Abstract:
:To establish the enzyme defect in gyrate atrophy, we measured the activity of ornithine aminotransferase in phytohemagglutinin stimulated lymphocytes in a patient with gyrate atrophy, her daughter, and three normal controls. The patient's cells had no detectable ornithine aminotransferase activity and the daughter's cells had 44% of control activity. This intermediate value is characteristic of an obligate heterozygote. These results are the first demonstration of an enzyme defect in gyrate atrophy.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Kaiser-Kupfer MI,Valle D,Del Valle LAdoi
10.1016/s0002-9394(14)75948-3subject
Has Abstractpub_date
1978-02-01 00:00:00pages
200-4issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(14)75948-3journal_volume
85pub_type
杂志文章abstract:PURPOSE:To determine iridocorneal angle changes produced after 2 years of implantable collamer lens (ICL) V4c (STAAR Surgical AG, Nidau, Switzerland) placement by Fourier-domain optical coherence tomography (FD-OCT). DESIGN:Prospective interventional case series. METHODS:In 54 eyes of 27 myopic subjects FD-OCT iridoc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2017.06.018
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To report the occurrence of transient formed visual hallucinations following macular translocation. METHODS:Two case reports. RESULTS:Two white women aged 84 and 83 years with bilateral age-related macular degeneration and unilateral subfoveal choroidal neovascularization underwent macular translocation with ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00934-x
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:We sought to analyze the incidence and risk of noninfectious uveitis (NIU) among postdelivery women with a history of pre-eclampsia/eclampsia (PEE). DESIGN:Population-based retrospective matched cohort study. METHODS:All participant data were retrieved from the Longitudinal Health Insurance Database 2005. Two...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.10.009
更新日期:2019-02-01 00:00:00
abstract::Standard retinal function tests are of limited value in assessing retinal function in eyes with opaque vitreous. We developed a method for obtaining an electroretinogram (ERG) from eyes with significant vitreous opacity by utilizing a much brighter than normal stimulating light. Of 115 eyes with vitreous opacities and...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90135-x
更新日期:1975-08-01 00:00:00
abstract:PURPOSE:To evaluate the safety of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage. DESIGN:Two prospective, randomized, placebo-controlled, double-masked studies. Pooled efficacy data are presented in a companion article in this issue of The Journal. METHODS:Subjects with vitreous hemorrhag...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2005.06.022
更新日期:2005-10-01 00:00:00
abstract::Ultrashort, Q-switched or mode-locked, neodymium-YAG laser pulses focused within 2 mm of the retina caused reproducible retinal damage in four eyes of two monkeys and in four eyes of three rabbits. The distance of the laser focus from the retina for clinically observed threshold retinal damage was characterized for pu...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77782-7
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:To measure lead and cadmium in retinal tissues of human donor eyes with and without age-related macular degeneration (AMD). DESIGN:Laboratory investigation. METHODS:Lead and cadmium concentrations in retinal tissues (neural retina and retinal pigment epithelium [RPE]-choroid complex) in 25 subjects with AMD (...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.07.001
更新日期:2009-12-01 00:00:00
abstract::A 35-year-old woman with Engelmann's disease and systemic lupus erythematosus developed spontaneous luxation of the globe and glaucoma. Radiological studies demonstrated increased sclerosis of the orbital bones and decreased orbital volumes, the probable cause of the luxation and the glaucoma. The glaucoma was control...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(77)90917-5
更新日期:1977-06-01 00:00:00
abstract:PURPOSE:To evaluate the safety and potential efficacy of gevokizumab, an anti-interleukin 1β (IL-1β) monoclonal antibody, in the treatment of active, noninfectious, non-necrotizing anterior scleritis. DESIGN:Phase 1/2, open label, nonrandomized, prospective, single-arm pilot trial. METHODS:Eight patients with active,...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ajo.2016.09.017
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To evaluate the long-term safety and efficacy, in a large series of patients, of polyacrylic intraocular lens implants 1 and 3 years after surgery, compared with polymethylmethacrylate intraocular lens implants. METHODS:This was a randomized, prospective study of 1,514 eyes of 1,202 patients that were examined...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-9394(00)00490-6
更新日期:2000-09-01 00:00:00
abstract:PURPOSE:To report molluscum contagiosum as the initial manifestation in acquired immunodeficiency syndrome (AIDS). METHOD:Case report. A 34-year-old man was examined with atypical, extensive molluscum contagiosum of the eyelids. RESULTS:Biopsy of the lesions confirmed molluscum contagiosum, and a previously normal fu...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70791-3
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between subjective symptoms and clinical signs in dry eye disease (DED) in office workers using visual display terminals (VDTs). DESIGN:Cross-sectional study. METHODS:This study involved 672 Japanese young and middle-aged office workers who use VDTs. The subjects completed questio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.12.019
更新日期:2015-04-01 00:00:00
abstract::We obtained serial electroretinograms in four patients aged between 6 months and 5 years with Alström's syndrome and studied the early stages of the severe retinopathy that is characteristic of that disease. The weak electroretinographic signals found at age 6 months demonstrate a severe early cone dysfunction; one ye...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71466-7
更新日期:1993-05-15 00:00:00
abstract:PURPOSE:To determine the long-term outcome of glaucoma filtration surgery in preserving vision. Visual loss from progressive glaucomatous damage and from complications of surgery, both short and long term, were included. METHODS:A retrospective, community-based, longitudinal study of residents of Olmsted County, Minne...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)00923-0
