Autoimmune retinopathy.


PURPOSE:To provide a detailed review of current clinical guidelines for the diagnosis, work-up and treatment of autoimmune retinopathy and to preview briefly possible future therapies. DESIGN:Perspective based on literature review and clinical expertise. METHODS:Interpretation of current literature, relying on the authors' clinical experience. RESULTS:Autoimmune retinopathy is a rare immunologic disease characterized by the presence of circulating antiretinal antibodies along with electroretinographic and visual field abnormalities. An ophthalmic examination can be normal or show minimal findings. The diagnosis of autoimmune retinopathy is made difficult by diagnostic criteria that are both limited and nonstandardized. Currently, the diagnosis is made based on the demonstration of serum antiretinal antibodies and the presence of clinical manifestations (including abnormal electroretinographic findings). The mere presence of these antibodies is not diagnostic. Lack of an accepted gold standard for antiretinal antibodies detection and poor interlaboratory concordance make the diagnosis challenging. There are anecdotal reports of immunosuppressive therapy in autoimmune retinopathy; however, the response to treatment is variable, with more favorable results achieved in paraneoplastic retinopathy, particularly cancer-associated retinopathy, with a combination of chemotherapy and immunosuppression. Whether an earlier attempt to treat nonparaneoplastic autoimmune retinopathy would be more beneficial is unknown. Early treatment attempts are limited by lack of sensitive and specific assays and definitive clinical criteria. CONCLUSIONS:Little is known about the clinical course, prognosis and treatment of autoimmune retinopathy. Additional studies should examine the specificity and pathogenicity of antiretinal antibodies and screen for biomarkers, and they should be conducted concurrently with studies seeking to identify appropriate treatment.


Am J Ophthalmol


Grange L,Dalal M,Nussenblatt RB,Sen HN




Has Abstract


2014-02-01 00:00:00














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    abstract:PURPOSE:To report a case of porphyria cutanea tarda presenting as cicatricial conjunctivitis. DESIGN:Observational study. METHODS:A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection. RESULTS:Four ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Park AJ,Webster GF,Penne RB,Raber IM

    更新日期:2002-10-01 00:00:00

  • Chorioretinal involvement in primary systemic nonfamilial amyloidosis.

    abstract:PURPOSE:To report a case of primary systemic nonfamilial amyloidosis studied by fluorescein angiography and indocyanine green angiography. METHODS:Case report. A 59-year-old woman with primary systemic nonfamilial amyloidosis presented bilateral diffuse deep hemorrhages and pigmentary mottling at the posterior pole. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Pece A,Yannuzzi L,Sannace C,Scassellati Sforzolini B,Brancato R

    更新日期:2000-08-01 00:00:00

  • Incidence of outer foveal defect after macular hole surgery.

    abstract:PURPOSE:To determine the incidence of outer foveal defects after macular hole surgery and to evaluate the relationship between the defect and visual outcome. DESIGN:Retrospective, observational case series. METHODS:A retrospective analysis was performed on 50 eyes from 50 patients who underwent macular hole surgery w...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Kawano H,Uemura A,Sakamoto T

    更新日期:2011-02-01 00:00:00

  • Malignant melanoma of the choroid associated with spontaneous expulsive choroidal hemorrhage.

    abstract::A 79-year-old man initially had a perforated corneal ulcer of his blind right eye. The next day a spontaneous expulsive choroidal hemorrhage occurred just before scheduled enucleation. Histopathologic examination of the enucleated eye revealed a severe necrosis of several posterior ciliary arteries in the expulsive ch...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Perry HD,Hsieh RC,Evans RM

    更新日期:1977-08-01 00:00:00

  • Lyophilized Autologous Serum Eyedrops: Experimental and Comparative Study.

    abstract:PURPOSE:To analyze the biological stability of autologous serum eyedrops after lyophilization. DESIGN:Prospective, comparative experimental study. METHODS:This was a comparative study with serum obtained from 12 healthy volunteers. The concentrations of different epitheliotropic factors (eg, transforming growth facto...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: López-García JS,García-Lozano I,Rivas L,Viso-Garrote M,Raposo R,Méndez MT

    更新日期:2020-05-01 00:00:00

  • Motivations and Decision Making Processes of Men With X-linked Retinoschisis Considering Participation in an Ocular Gene Therapy Trial.

