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The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery.

Abstract：

PURPOSE:To provide evidence that corticosteroid-induced ocular hypertension has a genetic component. DESIGN:Evidence-based perspective. METHODS:We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. RESULTS:Studies demonstrating increased risk of corticosteroid-induced ocular hypertension among first-degree relatives of affected individuals support a genetic contribution to the disease. Family and personal history of primary open-angle glaucoma also increases the risk of corticosteroid-induced intraocular pressure elevation, suggesting common genetic etiologies. A number of studies have attempted to identify predisposing genetic factors; however, reproducible findings have not yet been reported. The recent availability of large data sets with clinical and genetic data for patients affected by corticosteroid-induced ocular hypertension and glaucoma provides new opportunities to study the genetic underpinnings of this important condition. CONCLUSIONS:There is substantial evidence suggesting a genetic component to corticosteroid-related ocular hypertension and glaucoma, but specific genetic risk factors have yet to be identified. The current confluence of large genetic data sets and affordable genetic sequencing technologies has great potential for discovering the genes that increase risk for this blinding complication of corticosteroid therapy.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Chan W,Wiggs JL,Sobrin L

doi

10.1016/j.ajo.2019.02.001

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1-5

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(19)30052-2

journal_volume

202

pub_type

杂志文章,评审

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