Association of HLA-DRw2 antigen with presumed ocular histoplasmosis.

Abstract:

:Patients with presumed ocular histoplasmosis syndrome were typed for HLA-A, B, C, and DR antigens. It was found that 21 (81%) of 26 of the presumed ocular histoplasmosis syndrome patients with disciform macular scarring and 8 (62%) of 13 of the presumed ocular histoplasmosis syndrome patients with peripheral atrophic spots typed for DRw2. The frequency of DRw2 in normal blood donors was 28%. The 77% (20 patients) frequency of B7 in 26 of the presumed ocular histoplasmosis syndrome patients with disciform scarring was also significantly higher than the 25.6% frequency of B7 in normal blood donors. In contrast, no significant differences were observed in any HLA antigen frequency for patients with disciform scarring of degenerative choroidopathy. These observations suggest that an association with DRw2 may play a role in the pathogenesis of the eye lesions after Histoplasma capsulatum infection.

journal_name

Am J Ophthalmol

authors

Meredith TA,Smith RE,Duquesnoy RJ

doi

10.1016/0002-9394(80)90232-9

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

70-6

issue

1

eissn

0002-9394

issn

1879-1891

pii

0002-9394(80)90232-9

journal_volume

89

pub_type

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