Abstract:
PURPOSE:To identify factors related to variations in the appearance of untreated AIDS-related cytomegalovirus (CMV) retinitis in severely immunodeficient individuals before the availability of highly active antiretroviral therapy (HAART) and to draw inferences regarding early events in the natural history of CMV retinitis based on clinical findings. DESIGN:Retrospective, observational case series. METHODS:We evaluated a series of 100 adult patients with AIDS and newly diagnosed CMV retinitis before the HAART era who were not being treated with specific anti-CMV therapy. Demographic factors, ophthalmic findings, and the influence of drug therapy (zidovudine, acyclovir) on lesion characteristics were evaluated. Lesion border opacity was scored using a four-point scale of severity. RESULTS:Lesions could be categorized by type (fulminant/edematous or indolent/granular) in only 66% of eyes. Severe lesion border opacity (4+) was related to presence of zone 1 lesions (P = .032) and greater extent of disease (P = .004). Acyclovir use was associated with less severe opacity (P = .029) and less zone 1 involvement (P = .016). Early lesions were adjacent to vessels in 73% of eyes; the fovea was involved in 13% of eyes. CONCLUSIONS:Lesion location and drug use that affects virus activity may influence the severity of lesion border opacity, a measure that may be more useful than lesion type in future clinical studies of CMV retinitis. In contrast to earlier concepts, CMV retinitis does not seem to be a fovea-sparing disease. Findings in this study can serve as a reference for investigations into possible changes in CMV retinitis since the introduction of HAART.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Holland GN,Vaudaux JD,Jeng SM,Yu F,Goldenberg DT,Folz IC,Cumberland WG,McCannel CA,Helm CJ,Hardy WD,UCLA CMV Retinitis Study Group.doi
10.1016/j.ajo.2007.09.023subject
Has Abstractpub_date
2008-01-01 00:00:00pages
5-11issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(07)00846-Xjournal_volume
145pub_type
杂志文章abstract:PURPOSE:To report the cotransmission of retinitis punctata albescens (RPA) and congenital sensorineural deafness. METHODS:Case reports of two siblings with nyctalopia and profound bilateral sensorineural deafness. RESULTS:The affected siblings, an 11-year-old female and a 7-year-old male, presented with decreased vis...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00060-4
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:Report incidence and risk of retinal detachment (RD)after coaxial phacoemulsification in high myopic patients. DESIGN:Retrospective consecutive interventional study. METHODS: SETTING:Vissum-Instituto Oftalmologico de Alicante, Spain. PATIENT OR STUDY POPULATION: A total of 439 eyes from 274 high myopic patie...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.03.043
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To describe a case with bullous keratopathy and anterior segment inflammation associated with heavy liquids. DESIGN:Observational case report. METHODS:Review of clinical and histopathologic changes. RESULTS:A 65-year-old patient underwent a pars plana vitrectomy for a rhegmatogenous retinal detachment. Perfl...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.01.034
更新日期:2005-08-01 00:00:00
abstract::We assessed 81 patients in four groups (normal, low- and high-risk ocular hypertension, and early glaucoma) with the standard Octopus G1 central visual field program in addition to two quantitative programs, PFN (peripheral field-nasal) and PFT (peripheral field-temporal), designed for this study to test the nasal and...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(88)90831-8
更新日期:1988-08-15 00:00:00
abstract::We undertook an in vitro investigation of the role of the design of the eyedrop dispenser in bacterial contamination. The nozzle tips of pipette and squeeze bottles containing Fluress (pH 5.0) were inoculated with 10 microliter of an ocular isolate of Pseudomonas aeruginosa (5.5 X 10(5) bacteria/ml). Cultures of singl...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(84)90238-1
更新日期:1984-11-01 00:00:00
abstract::Beta-aminopropionitrile, an inhibitor of collagen cross-linking, effectively limited the degree of posttraumatic vitreous proliferation in rabbits three weeks after double perforating injury. Light microscopic examination of the sites of perforating injury after five weeks showed minimal intravitreal fibrous prolifera...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(83)90337-9
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:To measure the changes in optic disk morphology after unilateral disk hemorrhage and to compare the changes between eyes. DESIGN:Observational case series. METHODS:Ten glaucoma patients who had a unilateral disk hemorrhage were enrolled. The baseline measurements obtained by Heidelberg Retina Tomograph (HRT) ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01791-9
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To report a case in which silicone oil in the eye migrated into the cerebral ventricles and the subarachnoid space. DESIGN:Observational case report. METHODS:A 62-year-old woman presented with proliferative diabetic retinopathy and tractive retinal detachment in her left eye. Par plana vitrectomy and injectio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.01.006
更新日期:2005-07-01 00:00:00
abstract::We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76658-9
更新日期:1978-01-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)02240-7
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To investigate cataract risk associated with the use of atypical antipsychotics. DESIGN:Retrospective, nested case-control study. METHODS:A large health claims database (The British Columbia Ministry of Health Databases) from British Columbia, Canada, was used from January 2000 through December 2007. Cases we...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.07.012
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:We studied patients with chronic open-angle glaucoma who had similar intraocular pressures to determine whether surgical or medical therapy is more effective in preventing progressive, long-term, glaucomatous damage. METHODS:Included in this study were patients with chronic open-angle glaucoma who were followe...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70372-1
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:A defect in the visual field is one of the serious complications of macular hole surgery. We investigated the relationship between the occurrence of visual field defect and the location of infusion cannula and air pressure during fluid-air exchange. METHODS:We studied 100 eyes from 90 patients with macular hol...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00597-3
