Abstract：
:To study further the transient increase in trabecular cell division within the first two days after laser trabeculoplasty in human corneoscleral explant organ cultures, we used a pulse-chase protocol in which immediately after laser treatment 3H-thymidine was added to the culture medium for 48 hours (the pulse period). Fresh medium without radiolabel was then added for variable times (the chase period) before termination of the experiment. Autoradiography was used to follow changes in the regional distribution of the cells that divided during the pulse period and had 3H-thymidine-labeled DNA. Laser-treated explants, evaluated after a pulse with no chase, showed a fourfold increase in cell division (P less than .001) over nontreated controls. Nearly 60% of this cell division was localized to the anterior, nonfiltering region of the trabecular meshwork where it inserts into the cornea beneath Schwalbe's line. Trabecular cell division in other regions of the meshwork was not increased over controls at this time. After seven or 14 days of chase without radiolabel, the regional distribution of radiolabeled cells changed in laser-treated explants but not in controls. By 14 days, only 26% of the labeled cells remained in this anterior insert region, while 60% were found in the region of the burn sites. Macroautoradiography of whole explants corroborated these observations. Our data support the hypothesis that laser trabeculoplasty causes early cell division by a population of cells in the anterior meshwork; these new cells then migrate and repopulate the burn sites over the next few weeks.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Acott TS,Samples JR,Bradley JM,Bacon DR,Bylsma SS,Van Buskirk EMdoi
10.1016/0002-9394(89)90805-2subject
Has Abstractpub_date
1989-01-15 00:00:00pages
1-6issue
1eissn
0002-9394issn
1879-1891pii
0002-9394(89)90805-2journal_volume
107pub_type
杂志文章abstract：:T-cell and B-cell lymphocyte subpopulations, monocytes, granulocytes, and immunoglobulin receptors were measured with monoclonal antibodies and flow cytometric techniques in the peripheral blood of 266 patients with posterior uveal melanoma before therapy. Statistically significant differences were found in T-helper/i...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90587-8
更新日期：1986-02-15 00:00:00
abstract：PURPOSE:To examine surgical and refractive outcomes of phacoemulsification with intraocular lens (IOL) implant in eyes with prior trabeculectomy. DESIGN:Retrospective observational case-control study. METHODS:The study compared eyes that underwent phacoemulsification with IOL implant at least 3 months post-trabeculec...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.11.023
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:To design and validate a vision-specific quality-of-life assessment tool to be used in a clinical setting to evaluate low-vision rehabilitation strategy and management. METHODS:Previous vision-related questionnaires were assessed by low-vision rehabilitation professionals and patients for relevance and coverag...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00610-3
更新日期：2000-12-01 00:00:00
abstract：PURPOSE/METHODS:We studied a case of crystalline retinopathy occurring after prolonged use of oral canthaxanthin. The patient was followed up for 38 months during which time she sustained a branch retinal vein occlusion in her left eye. RESULTS/CONCLUSIONS:An asymmetric appearance to the crystalline deposition was not...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72791-6
更新日期：1995-06-01 00:00:00
abstract：:Topical ketoconazole (2% ointment three times per day for three weeks) markedly reduced the severity of keratitis produced with Candida albicans inoculation in the right eyes of 20 rabbits. Clinical scores of affected eyes were significantly lower in the treated eyes than in the controls, which consisted of the 20 ino...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90084-x
更新日期：1986-10-15 00:00:00
abstract：:We reviewed the records of 1,323 patients with retinoblastoma treated here between 1922 and 1978. Twenty-eight patients underwent bilateral enucleation alone and received no additional treatment for their advanced tumors. Of the 28 patients, 22 (92%) survived. Four patients were lost to follow-up, and two died of meta...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90293-9
更新日期：1979-05-01 00:00:00
abstract：PURPOSE:To describe the results of strabismus surgery on three patients with chronic progressive external ophthalmoplegia, a group of rare disorders characterized by ptosis and slowly progressive ophthalmoparesis that has been shown to result from defects in mitochondrial DNA. METHODS:Strabismus surgery using the adju...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71041-4
