当前位置： SCI文献检索 > AMERICAN JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > Autoimmune retinopathy.

Autoimmune retinopathy.

Abstract：

PURPOSE:To provide a detailed review of current clinical guidelines for the diagnosis, work-up and treatment of autoimmune retinopathy and to preview briefly possible future therapies. DESIGN:Perspective based on literature review and clinical expertise. METHODS:Interpretation of current literature, relying on the authors' clinical experience. RESULTS:Autoimmune retinopathy is a rare immunologic disease characterized by the presence of circulating antiretinal antibodies along with electroretinographic and visual field abnormalities. An ophthalmic examination can be normal or show minimal findings. The diagnosis of autoimmune retinopathy is made difficult by diagnostic criteria that are both limited and nonstandardized. Currently, the diagnosis is made based on the demonstration of serum antiretinal antibodies and the presence of clinical manifestations (including abnormal electroretinographic findings). The mere presence of these antibodies is not diagnostic. Lack of an accepted gold standard for antiretinal antibodies detection and poor interlaboratory concordance make the diagnosis challenging. There are anecdotal reports of immunosuppressive therapy in autoimmune retinopathy; however, the response to treatment is variable, with more favorable results achieved in paraneoplastic retinopathy, particularly cancer-associated retinopathy, with a combination of chemotherapy and immunosuppression. Whether an earlier attempt to treat nonparaneoplastic autoimmune retinopathy would be more beneficial is unknown. Early treatment attempts are limited by lack of sensitive and specific assays and definitive clinical criteria. CONCLUSIONS:Little is known about the clinical course, prognosis and treatment of autoimmune retinopathy. Additional studies should examine the specificity and pathogenicity of antiretinal antibodies and screen for biomarkers, and they should be conducted concurrently with studies seeking to identify appropriate treatment.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Grange L,Dalal M,Nussenblatt RB,Sen HN

doi

10.1016/j.ajo.2013.09.019

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

266-272.e1

issue

2

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(13)00641-7

journal_volume

157

pub_type

杂志文章,评审

相关文献

AMERICAN JOURNAL OF OPHTHALMOLOGY文献大全
  • Risk factors for blindness in children with primary congenital glaucoma - follow-up of a registry cohort.

    abstract：PURPOSE:The aim of this study was to evaluate the baseline features associated with blindness in a cohort of children with primary congenital glaucoma (PCG) from a hospital registry. METHODS:Setting: Observational cohort study DESIGN: Retrospective clinical cohort study STUDY POPULATION: The registry included all chil...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2020.12.014

    authors： Alshigari R,Freidi A,Souru C,Edward DP,Malik R

    更新日期：2020-12-21 00:00:00

  • Variable genotype of Leber's hereditary optic neuropathy patients.

    abstract：:Leber's hereditary optic neuropathy is caused by a single nucleotide change in the mitochondrial deoxyribonucleic acid (mtDNA). Each cell contains thousands of mitochondrial DNA molecules. We demonstrated that in certain isolated instances, the proband and close maternal lineage relatives can have mixtures of mutant a...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)72429-8

    authors： Lott MT,Voljavec AS,Wallace DC

    更新日期：1990-06-15 00:00:00

  • Treatment of microsporidial keratoconjunctivitis with repeated corneal swabbing.

    abstract：PURPOSE:To report the effect of repeated corneal swabbing in patients with microsporidial keratoconjunctivitis. DESIGN:Retrospective noncomparative case series. METHODS:Sixteen eyes of 14 healthy patients with microsporidial keratoconjunctivitis were diagnosed based on the detection of microsporidia in corneal scrapi...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2012.06.002

    authors： Fan NW,Lin PY,Chen TL,Chen CP,Lee SM

    更新日期：2012-12-01 00:00:00

  • Rod and cone opsin mislocalization in an autopsy eye from a carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the RPGR gene.

    abstract：PURPOSE:We investigated whether opsin mislocalization occurs in photoreceptors in a female carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the retinitis pigmentosa GTPase regulator gene (RPGR). DESIGN:Histologic findings in autopsy eyes from a carrier were compared with those from a normal female...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2006.03.061

    authors： Adamian M,Pawlyk BS,Hong DH,Berson EL

    更新日期：2006-09-01 00:00:00

  • Treatment outcomes in the tube versus trabeculectomy study after one year of follow-up.

