Abstract：
PURPOSE:To determine whether clinically isolated anterior segment recurrence is associated with concomitant subclinical choroidal inflammation in Vogt-Koyanagi-Harada (VKH) disease. DESIGN:Interventional, retrospective case series. METHODS:Nine patients with recurrent VKH disease who satisfied the following criteria: 1) presence of anterior chamber (AC) inflammation of at least 1+ cells after a period of quiescence of three months or more, 2) no posterior segment involvement, and 3) indocyanine green angiography (ICGA) performed during the time of anterior segment recurrence at the Singapore National Eye Centre. ICGA was performed. Therapy was administered based on clinical features. The main outcome measures were the ICGA features. RESULTS:Twelve eyes of nine patients were included in the study. All eyes had mild AC inflammation of 1 to 2+ cells, except for one eye that had 3+ cells. ICGA showed early large vessel hyperfluorescence, becoming fuzzy in character in the intermediate phase in 11 of 12 eyes with AC inflammation. In four eyes, few hypofluorescent dots were seen in the intermediate phase that remained hypofluorescent in the late phases. Late diffuse hyperfluorescence was observed in five eyes. All patients received high-dose oral prednisolone and topical prednisolone acetate. Four patients required additional steroid-sparing immunosuppressants. All patients attained clinical quiescence within two weeks to two months. Repeat ICGA showed absence of active leakage, significant decrease in choroidal vascular leakage, or no change in the number and density of hypofluorescent spots. CONCLUSIONS:Isolated anterior segment recurrence in VKH disease may occur concomitantly with subclinical choroidal inflammation and requires systemic therapy.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Bacsal K,Wen DS,Chee SPdoi
10.1016/j.ajo.2007.10.012subject
Has Abstractpub_date
2008-03-01 00:00:00pages
480-486issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(07)00919-1journal_volume
145pub_type
杂志文章abstract：:Eikenella corrodens is a gram-negative, facultative anaerobic bacillus with specific culture and growth requirements and unusual antibacterial susceptibilities. It has only recently been recognized as a human pathogen. Ocular and adnexal infections with this organism are rare especially in children. We treated two chi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74487-3
更新日期：1992-11-15 00:00:00
abstract：PURPOSE:To report a physician survey, laboratory studies, and clinical observations of intraoperative crystallization on the surface of the intraocular lens (IOL). METHOD:We sent a survey to all ophthalmologists in the states of Wyoming, Idaho, Montana, Utah, and Colorado asking whether crystallization on the IOL surf...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00076-2
更新日期：1998-08-01 00:00:00
abstract：PURPOSE:To evaluate qualitatively the structural characteristics and the associated features that antedate the occurrence of a disk hemorrhage in patients with glaucoma. METHODS:Retrospective observational case series. A total of 4018 pairs of stereoscopic optic disk images obtained over 15 years were reviewed. All ey...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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abstract：PURPOSE:To investigate the efficacy of ciliary body endophotocoagulation during pars plana vitrectomy in eyes of pediatric patients with medically uncontrolled glaucoma. METHOD:We compared preoperative and postoperative intraocular pressure and visual acuity in five eyes of five patients aged between 10 months and 14....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00184-6
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:To determine risk factors for poor visual acuity outcomes in patients with endogenous Klebsiella pneumoniae endophthalmitis. DESIGN:Retrospective case-control study. METHODS:We reviewed all consecutive patients diagnosed with endogenous Klebsiella pneumoniae endophthalmitis over 20 years. Data collected inclu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.036
更新日期：2011-02-01 00:00:00
abstract：:We analyzed the surgical results for 197 eyes that underwent vitrectomy for diabetic traction detachment of the macula. The retina was successfully reattached in 130 of the 197 cases (66%), although the final level of vision depended on the amount of permanent macular damage from the previous detachment and on the eff...
journal_title：American journal of ophthalmology
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更新日期：1983-01-01 00:00:00
abstract：PURPOSE:To investigate the impact of Bruch membrane pathology on the choroid in pseudoxanthoma elasticum (PXE). DESIGN:Monocenter cross-sectional prospective case series. METHODS:The study included 61 eyes of 51 patients with PXE and 54 eyes of 54 normal subjects. The diagnosis of PXE was based on skin biopsy, geneti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
abstract：PURPOSE:We sought to assess the effects of exposure to secondhand smoke (SHS) on peripapillary retinal nerve fiber layer (p-RNFL) thickness in children. DESIGN:Cross-sectional study. METHODS:Children 6-8 years of age were consecutively recruited from the population-based Hong Kong Children Eye Study. All participants...