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:To compare the efficacy and visual results of phacoemulsification vs manual sutureless small-incision extracapsular cataract surgery (SICS) for the treatment of cataracts in Nepal. DESIGN:Prospective, randomized comparison of 108 consecutive patients with visually significant cataracts. METHODS:settings: Outr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2006.07.023
更新日期：2007-01-01 00:00:00
abstract：:To establish the enzyme defect in gyrate atrophy, we measured the activity of ornithine aminotransferase in phytohemagglutinin stimulated lymphocytes in a patient with gyrate atrophy, her daughter, and three normal controls. The patient's cells had no detectable ornithine aminotransferase activity and the daughter's c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75948-3
更新日期：1978-02-01 00:00:00
abstract：:One hundred consecutive eyes underwent vitrectomy with the disposable vitrophage via a pars plana approach. Eyes were divided into two main categories based on opacity location-in the anterior or posterior segment. Patients with posterior segment opacities had diabetic retinopathy, nondiabetic vitreous hemorrhages, re...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90239-7
更新日期：1976-03-01 00:00:00
abstract：PURPOSE:To describe a case with bullous keratopathy and anterior segment inflammation associated with heavy liquids. DESIGN:Observational case report. METHODS:Review of clinical and histopathologic changes. RESULTS:A 65-year-old patient underwent a pars plana vitrectomy for a rhegmatogenous retinal detachment. Perfl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.01.034
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:To evaluate management options for acutely symptomatic stage I macular holes, and vitrectomy with intraocular gas tamponade for advanced stage I macular holes. METHODS:Retrospective noncomparative study. SETTING:Clinical practice. STUDY POPULATION:Acutely symptomatic stage I macular holes. MANAGEMENT OPTIONS...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01266-1
更新日期：2002-02-01 00:00:00
abstract：PURPOSE:To report one-year results of the Tube Versus Trabeculectomy (TVT) Study. DESIGN:Multicenter randomized clinical trial. METHODS: SETTING:17 Clinical Centers. STUDY POPULATION:Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and unco...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2006.07.020
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To evaluate performance of optical coherence tomography (OCT) for detection of early glaucoma. DESIGN:Observational case-control study. METHODS: SETTING:University-based tertiary care center. STUDY POPULATION:One eye from 50 normals, 42 glaucoma suspects, and 59 early glaucoma patients meeting the following...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.09.004
更新日期：2004-02-01 00:00:00
abstract：:We used monoclonal antibodies against specific T cell, B cell, and macrophage antigens to detect immune system cells in the vitreous gel of retinitis pigmentosa patients. Vitreous samples were obtained by biopsy from three patients and by dissection from eight postmortem donor eyes. All samples contained CD4, T helper...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90050-5
更新日期：1988-06-15 00:00:00
abstract：:We devised a new binocular indirect ophthalmoscope and a complimentary examination technique that provide enhanced fundus magnification and optimum stereopsis through a wide range of patient pupillary apertures. The lightweight, mechanically simple instrument uses a variable focus Galilean telescopic observation syste...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90182-4
更新日期：1978-11-01 00:00:00
abstract：:We performed serial slit-lamp examinations and topography analysis on a patient whose initial topographic map suggested a diagnosis of keratoconus to us but which others interpreted as normal topography. Topography analysis documented cone progression during a two-year period. The initial map showed a cone apex power ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76210-5
更新日期：1991-07-15 00:00:00
abstract：PURPOSE:To investigate the effect of yellow-tinted intraocular lenses (IOLs) on short-wavelength automated perimetry (SWAP). DESIGN:Cross-sectional observation study. METHODS:Twenty-two patients who had implantation of yellow-tinted IOLs (AcrySof SN60AT or SN60WF; Alcon Laboratories) in 1 eye and nontinted IOLs (Acry...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.02.023
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:To evaluate the rate of peripapillary choroidal thinning in glaucoma patients and healthy controls using spectral domain optical coherence tomography. DESIGN:Cohort study. METHODS:Participants from the multicenter African Descent and Glaucoma Evaluation Study and Diagnostic Innovations in Glaucoma Study were ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2017.10.025
