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Color fundus photography versus fluorescein angiography in identification of the macular center and zone in retinopathy of prematurity.

Abstract：

PURPOSE:To examine the usefulness of fluorescein angiography (FA) in identifying the macular center and diagnosis of zone in patients with retinopathy of prematurity (ROP). DESIGN:Validity and reliability analysis of diagnostic tools. METHODS:Thirty-two sets (16 color fundus photographs and 16 color fundus photographs paired with the corresponding FA images) of wide-angle retinal images obtained from 16 eyes of 8 infants with ROP were compiled on a secure web site. Nine ROP experts (3 pediatric ophthalmologists and 6 vitreoretinal surgeons) participated in the study. For each image set, experts identified the macular center and provided a diagnosis of zone. MAIN OUTCOME MEASURES:(1) Sensitivity and specificity of zone diagnosis and (2) computer-facilitated diagnosis of zone, based on precise measurement of the macular center, optic disc center, and peripheral ROP. RESULTS:Computer-facilitated diagnosis of zone agreed with the expert's diagnosis of zone in 28 (62%) of 45 cases using color fundus photographs and in 31 (69%) of 45 cases using FA images. Mean (95% confidence interval) sensitivity for detection of zone I by experts compared with a consensus reference standard diagnosis when interpreting the color fundus images alone versus interpreting the color fundus photographs and FA images was 47% (range, 35.3% to 59.3%) and 61.1% (range, 48.9% to 72.4%), respectively (t(9) ≥ (2.063); P = .073). CONCLUSIONS:There is a marginally significant difference in zone diagnosis when using color fundus photographs compared with using color fundus photographs and the corresponding FA images. There is inconsistency between traditional zone diagnosis (based on ophthalmoscopic examination and image review) compared with a computer-facilitated diagnosis of zone.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Patel SN,Klufas MA,Ryan MC,Jonas KE,Ostmo S,Martinez-Castellanos MA,Berrocal AM,Chiang MF,Chan RV

doi

10.1016/j.ajo.2015.01.027

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

950-7.e2

issue

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(15)00056-2

journal_volume

159

pub_type

杂志文章

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Color fundus photography versus fluorescein angiography in identification of the macular center and zone in retinopathy of prematurity.