journal_title：American journal of ophthalmology
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更新日期：2020-10-29 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2010-10-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2017-06-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1995-02-01 00:00:00
abstract：:A 57-year-old man had a clinically suspected malignant melanoma in his left eye. On microscopic study, the enucleated eye harbored an unusual choroidal tumor that had extended extraocularly. This tumor had been variously interpreted microscopically as an angiosarcoma, an atpical angioma, a glioma, or a neurilemoma. El...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90419-0
更新日期：1976-08-01 00:00:00
abstract：PURPOSE:To report the use of an Apligraf (Organogenesis, Inc., Canton, Massachusetts, USA) human skin equivalent for repair of cicatricial ectropion in a patient with harlequin ichthyosis. DESIGN:Interventional case report. METHODS:A 6-week-old male child with harlequin ichthyosis and severe bilateral upper eyelid ci...
journal_title：American journal of ophthalmology
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doi：10.1016/s0002-9394(02)01567-2
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To evaluate the correlation between tear film lipid layer thickness and other objective measurements such as tear film break-up time (TBUT), upper and lower meibomian gland losses, and Schirmer 1 test in patients with obstructive meibomian gland dysfunction (MGD) and normal controls. DESIGN:Cross-sectional stu...
journal_title：American journal of ophthalmology
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更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To compare the accuracy and speed of using the computerized MatchedFlicker software program (EyeIC Inc, Narberth, Pennsylvania, USA) to evaluate glaucomatous optic disc change against the traditional gold standard of manually examining stereoscopic disc photographs. DESIGN:A prospective evaluation of diagnosti...
journal_title：American journal of ophthalmology
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更新日期：2016-07-01 00:00:00
abstract：:Corneas for penetrating keratoplasty that have been excised from the globe for storage ordinarily require punching of the donor tissue from the posterior surface. They may be trephined from the anterior surface when they are mounted on an instrument that forms a seal around the scleral rim of the excised cornea, allow...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90021-0
更新日期：1976-11-01 00:00:00
abstract：PURPOSE:To detect the abnormalities of gray matter in children with amblyopia by voxel-based morphometry (VBM). DESIGN:Prospective, nonrandomized clinical trial. METHODS:Thirteen children with amblyopia and 14 normally sighted children underwent magnetic resonance (MR) examination. The two groups were age-matched wit...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2006.11.039
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:To report the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) in a real-world clinical setting and to assess the efficacy of subsequent alternative treatments in eyes with suboptimal response to anti-VEGF. DESIGN:Retrospective interve...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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abstract：:Visual loss secondary to vitreous hemorrhage or retinal detachment can occur in proliferative sickle retinopathy. Severe complications including a high incidence of anterior segment necrosis have been reported in both vitrectomy and scleral buckling operations in patients with this disease. We examined four patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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abstract：PURPOSE:To provide additional evidence that anterior uveitis can be a manifestation of poststreptococcal syndrome. METHOD:A case report providing follow-up information on a previously described patient. RESULTS:An adolescent girl in whom anterior uveitis was the only manifestation of poststreptococcal syndrome subseq...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Twelve patients (14 eyes) had intraocular pressure elevations induced by repository coritcosteroids. The duration and severity of the resulting pressure elevations were directly related to the decreasing solubility of the agent employed. Ten patitens had received intensive topical corticosteroids before injection, res...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90669-3
更新日期：1976-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.11.023
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:To develop comprehensive predictive models for choroidal neovascularization (CNV) and geographic atrophy (GA) incidence within 3 years that can be applied realistically to clinical practice. DESIGN:Retrospective evaluation of data from a longitudinal study to develop and validate predictive models of CNV and G...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.09.019
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:To examine the relationship between hypertension and lens opacities, and the use of antihypertensive agents. METHODS:A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70223-5
更新日期：1995-05-01 00:00:00
abstract：PURPOSE:To measure the area of the optic nerve subarachnoid space (ONSASA) in patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), and controls and examine its association with relevant ocular and systemic parameters. DESIGN:Cross-sectional study. METHODS:The study included 40 patients wit...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-02-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic performance characteristics of the Van Herick assessment (VHA) for identifying angle closure compared to gold-standard gonioscopy, as conducted by trained observers of varying expertise. DESIGN:Reliability analysis. METHODS:Patients (n = 131) from a glaucoma referral clinic aged ≥50...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.07.026
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To investigate the effect of posterior subtenon injections of corticosteroids on intraocular pressure in a variety of ocular diseases. METHODS:We retrospectively analyzed 202 consecutive posterior subtenon corticosteroid injections (148 of methylprednisolone acetate, 80 mg, and 54 of triamcinolone acetonide, 4...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80085-3
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:To report atypical kerato-conjunctivitis as a manifestation of Hodgkin disease. METHODS:Case report. RESULTS:A 19-year old woman presented with conjunctival nodules and corneal infiltrates. Diffuse lymph node enlargement occurred, but not in the preauricular or submandibular areas. Extensive microbiologic exa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00895-3
更新日期：2001-06-01 00:00:00