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:compare the results of vitrectomy with or without arteriovenous (AV) crossing sheathotomy for macular edema associated with branch retinal vein occlusion (BRVO). DESIGN:Interventional case series. METHODS:A retrospective study of 36 eyes with BRVO-associated macular edema. Twenty eyes underwent AV sheathotomy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.061
更新日期：2004-12-01 00:00:00
abstract：PURPOSE:To investigate the validity of assigning patients whose eyes have been removed for ciliary body or choroidal melanoma to risk groups for metastasis based on the identification of microcirculatory patterns in one cross-section taken from the center of the tumor. METHODS:Multiple levels were cut through the bloc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00092-0
更新日期：1998-09-01 00:00:00
abstract：:Between 1976 and 1982, we examined 13 patients with clinical and radiographic findings consistent with optic nerve sheath meningioma. All patients had visual loss, evidence of optic nerve dysfunction, centrocecal visual field defects, and echographic and computed tomographic evidence of optic nerve or sheath enlargeme...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90506-9
更新日期：1985-09-15 00:00:00
abstract：PURPOSE:To assess the prevalence of refractive error and vision impairment in school age children in the terai area of the Mechi zone in Eastern Nepal. METHODS:Random selection of village-based clusters was used to identify a sample of children 5 to 15 years of age. Children in the 25 selected clusters were enumerated...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(99)00453-5
更新日期：2000-04-01 00:00:00
abstract：PURPOSE:We investigated whether opsin mislocalization occurs in photoreceptors in a female carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the retinitis pigmentosa GTPase regulator gene (RPGR). DESIGN:Histologic findings in autopsy eyes from a carrier were compared with those from a normal female...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.061
更新日期：2006-09-01 00:00:00
abstract：:We used contact irradiation with iodine 125 seeds to treat a large, exulcerative, nodular, amelanotic malignant eyelid melanoma with metastasis to the regional lymph nodes in an 80-year-old man. The procedure was similar to iodine 125 plaque irradiation of malignant choroidal melanoma; special equipment, however, was ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76936-3
更新日期：1990-07-15 00:00:00
abstract：PURPOSE:Cooling can reduce clinical symptoms and pain caused by traumatic swelling or fracture of extremities. We obtained subjective and objective measures of the effects of cooling of the eyes after cataract surgery. METHODS:Twenty patients with bilateral cataracts were enrolled in this study. For each patient, an i...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71171-7
更新日期：1995-03-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of adjunctive subconjunctival antibiotic injection in the treatment of acute postcataract extraction endophthalmitis. DESIGN:Retrospective cohort study. METHODS:Patients who presented with hand motions or better vision and received subconjunctival antibiotics (SC+ group) were compared...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.12.042
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:To compare race-related differences in estimated rate of change of Bruch's membrane opening-minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) in healthy, glaucoma suspect, and glaucoma eyes of individuals of European (ED) and African descent (AD). DESIGN:Prospective co...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.08.050
更新日期：2018-12-01 00:00:00
abstract：:A prospective study of ophthalmologic findings in 20 African patients with the acquired immunodeficiency syndrome (Group 1) and nine patients with acquired immune deficiency syndrome related complex (Group 2) disclosed that 11 patients in Group 1 and two patients in Group 2 had ocular involvement. Cotton-wool spots, R...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90787-1
更新日期：1985-08-15 00:00:00
abstract：PURPOSE:To show that extending Doppler imaging into the high-frequency domain could allow detection and characterization of blood flow in small arterioles and capillaries. METHODS:A 40-MHz continuous wave Doppler system and a 60-MHz pulsed-wave Doppler system were constructed, tested, and used to examine the ciliary b...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00122-6
更新日期：1998-10-01 00:00:00
