Abstract：
PURPOSE:To determine whether clinically isolated anterior segment recurrence is associated with concomitant subclinical choroidal inflammation in Vogt-Koyanagi-Harada (VKH) disease. DESIGN:Interventional, retrospective case series. METHODS:Nine patients with recurrent VKH disease who satisfied the following criteria: 1) presence of anterior chamber (AC) inflammation of at least 1+ cells after a period of quiescence of three months or more, 2) no posterior segment involvement, and 3) indocyanine green angiography (ICGA) performed during the time of anterior segment recurrence at the Singapore National Eye Centre. ICGA was performed. Therapy was administered based on clinical features. The main outcome measures were the ICGA features. RESULTS:Twelve eyes of nine patients were included in the study. All eyes had mild AC inflammation of 1 to 2+ cells, except for one eye that had 3+ cells. ICGA showed early large vessel hyperfluorescence, becoming fuzzy in character in the intermediate phase in 11 of 12 eyes with AC inflammation. In four eyes, few hypofluorescent dots were seen in the intermediate phase that remained hypofluorescent in the late phases. Late diffuse hyperfluorescence was observed in five eyes. All patients received high-dose oral prednisolone and topical prednisolone acetate. Four patients required additional steroid-sparing immunosuppressants. All patients attained clinical quiescence within two weeks to two months. Repeat ICGA showed absence of active leakage, significant decrease in choroidal vascular leakage, or no change in the number and density of hypofluorescent spots. CONCLUSIONS:Isolated anterior segment recurrence in VKH disease may occur concomitantly with subclinical choroidal inflammation and requires systemic therapy.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Bacsal K,Wen DS,Chee SPdoi
10.1016/j.ajo.2007.10.012subject
Has Abstractpub_date
2008-03-01 00:00:00pages
480-486issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(07)00919-1journal_volume
145pub_type
杂志文章abstract：PURPOSE:To describe a case with bullous keratopathy and anterior segment inflammation associated with heavy liquids. DESIGN:Observational case report. METHODS:Review of clinical and histopathologic changes. RESULTS:A 65-year-old patient underwent a pars plana vitrectomy for a rhegmatogenous retinal detachment. Perfl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.01.034
更新日期：2005-08-01 00:00:00
abstract：:We used 2.15 to 2.3% collodion in amyl acetate to form a replica of the corneal surface epithelium in vivo in seven rabbit eyes and ten human eyes. When it was peeled off the replica removed superficial epithelial cells in patches. The corneal epithelium regenerated within one week. Repeated applications at weekly int...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90333-6
更新日期：1977-07-01 00:00:00
abstract：PURPOSE:To report the echographic appearance of a scleral fold in hypotony. METHOD:We performed ultrasonography on a patient who, after trabeculectomy with mitomycin C, had an intraocular pressure of 1 mm Hg, an opaque cataract, and suspected hypotonous maculopathy in the left eye. RESULTS:An area of dome-shaped eyew...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70801-3
更新日期：1997-08-01 00:00:00
abstract：:We performed a histologic study to support our clinical observations on the mechanisms responsible for traction retinal detachment after a penetrating injury in the rhesus monkey eye. The monkey eyes (40 eyes; 40 monkeys) were characterized by intraocular fibrosis with the formation of a cyclitic membrane and epiretin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90469-0
更新日期：1979-08-01 00:00:00
abstract：:We studied five cases of leukemia with invasion of the optic disk and optic nerve. Two patients had acute lymphoblastic leukemia and three had acute myelogenous leukemia. All patients received intrathecal injections of chemotherapeutic drugs including methotrexate, cytarabine, and prednisolone. Three patients underwen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90013-x
更新日期：1988-03-15 00:00:00
abstract：PURPOSE:We present two cases with early macular holes (MH) complicated by retinoschisis and foveal detachment (RSFD). DESIGN:Case reports. CASE REPORT:A 46-year-old woman and a 70-year-old woman, both with high myopia, presented visual loss and a small MH associated with RSFD. Vitrectomy and gas tamponade were perfor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00319-2
更新日期：2003-10-01 00:00:00
abstract：:Deposits resembling foreign-body giant cells, which can be seen on specular reflex slit-lamp examination, were studied in vivo with a wide-field specular microscope using a low-power dipping cone lens in three cases of posterior chamber lens implantation. The deposits seen as iris pigment on routine examination showed...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90360-5
