January 1, 1980 and J...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ajo.2009.01.023
更新日期:2009-07-01 00:00:00
abstract::In an 8-year-old girl with asymptomatic proptosis, computed tomographic scans showed a large medial orbital mass that contoured the globe anteriorly, bowed the optic nerve laterally, and extended posteriorly to the orbital apex. T1-weighted coronal magnetic resonance images showed the mass to be a diffusely enlarged m...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77878-x
更新日期:1990-11-15 00:00:00
abstract::A 1:2000 solution of a radiomimetic alkylating agent-triethylene thiophosphoramide (thio-tepa, Lederle Laboratories) with a proven inhibitory action on proliferating vascular endothelium, was used topically as an adjunct to pterygium surgery in an attempt to decrease the incidence of recurrence. A bare-sclera techniqu...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(66)90931-7
更新日期:1966-05-01 00:00:00
abstract:PURPOSE:To describe a modified laser technique for identification of bullous retinoschisis. DESIGN:Retrospective interventional case series collected over 10 years. METHODS:Forty-one eyes with presumed bullous retinoschisis and breaks in the inner layers underwent a low-energy argon green laser application at the sam...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00485-9
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To describe the effect of internal limiting membrane peeling in chronic recalcitrant pseudophakic cystoid macular edema. DESIGN:Two interventional case reports. METHODS:Two consecutive patients with chronic pseudophakic cystoid macular edema of 11-22 months duration, after uncomplicated cataract surgery, unre...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01402-7
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:To analyze the features of retinal detachment (RD) occurring after cataract surgery performed by Kelman phacoemulsification (KPE) and to identify any potential correlations between KPE intraoperative complications and the features of RD (incidence apart) as well as the final visual outcome. DESIGN:Intervention...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01347-8
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To report the outcome of balloon catheter dilation of the lacrimal duct for treatment of children with persistent nasolacrimal duct obstruction after previous surgery. DESIGN:Interventional case series. METHODS:Thirty-two consecutive children with a history of persistent nasolacrimal duct obstruction followin...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01403-9
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To evaluate whether cost, insurance prior authorization, pregnancy considerations, and subspecialty practice lead to changes in therapeutic decisions among uveitis and retina specialists in the treatment of intermediate and posterior uveitis. DESIGN:Prospective cross-sectional study. METHODS:A total of 934 uv...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.10.015
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae-induced rash and mucositis (MIRM) and propose a treatment algorithm. DESIGN:Retrospective, interventional case series. METHODS:Retrospective chart review of all MIRM patients examined by the department of ophthalmology at a ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.06.010
更新日期:2020-11-01 00:00:00
abstract::A simple makeshift retinoscopy rack consists of various trial lenses placed into the slots of a nonfrosted, 35-mm slide viewing sheet. It is useful in determining the patient's refractive error at the bedside and in the operating room. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(80)90242-1
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU). DESIGN:Retrospective, interventional, consecutive case series. METHODS:A consecutive series of eyes undergoing Ahmed valve imp...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.04.008
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of surgeries for macular holes using trypan blue to facilitate delamination of the internal limiting membrane. DESIGN:A retrospective series of 18 patients. METHOD:All patients underwent a three-port pars plana vitrectomy with internal limiting membrane delamination using trypan blue 0...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)02239-0
更新日期:2003-06-01 00:00:00
abstract::In the elderly patient with a massive vitreous hemorrhage in one eye and senile macular choroidal degenerative changes in the fellow eye, a hemorrhagic disciform detachment causing this massive vitreous hemorrhage must be considered in the differential diagnosis. Ultrasonography selectively combined with radioactive p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75023-8
更新日期:1980-10-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of ophthalmic formulations of bimatoprost 0.01% and 0.0125% compared with bimatoprost 0.03%. DESIGN:Prospective, randomized, double-masked, multicenter clinical trial. METHODS:Patients with glaucoma or ocular hypertension were randomized ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2009.12.003
更新日期:2010-04-01 00:00:00
abstract::We managed three cases of congenital iris stromal cysts and compared them with 22 cases in the published reports to delineate the clinical features of this condition and determine the best treatment. Our first patient, a 5-month-old girl, had injection of a cyst with trichloroacetic acid, but developed a cataract and ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0002-9394(14)71291-7
更新日期:1993-08-15 00:00:00
