Abstract：
:We obtained serial electroretinograms in four patients aged between 6 months and 5 years with Alström's syndrome and studied the early stages of the severe retinopathy that is characteristic of that disease. The weak electroretinographic signals found at age 6 months demonstrate a severe early cone dysfunction; one year later the cone activity is undetectable. The rod component of the electroretinogram is initially normal but can rapidly deteriorate to become undetectable as early as 5 years of age. These unusual electroretinographic findings are pathognomonic of Alström's syndrome and different from other cone-rod dystrophies or other syndromes with similar phenotypes such as Bardet-Biedl, Laurence-Moon, and Cohen syndromes.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Tremblay F,LaRoche RG,Shea SE,Ludman MDdoi
10.1016/s0002-9394(14)71466-7subject
Has Abstractpub_date
1993-05-15 00:00:00pages
657-65issue
5eissn
0002-9394issn
1879-1891pii
S0002-9394(14)71466-7journal_volume
115pub_type
杂志文章abstract：:We performed 115 scleral-buckling procedures for primary rhegmatogenous retinal detachments in which the argon endolaser drained subretinal fluid. The laser was set at 0.80 to 1.25 W and 0.5 second; the endolaser probe was held adjacent to, but not touching, the choroid. The procedure was successful in 112 of 115 (97....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73643-8
更新日期：1993-06-15 00:00:00
abstract：PURPOSE:To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT). DESIGN:Prospective, observational case series. METHODS:Thirty-nine full-term newborn infants underwent dilated retinal examinations by indirect ophthalmoscopy and retinal imaging ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.06.017
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:We performed a histopathologic and immunohistologic study to determine the macromolecular and cellular components of subfoveal neovascular membranes removed at the time of submacular surgery. METHODS:Subfoveal neovascular membranes were surgically removed from ten patients (seven with age-related macular degen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72158-0
更新日期：1995-09-01 00:00:00
abstract：:We studied the in vivo measurements of the autofluorescence of the clear lens in 80 juvenile diabetics and 25 young healthy subjects. When the diabetes was of seven years' duration or more, no overlap with the control subjects was found. The pathologic autofluorescence of the diabetic lens showed a positive correlatio...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:We evaluated the reliability of optic disk area and disk rim area measurements obtained with the Humphrey Retinal Analyzer from ten repeat fundus images each of one eye of ten normal subjects and ten subjects with increased intraocular pressure. Variability of rim and disk areas was not significantly different between...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73309-4
更新日期：1989-10-15 00:00:00
abstract：:To determine current practices in the management of ocular toxoplasmosis, 72 of 85 uveitis specialists (85%) in the American Uveitis Society completed a detailed questionnaire. Questions involved the indications for beginning treatment, choice of antiparasitic/antimicrobial agents, and experience with treatment of ocu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73706-7
更新日期：1991-05-15 00:00:00
abstract：PURPOSE:To evaluate the importance of nutritional supplements, dietary pattern, and genetic associations in age-related macular degeneration (AMD); and to discuss the technique of artificial intelligence/deep learning to potentially enhance research in detecting and classifying AMD. DESIGN:Retrospective literature rev...
journal_title：American journal of ophthalmology
pub_type：
doi：10.1016/j.ajo.2020.05.042
更新日期：2020-09-01 00:00:00
abstract：:In 98 patients, 112 eyes with chronic closed-angle or combined glaucoma were operated on using filtering iridocycloretraction, including preparation of two limbal-based scleral strips that were introduced through scleral incisions into the anterior chamber and the supraciliary space. The intraocular pressure was contr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90366-6
更新日期：1985-03-15 00:00:00
abstract：PURPOSE:To report a case of chronic unilateral ptosis in a 63-year-old, otherwise healthy woman with visual restriction. METHODS:We performed a biopsy on an enlarged tarsal plate that we believed had caused ptosis. A levator aponeurotic advancement was performed subsequently. RESULTS:Histologic and ultrastructural ex...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71145-6
更新日期：1997-06-01 00:00:00
abstract：:Surgical recession of the inferior oblique muscle is simpler to perform if the inferior rectus muscle, rather than either the lateral rectus muscle or the inferior oblique muscle insertion, is used as a landmark. We measured 200 consecutive autopsy eyes to determine the distance from the commonly used 8-mm recession s...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76672-3
更新日期：1978-01-01 00:00:00
abstract：PURPOSE:Report incidence and risk of retinal detachment (RD)after coaxial phacoemulsification in high myopic patients. DESIGN:Retrospective consecutive interventional study. METHODS: SETTING:Vissum-Instituto Oftalmologico de Alicante, Spain. PATIENT OR STUDY POPULATION: A total of 439 eyes from 274 high myopic patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.03.043
更新日期：2007-07-01 00:00:00
abstract：:We studied the clinical and microscopic appearances of the optic nerve head in squirrel monkeys with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaini...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90138-6
更新日期：1977-05-01 00:00:00
abstract：PURPOSE:To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses. DESIGN:Retrospective, observational chart review. METHODS:Scans of 184 healthy and diseased eyes from 106 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.11.019
更新日期：2009-05-01 00:00:00
abstract：:Antibiotics in a corneal preservation solution probably have little effect during storage at 4 C, but are effective as the tissue is warmed. The tissue acts as a sponge, soaking up the antibiotic from the solution and releasing it into the eye, where the bactericidal effect is achieved. Currently, high concentrations ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74729-4