    abstract:PURPOSE:To describe the motivations, expectations, and other factors men with X-linked retinoschisis (XLRS) consider when making decisions to participate in an early phase ocular gene therapy clinical trial. DESIGN:Qualitative interview study. METHODS:Men with XLRS who were considering participation in a phase I/IIa ...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章


    authors: Turriff A,Blain D,Similuk M,Biesecker B,Wiley H,Cukras C,Sieving PA

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  • Free conjunctival patch for repair of persistent late bleb leak.

    abstract::In four patients, we repaired leaking blebs by using a new technique of excision of the cystic bleb and replacement with free conjunctival autograft. The leaks were repaired successfully, and bleb function was maintained in all four patients. This technique should be considered when surgical management of a leaking bl...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Wilson MR,Kotas-Neumann R

    更新日期:1994-05-15 00:00:00

  • Osteogenic sarcoma of the humerus after cobalt plaque treatment for retinoblastoma.

    abstract::A 13-year-old boy developed an osteogenic sarcoma of the right humerus ten years after treatment for bilateral retinoblastoma. The bilateral retinoblastoma has been managed with enucleation of one eye and successful treatment of the solitary tumor in the other eye with a single application of a local 10-mm round cobal...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


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    更新日期:1980-09-01 00:00:00

  • Early outcomes of descemet stripping automated endothelial keratoplasty in pseudophakic eyes with anterior chamber intraocular lenses.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Gupta PK,Bordelon A,Vroman DT,Afshari NA,Kim T

    更新日期:2011-01-01 00:00:00

  • Longitudinal Changes of Fixation Location and Stability Within 12 Months in Stargardt Disease: ProgStar Report No. 12.

    abstract:PURPOSE:To investigate the natural history of Stargardt disease (STGD1) using fixation location and fixation stability. DESIGN:Multicenter, international, prospective cohort study. METHODS:Fixation testing was performed using the Nidek MP-1 microperimeter as part of the prospective, multicenter, natural history study...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究


    authors: Schönbach EM,Strauss RW,Kong X,Muñoz B,Ibrahim MA,Sunness JS,Birch DG,Hahn GA,Nasser F,Zrenner E,Sadda SR,West SK,Scholl HPN,ProgStar Study Group.

    更新日期:2018-09-01 00:00:00

  • Assessment of axonal degeneration along the human visual pathway using diffusion trace analysis.

    abstract:PURPOSE:The effectiveness of diffusion trace value analysis for non-invasive assessment of retinal ganglion cell (RGC) axonal degeneration at multiple anatomic levels along the human visual pathway under clinical setting was evaluated. DESIGN:Imaging study. METHODS:Ten patients with unilateral chronic optic neuropath...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ueki S,Fujii Y,Matsuzawa H,Takagi M,Abe H,Kwee IL,Nakada T

    更新日期:2006-10-01 00:00:00

  • Fibrous histiocytoma of the corneoscleral limbus.

    abstract::A 21-year-old white woman had an apparently benign fibrous histiocytoma at the corneoscleral limbus. By histopathologic and ultrastructural studies, the tumor consisted of lipid-containing histiocytes and fibrocytic cells arranged in a storiform configuration with a collagenous interstitium. After an excision, the les...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Faludi JE,Kenyon K,Green WR

    更新日期:1975-10-01 00:00:00

  • Glaucoma in patients with ocular chemical burns.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Lin MP,Ekşioğlu Ü,Mudumbai RC,Slabaugh MA,Chen PP

    更新日期:2012-09-01 00:00:00

  • Occult anterior-chamber metallic fragment post-phacoemulsification masquerading as chronic recalcitrant postoperative inflammation.

    abstract:PURPOSE:To report a case of an occult, metallic, anterior-chamber intraocular foreign body after uneventful phacoemulsification that was masquerading as chronic recalcitrant postoperative inflammation. DESIGN:Interventional case report. METHODS:A 73-year-old patient was referred to us for recalcitrant anterior-chambe...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Stangos AN,Pournaras CJ,Petropoulos IK

    更新日期:2005-03-01 00:00:00

  • Adherence in glaucoma: objective measurements of once-daily and adjunctive medication use.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Robin AL,Novack GD,Covert DW,Crockett RS,Marcic TS

    更新日期:2007-10-01 00:00:00

  • Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung.

    abstract:PURPOSE:To present a case of cancer-associated retinopathy (CAR) in a patient with small cell carcinoma of the lung and antiretinal antibodies who experienced visual symptoms before diagnosis of cancer. DESIGN:Case report. METHODS:A 61-year-old man with a sudden loss of vision and photophobia was referred to the opht...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Dot C,Guigay J,Adamus G