更新日期：1985-03-15 00:00:00
abstract：PURPOSE:To examine the influence of astigmatism on the visual acuity of patients with multifocal and monofocal intraocular lenses. METHODS:Thirty eyes of 30 patients who underwent five-zone refractive multifocal intraocular lens implantation and 30 eyes of 30 age-matched patients who had monofocal intraocular lens imp...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00526-2
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:The prediction of atherosclerosis using retinal fundus images and deep learning has not been shown possible. The purpose of this study was to develop a deep learning model which predicted atherosclerosis by using retinal fundus images and to verify its clinical implications by conducting a retrospective cohort ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.03.027
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To correlate the anatomic features of the macula with functional parameters like location and stability of fixation in patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab injections. DESIGN:Retrospective analysis. METHODS:The location and stability of fixation were...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.08.034
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:To determine factors of uveal malignant melanoma that would help to predict prognosis in Japanese patients. METHODS:From 1969 to 1994, 23 eyes with uveal malignant melanoma were enucleated from 23 Japanese patients, and 16 of these patients were studied. In the 16 patients, enucleated eyes were evaluated for t...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70275-2
更新日期：1996-03-01 00:00:00
abstract：:Of 30 consecutive patients with ocular adnexal basal cell carcinoma, 18 (60%) had at least one additional unsuspected foci of basal cell carcinoma. The patients most likely to have additional basal cell skin cancer were women, those with previous basal cell carcinoma, and those whose eyelid lesions were recurrent, loc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90002-2
更新日期：1982-11-01 00:00:00
abstract：:The haptic of a semiflexible anterior chamber intraocular lens (Kelman Quadraflex) broke inside the eye of a 70-year-old man. No history of major eye or head trauma could be elicited from the patient. Clinical manifestations included inferior corneal edema progressing toward the optical axis resulting from a free-floa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90226-0
更新日期：1985-02-15 00:00:00
abstract：PURPOSE/METHODS:We examined a patient with progressive outer retinal necrosis, which is presumably caused by the varicella-zoster virus in patients with the acquired immunodeficiency syndrome. RESULTS/CONCLUSIONS:The patient was successfully treated with a combination of intravitreal ganciclovir and oral sorivudine. T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71242-5
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:To report a case of chronic unilateral ptosis in a 63-year-old, otherwise healthy woman with visual restriction. METHODS:We performed a biopsy on an enlarged tarsal plate that we believed had caused ptosis. A levator aponeurotic advancement was performed subsequently. RESULTS:Histologic and ultrastructural ex...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71145-6
更新日期：1997-06-01 00:00:00
abstract：PURPOSE:To report a novel mutation of the CYP1B1 gene in a Japanese patient with primary infantile glaucoma. METHODS:DNA was extracted from leukocytes of six unrelated patients with primary infantile glaucoma. The coding regions of the CYP1B1 gene were amplified by polymerase chain reaction, examined by agarose gel se...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00143-9
更新日期：1999-09-01 00:00:00
abstract：:A new sorting test requires only two minutes for quantitative estimation of saturation thresholds for bluish pigment colors. The test is highly sensitive to and specific for differences between normal subjects and individuals with acquired color vision defects. When combined with Ishihara's pseudo-isochromatic plates,...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90781-9
更新日期：1981-08-01 00:00:00
abstract：PURPOSE:To examine the effect of basic fibroblast growth factor on induced choriocapillaris atrophy in vivo. METHODS:Choriocapillaris atrophy was surgically induced in rabbits by a hydraulic retinal detachment followed by debridement of the retinal pigment epithelium under the detached retina. Three concentrations of ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)00921-7