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:To describe the spectral-domain optical coherence tomography (SD-OCT) features of choroidal tumors imaged using enhanced depth imaging (EDI) technique. DESIGN:Prospective observational case series. METHODS:One tumor each from 23 eyes of 23 patients was included. All the patients underwent clinical fundus phot...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.09.028
更新日期:2011-04-01 00:00:00
abstract::Severe retrobulbar hemorrhage may occur as a complication of a retrobulbar injection or from blunt or sharp injury to the orbit during an orbital or periorbital operation. When the patient with a severe retrobulbar hemorrhage does not respond to intermittent ocular massage, or paracentesis, or a lateral canthotomy, pr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71740-4
更新日期:1993-07-15 00:00:00
abstract:PURPOSE:To determine factors of uveal malignant melanoma that would help to predict prognosis in Japanese patients. METHODS:From 1969 to 1994, 23 eyes with uveal malignant melanoma were enucleated from 23 Japanese patients, and 16 of these patients were studied. In the 16 patients, enucleated eyes were evaluated for t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70275-2
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:To describe changes in the acquired immunodeficiency syndrome (AIDS) epidemic that are important to ophthalmologists, to provide an overview of issues relevant to current evaluation and treatment of human immunodeficiency virus (HIV)-related eye disease, and to identify problems related to the eye and vision th...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2007.12.001
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To determine the association between cystoid macular edema and vascular endothelial growth factor concentration in the aqueous humor and plasma of uveitis patients. METHODS:Cross-sectional study. Vascular endothelial growth factor concentrations were measured by enzyme-linked immunosorbent assay in the aqueous...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01103-5
更新日期:2001-11-01 00:00:00
abstract::On the basis of preoperative assessment of patient characteristics, intraoperative obtainment of a lens-capsule and epithelium specimen, histopathologic investigation of lens capsule and epithelium, and biochemical analysis of glutathione reductase in lens epithelium, age-related cataract was studied in 50 adult patie...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76729-7
更新日期:1991-09-15 00:00:00
abstract:PURPOSE:To evaluate the efficacy of autologous plasmin (AP)-assisted vitrectomy for stage 5 retinopathy of prematurity (ROP). DESIGN:Interventional case series. METHODS:Six consecutive eyes of four children with stage 5 ROP were treated. The patients' ages at the surgery ranged from five to eight months after birth. ...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ajo.2007.03.020
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To investigate the impact of Bruch membrane pathology on the choroid in pseudoxanthoma elasticum (PXE). DESIGN:Monocenter cross-sectional prospective case series. METHODS:The study included 61 eyes of 51 patients with PXE and 54 eyes of 54 normal subjects. The diagnosis of PXE was based on skin biopsy, geneti...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.04.005
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:To determine whether the frequency doubling perimeter (FDP) can grade glaucomatous visual function loss in a clinically relevant manner. Sinusoidal gratings < 1 cpd that undergo counterphase flicker > 15 Hz appear to have twice as many bands of light, a phenomenon referred to as the "frequency doubling illusion...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00047-6
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:To report a patient with unilateral vision loss and neovascular glaucoma after attempted superior ophthalmic vein embolization in the treatment of a carotid-cavernous sinus fistula. METHODS:A 69-year-old man with a history of a left dural carotid-cavernous sinus fistula underwent attempted treatment with super...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71711-8
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To compare rotational stability and its influencing factors in 3 different widely used hydrophobic acrylic intraocular lenses (IOLs) from the end of surgery (EoS) to 4-7 months (6 months) in over 380 eyes. DESIGN:Prospective interventional comparative clinical study. METHODS:Setting: Department of Ophthalmolo...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ajo.2020.07.019
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To evaluate whether cost, insurance prior authorization, pregnancy considerations, and subspecialty practice lead to changes in therapeutic decisions among uveitis and retina specialists in the treatment of intermediate and posterior uveitis. DESIGN:Prospective cross-sectional study. METHODS:A total of 934 uv...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.10.015
更新日期:2015-02-01 00:00:00
abstract::We treated nontraumatic ectopia lentis with the irrigation and aspiration method in 30 children and the Keeler/SITE instrument in three. Preoperative visual acuities were 6/21 (20/70) or worse in all patients; postoperatively, visual acuities improved in 29 of the 30 eyes and were 6/18 (20/60) or better in 24 (80%). A...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(81)90354-8
更新日期:1981-01-01 00:00:00
abstract:PURPOSE/METHODS:By fundus photography and histopathologic examination, we documented a case of early endogenous Aspergillus endophthalmitis in a 29-year-old man after lung transplantation. RESULTS/CONCLUSIONS:The clinical and histopathologic features of this case are consistent with those of previous case reports of e...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73829-2
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:To investigate the imaging capabilities of anterior segment optical coherence tomography (AS OCT) in microbial keratitis and to assess whether measurements of the quantitative parameters, infiltrate thickness and corneal thickness, were possible. DESIGN:Prospective, noncomparative, observational case series. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.05.030
更新日期:2008-10-01 00:00:00
abstract::The files of 45 human immunodeficiency virus-infected patients with ocular toxoplasmosis were reviewed, with a median follow-up of eight months. The condition was unilateral in 37 of the 45 patients (82%) and was bilateral in eight (18%). Inflammation of the anterior chamber and the vitreous was present in 32 of 53 ey...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73975-3
更新日期:1992-08-15 00:00:00
abstract:PURPOSE:Periocular injection of corticosteroids is a common treatment for vision loss in patients with intermediate uveitis. However, this treatment has the potential for serious side effects. We sought to determine the effects of such injections in a series of patients. METHODS:We reviewed charts of 20 consecutive pa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73759-6
更新日期:1995-07-01 00:00:00