    更新日期:2005-04-01 00:00:00

  • Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone.

    abstract:PURPOSE:To use the capillary-free zone along retinal arteries, a physiologic area of superficial avascularization, as an anatomic paradigm to investigate the reliability of optical coherence tomography angiography (OCTA) for visualizing the deep retinal circulation. DESIGN:Validity analysis and laboratory investigatio...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Balaratnasingam C,An D,Sakurada Y,Lee CS,Lee AY,McAllister IL,Freund KB,Sarunic M,Yu DY

    更新日期:2018-05-01 00:00:00

  • A value-based medicine cost-utility analysis of idiopathic epiretinal membrane surgery.

    abstract:PURPOSE:To perform a reference case, cost-utility analysis of epiretinal membrane (ERM) surgery using current literature on outcomes and complications. DESIGN:Computer-based, value-based medicine analysis. METHODS:Decision analyses were performed under two scenarios: ERM surgery in better-seeing eye and ERM surgery i...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Gupta OP,Brown GC,Brown MM

    更新日期:2008-05-01 00:00:00

  • Pediatric Corneal Cross-linking: Comparison of Visual and Topographic Outcomes Between Conventional and Accelerated Treatment.

    abstract:PURPOSE:To compare visual and topographic outcomes 1 year after conventional (C-CXL) vs accelerated corneal cross-linking (A-CXL) in pediatric keratoconus (KC). DESIGN:Comparative, retrospective, consecutive case series. METHODS:Patients with topography-confirmed, progressive KC and a corneal thickness of ≥400 μm at ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Baenninger PB,Bachmann LM,Wienecke L,Thiel MA,Kaufmann C

    更新日期:2017-11-01 00:00:00

  • Subretinal neovascular membranes in Vogt-Koyanagi-Harada syndrome.

    abstract::Subretinal neovascular membranes cause late visual loss and are important determinants of final visual acuity in patients with Vogt-Koyanagi-Harada syndrome. The purpose of this study was to determine the prevalence and risk factors associated with the development of subretinal neovascular membranes in Vogt-Koyanagi-H...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Moorthy RS,Chong LP,Smith RE,Rao NA

    更新日期:1993-08-15 00:00:00

  • Insights from experimental data on ciprofloxacin in the treatment of bacterial keratitis and ocular infections.

    abstract::Ciprofloxacin is a potent fluoroquinolone antibiotic with in vitro activity against many significant gram-positive and gram-negative ocular pathogens. A review of the experimental studies of this antibiotic shows bactericidal activity, a broad antimicrobial spectrum, and a low incidence of resistance. The growing body...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,评审


    authors: Cokingtin CD,Hyndiuk RA

    更新日期:1991-10-01 00:00:00

  • Diabetic vacuolation of the iris pigment epithelium.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Smith ME,Glickman P

    更新日期:1975-05-01 00:00:00

  • Effect of Refractive Astigmatism on All-Distance Visual Acuity in Eyes With a Trifocal Intraocular Lens.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Hayashi K,Yoshida M,Igarashi C,Hirata A

    更新日期:2021-01-01 00:00:00

  • Conjunctival intraepithelial neoplasia presenting as corneal ulcer.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Sridhar MS,Honavar SG,Vemuganti G,Rao GN

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Thorne JE,Jabs DA,Peters GB,Hair D,Dunn JP,Kempen JH

    更新日期:2005-07-01 00:00:00

  • Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Dudney BW,Malecha MA

    更新日期:2004-05-01 00:00:00

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Cross HE,Hansen RC,Morrow G 3rd,Davis JR

    更新日期:1977-10-01 00:00:00

  • Early macular holes with retinoschisis in highly myopic eyes.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ikuno Y,Tano Y

    更新日期:2003-10-01 00:00:00

  • Patient tolerance to carbonic anhydrase inhibitors.

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    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lichter PR,Newman LP,Wheeler NC,Beall OV

    更新日期:1978-04-01 00:00:00

  • A magnetic resonance imaging study of the upshoot-downshoot phenomenon of Duane's retraction syndrome.

    abstract::Patients with Duane's retraction syndrome may have an associated upshoot or downshoot of the involved eye in adduction. This vertical movement has been attributed to the lateral rectus muscle slipping over or under the globe and acting as an elevator or depressor, respectively ("bridle-effect"). We used magnetic reson...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Bloom JN,Graviss ER,Mardelli PG

    更新日期:1991-05-15 00:00:00