更新日期：1992-05-15 00:00:00
abstract：PURPOSE:To compare the accuracy and speed of using the computerized MatchedFlicker software program (EyeIC Inc, Narberth, Pennsylvania, USA) to evaluate glaucomatous optic disc change against the traditional gold standard of manually examining stereoscopic disc photographs. DESIGN:A prospective evaluation of diagnosti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.03.031
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:Congenital macular lesions attributed to toxoplasmosis may limit potential visual acuity. The appearance and location of these scars may cause physicians to overlook associated amblyopia. This study reviews the visual outcomes and benefits of amblyopia therapy in children with foveal toxoplasmosis scars. DESIG...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.01.034
更新日期：2020-06-01 00:00:00
abstract：:To determine the hereditary pattern of acute anterior uveitis, we examined seven families-one family with four cases, one family with three cases, and four families with two cases of acute anterior uveitis. A total of 16 patients with uveitis and 28 relatives underwent ocular examinations and serologic determination o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90003-9
更新日期：1981-06-01 00:00:00
abstract：:Multiple endocrine neoplasia type 2b is a syndrome, often familial, characterized by medullary carcinoma of the thyroid gland, pheochromocytoma, and many mucosal neuromas in patients who frequently have a marfanoid habitus. The ophthalmic findings are distinctive and include conjunctival and eyelid neuromas, keratocon...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90349-4
更新日期：1981-01-01 00:00:00
abstract：PURPOSE:To describe a simplified new technique for repositioning and attaching a suture to the haptic of a displaced posterior chamber intraocular lens (IOL). METHODS:We describe a double-knot technique for repositioning and transscleral suture fixation of a subluxed posterior chamber IOL after penetrating keratoplast...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00244-5
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:To observe longitudinal changes in the corneal endothelium after pediatric cataract surgery with intraocular lens implantation. DESIGN:Prospective, longitudinal study. METHODS:settings: Iladevi Cataract and IOL Research Centre, Ahmedabad, India. study population: This study included 100 pediatric eyes undergo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.02.018
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:To describe a group of patients with dense visual field defects following macular hole surgery. METHODS:Nine (7%) of 125 patients reviewed noted onset of dense visual field defects following uncomplicated vitrectomy with gas-fluid exchange for the treatment of macular hole. Patient records were reviewed to inv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72064-1
更新日期：1996-09-01 00:00:00
abstract：PURPOSE:To investigate changes in anterior chamber angle configuration with indentation ultrasound biomicroscopy gonioscopy of relative pupillary block (RPB). DESIGN:Cross-sectional study. METHODS:This study included 26 eyes of 26 patients with RPB. We determined angle opening distance 500 and angle recess area using...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.08.048
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:To report a neovascular age-related macular degeneration pattern refractory to ranibizumab. DESIGN:Retrospective, observational case series. METHODS:Between March and May 2009, cases with neovascular age-related macular degeneration refractory to ranibizumab were investigated with indocyanine green angiograph...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.05.035
更新日期：2010-11-01 00:00:00
abstract：:We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)75247-x
更新日期：1978-04-01 00:00:00
abstract：PURPOSE:Epiretinal membranes (ERMs) in highly myopic eyes may result in macular holes and subsequent retinal detachment. However, removing friable, thin ERMs from detached retinas is often difficult. We report the efficacy of a diamond-dusted silicone cannula in the removal of ERMs from detached retinas. METHODS:Seven...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-9394(98)00180-9
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:To report one surgeon's experiences with bilateral lateral rectus resections in dysthyroid ophthalmopathy patients with residual esotropia after initial bilateral medial rectus recession. DESIGN:Retrospective interventional case series evaluating outcomes. METHODS:Medical records for patients with dysthyroid ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.08.029
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:We studied the incidence of vitreous hemorrhage in a well-defined population to determine the underlying causes of such hemorrhages. METHODS:We prospectively studied all eyes with dense spontaneous first-time vitreous hemorrhage during a 2 1/2-year period in the greater Göteborg area (542,000 inhabitants). Fol...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71232-2
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:Although the association of cystoid macular edema with peripheral choroidal melanoma has been studied previously, the pathogenesis of cystoid macular edema as evaluated by light and electron microscopy remains controversial. We evaluated the cause of cystoid macular edema at the retinal capillary level. METHOD...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73867-x
更新日期：1995-02-01 00:00:00
abstract：PURPOSE:To report a case of congenital superior oblique palsy with an unusually large Bielschowsky head-tilt phenomenon (BHP) and disproportional inconspicuous vertical deviation. METHODS:Case report. RESULTS:An 18-year-old woman presented with slight compensatory head tilting and a Bielschowsky head-tilt phenomenon ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00639-5
更新日期：2000-12-01 00:00:00
abstract：:A patient who used contact lenses and had a history of blunt trauma developed vaccinia keratouveitis after accidental ocular autoinoculation from a recent vaccination site. Corneal and conjunctival cultures were taken for bacteria, fungi, Acanthamoeba, and viruses. Viral-like cytopathic effects became evident in tissu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70008-x
更新日期：1994-04-15 00:00:00