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:To study the appearance of margins of geographic atrophy in high-resolution optical coherence tomography (OCT) images and to correlate those changes with fundus autofluorescence (FAF) imaging. DESIGN:Retrospective, observational case study. METHODS:Patients with geographic atrophy secondary to dry age-related...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.04.022
更新日期：2009-09-01 00:00:00
abstract：:We used wide-field color specular microscopy of the human corneal surface to study the morphologic changes that occur under extended-wear contact lenses. There was a shift in the frequency distribution of surface cells by size to larger cells, suggesting a prolonged residence time on the ocular surface. Other abnormal...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90818-4
更新日期：1986-03-15 00:00:00
abstract：:One of the problems with corneal grafting is the occurrence of rejection. Immune reaction is considered to be an important cause of graft failure. Early recognition of such graft reaction can frequently be treated successfully with intensive topical administration of corticosteroids. Generally, I prefer to add systemi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74983-9
更新日期：1985-07-15 00:00:00
abstract：PURPOSE:To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for alternative approaches to reduce the impact of rejection. DESIGN:Perspective, including prospec...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2005.07.024
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To present a new surgical technique for severe, symptomatic conjunctivochalasis and our hypothesis of the pathogenesis of this condition. METHODS:Six eyes of three patients with conjunctivochalasis (average age +/-SD, 70.0 +/- 9.6 years; range, 56-78 years) were treated with a conjunctival fixation to sclera w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00384-0
更新日期：2000-03-01 00:00:00
abstract：:Twenty-six eyes of 25 patients with chronic open-angle glaucoma and surgical aphakia with inadequate control of intraocular pressure (IOP) despite maximal medical treatment were treated with cyclocryotherapy, according to a prospective protocol and specific technique. (Neovascular and synechial glaucoma were excluded ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77093-x
更新日期：1978-05-01 00:00:00
abstract：PURPOSE:To investigate the magnitude, with-the-rule (WTR) or against-the-rule (ATR) orientation, and vector components (Jackson astigmatic vectors [J0 and J45] and blurring strength) of the anterior and posterior corneal astigmatism (ACA and PCA) in patients with keratoconus (KC) in a retrospective study, and to try to...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.03.051
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To report a series of patients in whom infectious scleritis developed after vitreoretinal surgery. DESIGN:Interventional case series of four patients. METHODS:Medical records of patients at a single institution in whom infectious scleritis developed after vitreoretinal surgery were reviewed. RESULTS:In three...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.11.024
更新日期：2008-04-01 00:00:00
abstract：:We used contact irradiation with iodine 125 seeds to treat a large, exulcerative, nodular, amelanotic malignant eyelid melanoma with metastasis to the regional lymph nodes in an 80-year-old man. The procedure was similar to iodine 125 plaque irradiation of malignant choroidal melanoma; special equipment, however, was ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76936-3
更新日期：1990-07-15 00:00:00
abstract：PURPOSE:To introduce a surgical approach for removing intruded scleral buckle resulting from Miragel's implant. DESIGN:Interventional case report. METHODS:After cutting and releasing scleral band externally, a pars plana Fragmatome was used to break up and aspirate pieces of the Miragel's implant that had grown into ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.07.032
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:To describe the clinical features and complications of diabetic retinopathy, visual acuity, and number of repeat treatments after panretinal photocoagulation for proliferative diabetic retinopathy in a tertiary care center. METHODS:A cohort study was conducted with data collection from medical records of patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00322-0
更新日期：2000-02-01 00:00:00
abstract：:Confirmation of iodine-125 plaque position was determined with a modified fiberoptic light pipe that directed light at right angles to the long axis of the fiberoptic pipe. While the examiner observed the interior of the eye with indirect ophthalmoscopy, the point source of light from the fiberoptic light pipe was mov...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74171-6
更新日期：1987-01-15 00:00:00