abstract:PURPOSE:To evaluate the outcomes of epiretinal membrane (ERM) surgery in highly myopic eyes without traction maculopathy, and to compare them with those from non-highly myopic eyes. DESIGN:Retrospective nested case-control study from a cohort of 509 consecutive patients (509 eyes) who underwent pars plana vitrectomy w...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.03.035
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To assess the efficacy and safety of systemic propranolol for infantile capillary hemangiomas of the eyelid. DESIGN:Prospective, interventional cases series. METHODS:All patients with eyelid infantile capillary hemangiomas at risk of developing amblyopia seen between January 2009 and January 2012 at the Unive...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.06.021
更新日期:2013-01-01 00:00:00
abstract::We compared quantitative histologic counts of ten subjects with vernal conjunctivitis to counts of 15 subjects with contact lens-associated giant papillary conjunctivitis and to counts of 15 normal subjects. Both vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis subjects had abnormalitie...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90247-2
更新日期:1979-04-01 00:00:00
abstract:PURPOSE:To determine provider compliance with hydroxychloroquine screening following the revised recommendations published in 2011 by the American Academy of Ophthalmology. DESIGN:Evaluation of adherence to a screening protocol. METHODS:Subjects were identified with hydroxychloroquine as a medication by electronic qu...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.06.009
更新日期:2015-09-01 00:00:00
abstract::Graft edema developed after removal of continuous monofilament sutures in six eyes of six patients in whom no wound dehiscence occurred. All sutures were removed at least one year after penetrating keratoplasty, and graft edema was noted one day after suture removal. In all cases, partial or total resolution of graft ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90461-6
更新日期:1979-08-01 00:00:00
abstract::To facilitate placing pars plana infusion ports, we modified the shaft of a piece of 10-gauge tubing or of a hypodermic needle by removing the beveled tip and Luer hub, passing the tubing through the inserter sleeve, and then reattaching the tubing to the Luer hub. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(78)90251-9
更新日期:1978-09-01 00:00:00
abstract:PURPOSE:To describe rifabutin-associated uveitis with opacities in the inferior and posterior vitreous in three patients with acquired immunodeficiency syndrome. METHOD:Case reports of the three patients are presented. RESULTS:The patients, who were being treated with rifabutin and fluconazole, developed anterior and...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72124-5
更新日期:1996-10-01 00:00:00
abstract::We used contact irradiation with iodine 125 seeds to treat a large, exulcerative, nodular, amelanotic malignant eyelid melanoma with metastasis to the regional lymph nodes in an 80-year-old man. The procedure was similar to iodine 125 plaque irradiation of malignant choroidal melanoma; special equipment, however, was ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76936-3
更新日期:1990-07-15 00:00:00
abstract:PURPOSE:To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry. DESIGN:Prospective case-control study. METHODS:Central precorneal tear film thickness was measured noninvasively using an interference thin-film thickness measurement device (Quore MSPA1...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.07.019
更新日期:2011-01-01 00:00:00
abstract::We studied the clinical and histopathologic ocular findings in four related males with a newly recognized syndrome consisting of microphthalmos, microencephaly, mental retardation, agenesis of the corpus callosum, hypospadius, and cryptorchidism with X-linked recessive inheritance. The ocular abnormalities include mic...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75866-0
更新日期:1985-01-15 00:00:00
abstract:PURPOSE:To report a case of progressive axial myopia associated with traumatic glaucoma in a juvenile patient with no systemic disease. DESIGN:Interventional case report. METHODS:In a 15-year-old male, serial ocular examinations, including manifest refraction, tonometry, and axial eye length measurement, were perform...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01330-2
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To assess the relationship between iris color and intraocular pressure (IOP). DESIGN:Population-based, cross-sectional study. METHODS:The Blue Mountains Eye Study examined 3,654 largely Caucasian participants, aged 49 to 97 years, from 1992 to 1994. Information was collected about glaucoma risk factors, and G...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01967-0
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:To determine a possible correlation specifically between hemoglobin A1C (HgbA1C) levels and the presence and severity of retinopathy during diabetic eye screening. DESIGN:Retrospective medical record review of all new patients examined in a Veteran Affairs Medical Center (VAMC) diabetic screening clinic in 200...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.04.008
更新日期:2007-09-01 00:00:00
abstract::I fitted nine aphakic patients who had undergone penetrating keratoplasty with extended-wear hydrophilic contact lenses (55% to 80% water content). All patients had edematous host corneas. Eight of nine developed vascularization of the graft after two to 30 weeks of contact lens wear. One patient developed a presumed ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74912-8
更新日期:1980-09-01 00:00:00