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Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts.

Abstract：

PURPOSE:To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS OCT) and the frequency and type of scan artifacts. DESIGN:Prospective evaluation of new diagnostic technology. METHODS:Thirty healthy subjects were recruited prospectively and underwent imaging with a prototype SS OCT instrument. Undilated scans of 54 eyes of 27 subjects (mean age, 35.1 ± 9.3 years) were obtained. Each subject had 4 SS OCT protocols repeated 3 times: 3-dimensional (3D) 6 × 6-mm raster scan of the optic disc and macula, radial, and line scan. Automated measurements were obtained through segmentation software. Interscan repeatability was assessed by intraclass correlation coefficients (ICCs). RESULTS:ICCs for choroidal measurements were 0.92, 0.98, 0.80, and 0.91, respectively, for 3D macula, 3D optic disc, radial, and line scans. ICCs for retinal measurements were 0.39, 0.49, 0.71, and 0.69, respectively. Artifacts were present in up to 9% scans. Signal loss because of blinking was the most common artifact on 3D scans (optic disc scan, 7%; macula scan, 9%), whereas segmentation failure occurred in 4% of radial and 3% of line scans. When scans with image artifacts were excluded, ICCs for choroidal thickness increased to 0.95, 0.99, 0.87, and 0.93 for 3D macula, 3D optic disc, radial, and line scans, respectively. ICCs for retinal thickness increased to 0.88, 0.83, 0.89, and 0.76, respectively. CONCLUSIONS:Improved repeatability of automated choroidal and retinal thickness measurements was found with the SS OCT after correction of scan artifacts. Recognition of scan artifacts is important for correct interpretation of SS OCT measurements.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Mansouri K,Medeiros FA,Tatham AJ,Marchase N,Weinreb RN

doi

10.1016/j.ajo.2014.02.008

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

1022-32

issue

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)00071-3

journal_volume

157

pub_type

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Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts.