Abstract：
PURPOSE:To detect the abnormalities of gray matter in children with amblyopia by voxel-based morphometry (VBM). DESIGN:Prospective, nonrandomized clinical trial. METHODS:Thirteen children with amblyopia and 14 normally sighted children underwent magnetic resonance (MR) examination. The two groups were age-matched with a mean age of 5.8 years. In the amblyopia group, five children had strabismus amblyopia, and eight had anisometropic amblyopia. We analyzed the original 3-dimensional T1 brain images using the VBM module within the widely used analysis software package SPM2 (Welcome Department of Cognitive Neurology, London, United Kingdom). After normalization, segmentation, and smoothing of the images, comparison between amblyopic and control groups was derived for the gray matter of the entire brain using parametric statistics. RESULTS:The results of VBM analysis indicated that the amblyopic group had decreased gray matter density in the middle frontal gyrus, parahippocampal gyrus, fusiform gyrus, inferior temporal gyrus of the left hemisphere, and the bilateral calcarine cortices. The radii of these regions ranged from 12 to 36 voxels. These abnormalities were consistent with morphologic changes in brain regions related to visual function. CONCLUSIONS:Using MR and VBM analysis, we detected morphologic changes in the visual cortex of children with amblyopia, which may indicate developmental abnormalities of visual cortex during the critical growth period.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Xiao JX,Xie S,Ye JT,Liu HH,Gan XL,Gong GL,Jiang XXdoi
10.1016/j.ajo.2006.11.039subject
Has Abstractpub_date
2007-03-01 00:00:00pages
489-93issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(06)01325-0journal_volume
143pub_type
临床试验,杂志文章abstract：PURPOSE:To compare 1-muscle vs 2-muscle surgery for moderate-angle hyperdeviations owing to presumed unilateral fourth nerve palsy. DESIGN:Retrospective chart review. METHODS:Seventy-three patients (aged 5-86 years) underwent either 1- or 2-muscle surgery at our institution for moderate hyperdeviation owing to presum...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.06.030
更新日期：2017-10-01 00:00:00
abstract：:Between 1976 and 1982, we examined 13 patients with clinical and radiographic findings consistent with optic nerve sheath meningioma. All patients had visual loss, evidence of optic nerve dysfunction, centrocecal visual field defects, and echographic and computed tomographic evidence of optic nerve or sheath enlargeme...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90506-9
更新日期：1985-09-15 00:00:00
abstract：PURPOSE:To report an inter-eye difference of the ocular pulse amplitude (OPA) in a case of innominate steal syndrome, as measured by recording applanation tonometry. METHODS:OPA was measured in a 49-year-old male before and after percutaneous transluminal angioplasty of the innominate artery. RESULTS:Before dilation ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01249-1
更新日期：2002-01-01 00:00:00
abstract：PURPOSE:To determine the testability of several vision and refraction tests in preschool-aged children. DESIGN:Population-based study of Chinese preschool-aged children in Singapore. METHODS:One thousand five hundred and forty-two Singaporean Chinese children aged 6 to 72 months were recruited through door-to-door sc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.02.037
更新日期：2009-08-01 00:00:00
abstract：:We developed a method that models the effect of irregular corneal surface topography on corneal optical performance. A computer program mimics the function of an optical bench. The method generates a variety of objects (single point, standard Snellen letters, low contrast Snellen letters, arbitrarily complex objects) ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74602-1
更新日期：1990-04-15 00:00:00
abstract：:Six patients had peripheral to midperipheral pale yellow retinal exudates typical of acute retinal necrosis syndrome but which extended gradually to the posterior pole and remained isolated without becoming confluent. These exudates resulted in localized retinochoroidal degeneration without retinal detachment, in cont...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1988-06-15 00:00:00
abstract：PURPOSE:To determine with electronic monitoring an objective measurement of adherence in two populations of subjects: those using once-daily prostaglandin analogs as sole ocular hypotensive therapy (one-drug group) and those requiring an adjunctive medicine to the prostaglandin analog (two-drug group). DESIGN:Single-s...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
abstract：PURPOSE:To determine the association between cystoid macular edema and vascular endothelial growth factor concentration in the aqueous humor and plasma of uveitis patients. METHODS:Cross-sectional study. Vascular endothelial growth factor concentrations were measured by enzyme-linked immunosorbent assay in the aqueous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01103-5
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:To report a case of bilateral endogenous Phialemonium curvatum endophthalmitis, secondary to intrapenile injections for erectile dysfunction. DESIGN:Observational case report. METHODS:A 71-year-old man with P. curvatum endocarditis and bilateral decreased vision was diagnosed as having bilateral endogenous en...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.04.037
更新日期：2005-10-01 00:00:00
abstract：PURPOSE:To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled type 1 DM and to compare the results obtained with those in healthy children. DESIGN:Cross-sectional prospective study. METHODS:This multicenter stud...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2017.05.010
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:Congenital macular lesions attributed to toxoplasmosis may limit potential visual acuity. The appearance and location of these scars may cause physicians to overlook associated amblyopia. This study reviews the visual outcomes and benefits of amblyopia therapy in children with foveal toxoplasmosis scars. DESIG...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
abstract：:We performed strabismus surgery on 170 children on an outpatient basis. Endotracheal intubation was utilized in all cases as the means of delivery of the anesthetic agent. Atropine used alone as a preoperative medication reduced the incidence of postoperative vomiting. Parental acceptance of this method of surgery was...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90221-4
更新日期：1975-09-01 00:00:00
abstract：:To study further the transient increase in trabecular cell division within the first two days after laser trabeculoplasty in human corneoscleral explant organ cultures, we used a pulse-chase protocol in which immediately after laser treatment 3H-thymidine was added to the culture medium for 48 hours (the pulse period)...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90805-2
更新日期：1989-01-15 00:00:00
abstract：PURPOSE:To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination with either anterior chamber intraocular lens implantation (ACIOL) or scleral suturing of posterior chamber lens (PCIOL). DESIGN:Retrospective comparative case series. METHODS:All eyes presented with aphakia or lux...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.05.006
更新日期：2016-08-01 00:00:00
abstract：:I fitted nine aphakic patients who had undergone penetrating keratoplasty with extended-wear hydrophilic contact lenses (55% to 80% water content). All patients had edematous host corneas. Eight of nine developed vascularization of the graft after two to 30 weeks of contact lens wear. One patient developed a presumed ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74912-8
更新日期：1980-09-01 00:00:00
abstract：PURPOSE:To evaluate whether quantity of choroidal tissue directly adjacent to the optic nerve differs between eyes with and without glaucoma and whether beta-zone parapapillary atrophy influences this relationship. DESIGN:Prospective cohort study. METHODS:Subjects were enrolled in a longitudinal, observational study ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2015.06.024
更新日期：2015-10-01 00:00:00
abstract：:We have constructed an ophthalmic fixation device that stabilizes an enucleated eye, and helps both in the pathologic examination of the eye and in ophthalmic practice surgery. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74929-3
更新日期：1980-09-01 00:00:00
abstract：:We performed 115 scleral-buckling procedures for primary rhegmatogenous retinal detachments in which the argon endolaser drained subretinal fluid. The laser was set at 0.80 to 1.25 W and 0.5 second; the endolaser probe was held adjacent to, but not touching, the choroid. The procedure was successful in 112 of 115 (97....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73643-8
更新日期：1993-06-15 00:00:00
abstract：:Four patients (three men, 32, 43, and 53 years old, and one 37-year-old woman) with syphilitic neuroretinitis had cerebrospinal fluid evidence of neurosyphilis. Therapy failed in one patient given penicillin G benzathine intramuscularly and it may have failed in a second patient. Another treatment failure occurred in ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90268-4
更新日期：1983-04-01 00:00:00
abstract：PURPOSE:To treat a 30-year-old man with a ventriculoperitoneal shunt who had progressive visual loss. METHODS:The patient underwent computed tomographic and magnetic resonance imaging scans and ocular examination. RESULTS:He was diagnosed with ventriculoperitoneal shunt failure despite the lack of ventriculomegaly on...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71980-4
更新日期：1996-07-01 00:00:00
abstract：PURPOSE:To describe the natural history of Leber congenital amaurosis (LCA) associated with GUCY2D variants (GUCY2D-LCA) in a cohort of children and adults, in preparation for trials of novel therapies. DESIGN:Retrospective case series. METHODS:Participants: Patients with GUCY2D-LCA at a single referral center. PROC...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
abstract：PURPOSE:To report the efficacy and safety of outpatient fluid-gas exchange for open macular hole after primary vitrectomy. DESIGN:Retrospective interventional case series. METHODS:setting: Institutional. patients: Thirty-six patients with primary failed closure or reopened holes after primary vitrectomy. intervention...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.03.031
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To compare the effectiveness of arcuate keratotomy (AK) performed with a femtosecond laser (FSL) or Hanna keratome (Moria, Anthony, France) for correction of postkeratoplasty astigmatism. DESIGN:Prospective, randomized study. METHODS:This clinical study included 20 eyes. Two groups of 10 eyes underwent AK usi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2008.12.017
更新日期：2009-05-01 00:00:00
abstract：:Of two patients with type 5 hyperlipoproteinemia, one exhibited lipemia retinalis with multiple retinal hemorrhages and intraretinal lipid extravasations. Postmortem examination showed hemorrhages in the inner retinal layers and lipid deposits largely in the outer plexiform layer. Lipid within the walls of the retinal...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90661-9
更新日期：1976-07-01 00:00:00
abstract：PURPOSE:To evaluate the importance of nutritional supplements, dietary pattern, and genetic associations in age-related macular degeneration (AMD); and to discuss the technique of artificial intelligence/deep learning to potentially enhance research in detecting and classifying AMD. DESIGN:Retrospective literature rev...
journal_title：American journal of ophthalmology
pub_type：
doi：10.1016/j.ajo.2020.05.042
更新日期：2020-09-01 00:00:00
abstract：:Bleomycin was administered to 126 normal or human-tumor-bearing baby rats we observed for the development of cataracts. Eighty-four percent of the rats receiving this drug before the age of 10 days developed lens opacities. Bleomycin given to 10-day-old rats or older did not induce cataract formation. The cataracts in...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90223-8
更新日期：1975-09-01 00:00:00
abstract：PURPOSE:To detect the prognostic factors associated with initial reattachment after primary pars plana vitrectomy (PPV) with gas tamponade for retinal detachment attributable to macular hole (MHRD). DESIGN:Retrospective, multicenter, interventional case series. METHODS:This study included 49 eyes of 48 patients with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2008.04.022
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To assess quantitatively the cumulative effect of hyperglycemia on lens transparency in patients with juvenile type 1 diabetes mellitus. METHODS:Subjects were 30 patients (30 eyes) with type 1 diabetes mellitus who had well-documented records on the duration of diabetes mellitus and condition of glycemic contr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00804-7
更新日期：2001-03-01 00:00:00
abstract：:Two patients underwent vitrectomy with the use of intraocular gas. In one patient the cornea decompensated because of lens-cornea contact and in the second patient a surgical technique devised to protect the cornea from lens contact was used successfully. The technique consisted of injecting a smaller gas bubble into ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90284-6
更新日期：1980-05-01 00:00:00
abstract：:In several tumors of different organ sites, the amount of DNA in a cell (ploidy) is associated with malignancy. We performed DNA quantitation in 21 choroidal melanomas and compared flow cytometry with image analysis in 11 of these melanomas. We modified our preparation technique to overcome problems with pigment and c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73592-5
更新日期：1993-03-15 00:00:00
