Vaccinia keratouveitis manifesting as a masquerade syndrome.

Abstract:

:A patient who used contact lenses and had a history of blunt trauma developed vaccinia keratouveitis after accidental ocular autoinoculation from a recent vaccination site. Corneal and conjunctival cultures were taken for bacteria, fungi, Acanthamoeba, and viruses. Viral-like cytopathic effects became evident in tissue culture within three days. Immunofluorescence studies were negative for varicella-zoster virus, herpes simplex virus, adenovirus, measles, mumps, parainfluenza, and influenza. Pox viral particles were identified in the infected tissue cultures by electron microscopy. The Hind III restriction endonuclease profile of the viral DNA isolate was similar to the Lister strain of vaccinia virus. Ocular vaccinia may manifest as a masquerade syndrome and may mimic signs of herpes simplex virus, varicella-zoster virus, and Acanthamoeba infection. Although vaccination with vaccinia is currently limited to a few populations throughout the world, vaccinia must still be considered in the differential diagnosis of infectious keratouveitis.

journal_name

Am J Ophthalmol

authors

Lee SF,Buller R,Chansue E,Hanika WC,Brunt EM,Aquino T,Storch GA,Pepose JS

doi

10.1016/s0002-9394(14)70008-x

subject

Has Abstract

pub_date

1994-04-15 00:00:00

pages

480-7

issue

4

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)70008-X

journal_volume

117

pub_type

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