    abstract：PURPOSE:To report one-year results of the Tube Versus Trabeculectomy (TVT) Study. DESIGN:Multicenter randomized clinical trial. METHODS: SETTING:17 Clinical Centers. STUDY POPULATION:Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and unco...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ajo.2006.07.020

    authors： Gedde SJ,Schiffman JC,Feuer WJ,Herndon LW,Brandt JD,Budenz DL

    更新日期：2007-01-01 00:00:00

  • Ptosis secondary to amyloidosis of the tarsal conjunctiva and tarsus.

    abstract：PURPOSE:To report a case of chronic unilateral ptosis in a 63-year-old, otherwise healthy woman with visual restriction. METHODS:We performed a biopsy on an enlarged tarsal plate that we believed had caused ptosis. A levator aponeurotic advancement was performed subsequently. RESULTS:Histologic and ultrastructural ex...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)71145-6

    authors： Hill VE,Brownstein S,Jordan DR

    更新日期：1997-06-01 00:00:00

  • A method to confirm correct orientation of descemet membrane during descemet membrane endothelial keratoplasty.

    abstract：PURPOSE:Descemet membrane endothelial keratoplasty is a new technique for the replacement of diseased corneal endothelium with healthy donor endothelium. During this procedure, manipulation of the donor endothelium-Descemet membrane layer within the recipient anterior chamber can be associated with loss of the correct ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2010.01.005

    authors： Bachmann BO,Laaser K,Cursiefen C,Kruse FE

    更新日期：2010-06-01 00:00:00

  • Sneezing reflex associated with intravenous sedation and periocular anesthetic injection.

    abstract：PURPOSE:To assess and compare the frequency of reflex sneezing occurring during periocular anesthetic injections with and without intravenous sedation. DESIGN:Retrospective, comparative case series. METHODS:Seven hundred and twenty-two patients undergoing oculoplastic surgical procedures were included in this study. ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2008.02.013

    authors： Ahn ES,Mills DM,Meyer DR,Stasior GO

    更新日期：2008-07-01 00:00:00

  • Leber's miliary aneurysms associated with telangiectasia of the nasal mucosa.

    abstract：:A 20-year-old woman, treated with cryopexy and xenon- and argon-laser photocoagulation for Leber's miliary aneurysms in her right eye, suffered from repeated epistaxis. She underwent an endoscopy that showed an unusual number of telangiectatic veins. Laboratory results and routine physical and neurologic examinations ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(75)90456-0

    authors： Gärtner J,Draf W

    更新日期：1975-01-01 00:00:00

  • Nodular adenomatosis of iris pigment epithelium.

    abstract：:A 62-year-old man manifested multiple nodular growths in his left iris and unilateral glaucoma. Detailed clinical and pathologic studies showed that these lesions were adenomas derived from the spurs of Fuchs, Michel, and Grunert in the iris pigment epithelium. We suggest terming this newly described entity nodular ad...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)74989-x

    authors： Tso MO,Goldberg MF,Sugar J

    更新日期：1985-07-15 00:00:00

  • Acute posterior multifocal placoid pigment epitheliopathy associated with an adenovirus type 5 infection.

    abstract：:A 19-year-old black man with acute posterior multifocal placoid pigment epitheliopathy had concurrent positive viral cultures and rising antibodies to adenovirus type 5. This finding, considered together with earlier reports of viral-like syndromes accompanying the disease, supports the implication of a respiratory vi...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(75)90328-1

    authors： Azar P Jr,Gohd RS,Waltman D,Gitter KA

    更新日期：1975-12-01 00:00:00

  • Optical coherence tomography in uveitis patients.

    abstract：PURPOSE:To evaluate optical coherence tomography in allergy-prone uveitis patients. METHODS:Thirty-four patients (43 eyes) with posterior uveitis (31 eyes) and intermediate uveitis (12 eyes) were evaluated by fluorescein angiography, indocyanine green angiography, and optical coherence tomography. Follow-up examinatio...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(00)00586-9

    authors： Hassenstein A,Bialasiewicz AA,Richard G

    更新日期：2000-11-01 00:00:00

  • A simplified technique of orbital decompression for severe retrobulbar hemorrhage.

    abstract：:Severe retrobulbar hemorrhage may occur as a complication of a retrobulbar injection or from blunt or sharp injury to the orbit during an orbital or periorbital operation. When the patient with a severe retrobulbar hemorrhage does not respond to intermittent ocular massage, or paracentesis, or a lateral canthotomy, pr...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)71740-4

    authors： Liu D

    更新日期：1993-07-15 00:00:00

  • Local ocular hypotensive effect of topically applied acetazolamide.

