Abstract：
PURPOSE:To report the effect of repeated corneal swabbing in patients with microsporidial keratoconjunctivitis. DESIGN:Retrospective noncomparative case series. METHODS:Sixteen eyes of 14 healthy patients with microsporidial keratoconjunctivitis were diagnosed based on the detection of microsporidia in corneal scrapings using Gram stain, the modified Kinyoun acid-fast stain, or both. Polymerase chain reaction plus gene analysis of the microsporidian 16S ribosomal RNA had been performed in 10 patients who sought treatment between 2010 and 2011. Some of the lesions were scraped for procurement of specimens. The remaining lesions were wiped off gently by cotton swabs. Repeated swabbing was performed if infection persisted or new lesions were observed at follow-up. To prevent secondary bacterial infection, 0.3% norfloxacin or 0.25 % chloramphenicol were prescribed. RESULTS:The mean age was 52.2 years. All patients had the characteristic disseminated, punctate, slightly elevated, white epithelial lesions. The denser white lesions could be removed easily after gentle swabbing, and most epithelium remained intact. The 10 cases with positive polymerase chain reaction results were all identified to be Vittaforma corneae. The mean number of corneal swabbing was 3.3, and the mean disease resolution time was 6.6 days. No patients had recurrence or loss of visual acuity at last follow-up. CONCLUSIONS:Repeated swabbing effectively can eradicate corneal epithelial microsporidial lesions in approximately 1 week. It is easy to perform, less painful, and more acceptable for the patients.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Fan NW,Lin PY,Chen TL,Chen CP,Lee SMdoi
10.1016/j.ajo.2012.06.002subject
Has Abstractpub_date
2012-12-01 00:00:00pages
927-933.e1issue
6eissn
0002-9394issn
1879-1891pii
S0002-9394(12)00433-3journal_volume
154pub_type
杂志文章abstract：PURPOSE:Photorefractive keratectomy has the potential to cause transient corneal haze. The purpose of this study was to evaluate the relationship between transient corneal haze as measured by an objective means and high and low contrast visual performance. METHODS:In a prospective study, 44 eyes of 28 patients were ex...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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doi：
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更新日期：2007-10-01 00:00:00
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更新日期：1999-02-01 00:00:00
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更新日期：2009-04-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2015-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2006-02-01 00:00:00