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To evaluate the effectiveness of an orbital tissue expander designed to stimulate orbital bone growth in an anophthalmic socket. DESIGN:Retrospective, noncomparative, interventional case series. METHODS: SETTINGS:Institutional. STUDY POPULATION:Nine consecutive patients with unilateral congenital anophthalm...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.09.009
更新日期:2011-03-01 00:00:00
abstract::Twenty-six eyes of 25 patients with chronic open-angle glaucoma and surgical aphakia with inadequate control of intraocular pressure (IOP) despite maximal medical treatment were treated with cyclocryotherapy, according to a prospective protocol and specific technique. (Neovascular and synechial glaucoma were excluded ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77093-x
更新日期:1978-05-01 00:00:00
abstract:PURPOSE:To report a case of extensive cephalic and basilic venous thrombosis after fluorescein angiography. DESIGN:Interventional case report. METHODS:A 38-year-old Chinese male presented with blurring of vision in his left eye. Clinical examination revealed central serous retinopathy, and a routine fluorescein angio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.10.058
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To evaluate visual and optical quality of the implantable collamer lens for different powers and sizes of incision surgery. DESIGN:Prospective study in humans. METHODS:An adaptive optics visual simulator was used to measure 3 powers of implantable collamer lenses and simulate the implantable collamer lens wav...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.09.031
更新日期:2013-03-01 00:00:00
abstract::We studied the clinical and microscopic appearances of the optic nerve head in squirrel monkeys with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaini...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(77)90138-6
更新日期:1977-05-01 00:00:00
abstract:PURPOSE:To report an HIV-negative lymphoma patient who developed progressive outer retinal necrosis syndrome and who had a good visual outcome after treatment with two-drug antiviral therapy and intravenous immunoglobulin. METHODS:Case report. RESULTS:A 43-year-old man with small lymphocytic lymphoma was diagnosed wi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00951-x
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To evaluate optical coherence tomography in allergy-prone uveitis patients. METHODS:Thirty-four patients (43 eyes) with posterior uveitis (31 eyes) and intermediate uveitis (12 eyes) were evaluated by fluorescein angiography, indocyanine green angiography, and optical coherence tomography. Follow-up examinatio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00586-9
更新日期:2000-11-01 00:00:00
abstract::Forty-three patients who initially presented with Krikenberg's spindles but with no glaucomatous field defects were observed for an average of 5.8 years in an attempt to evaluate the prognostic implication of spindle presence. Twenty-two of the patients had been followed for a minimum of five years. Analysis of the st...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90075-6
更新日期:1975-02-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of transconjunctival Müller muscle recession and graded levator disinsertion for eyelid retraction in patients with thyroid-related orbitopathy (TRO). DESIGN:Retrospective consecutive case series. METHODS:Medical record review of 78 TRO patients (107 eyelids) who underwent surgery for...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.02.034
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To compare the effects of extracapsular cataract extraction with posterior chamber intraocular lens (ECCE/PC-IOL) vs intracapsular cataract extraction with aphakic glasses (ICCE-AG) on everyday visual functioning and quality of life. METHODS:In a nonmasked randomized controlled clinical trial, 3,400 bilateral ...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-9394(99)80231-1
更新日期:1998-01-01 00:00:00
abstract::Seventeen patients (ten women and seven men, 23 to 72 years old) with stromal herpetic disease were treated with topical and oral acyclovir for 14 days. Of the 12 patients with disciform edema, five showed minimal improvement, four showed no change, and three showed worsening of their disease. Of the five patients wit...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(84)90237-x
更新日期:1984-11-01 00:00:00
abstract::Of 76 members of a large pedigree with familial aniridia, 61% of the 38 affected patients had visual acuity of 6/9 (20/30) or better and only 5% had acuity of 6/60 (20/200) or worse. Cataracts were present in 18% of affected patients; glaucoma in 13%; and strabismus in 34%. Sixteen percent of affected patients had str...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(77)90139-8
更新日期:1977-05-01 00:00:00
abstract::We studied 20 patients with Vogt-Koyanagi-Harada syndrome. They represented 3.7% of referred patients with uveitis. American Indian ancestry appears to be the link to Oriental racial type. Five patients had a forme fruste retinal detachment. After extensive treatment with corticosteroids, detachments flattened within ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract:PURPOSE:To investigate the validity of assigning patients whose eyes have been removed for ciliary body or choroidal melanoma to risk groups for metastasis based on the identification of microcirculatory patterns in one cross-section taken from the center of the tumor. METHODS:Multiple levels were cut through the bloc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00092-0
更新日期:1998-09-01 00:00:00
abstract::We evaluated whether the rate of occurrence of glaucomatous disk damage in eyes with an optic disk hemorrhage differed from the rate of occurrence in control eyes. We compared 24 patients with a disk hemorrhage to 24 control patients, who had been matched for diagnosis, disk appearance, and visual fields. Cup volume a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74272-2
更新日期:1987-04-15 00:00:00
abstract:PURPOSE:To investigate whether the statin class of drugs reduces the risk of cataract extraction. DESIGN:Case-control study. METHOD:setting: Kaiser Permanente Southern California, which provides prepaid healthcare for 3.2 million residents by 6000 physicians. patient population: Eligible patients were those who had 5...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.08.001
更新日期:2012-02-01 00:00:00