    abstract：:Acetazolamide's usefulness in the treatment of the glaucomas is limited by the systemic side effects that often accompany its oral administration, and topical administration was initially thought to have no effect upon the intraocular pressures of human and rabbit eyes. Recent studies, however, have shown the usefulne...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(84)90190-9

    authors： Flach AJ,Peterson JS,Seligmann KA

    更新日期：1984-07-15 00:00:00

  • Concomitant Simple Limbal Epithelial Transplantation After Surgical Excision of Ocular Surface Squamous Neoplasia.

    abstract：PURPOSE:To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide excisional biopsy with and without primary simple limbal epithelial transplantation (p-SLET). DESIGN:Nonrandomized clinical study with historical controls. METHODS:setting: Single-institutional study. PATIENTS:Eight p...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2016.10.021

    authors： Kaliki S,Mohammad FA,Tahiliani P,Sangwan VS

    更新日期：2017-02-01 00:00:00

  • Ocular abnormalities in the Freeman-Sheldon syndrome.

    abstract：:Ocular abnormalities were present in five of 11 patients with Freeman-Sheldon syndrome. The predominant ocular findings were strabismus and blepharoptosis. Stiffness of the extraocular muscles, demonstrated in three patients by forced duction testing, made surgery difficult. Two patients underwent frontalis muscle sli...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(86)90009-7

    authors： O'Keefe M,Crawford JS,Young JD,Macrae WG

    更新日期：1986-09-15 00:00:00

  • Clinical and histologic effects of extreme intraocular hypothermia.

    abstract：:Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. R...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)74615-x

    authors： Zilis JD,Chandler D,Machemer R

    更新日期：1990-04-15 00:00:00

  • Topical ketoconazole for fungal keratitis.

    abstract：:Six patients (five men and one woman, 19 to 57 years old) with laboratory-proven fungal corneal infections were successfully treated with topical ketoconazole, a synthetic imidazole derivative. No signs of progression of the corneal infection were seen after the antifungal therapy was initiated. The clinical signs of ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(85)90795-0

    authors： Torres MA,Mohamed J,Cavazos-Adame H,Martinez LA

    更新日期：1985-08-15 00:00:00

  • Experimental transplantation of human retinal pigment epithelial cells on collagen substrates.

    abstract：:We studied the use of human retinal pigment epithelial cells cultured on a collagen support as a potential transplantation therapy to replace diseased or damaged retinal pigment epithelium. Using a transvitreal approach, we transplanted human retinal pigment epithelial cells attached to either a sheet of noncross-link...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)73079-x

    authors： Bhatt NS,Newsome DA,Fenech T,Hessburg TP,Diamond JG,Miceli MV,Kratz KE,Oliver PD

    更新日期：1994-02-15 00:00:00

  • Monitoring compliance with pilocarpine therapy.

    abstract：:I used a recording medication monitor to obtain objective information on self-medication by date and hour from a group of 82 patients using pilocarpine three times daily to prevent visual loss from glaucoma. Doses meant to be taken during the day were missed more than twice as often as morning or evening doses. Of the...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)74670-7

    authors： Norell SE

    更新日期：1981-11-01 00:00:00

  • Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention.

    abstract：PURPOSE:To describe the immune alterations associated with age-related macular degeneration (AMD); and, based on these findings, to offer an approach to possibly prevent the expression of late disease. DESIGN:Perspective. METHODS:Review of the existing literature dealing with epidemiology, models, and immunologic fin...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajo.2014.03.014

    authors： Nussenblatt RB,Lee RW,Chew E,Wei L,Liu B,Sen HN,Dick AD,Ferris FL

    更新日期：2014-07-01 00:00:00

  • Optical coherence tomography enhanced depth imaging of choroidal tumors.

    abstract：PURPOSE:To describe the spectral-domain optical coherence tomography (SD-OCT) features of choroidal tumors imaged using enhanced depth imaging (EDI) technique. DESIGN:Prospective observational case series. METHODS:One tumor each from 23 eyes of 23 patients was included. All the patients underwent clinical fundus phot...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2010.09.028

    authors： Torres VL,Brugnoni N,Kaiser PK,Singh AD

    更新日期：2011-04-01 00:00:00

  • Increase of the short-term fluctuation of the differential light threshold around a physiologic scotoma.

    abstract：:Because determination of the differential light threshold of a visual field is a psychophysiologic test, the results can be subject to variation. This scatter measured during a single examination is usually called the short-term fluctuation. Increases of the short-term fluctuation were thought to occur primarily in ab...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(89)90667-3

    authors： Haefliger IO,Flammer J

    更新日期：1989-04-15 00:00:00

  • Comparison of visual function after foveal translocation with 360 degrees retinotomy and with scleral shortening in a patient with bilateral myopic neovascular maculopathy.

    abstract：PURPOSE:To compare the visual outcome after foveal translocation by scleral shortening and that after 360 degrees retinotomy with extraocular muscle surgery in a patient with bilateral myopic neovascular maculopathy. METHODS:Case report. RESULTS:A 52-year-old woman with bilateral myopic neovascular maculopathy underw...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(00)00582-1

    authors： Fujikado T,Ohji M,Hosohata J,Hayashi A,Oda K,Tano Y

    更新日期：2000-10-01 00:00:00

  • Vaccinia keratouveitis manifesting as a masquerade syndrome.

    abstract：:A patient who used contact lenses and had a history of blunt trauma developed vaccinia keratouveitis after accidental ocular autoinoculation from a recent vaccination site. Corneal and conjunctival cultures were taken for bacteria, fungi, Acanthamoeba, and viruses. Viral-like cytopathic effects became evident in tissu...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)70008-x

    authors： Lee SF,Buller R,Chansue E,Hanika WC,Brunt EM,Aquino T,Storch GA,Pepose JS

    更新日期：1994-04-15 00:00:00

  • The effect of internal limiting membrane peeling on chronic recalcitrant pseudophakic cystoid macular edema: a report of two cases.

    abstract：PURPOSE:To describe the effect of internal limiting membrane peeling in chronic recalcitrant pseudophakic cystoid macular edema. DESIGN:Two interventional case reports. METHODS:Two consecutive patients with chronic pseudophakic cystoid macular edema of 11-22 months duration, after uncomplicated cataract surgery, unre...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(01)01402-7

    authors： Peyman GA,Canakis C,Livir-Rallatos C,Conway MD

    更新日期：2002-04-01 00:00:00

  • Ocular screening in severe acute respiratory syndrome.

    abstract：PURPOSE:To investigate the ocular manifestations of patients with severe acute respiratory syndrome (SARS) and to monitor the possible ocular complications arising from the treatment regimen with high-dose systemic corticosteroid drugs. DESIGN:Prospective, observational cohort case series. METHODS:Ninety eyes from 45...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2003.09.060

    authors： Yuen KS,Chan WM,Fan DS,Chong KK,Sung JJ,Lam DS

    更新日期：2004-04-01 00:00:00

  • Spontaneous luxation of encapsulated intraocular lens onto the retina after a triple procedure of vitrectomy, phacoemulsification, and intraocular lens implantation.

    abstract：PURPOSE:To report the clinical and histological findings of a luxated intraocular lens (IOL) in the capsular bag. METHODS:Review of a case. RESULTS:Twenty-three months after a triple procedure of vitrectomy, phacoemulsification, and IOL implantation for diabetic vitreous hemorrhage and cataract, the encapsulated IOL ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(00)00630-9

    authors： Yasuda A,Ohkoshi K,Orihara Y,Kusano Y,Sakuma A,Yamaguchi T

    更新日期：2000-12-01 00:00:00

  • Incomplete congenital stationary night blindness associated with symmetrical retinal atrophy.

    abstract：PURPOSE:To describe a Japanese patient with incomplete congenital stationary night blindness (iCSNB) with atypical retinal atrophy and kinetic visual field defects. METHODS:An ophthalmologic examination was performed, and the CACNA1F gene was analyzed by direct genomic sequencing. RESULTS:The patient had a hemizygous...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(02)01541-6

    authors： Nakamura M,Ito S,Terasaki H,Miyake Y

    更新日期：2002-09-01 00:00:00

  • Idiopathic inflammatory perioptic neuritis simulating optic nerve sheath meningioma.

    abstract：:Between 1976 and 1982, we examined 13 patients with clinical and radiographic findings consistent with optic nerve sheath meningioma. All patients had visual loss, evidence of optic nerve dysfunction, centrocecal visual field defects, and echographic and computed tomographic evidence of optic nerve or sheath enlargeme...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(85)90506-9

    authors： Dutton JJ,Anderson RL

    更新日期：1985-09-15 00:00:00